LOCUS       NM_012719               3906 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus somatostatin receptor 1 (Sstr1), mRNA.
ACCESSION   NM_012719 XM_346770
VERSION     NM_012719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3906)
  AUTHORS   Bai,J., Liu,X., Le Goff,L., Gargala,G., Francois,A., Ballet,J.J.,
            Ducrotte,P., Favennec,L. and Towledahong,L.
  TITLE     Octreotide modulates the expression of somatostatin receptor
            subtypes in inflamed rat jejunum induced by Cryptosporidium parvum
  JOURNAL   PLoS One 13 (3), e0194058 (2018)
   PUBMED   29522573
  REMARK    GeneRIF: In the jejunums of Cryptosporidium-parvum-infected rats,
            daily octreotide therapy decreased mRNA levels of SSTR1 on day 14
            post-infection, although it increased mRNA levels of SSTR1 on day
            50 post-infection. Specific SSTRs may regulate the inflammatory
            pathway in the rat intestinal inflammation model.
            Erratum:[PLoS One. 2018 May 24;13(5):e0198377. doi:
            10.1371/journal.pone.0198377.. PMID: 29795701]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3906)
  AUTHORS   Ludvigsen,E., Carlsson,C., Tiensuu Janson,E., Sandler,S. and
            Stridsberg,M.
  TITLE     Somatostatin receptor 1-5; expression profiles during rat
            development
  JOURNAL   Ups J Med Sci 120 (3), 157-168 (2015)
   PUBMED   25926390
  REMARK    GeneRIF: All SSTR1-5 proteins were observed at embryonal day 10 and
            increased with time in major structures, but the localization
            varied between the different subtypes. Only SSTR1 protein
            co-localized to a higher extent with the islet hormones studied.
REFERENCE   3  (bases 1 to 3906)
  AUTHORS   Parks,G.S., Wang,L., Wang,Z. and Civelli,O.
  TITLE     Identification of neuropeptide receptors expressed by
            melanin-concentrating hormone neurons
  JOURNAL   J Comp Neurol 522 (17), 3817-3833 (2014)
   PUBMED   24978951
  REMARK    GeneRIF: This study demonistrated that sstr1 and
            Melanin-concentrating hormone colization in neuron in the lateral
            hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely
            expressed throughout the brain.
REFERENCE   4  (bases 1 to 3906)
  AUTHORS   Yuan,D., Shen,J., Yan,Y., Wu,X., Li,A., Guo,A., Wu,Y., Duan,C.,
            Shen,J., Tang,C., Zhang,D. and Ji,Y.
  TITLE     Upregulated expression of SSTR1 is involved in neuronal apoptosis
            and is coupled to the reduction of bcl-2 following intracerebral
            hemorrhage in adult rats
  JOURNAL   Cell Mol Neurobiol 34 (7), 951-961 (2014)
   PUBMED   25035058
  REMARK    GeneRIF: up-regulated SSTR1 contributed to neuronal apoptosis after
            intracerebral hemorrhage, which was accompanied with reduced
            expression of bcl-2.
REFERENCE   5  (bases 1 to 3906)
  AUTHORS   Gahete,M.D., Duran-Prado,M., Delgado-Niebla,E., Garrido,J.J.,
            Rhodes,S.J., Garcia-Navarro,S., Gracia-Navarro,F., Malagon,M.M.,
            Luque,R.M. and Castano,J.P.
  TITLE     Porcine sst1 can physically interact with other somatostatin
            receptors, and its expression is regulated by
            metabolic/inflammatory sensors
  JOURNAL   Am J Physiol Endocrinol Metab 306 (5), E483-E493 (2014)
   PUBMED   24368669
REFERENCE   6  (bases 1 to 3906)
  AUTHORS   Bruno,J.F., Xu,Y., Song,J. and Berelowitz,M.
  TITLE     Pituitary and hypothalamic somatostatin receptor subtype messenger
            ribonucleic acid expression in the food-deprived and diabetic rat
  JOURNAL   Endocrinology 135 (5), 1787-1792 (1994)
   PUBMED   7956902
REFERENCE   7  (bases 1 to 3906)
  AUTHORS   Fitzpatrick,V.D. and Vandlen,R.L.
  TITLE     6agonist selectivity determinants in somatostatin receptor subtypes
            I and II
  JOURNAL   J Biol Chem 269 (40), 24621-24626 (1994)
   PUBMED   7929134
REFERENCE   8  (bases 1 to 3906)
  AUTHORS   Li,X.J., Forte,M., North,R.A., Ross,C.A. and Snyder,S.H.
  TITLE     Cloning and expression of a rat somatostatin receptor enriched in
            brain
  JOURNAL   J Biol Chem 267 (30), 21307-21312 (1992)
   PUBMED   1400442
REFERENCE   9  (bases 1 to 3906)
  AUTHORS   Yamada,Y., Post,S.R., Wang,K., Tager,H.S., Bell,G.I. and Seino,S.
  TITLE     Cloning and functional characterization of a family of human and
            mouse somatostatin receptors expressed in brain, gastrointestinal
            tract, and kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 251-255 (1992)
   PUBMED   1346068
REFERENCE   10 (bases 1 to 3906)
  AUTHORS   Meyerhof,W., Paust,H.J., Schonrock,C. and Richter,D.
  TITLE     Cloning of a cDNA encoding a novel putative G-protein-coupled
            receptor expressed in specific rat brain regions
  JOURNAL   DNA Cell Biol 10 (9), 689-694 (1991)
   PUBMED   1661599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 16, 2013 this sequence version replaced NM_012719.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The exon structure and extent of
            this transcript is supported by orthologous data from mouse
            transcripts (NM_009216.3 and BY236756.1; GID 20605).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840106,
                              SAMN12840129 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000006.1  81567483-81567589
            108-3906            JAXUCZ010000006.1  81567957-81571755
FEATURES             Location/Qualifiers
     source          1..3906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..3906
                     /gene="Sstr1"
                     /gene_synonym="Gpcrrna"
                     /note="somatostatin receptor 1"
                     /db_xref="GeneID:25033"
                     /db_xref="RGD:3762"
     exon            1..107
                     /gene="Sstr1"
                     /gene_synonym="Gpcrrna"
                     /inference="alignment:Splign:2.1.0"
     exon            108..3906
                     /gene="Sstr1"
                     /gene_synonym="Gpcrrna"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1638
                     /gene="Sstr1"
                     /gene_synonym="Gpcrrna"
                     /note="SS1R; SRIF-2; SS1-R; SS-1-R; Somatostatin receptor
                     subtype 1; RNGPCRRNA"
                     /codon_start=1
                     /product="somatostatin receptor type 1"
                     /protein_id="NP_036851.1"
                     /db_xref="GeneID:25033"
                     /db_xref="RGD:3762"
                     /translation="MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRN
                     SSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAI
                     ADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVV
                     HPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQR
                     WLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMV
                     VMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSF
                     QRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL"
ORIGIN      
        1 agacctcaca agcactttgc aagggccatc tggagacatc gatttaggga cccgacgacc
       61 tgaaatctcc aggtacagtt ttgaagaact ggcaagcagg aaaggagctg ctgacgcgat
      121 ggtgctgctt attaatcatt catcagtcca gagcctttcc acttaatgga tatgtcgcgc
      181 tgggctctag cctcttgacc tctcctctcc tcttctttcc acgctccagt gtatccagga
      241 cccccagagc tgcaagagac agcgctcaag caagcagccg ccgggcgttg cgccagacgg
      301 cctcagttgg agccgcgctc gccacagctg ctgcgcgctg ccgggaggcg ccaggcgccg
      361 gtgagctgtg agcttggagc cttgagccta gggagggcgc aggcagcaag ggcgcaaggt
      421 gagcgtccca accggcggcc acaccggccc acttcagctg ggatgttccc caatggcacc
      481 gccccctctc ccacctcttc tcccagctcc agcccaggcg gctgcgggga aggagtctgc
      541 agcaggggtc ccgggtccgg cgctgcggac ggcatggaag aacctggacg aaactcttcc
      601 cagaacggga ctttaagcga gggtcagggt agcgccattc tcatctcttt catctactcc
      661 gtggtatgct tggtgggact gtgtgggaac tccatggtca tttacgtgat cctgcgctac
      721 gccaagatga agaccgcaac caacatctac attctaaacc tggccattgc tgatgagctg
      781 ctcatgctca gcgtgccctt tctggtcact tccacgctgt tgcgccactg gccctttggc
      841 gcgctacttt gccgcctggt gctcagcgtg gatgcagtca acatgttcac cagcatctac
      901 tgtctgactg tgcttagtgt ggaccgctat gtggctgtgg tgcacccgat caaggcagcg
      961 cgctaccgtc ggcccactgt ggccaaagta gtgaacctgg gcgtgtgggt gctgtcgcta
     1021 ctggttatct tgcccatcgt ggtcttctca cgcaccgcag ccaacagcga tggcacggtg
     1081 gcctgcaaca tgctcatgcc cgagcccgcc cagcgctggt tggtgggctt cgtcttatac
     1141 acatttctca tgggcttcct gctgcctgtc ggggccatct gcctgtgtta cgtgctcatc
     1201 attgccaaga tgcgcatggt ggccctcaag gccggctggc agcagcgcaa gcgctcagag
     1261 cgcaagatca ctctaatggt gatgatggtg gtgatggttt ttgtcatctg ctggatgcct
     1321 ttctacgtgg tacagctagt caacgtgttc gccgagcaag acgacgccac ggtgagccag
     1381 ttgtctgtca tcctcggcta tgccaatagc tgtgccaacc ccatcctcta cggcttcctg
     1441 tcggacaact tcaagcgctc tttccagcgc atcctgtgcc tcagctggat ggataacgct
     1501 gcggaggagc ctgttgacta ctacgccact gccctgaaga gtcgtgccta cagtgtggag
     1561 gacttccagc ctgagaatct ggaatctgga ggcgttttcc gtaatggcac ctgcgcttcc
     1621 aggatcagca cgctttgagg ccggacgcta accggagggg gagagtggtc agaaaggtgg
     1681 agaggggaag caggtgggag ggaatgatag ccgcacacca ggtgctatgg gagtagtgcg
     1741 tgacagcgat gcagcgcccc tgtttagcaa agctatgtga ctaaggtaaa cgggagagat
     1801 ttgagaatgt tttcgggcca tctggtattc tgaactgtgt tctccaaacc cgataatttc
     1861 catcctccct cccagttctg ctagtacaaa ctgcaaactt aacgtcgcca actccgtttg
     1921 accctttccc tctcaagctg ttatttctgc ttctttaaac tgagccatct tgtgtttctt
     1981 ttgggctgag tccccacctt gcgctgaacc ccctgcgcag gtccccgggc cagactcttc
     2041 agagcggcta ccagactgtc cccagttacc gctccccttt tgcacagcct tactgtcaag
     2101 taagcccagc tccaggatga ccaggcaact ggtcttttct actctcaaag aaggcaccat
     2161 cttcccttgg gccctttctc tgcttcactg catccagagc agagctgggt gcttaagaaa
     2221 aagtcctgtg cccagatggc cagacttggt gtagtcccac ccattccctc ctttggagca
     2281 caaaaaggag ctaagagcca gcagaagggc aagtttctaa gattcctggg ctgtggttgt
     2341 gggtgccaga gaagccaccc tcccatagag ctcaggacct gagcactagg cttggaggtc
     2401 ccagctaggg gagctcccgg cttgtgaata acttatgcac cctggtgtgt gaacctgaat
     2461 tgcacagcag ttccccttgg aggtctccct agaataacaa aggattgggt tgcctgctcc
     2521 ctttcctagt ccagctcctg ttccagtgac aaaccgcaga gcccttgcca aagctggatg
     2581 gctaacttca gcttgtctgg tccctgacat tttttgcctt tcaagcggtg cctaataagt
     2641 tatttcttgt ttgacatatt tatttattta tttatagtgt tgaaaaaaaa gtgtgtttcc
     2701 actttctttt tctgtatttg cctaacaggg ctgttcttga gaatcctctg gcaggcacgt
     2761 ggtggtgtgg aggtgtggag gggagcaggg gtggagaaag ttctctcacc ccaagactcc
     2821 ctcagaagtt tccctctttt gcactccatt ggccttttct tgatccttct tggttttgct
     2881 tgtgtccagt gaagtttgga gattttaaaa atatattttt actgtagttt tgtcttgtta
     2941 aaataagtac atggcaattt ggtttaactt ttgtcagtgt ggagtggaag gcctgaatcc
     3001 ctggcatccc agaaaacaca ggggaacaaa tcacatgatc cgtgatgtat gtctgtatat
     3061 gtgctgtcac acacaagtca catatatacg tgtatatata tatcatatat gtacacacac
     3121 atataaaggt agatttgtca atcttgacaa ctgtcactag ttcatgacaa ttataaggac
     3181 acccacaatg tgtgacctga gctgtagcac tccagctggg atctgagaaa cgtcagagat
     3241 tggagtcgct gctgaagatg ctgctgcctt tttctatccc ctcagaggtg attcttaccc
     3301 agtaagtcta gtcacttttg ttgaggaatg gaagcgaaac aattgtgtct gcatttactg
     3361 actaccgtgg aaacctgaac acggaaggac ccatctcttc acttgttgca tttgctgtgt
     3421 tcctgtgtat gctcgtttgt acataggggc cactgaaagg atatcttgct tggttgttta
     3481 aggaagccag tgtatatcag tggtcttaga acaatgaacc tggggttctc gggtccacag
     3541 tgacctgaca tctaacctgc aatggtcgaa tgcactgttg aaaatggtgt tttgtgtaca
     3601 tttgcttcaa gaacacatcc atgcttttct aaaagcagga accaagagtt aaactgtctc
     3661 ttctgttttg tttaaataaa tgaacaaata tgcttttgat cataagtgag aaagtttaga
     3721 tcttttccta agaatagtat atatatatat gtatatatat atacttttct gttaattaga
     3781 ttttttaacc gataagaaga gtgaacttta taaactgaaa tctccatcat tatcatctcg
     3841 acaggataaa aatgtagtgc tcttaccctg taatagtaac tgaataaaaa gatgtattat
     3901 gctgtt
//
