LOCUS       NM_001107024            6343 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus slingshot protein phosphatase 2 (Ssh2), mRNA.
ACCESSION   NM_001107024 XM_001080672 XM_001080678 XM_220743
VERSION     NM_001107024.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6343)
  AUTHORS   Bohm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W,
            Lebrecht A, Schmidt M, Kolbl H, Pfeiffer N and Grus FH.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 6343)
  AUTHORS   Horita Y, Ohashi K, Mukai M, Inoue M and Mizuno K.
  TITLE     Suppression of the invasive capacity of rat ascites hepatoma cells
            by knockdown of Slingshot or LIM kinase
  JOURNAL   J Biol Chem 283 (10), 6013-6021 (2008)
   PUBMED   18171679
  REMARK    GeneRIF: both LIMK1-mediated phosphorylation and SSH1/SSH2-mediated
            dephosphorylation of cofilin/ADF are critical for the migration and
            invasion of tumor cells
REFERENCE   3  (bases 1 to 6343)
  AUTHORS   Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K and Uemura T.
  TITLE     Control of actin reorganization by Slingshot, a family of
            phosphatases that dephosphorylate ADF/cofilin
  JOURNAL   Cell 108 (2), 233-246 (2002)
   PUBMED   11832213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080678.1, XM_220743.4, XM_001080672.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132294,
                              SAMD00132298 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6343
                     /gene="Ssh2"
                     /note="slingshot protein phosphatase 2"
                     /db_xref="GeneID:303342"
                     /db_xref="RGD:1309389"
     exon            1..270
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..4435
                     /gene="Ssh2"
                     /note="slingshot homolog 2"
                     /codon_start=1
                     /product="protein phosphatase Slingshot homolog 2"
                     /protein_id="NP_001100494.1"
                     /db_xref="GeneID:303342"
                     /db_xref="RGD:1309389"
                     /translation="MTLSTLADERKAPPASTCSLGGPDMIPYFSANAVISQNAINQLI
                     SESFLTVKGAALFLPRGNGSSTPRISHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVR
                     LESTYQNRTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLD
                     GDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARMHNYYPGSLFLTWVSYYES
                     HINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLEN
                     ITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLE
                     DLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHG
                     SKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYEYVKERRTVTKPNPSFMRQLEEYQ
                     GILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELNKKEMTTSADQITEVKTVESLA
                     AMPPVFMEHVVPQDVNQKGLRTKERVICLEFSSQEFHAGQIEDELNLNDINGCSSGCC
                     LSESKFPLDNCHASKALLQPGQAPDIANKFPDLAVEDLETDALKADVRVHLLPMEELT
                     SRLKDLPMSPDLESPSPQAGCQAAISDFSTDRIDFFSALEKFVELSQETRSRSFSHSR
                     IEELGGGRSEGCRLSVMEMAPSEMVTDDQRSSSLSDTPHASEESSVDEDQPKAVSELV
                     SPDIIMQSHSENAISVKEIVTEIESISQGVGQVQLKGDILSNPCHTPKKNIIHELPLE
                     RVQGPENKPGHLEQDESFCSVQLELARDSGKCAPEEGCLATLSSTGDLEEEEPVEGEH
                     DWGPGTHPGAKWCPGSVRRATLEFEERLRQEQENHGTASPGPTLSNRKNSKNDSSVAD
                     LMPKWKSDETASEHSLSPKEAEPGKGKGKCSGSEAGPLSHCEHNPAAAAPQLLEHHPS
                     PAPQDCLGSESRSEKQEEDLRKQRTVVSNQECETQAALLPLPKKIEIIEYTPTVTSLD
                     HTEPGGETTPSKESEKQELRKVKMERSITMFCTLDENLNRTLDPSQVSLRPQVLPLPH
                     SSSEYDRLTDPTPMLSSPQDKGDSPSTPFKTPARLVGCSTQGASVSLDCSHRHSVLHL
                     EGCTEQSSTTDSRLSSEHMNWEDSQGDFLSSSTGMAHTSSPLTNEDLSLINKLGDSVG
                     VLPKKLDPSPEACRIPHSSSSENIRDLSHGPGVVKEHAKEIEPRVIFQAAFSKTSQMR
                     RSASLAKLGYLDLCKDYLPDRELGSSESPHLKLLQPFLRTDSGMHALMVHEPSESPGA
                     HPNPQPTKYFVEQLKTTECVVQSKPVERPHVQYAKEFGFSQQCLLPKARPELTSSEGG
                     LPLLQTQGLQYPGPSPGLAVAPRQQHGRTHPLRRLKRANDKKRTTNPFYNTM"
     exon            271..374
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..439
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..561
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..630
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..696
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..891
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..985
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1114
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1161
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1308
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1509
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2344
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..6343
                     /gene="Ssh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacagcgg agtcccgggg cttcggcggc tgcctcggaa ctcccgggcg gacccaggtc
       61 agctgccggg aaccagcgtc tctggctcgg gtttttccaa cgccggtcca ggatgcggag
      121 ctgttcatcg tgagtcggct tcatgaccct tagcactttg gccgacgaaa ggaaagcgcc
      181 ccctgccagc acctgcagcc tcggtggccc cgacatgatc ccctacttct ctgccaatgc
      241 ggttatctcg cagaacgcca tcaaccagct catcagcgag agctttttaa ctgtcaaagg
      301 tgctgccctt tttctaccac gagggaatgg ctcgtctaca ccacgaatca gccacagacg
      361 caacaagcat gcaggagatc tccaacagca tcttcaagca atgttcatat tactccgccc
      421 agaagacaac ataaggctgg ctgtaagact ggaaagtact taccaaaatc gaacacgcta
      481 tatggtagtg gtttcaacta acggtagaca agacactgaa gaaagcattg tcctgggaat
      541 ggatttttct tctaatgaca gtagcacttg taccatgggc ttggtcttgc ctctctggag
      601 cgacacccta attcatttgg atggtgatgg tgggttcagc gtgtcaacag ataacagagt
      661 tcacatattc aagcctgtat ctgtgcaagc aatgtggtct gcactacaga gtttgcacaa
      721 agcttgtgaa gtggccagga tgcataacta ctatccaggc agcctttttc tcacttgggt
      781 gagttactat gagagccaca taaactcaga ccagtcctca gtcaacgaat ggaatgctat
      841 gcaggatgtg cagtctcatc ggcctgactc tccggccctc ttcacagaca taccaactga
      901 acgtgagcga acagaaaggc ttattaagac taagttaagg gagattatga tgcaaaagga
      961 tttggagaat atcacatcca aagagatacg cacagaactg gaaatgcaga tggtgtgcaa
     1021 cttgcgggag tttaaggagt tcatagataa cgagatgatc gtgatcctgg gtcagatgga
     1081 cagtccgacc cagatatttg agcacgtgtt cctgggctca gaatggaatg cgtcaaactt
     1141 agaggacttg cagaaccgag gggtgcggta tattttgaat gtcactcgag agatagataa
     1201 cttcttccct ggagtctttg agtatcataa cattcgagta tatgatgaag aggcaacaga
     1261 tctcctggct tactggaatg acacttacaa attcatctct aaagcaaaga aacatggatc
     1321 taaatgtctt gtgcactgca aaatgggggt gagtcgctca gcctccactg tgattgccta
     1381 tgcgatgaag gagtatggat ggaatctgga tcgcgcctat gagtacgtga aggaacgacg
     1441 aacagtgacc aagcccaacc ccagcttcat gagacaacta gaagaatacc aagggatctt
     1501 gctggccagc aaacagcggc ataacaaact ctggagatct cattcagata gtgacctctc
     1561 agaccaccac gaacccatct gtaaacctgg gctcgagctc aacaagaagg agatgaccac
     1621 ttcagcagac cagatcactg aggtgaagac tgtggagagc cttgcagcca tgcctcccgt
     1681 cttcatggaa catgtggtcc cacaagatgt aaatcagaaa ggactgcgca ccaaagaaag
     1741 agtcatctgc ttggagtttt cttcacaaga gtttcatgcc ggccagattg aagatgaatt
     1801 aaacttaaat gacattaatg gatgctcgtc agggtgttgt ctcagcgaat caaaattccc
     1861 tcttgacaac tgccatgcat ctaaagcctt actccaacct ggacaggccc cggacattgc
     1921 caacaagttc ccggacttag cggtggaaga cttggagaca gatgcactga aagcagacgt
     1981 gagggtccac ttactgccaa tggaagagtt gacatcgaga ctgaaagacc tccctatgtc
     2041 acctgatctg gagtcaccaa gcccccaagc cggttgccaa gctgccatct ctgattttag
     2101 tacagatcgc attgattttt ttagtgccct agagaaattt gtagagcttt ctcaggaaac
     2161 ccggtctcgg tctttttctc actcaaggat agaagaatta ggaggaggaa ggagcgaggg
     2221 ctgtcgcctg tcggtgatgg aaatggcacc ttcagaaatg gtgactgatg accagagaag
     2281 cagctctttg agtgatactc cccacgcatc tgaagagtct tctgtggatg aggaccagcc
     2341 gaaggcagtc tcagaacttg tcagcccaga catcatcatg caatctcact cagaaaatgc
     2401 aatttcagtc aaagaaattg tcactgaaat tgagtccatt agtcaaggag ttgggcaggt
     2461 tcagttaaaa ggagacatcc tctctaaccc atgccataca ccaaagaaga acatcattca
     2521 tgagctgccc ctggagagag tacaaggccc tgagaacaaa cctggacatt tggagcagga
     2581 tgagagtttc tgtagtgtcc aactagaact agccagagac tcggggaagt gtgccccaga
     2641 ggagggctgt ctggccacac tctcgtccac aggagacttg gaagaagagg aaccagttga
     2701 gggtgaacat gactggggcc cagggacaca ccctggtgcc aagtggtgcc ctgggtctgt
     2761 gaggcgagcc accctggagt ttgaagagcg cttgcgacaa gagcaggaga accatgggac
     2821 agcctctcca ggtcccacgt tatccaatcg caaaaactct aagaatgact cttctgtggc
     2881 agacctaatg ccaaaatgga aaagcgatga aaccgcctca gagcattcac tttcccccaa
     2941 ggaagccgag cccggcaagg gtaaagggaa gtgcagtggc tctgaggccg gacccctgtc
     3001 ccactgtgag cataatcccg ctgctgcagc cccccagctg ctggagcatc acccctcgcc
     3061 agctcctcag gactgcctgg ggtcagagag cagaagtgag aagcaggaag aagacctgag
     3121 gaagcagagg actgtggttt caaaccagga atgtgagaca caggccgccc ttcttcccct
     3181 ccccaagaaa atagaaatca ttgagtatac accaacagtt acatcacttg atcacactga
     3241 gccaggaggt gagacaacac ccagcaaaga gagtgagaag caagagctga ggaaggtgaa
     3301 gatggagagg tctatcacta tgttttgcac tctggatgaa aatctgaaca ggactctgga
     3361 ccccagtcag gtttctctgc gtccccaagt gctacctctg cctcattctt cctctgagta
     3421 tgacaggctc actgacccaa cccctatgtt aagtagccct caagacaaag gggacagccc
     3481 atccacaccc ttcaagacac cagcgcgttt ggtcggttgc agtacccaag gagcatctgt
     3541 cagcttggat tgttcgcatc gccattctgt gcttcacctg gaaggctgca cagagcaaag
     3601 cagtaccaca gacagcagac tgtcttcaga gcacatgaac tgggaggaca gccaggggga
     3661 cttcctttcc agtagtactg gaatggcaca cacgtcctct ccattaacaa atgaagacct
     3721 aagtttaatt aacaaacttg gtgacagtgt tggcgtgtta ccgaaaaaac tggatccatc
     3781 accggaagcc tgtcgaatcc cacatagctc tagtagtgaa aatataagag atctcagcca
     3841 cggccctggt gtggtgaagg agcatgctaa agaaattgag cctcgagtga tcttccaggc
     3901 ggcgttctcc aaaacatcac aaatgaggcg ctcagcttcg ctggccaagt tgggttacct
     3961 ggacctttgt aaagactact taccggatag agagcttggc tcctcagaat cccctcatct
     4021 caaattgctt cagcccttcc tcagaacaga ctcaggcatg catgccttga tggtccatga
     4081 gccctcagaa agcccaggtg cccacccaaa cccacagccc accaagtatt ttgtagagca
     4141 actcaaaaca acagagtgtg ttgtgcagag caagccagtg gagaggcccc atgtgcagta
     4201 tgccaaagag tttggtttca gtcagcagtg tttgctcccc aaggcaagac cagaattgac
     4261 tagttctgaa ggaggccttc ctttgctaca gacacagggt ctgcagtatc caggcccctc
     4321 tccagggctg gctgtggctc cccgtcagca gcatggcagg actcacccgc ttaggagact
     4381 aaaaagagca aatgataaaa aacggacaac caaccccttc tataacacca tgtgatcctg
     4441 agcccataca cgtgattttc taagaaaatg tttgttaaag gggcggtgta atatgtaagg
     4501 aacatgcact ttattggtta attttataat atttttggtc attttactgt tcctggctca
     4561 tgcagggttt gggtttttcc atgtgtgtgc gtgcatgtat gtgtgtgtgt gtacgtgtaa
     4621 cgatttggat gacaagatca ttttatcatt tttttatttt taaaaaattc aaacctcaaa
     4681 aaaatttttt ttcaaagagc acctttatca aaggcaaatt gctgtttttc agtctactgc
     4741 cacctgtctc ttctcatttt gccctctgag aaaagacacg cctgcttggt tgagggaaag
     4801 aaacagatgg ggtgggtggc acagaagctg ggaactggaa atctcaccca ggcctgagga
     4861 gacctgtttg ctgaagggca gagggatgtg gctgctctca gcctcgctcc gccctcctcc
     4921 gttggagtac atgaagttgc aggctctgct ctgctttaag gcagttgaga ctccgtttct
     4981 tctgatattc caaaatgcat caatcattac agaaaaggga gtgataattg gcctactgac
     5041 agaaactacg aagcaaaata ttttaacttt ccccaagaaa acaatctgaa agtcaaaggg
     5101 aaccctaatc gaaattcaag gtcatctgta gagaaatata ttaagagaga aggtggggtc
     5161 aaaggtggaa acacagcccc tgagtcactg tggggccagt ggaatccaca caggtgagtc
     5221 ctggccccac cagccgggtc ccctcctgcc tagtgacagg ctctgcctct gcctcccaac
     5281 taaagacctg gaaacaggct ttaaagacag cagagtcggc tgtgcttgta aagtgagtgc
     5341 atgctgtggg ctttaaccct gttacttgaa tattctgtgg gccttctgag tttaatggcc
     5401 gtgcttttcc aagtgatttc ttctctcttg ctgtttcccc atccttccct tagttccaaa
     5461 gttatatttt aattgttaca atacatacat agaacctatt gaacacaaat ttttctgtta
     5521 tccctgttaa cacttgatgc aagttttttc ccctaatttt tcctagattt gtcttttctc
     5581 tacagttcat acacagtatt tatgtacata atgtcacttt tttaatgttt catgattgat
     5641 attgtgggtc ttttgattta ttcttgttaa ggagtagagt tgcaactgga aaagagagaa
     5701 acaccagaaa taaactggta gttttgggta gaaatcttta tttgttttaa ataaaaactt
     5761 gtcatagcca gctcctgcca aattaagtac ttcctcttga gaagaacccc ctgcaggctc
     5821 ccactagatc acactgaaca ctggcttctg tttgaggctg aagtcccagg tcattgtttg
     5881 ccagtacttg aagcacagct agatatgtgt cttcgatgcc cagactagaa gctcccaatg
     5941 tgaggctgag aggctggggc ggctcagcgg tcagccaagg gcacagattc catttaggat
     6001 actgttgctt tgttgctgtc ctgctgctct ttaacgctga actgcctgct atagacgtgc
     6061 ccctgagcat agtacagaaa acatctggag gtacccacca cagctcaaca gaactgaaga
     6121 gggctacaga cttgcctcct gcttgctttt gttgatatcc gaattgctga ggattgtctg
     6181 ggtaggagcc agggacttag gtttttaatt catcatagcc ctaattggaa aaagacacac
     6241 agattatctt tagagacaga atttggaggg agcaggtagt aggatacagg aaaggtagac
     6301 tgcctccatt ttcaagtgct ccagagctgg gagtctactt ggc
//
