LOCUS       NM_031119               1684 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus small RNA binding exonuclease protection factor
            La (Ssb), mRNA.
ACCESSION   NM_031119
VERSION     NM_031119.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Gao,L., Lv,Q., Huang,Y., Fan,Y., Zhao,L., Zhao,Y., Wang,X., Mo,D.,
            Lu,H. and Wang,D.
  TITLE     Effect of silencing SSB1 gene on the expression of NBS1 in
            irradiated rat submandibular gland cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 110-118 (2024)
   PUBMED   38372104
  REMARK    GeneRIF: Effect of silencing SSB1 gene on the expression of NBS1 in
            irradiated rat submandibular gland cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Jefferson,M., Donaszi-Ivanov,A., Pollen,S., Dalmay,T., Saalbach,G.
            and Powell,P.P.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J Virol 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1684)
  AUTHORS   Maraia,R.J. and Lamichhane,T.N.
  TITLE     3' processing of eukaryotic precursor tRNAs
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 362-375 (2011)
   PUBMED   21572561
  REMARK    Review article
REFERENCE   6  (bases 1 to 1684)
  AUTHORS   Tran,H.B., Ohlsson,M., Beroukas,D., Hiscock,J., Bradley,J.,
            Buyon,J.P. and Gordon,T.P.
  TITLE     Subcellular redistribution of la/SSB autoantigen during physiologic
            apoptosis in the fetal mouse heart and conduction system: a clue to
            the pathogenesis of congenital heart block
  JOURNAL   Arthritis Rheum 46 (1), 202-208 (2002)
   PUBMED   11817591
REFERENCE   7  (bases 1 to 1684)
  AUTHORS   Intine,R.V., Sakulich,A.L., Koduru,S.B., Huang,Y., Pierstorff,E.,
            Goodier,J.L., Phan,L. and Maraia,R.J.
  TITLE     Control of transfer RNA maturation by phosphorylation of the human
            La antigen on serine 366
  JOURNAL   Mol Cell 6 (2), 339-348 (2000)
   PUBMED   10983981
REFERENCE   8  (bases 1 to 1684)
  AUTHORS   McLaren,R.S., Caruccio,N. and Ross,J.
  TITLE     Human La protein: a stabilizer of histone mRNA
  JOURNAL   Mol Cell Biol 17 (6), 3028-3036 (1997)
   PUBMED   9154801
REFERENCE   9  (bases 1 to 1684)
  AUTHORS   Semsei,I., Troster,H., Bartsch,H., Schwemmle,M., Igloi,G.L. and
            Bachmann,M.
  TITLE     Isolation of rat cDNA clones coding for the autoantigen SS-B/La:
            detection of species-specific variations
  JOURNAL   Gene 126 (2), 265-268 (1993)
   PUBMED   7916708
REFERENCE   10 (bases 1 to 1684)
  AUTHORS   Chambers,J.C., Kenan,D., Martin,B.J. and Keene,J.D.
  TITLE     Genomic structure and amino acid sequence domains of the human La
            autoantigen
  JOURNAL   J Biol Chem 263 (34), 18043-18051 (1988)
   PUBMED   3192525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081780.1.
            
            On Sep 16, 2004 this sequence version replaced NM_031119.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081780.1, X67859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1684
                     /gene="Ssb"
                     /note="small RNA binding exonuclease protection factor La"
                     /db_xref="GeneID:81783"
                     /db_xref="RGD:620804"
     exon            1..76
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            77..168
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1350
                     /gene="Ssb"
                     /note="la ribonucleoprotein; la autoantigen homolog; mRNA
                     for autoantigen; Sjogren syndrome antigen B"
                     /codon_start=1
                     /product="lupus La protein homolog"
                     /protein_id="NP_112381.2"
                     /db_xref="GeneID:81783"
                     /db_xref="RGD:620804"
                     /translation="MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDE
                     GWVPLETMIKFNRLNRLTTDFNVIVQALSKSKANLMEVSADKTKIRRSPSRPLPEVTD
                     EYKNDVKNRSVYIKGFPTDATLDDIKEWLDDKGQILNIQMRRTLHKTFKGSIFAVFDS
                     IQSAKKFVDTPGQKYKDTNLLILFKEDYFAKKNEERKQSKVEAKLKAKQEHEGRHKPG
                     STETRALEGKMGCLLKFSGDLDDQTCREDLHFLFSNHGEIKWIDFVRGAKEGIILFKE
                     KAKDALEKARSANNGNLLLRNKKVTWKVLEGHAEKDAMKKITDDQQESLNKWKSKGGH
                     AARRFKGSHVFTAARRFKGRGKGNRPAYAGAPKGRGQFQGRRTRFDDDDHRRGPVKRG
                     RDGRDREEPASKHKKRENGARDK"
     exon            169..272
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            273..447
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            448..555
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            556..656
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            657..728
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..768
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            769..909
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1105
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1261
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1645
                     /gene="Ssb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggcgct cggaagtaga ggcgcttctg tcgttgttcg tgaagccgtg gtgactgcgg
       61 gatcagaatc tttgagtgtg agaaacttta cagatagcca caatggctga aaatggagat
      121 aacgaaaaaa tggctgctct ggaggccaaa atctgtcatc aaattgagta ttattttgga
      181 gacttcaatt tgccacgaga caagttttta aaagaacaga tcaaattgga tgaaggctgg
      241 gtacctttgg aaacaatgat aaaattcaac aggctaaacc gactgacaac agactttaat
      301 gtaatcgtgc aagcattgag caaatctaag gcaaatctca tggaagtgag tgcagacaaa
      361 actaaaatta gaagatcacc aagcagacca ctccctgaag tgacggatga gtataagaat
      421 gatgtgaaaa atagatctgt ttatattaaa ggcttcccaa ctgatgccac ccttgatgat
      481 ataaaagaat ggctagatga taaaggccaa atactgaata ttcagatgag aagaacattg
      541 cacaaaacat ttaaggggtc aatatttgct gtgtttgata gtattcagtc tgcaaagaag
      601 tttgtggaca cccccggcca gaagtacaaa gacactaatc tgctaatact cttcaaggaa
      661 gattactttg caaaaaaaaa tgaagaaaga aagcagagca aagtggaagc taaattaaaa
      721 gctaaacaag aacatgaagg acgacacaaa ccaggaagta ctgaaacaag agctctagaa
      781 ggaaaaatgg gatgcttact gaagttttca ggtgacttgg atgaccagac ctgtagagaa
      841 gatttacact tccttttctc aaatcatggt gaaataaaat ggattgactt tgtcagagga
      901 gcaaaagagg gaataattct cttcaaagaa aaggctaagg acgcacttga gaaagccaga
      961 agtgcaaata atggtaacct actgttaagg aacaaaaaag tgacttggaa agtactagaa
     1021 ggacatgcag aaaaagatgc aatgaaaaaa atcacagatg atcaacaaga atctctgaac
     1081 aaatggaagt caaaaggagg tcatgcagcc cgcagattta aaggaagtca tgtttttaca
     1141 gcagctcgca gatttaaagg aagagggaaa ggtaatagac ctgcttatgc tggggcaccc
     1201 aaaggaagag gacagtttca aggaaggagg acaagatttg atgatgatga tcatcgtcgt
     1261 ggaccagtga aaagaggaag agacggaaga gacagagaag aacccgcatc aaagcataag
     1321 aaaagagaga atggtgctag agacaagtag tttatttagt aagcagtgtt tttattcctt
     1381 agttaggttt taagctgctt tttgtcttca gaagctttta aaaagaaaag cgaattaggt
     1441 ccacttcaat gtccacctgt ataaaaggaa aagttttttg ttttacttgt ctttttgttg
     1501 ttatccaaat gaaagttttt taaaatgtat agttctgttt gtgtttggat gattaaaata
     1561 tgaaaaggaa gattcttcct cttaattgcc tttgtaatat gagaatgtat tagtacagac
     1621 ttgtaaaata tatactgtat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaa
//
