LOCUS       NM_019348               2103 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus somatostatin receptor 2 (Sstr2), mRNA.
ACCESSION   NM_019348
VERSION     NM_019348.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Gaskins,D.L., Burke,A.R., Sajdyk,T.J., Truitt,W.A., Dietrich,A.D.
            and Shekhar,A.
  TITLE     Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat
            Model of Chronic Anxiety
  JOURNAL   Neuroscience 477, 40-49 (2021)
   PUBMED   34487822
  REMARK    GeneRIF: Role of Basolateral Amygdalar Somatostatin 2 Receptors in
            a Rat Model of Chronic Anxiety.
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Jo,H., Park,Y., Kim,J., Kwon,H., Kim,T., Lee,J., Pyun,J.C., Lee,M.
            and Yun,M.
  TITLE     Elevated miR-16-5p induces somatostatin receptor 2 expression in
            neuroendocrine tumor cells
  JOURNAL   PLoS One 15 (10), e0240107 (2020)
   PUBMED   33045023
  REMARK    GeneRIF: Elevated miR-16-5p induces somatostatin receptor 2
            expression in neuroendocrine tumor cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Ishida,A., Tajima,Y., Okabe,Y., Matsushita,T., Sekiguchi,T.,
            Imaide,S., Nomura,Y., Tanaka,M., Nojima,S., Yoshida,A., Iyoda,Y.,
            Aoki,S., Nishio,T., Komagata,T., Iwaki,M., Shono,T., Naganawa,A.
            and Imagawa,A.
  TITLE     Discovery and SAR Studies of Orally Active Somatostatin Receptor
            Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly
  JOURNAL   ACS Chem Neurosci 11 (10), 1482-1494 (2020)
   PUBMED   32315148
  REMARK    GeneRIF: Discovery and SAR Studies of Orally Active Somatostatin
            Receptor Subtype-2 (SSTR2) Agonists for the Treatment of
            Acromegaly.
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Sugimoto,A., Tsuchida,H., Ieda,N., Ikegami,K., Inoue,N.,
            Uenoyama,Y. and Tsukamura,H.
  TITLE     Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse
            Suppression in Lactating Rats
  JOURNAL   Endocrinology 160 (2), 473-483 (2019)
   PUBMED   30544226
  REMARK    GeneRIF: suckling-induced activation of SST-SSTR2 signaling
            mediates, at least in part, the suppression of pulsatile LH
            secretion during lactation
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Memmert,S., Damanaki,A., Nokhbehsaim,M., Nogueira,A.V.B., Eick,S.,
            Cirelli,J.A., Jager,A. and Deschner,J.
  TITLE     Regulation of somatostatin receptor 2 by proinflammatory, microbial
            and obesity-related signals in periodontal cells and tissues
  JOURNAL   Head Face Med 15 (1), 2 (2019)
   PUBMED   30609928
  REMARK    GeneRIF: study suggests that SSTR2 might play a critical role in
            the aetiopathogenesis of periodontitis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Bruno,J.F., Xu,Y., Song,J. and Berelowitz,M.
  TITLE     Pituitary and hypothalamic somatostatin receptor subtype messenger
            ribonucleic acid expression in the food-deprived and diabetic rat
  JOURNAL   Endocrinology 135 (5), 1787-1792 (1994)
   PUBMED   7956902
REFERENCE   7  (bases 1 to 2103)
  AUTHORS   Fitzpatrick,V.D. and Vandlen,R.L.
  TITLE     6agonist selectivity determinants in somatostatin receptor subtypes
            I and II
  JOURNAL   J Biol Chem 269 (40), 24621-24626 (1994)
   PUBMED   7929134
REFERENCE   8  (bases 1 to 2103)
  AUTHORS   Kluxen,F.W., Bruns,C. and Lubbert,H.
  TITLE     Expression cloning of a rat brain somatostatin receptor cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4618-4622 (1992)
   PUBMED   1374909
REFERENCE   9  (bases 1 to 2103)
  AUTHORS   Hulmes,J.D., Corbett,M., Zysk,J.R., Bohlen,P. and Eppler,C.M.
  TITLE     Partial amino acid sequence of a somatostatin receptor isolated
            from GH4C1 pituitary cells
  JOURNAL   Biochem Biophys Res Commun 184 (1), 131-136 (1992)
   PUBMED   1348934
REFERENCE   10 (bases 1 to 2103)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96817.1, M93273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000010.1  99163353-99163631
            280-2103            JAXUCZ010000010.1  99168696-99170519
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2103
                     /gene="Sstr2"
                     /gene_synonym="Smstr2"
                     /note="somatostatin receptor 2"
                     /db_xref="GeneID:54305"
                     /db_xref="RGD:3763"
     exon            1..279
                     /gene="Sstr2"
                     /gene_synonym="Smstr2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..2103
                     /gene="Sstr2"
                     /gene_synonym="Smstr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1478
                     /gene="Sstr2"
                     /gene_synonym="Smstr2"
                     /note="SS2R; SRIF-1; SS2-R; SS-2-R; somatotropin
                     release-inhibiting factor receptor; somatostatin receptor
                     subtype 2"
                     /codon_start=1
                     /product="somatostatin receptor type 2"
                     /protein_id="NP_062221.1"
                     /db_xref="GeneID:54305"
                     /db_xref="RGD:3763"
                     /translation="MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNA
                     VLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQ
                     VALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAK
                     MINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFL
                     VPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFN
                     VSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSG
                     AEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI"
ORIGIN      
        1 gccaccggca cgctggcgag gccaccggcc cctggagcac cagtccgccg ctgggcgtcg
       61 atgatctaca ggccagggta gctctaccgg ggcccacgca agctctctca gacgccagga
      121 gggccagcac gagccagact gggaagctgc gagcccgaga gctactgcgg agcgccaaac
      181 accccctaaa cctgctgcgc tcccgggcgc ccggctgggt aaaggacagc ttctgggagc
      241 tagagaacac agagaagcga gtgctcgtgg aaaagcaaga tgtcacgata gacccttggc
      301 cccagagtcc actgaggtga gaggaagatc tctgggctgc ttggttctag gcggactgaa
      361 gagcagccat ggagttgacc tctgagcagt tcaatgggag ccaagtgtgg ataccttctc
      421 cctttgacct caacggctca ctggggccaa gcaatggctc caaccagaca gagccatact
      481 acgacatgac aagcaacgcg gtcctcacgt tcatctactt cgtggtgtgc gtggtggggc
      541 tgtgcggcaa cacgctcgtc atctacgtca tcctccgcta cgccaagatg aaaaccatca
      601 ccaacattta catcctcaac ctggccatcg cagatgaact cttcatgctg gggctgccct
      661 tcttggccat gcaggtggcg ctggtccact ggccttttgg caaggccatc tgccgggtgg
      721 tcatgactgt ggacggtatc aaccagttca ccagtatctt ctgcttgacg gtcatgagca
      781 tcgaccgtta cctggccgtg gtccacccca ttaagtcagc caaatggagg cgaccccgga
      841 cagccaagat gatcaacgtg gctgtgtggg gtgtgtccct gcttgtcatt ttgcccatca
      901 tgatatacgc tggcctccgg agcaaccagt ggggtaggag cagctgcacc atcaactggc
      961 cgggcgaatc cggggcatgg tacacgggtt tcattatcta tgccttcatc ctggggttcc
     1021 tggtacccct aaccatcatc tgtctctgct acctgttcat catcatcaag gtgaagtcct
     1081 ctgggatccg agtggggtcg tccaagagga aaaagtcaga gaaaaaggtg acccgaatgg
     1141 tatccatcgt ggtggctgtc ttcatcttct gctggctccc cttctatatc ttcaatgtct
     1201 cgtccgtgtc tgtggccatc agccccaccc ctgccctgaa aggcatgttt gactttgtgg
     1261 ttatcctcac ctacgccaac agctgcgcca accccatcct gtacgccttc ttgtccgaca
     1321 acttcaagaa gagcttccag aatgttcttt gcttggtcaa ggtgagtggt gcggaggatg
     1381 gggagcggag cgacagtaag caggacaaat cccggctgaa tgagaccacg gagacccaga
     1441 ggaccctcct caatggagac ctccaaacca gtatctgaaa caacccggga acgcaacgtg
     1501 cacacgcact agccaagccc cgcctcctgg cagtgcgagc cccattcacc cgcttcctgc
     1561 ctcccctacc catcacaccc ggcttttcta gagcagagcg ggatttgagt ctggcttgtc
     1621 cgaaagtata cccctctggt cacatctacc cctaaagtga acgttttcgt gcaggcagac
     1681 aattcaaaga ctggagaaga ggacacgatg gcctgggtgt gacccggtgg aaagcagcta
     1741 cccggcagaa accggaaaaa ccaaaactaa aatcaaagtt ccgcgcgtgt acgtgtgctt
     1801 gcccgctatg taatctcgtg atctgatatt tccgtttgta catcacctcc ccacccccac
     1861 cccggtctct gcggagccag tatacacgtg tcctgtgttt gtaaacccaa gtagctagtt
     1921 catgtgcgtc tagtataggt ggacatttac cacagcgctg aacctgacga caaggactca
     1981 ccatgtcaga gtcaatctaa tctaagcttc cagcatccct cttgcatggg cctttcccag
     2041 acccaggagg agcatgagca gtatgttcat ataataatac atttttgtaa aaagaaaaaa
     2101 aaa
//
