LOCUS       NM_012659                657 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus somatostatin (Sst), mRNA.
ACCESSION   NM_012659
VERSION     NM_012659.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 657)
  AUTHORS   Elrick,M.M., Samson,W.K., Corbett,J.A., Salvatori,A.S., Stein,L.M.,
            Kolar,G.R., Naatz,A. and Yosten,G.L.
  TITLE     Neuronostatin acts via GPR107 to increase cAMP-independent PKA
            phosphorylation and proglucagon mRNA accumulation in pancreatic
            alpha-cells
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (2), R143-R155 (2016)
   PUBMED   26561648
  REMARK    GeneRIF: Neuronostatin acts via GPR107 to increase cAMP-independent
            PKA phosphorylation and proglucagon mRNA accumulation in pancreatic
            alpha-cells.
REFERENCE   2  (bases 1 to 657)
  AUTHORS   Zou,S. and Kumar,U.
  TITLE     Colocalization of cannabinoid receptor 1 with somatostatin and
            neuronal nitric oxide synthase in rat brain hippocampus
  JOURNAL   Brain Res 1622, 114-126 (2015)
   PUBMED   26115586
  REMARK    GeneRIF: Study suggested that somatostatin and nNOS are expressed
            in most interneurons whereas CB1 receptor is present in both
            interneurons and projection neurons in hippocampal regions
REFERENCE   3  (bases 1 to 657)
  AUTHORS   Chen,W., Ke,J.B., Wu,H.J., Miao,Y., Li,F., Yang,X.L. and Wang,Z.
  TITLE     Somatostatin receptor-mediated suppression of gabaergic synaptic
            transmission in cultured rat retinal amacrine cells
  JOURNAL   Neuroscience 273, 118-127 (2014)
   PUBMED   24846611
  REMARK    GeneRIF: Results suggest that somatostatin suppresses GABA release
            from the amacrine cells by inhibiting presynaptic Ca2+ channels, in
            part through activating sst5/sst2 receptors, a process that is
            mediated by the intracellular cAMP-PKA signaling pathway
REFERENCE   4  (bases 1 to 657)
  AUTHORS   Takahashi,M., Takeda,M. and Matsumoto,S.
  TITLE     Somatostatin enhances tooth-pulp-evoked cervical dorsal horn
            neuronal activity in the rat via inhibition of GABAergic
            interneurons
  JOURNAL   Brain Res Bull 100, 76-83 (2014)
   PUBMED   24321530
  REMARK    GeneRIF: These results suggest that a local release of somatostatin
            facilitates the excitability of trigeminal nocicepitve C1 neuronal
            activity via inhibition of GABAergic neurons
REFERENCE   5  (bases 1 to 657)
  AUTHORS   Jovanovic,A.A., Babovic,S.S., Damjanovic,A., Puskas,L., Lazic,D.,
            Cvetic,T. and Jasovic-Gasic,M.
  TITLE     The role of C-Fos protein, somatostatin and neuropeptide Y in the
            pathogenesis of ischemic brain injuries based on animal model of
            cerebral ischemia
  JOURNAL   Coll Antropol 37 (3), 847-852 (2013)
   PUBMED   24308227
  REMARK    GeneRIF: The aim of this study was to define all the areas of
            changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic
            somatostatin (SS) and neuropeptide Y (NPY) in rat brain during
            experimental ischemia.
REFERENCE   6  (bases 1 to 657)
  AUTHORS   Benoit,R., Ling,N. and Esch,F.
  TITLE     A new prosomatostatin-derived peptide reveals a pattern for
            prohormone cleavage at monobasic sites
  JOURNAL   Science 238 (4830), 1126-1129 (1987)
   PUBMED   2891188
REFERENCE   7  (bases 1 to 657)
  AUTHORS   van den Pol,A.N.
  TITLE     Gamma-aminobutyrate, gastrin releasing peptide, serotonin,
            somatostatin, and vasopressin: ultrastructural immunocytochemical
            localization in presynaptic axons in the suprachiasmatic nucleus
  JOURNAL   Neuroscience 17 (3), 643-659 (1986)
   PUBMED   2422591
REFERENCE   8  (bases 1 to 657)
  AUTHORS   Hayes,T.E. and Dixon,J.E.
  TITLE     Z-DNA in the rat somatostatin gene
  JOURNAL   J Biol Chem 260 (13), 8145-8156 (1985)
   PUBMED   2861199
REFERENCE   9  (bases 1 to 657)
  AUTHORS   Goodman,R.H., Montminy,M.R., Low,M.J. and Habener,J.F.
  TITLE     Biosynthesis of rat preprosomatostatin
  JOURNAL   Adv Exp Med Biol 188, 31-47 (1985)
   PUBMED   2863939
REFERENCE   10 (bases 1 to 657)
  AUTHORS   Goodman,R.H., Jacobs,J.W., Dee,P.C. and Habener,J.F.
  TITLE     Somatostatin-28 encoded in a cloned cDNA obtained from a rat
            medullary thyroid carcinoma
  JOURNAL   J Biol Chem 257 (3), 1156-1159 (1982)
   PUBMED   6120163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 13, 2015 this sequence version replaced NM_012659.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG380788.1, BG380764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               JAXUCZ010000011.1  90461546-90461833
            289-657             JAXUCZ010000011.1  90462455-90462823
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..657
                     /gene="Sst"
                     /gene_synonym="Smst; SRIF; SS-14; SS-28"
                     /note="somatostatin"
                     /db_xref="GeneID:24797"
                     /db_xref="RGD:3761"
     exon            1..288
                     /gene="Sst"
                     /gene_synonym="Smst; SRIF; SS-14; SS-28"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..501
                     /gene="Sst"
                     /gene_synonym="Smst; SRIF; SS-14; SS-28"
                     /note="somatotropin release-inhibiting factor"
                     /codon_start=1
                     /product="somatostatin precursor"
                     /protein_id="NP_036791.1"
                     /db_xref="GeneID:24797"
                     /db_xref="RGD:3761"
                     /translation="MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATG
                     KQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERK
                     AGCKNFFWKTFTSC"
     exon            289..657
                     /gene="Sst"
                     /gene_synonym="Smst; SRIF; SS-14; SS-28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgacgtca gagagagagt ttaaaaaggg gagaccgtgg agagctcgat agcggctgaa
       61 ggagacgcta ctggagtcgt ctctgctgcc tgcggacctg cgtctagact gacccaccgc
      121 gctcaagctc ggctgtctga ggcaggggag atgctgtcct gccgtctcca gtgcgcgctg
      181 gccgcgctct gcatcgtcct ggctttgggc ggtgtcaccg gggcgccctc ggaccccaga
      241 ctccgtcagt ttctgcagaa gtctctggcg gctgccaccg ggaaacagga actggccaag
      301 tacttcttgg cagaactgct gtccgagccc aaccagacag agaacgatgc cctggagcct
      361 gaggatttgc cccaggcagc tgagcaggac gagatgaggc tggagctgca gaggtctgcc
      421 aactcgaacc cagccatggc accccgggaa cgcaaagctg gctgcaagaa cttcttctgg
      481 aagacattca catcctgtta gctttaatat tgttgtctca gccagacctc tgatccctct
      541 cctccaaatc ccatatctct tccttaactc ccagcccccc cccccaatgc tcaactagac
      601 cctgcgttag aaattgaaga ctgtaaatac aaaataaaat tatggtgaaa ttatgaa
//
