LOCUS       NM_001416740             513 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sex determining region Y (Sry), mRNA.
ACCESSION   NM_001416740
VERSION     NM_001416740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Prokop,J.W., Chhetri,S.B., van Veen,J.E., Chen,X., Underwood,A.C.,
            Uhl,K., Dwinell,M.R., Geurts,A.M., Correa,S.M. and Arnold,A.P.
  TITLE     Transcriptional analysis of the multiple Sry genes and
            developmental program at the onset of testis differentiation in the
            rat
  JOURNAL   Biol Sex Differ 11 (1), 28 (2020)
   PUBMED   32398044
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Lee,J., Pinares-Garcia,P., Loke,H., Ham,S., Vilain,E. and
            Harley,V.R.
  TITLE     Sex-specific neuroprotection by inhibition of the Y-chromosome
            gene, SRY, in experimental Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 116 (33), 16577-16582 (2019)
   PUBMED   31371505
  REMARK    GeneRIF: SRY directs a previously unrecognized male-specific
            mechanism of dopaminergic neuron cell death.
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Fan,W., Wang,B., He,S., Zhang,T., Yin,C., Chen,Y., Zheng,S.,
            Zhang,J. and Li,L.
  TITLE     A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region
            Interferes with Nuclear Import and Results in 46, XY Complete
            Gonadal Dysgenesis
  JOURNAL   PLoS One 11 (12), e0168484 (2016)
   PUBMED   28030592
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Racca,J.D., Chen,Y.S., Yang,Y., Phillips,N.B. and Weiss,M.A.
  TITLE     Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX
            REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION
            OF A MASTER TRANSCRIPTION FACTOR
  JOURNAL   J Biol Chem 291 (42), 22173-22195 (2016)
   PUBMED   27576690
  REMARK    GeneRIF: Chemical proteasome inhibition restored native-like SRY
            expression and transcriptional activity in association with
            restored occupancy of a sex-specific enhancer element in principal
            downstream gene Sox9, demonstrating that the variant SRY exhibits
            essentially native activity on a per molecule basis.
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Araujo,F.C., Milsted,A., Watanabe,I.K., Del Puerto,H.L.,
            Santos,R.A., Lazar,J., Reis,F.M. and Prokop,J.W.
  TITLE     Similarities and differences of X and Y chromosome homologous
            genes, SRY and SOX3, in regulating the renin-angiotensin system
            promoters
  JOURNAL   Physiol Genomics 47 (5), 177-186 (2015)
   PUBMED   25759379
  REMARK    GeneRIF: These results suggest that SRY regulation of the
            renin-angiotensin system is partially shared with its X-chromosome
            homolog SOX3.
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Prokop,J.W., Underwood,A.C., Turner,M.E., Miller,N., Pietrzak,D.,
            Scott,S., Smith,C. and Milsted,A.
  TITLE     Analysis of Sry duplications on the Rattus norvegicus Y-chromosome
  JOURNAL   BMC Genomics 14, 792 (2013)
   PUBMED   24228692
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 513)
  AUTHORS   Giese,K., Kingsley,C., Kirshner,J.R. and Grosschedl,R.
  TITLE     Assembly and function of a TCR alpha enhancer complex is dependent
            on LEF-1-induced DNA bending and multiple protein-protein
            interactions
  JOURNAL   Genes Dev 9 (8), 995-1008 (1995)
   PUBMED   7774816
REFERENCE   8  (bases 1 to 513)
  AUTHORS   Griffiths,R. and Tiwari,B.
  TITLE     Primers for the differential amplification of the sex-determining
            region Y gene in a range of mammal species
  JOURNAL   Mol Ecol 2 (6), 405-406 (1993)
   PUBMED   8162230
REFERENCE   9  (bases 1 to 513)
  AUTHORS   Ferrari,S., Harley,V.R., Pontiggia,A., Goodfellow,P.N.,
            Lovell-Badge,R. and Bianchi,M.E.
  TITLE     SRY, like HMG1, recognizes sharp angles in DNA
  JOURNAL   EMBO J 11 (12), 4497-4506 (1992)
   PUBMED   1425584
REFERENCE   10 (bases 1 to 513)
  AUTHORS   Jager,R.J., Anvret,M., Hall,K. and Scherer,G.
  TITLE     A human XY female with a frame shift mutation in the candidate
            testis-determining gene SRY
  JOURNAL   Nature 348 (6300), 452-454 (1990)
   PUBMED   2247151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000022.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               JAXUCZ010000022.1  465260-465772
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="Y"
                     /map="Yq11"
     gene            1..513
                     /gene="Sry"
                     /gene_synonym="Sry3B; SRYGENE; Tdf; Tdy"
                     /note="sex determining region Y"
                     /db_xref="GeneID:25221"
                     /db_xref="RGD:3759"
     CDS             1..513
                     /gene="Sry"
                     /gene_synonym="Sry3B; SRYGENE; Tdf; Tdy"
                     /note="testis-determining factor; sex-determining region Y
                     protein 3B; sex determining region of Chr Y; Testis
                     determining locus; sex determining region on Y"
                     /codon_start=1
                     /product="sex-determining region Y protein"
                     /protein_id="NP_001403669.1"
                     /db_xref="GeneID:25221"
                     /db_xref="RGD:3759"
                     /translation="MEGHVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKQLGYQWK
                     SLTEAEKRPFFQEAQRLKTLHREKYPNYKYQTHRRVKVPQRSYTLQREVASTKLYNLL
                     QWDNNLHTIIYGQDWARAAHQSSKNQKSIYLQPVDIPTGYPLQQKQQHQQQQHVHLQQ
                     QQQQQQHQFH"
     exon            1..513
                     /gene="Sry"
                     /gene_synonym="Sry3B; SRYGENE; Tdf; Tdy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagggcc atgtcaagcg ccccatgaat gcatttatgg tgtggtcccg tggagagagg
       61 cgcaagttgg ctcaacagaa tcccagcatg cagaattcag agatcagcaa gcagctggga
      121 tatcagtgga aaagccttac agaagccgaa aaaaggccct ttttccagga ggcgcagaga
      181 ctgaagaccc tacacagaga gaaatatcca aactataaat atcagactca tcgaagggtt
      241 aaagtgccac agaggagtta tactttgcag cgtgaagttg cctcaacaaa actgtacaac
      301 ctgttgcaat gggacaacaa cctacacact atcatatacg gacaggactg ggctagagct
      361 gcacaccagt cctccaagaa ccagaaaagc atttatttac agcctgtgga catccccact
      421 ggatacccac tacagcagaa acagcagcac cagcagcagc agcacgtgca cctgcagcag
      481 cagcagcagc agcagcagca ccagttccac tag
//
