LOCUS       NM_001047858            2878 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus sulfiredoxin 1 (Srxn1), mRNA.
ACCESSION   NM_001047858 XM_001058481 XM_215887
VERSION     NM_001047858.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2878)
  AUTHORS   Lan,W., Lin,J., Liu,W., Wang,F. and Xie,Y.
  TITLE     Sulfiredoxin-1 protects spinal cord neurons against oxidative
            stress in the oxygen-glucose deprivation/reoxygenation model
            through the bax/cytochrome c/caspase 3 apoptosis pathway
  JOURNAL   Neurosci Lett 744, 135615 (2021)
   PUBMED   33421493
  REMARK    GeneRIF: Sulfiredoxin-1 protects spinal cord neurons against
            oxidative stress in the oxygen-glucose deprivation/reoxygenation
            model through the bax/cytochrome c/caspase 3 apoptosis pathway.
REFERENCE   2  (bases 1 to 2878)
  AUTHORS   Wu,Z., Lu,Z., Ou,J., Su,X. and Liu,J.
  TITLE     Inflammatory response and oxidative stress attenuated by
            sulfiredoxin-1 in neuron-like cells depends on nuclear factor
            erythroid-2-related factor 2
  JOURNAL   Mol Med Rep 22 (6), 4734-4742 (2020)
   PUBMED   33173963
  REMARK    GeneRIF: Inflammatory response and oxidative stress attenuated by
            sulfiredoxin1 in neuronlike cells depends on nuclear factor
            erythroid2related factor 2.
REFERENCE   3  (bases 1 to 2878)
  AUTHORS   Wu,J., Chen,Y., Yu,S., Li,L., Zhao,X., Li,Q., Zhao,J. and Zhao,Y.
  TITLE     Neuroprotective effects of sulfiredoxin-1 during cerebral
            ischemia/reperfusion oxidative stress injury in rats
  JOURNAL   Brain Res Bull 132, 99-108 (2017)
   PUBMED   28552673
  REMARK    GeneRIF: Results suggest that Srxn1 can protect neurons from
            ischemia/reperfusion oxidative stress injury, and the underlying
            mechanism involves Prdxs activity. Srxn1, which might be a
            downstream gene of Nrf2, can resist cerebral ischemia and
            reperfusion by reversing overoxidized Prdx and restoring
            antioxidant activity of Prdx.
REFERENCE   4  (bases 1 to 2878)
  AUTHORS   Zhang,J., He,Z., Guo,J., Li,Z., Wang,X., Yang,C. and Cui,X.
  TITLE     Sulfiredoxin-1 protects against simulated ischaemia/reperfusion
            injury in cardiomyocyte by inhibiting PI3K/AKT-regulated
            mitochondrial apoptotic pathways
  JOURNAL   Biosci Rep 36 (2), e00325 (2016)
   PUBMED   26992405
  REMARK    GeneRIF: these results suggested that Srx-1 might protect
            cardiomyocyte injury upon SI/R by suppressing PI3K/AKT-mediated
            mitochondria dependent apoptosis, revealing a promising therapeutic
            agent against ischaemic cardiovascular diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2878)
  AUTHORS   Zhou,Y., Zhou,Y., Yu,S., Wu,J., Chen,Y. and Zhao,Y.
  TITLE     Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects
            against oxidative stress-induced injury in rat cortical astrocytes
            following exposure to oxygen-glucose deprivation and hydrogen
            peroxide
  JOURNAL   Int J Mol Med 36 (1), 43-52 (2015)
   PUBMED   25955519
  REMARK    GeneRIF: Srxn1 protects primary rat cortical astrocytes from
            oxygen-glucose deprivation- or H2O2-induced apoptosis and that
            involves the activation of the mitochondrial apoptotic pathway.
REFERENCE   6  (bases 1 to 2878)
  AUTHORS   Li,Q., Yu,S., Wu,J., Zou,Y. and Zhao,Y.
  TITLE     Sulfiredoxin-1 protects PC12 cells against oxidative stress induced
            by hydrogen peroxide
  JOURNAL   J Neurosci Res 91 (6), 861-870 (2013)
   PUBMED   23553940
  REMARK    GeneRIF: Srxn1 play a protective role against oxidative injury
REFERENCE   7  (bases 1 to 2878)
  AUTHORS   Wu,C.L., Yin,J.H., Hwang,C.S., Chen,S.D., Yang,D.Y. and Yang,D.I.
  TITLE     c-Jun-dependent sulfiredoxin induction mediates BDNF protection
            against mitochondrial inhibition in rat cortical neurons
  JOURNAL   Neurobiol Dis 46 (2), 450-462 (2012)
   PUBMED   22402332
  REMARK    GeneRIF: Sulfiredoxin induction is dependent on c-Jun expression
            and mediates brain-derived neurotrophic factor (BDNF) protection
            against mitochondrial inhibition.
REFERENCE   8  (bases 1 to 2878)
  AUTHORS   Soriano,F.X., Papadia,S., Bell,K.F. and Hardingham,G.E.
  TITLE     Role of histone acetylation in the activity-dependent regulation of
            sulfiredoxin and sestrin 2
  JOURNAL   Epigenetics 4 (3), 152-158 (2009)
   PUBMED   19430206
  REMARK    GeneRIF: the importance of histone acetylation in the regulation of
            Srxn1 and Sesn2, to understand more about how these genes are
            regulated by synaptic activity was investigated.
REFERENCE   9  (bases 1 to 2878)
  AUTHORS   Jeong,W., Park,S.J., Chang,T.S., Lee,D.Y. and Rhee,S.G.
  TITLE     Molecular mechanism of the reduction of cysteine sulfinic acid of
            peroxiredoxin to cysteine by mammalian sulfiredoxin
  JOURNAL   J Biol Chem 281 (20), 14400-14407 (2006)
   PUBMED   16565085
  REMARK    GeneRIF: analysis of the reduction of cysteine sulfinic acid of
            peroxiredoxin to cysteine by mammalian sulfiredoxin
REFERENCE   10 (bases 1 to 2878)
  AUTHORS   Chang,T.S., Jeong,W., Woo,H.A., Lee,S.M., Park,S. and Rhee,S.G.
  TITLE     Characterization of mammalian sulfiredoxin and its reactivation of
            hyperoxidized peroxiredoxin through reduction of cysteine sulfinic
            acid in the active site to cysteine
  JOURNAL   J Biol Chem 279 (49), 50994-51001 (2004)
   PUBMED   15448164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001047858.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167743.1, FQ142989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               JAXUCZ010000003.1  161064812-161065263
            453-2878            JAXUCZ010000003.1  161067947-161070372
FEATURES             Location/Qualifiers
     source          1..2878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2878
                     /gene="Srxn1"
                     /gene_synonym="Ab2-390; Npn3"
                     /note="sulfiredoxin 1"
                     /db_xref="GeneID:296271"
                     /db_xref="RGD:1307332"
     exon            1..452
                     /gene="Srxn1"
                     /gene_synonym="Ab2-390; Npn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..656
                     /gene="Srxn1"
                     /gene_synonym="Ab2-390; Npn3"
                     /EC_number="1.8.98.2"
                     /note="neoplastic progression 3"
                     /codon_start=1
                     /product="sulfiredoxin-1"
                     /protein_id="NP_001041323.3"
                     /db_xref="GeneID:296271"
                     /db_xref="RGD:1307332"
                     /translation="MVQPGRVKRPGGAVRQGSNMGLRAGGALRRASAGPGAPDGQGPS
                     GAQGGSIHSGCIDTVHNVPIAVLIRPLPSVLDPVKVQSLVDTILEDPDSVPPIDVLWI
                     KGAQGGDYYYSFGGCHRYAAYQQLQRETIPAKLVRSTLSDLRMYLGASTPDLQ"
     exon            453..2878
                     /gene="Srxn1"
                     /gene_synonym="Ab2-390; Npn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgacccg acgcgtccat taagcgcatc gcgagggggc ggcggggcgc ctcagcgggc
       61 agcgggcagc tagaacagcg tgggacgtgg ggctctggtc gagcggagcg ggggccgata
      121 catcacagcg tgagccgagc cactcggtgg gggcaagcgc agaaccgtcg cccccccgcg
      181 gccgcacgat ggtacagccc ggccgggtaa agaggccggg tggcgctgtc cgccaaggaa
      241 gcaatatggg gctacgcgcg ggtggagctc tccggagggc gagtgcgggg cctggggcgc
      301 ccgacggtca gggacccagt ggcgcgcaag gaggcagcat ccactctggc tgcatcgaca
      361 ctgtgcacaa cgtgccaatc gccgtgctca tccggccgct gccgtcggtg ctggacccgg
      421 tcaaggtgca gagcctcgtg gacacgatcc tggaggaccc tgacagtgtg ccccccatcg
      481 acgtcctctg gatcaaaggg gcccaaggcg gtgactacta ctactccttt gggggctgcc
      541 accgctatgc agcctaccag cagctacaga gagagaccat tcctgccaag ctcgtgaggt
      601 ctaccctttc agacctgagg atgtacctgg gtgcatccac accagacttg cagtagcaac
      661 ctcctgatac cccactcccg ccttttccac accagcacca cttcctggtg ctcagaagac
      721 acctgcaggc ccccgtgggc agacgttata gaaggaatat gttcttttcc tacttaagga
      781 ggggtgtctg cctcttggtg cctctgcact agcccccagg gactagctcc caagaatgag
      841 ggggttccgt tcttcagtct atgaaaagat aacacggcct tgaccctgat ggagtaccaa
      901 gaggaggaag taagaaagat ggactcggag acaaggactc tccattttac tctttatgat
      961 atcttatcac tacatgaact aggtactagg aagtgaagga aaacctaggt caccgtggct
     1021 taagtgagag acgcttgtta tccgcatagc ctgaaccctg gagcaggtga ctaacacagt
     1081 attatatcta acggagtgcc gtatcaatgc tcagtgaggg cggggcctcc tctcagtaat
     1141 ctcattgctc cttgcttcgt agtcacaaga tggctgctgt gtttctagaa atcatgtctg
     1201 ttgagaaaga accccgatag accaacttct gtcagaaagg aaaacctcgt tcagaggttt
     1261 gcacagtcgc cttggtctga gctggcgacc atcgccactc acagttgcaa agaaagcaga
     1321 cattaggaaa cgttatcaca gctgagcgtg gctgccttgt tcattccctg gaatcctgga
     1381 acaggccctt tgctccctgc aacacaattg gggatcccat tggcaggaga gggaggtagc
     1441 ctttgctacg aaacaagcca tccccagact caacagctaa ccaagtattc acgtacccgt
     1501 gattctgtgg gttagctaag ctcctttgag cagctctact agtgtggcct ggtcctgctc
     1561 atgagcccag tcacttctca cttcagctgg ggctggttag gctggggtca cccagccatt
     1621 gtagcaagtg ttggttgcat cggcttggtt aaccttgttg cccctctagc aggtcagagc
     1681 aggcttattt tcatgatggc ctcagggttc caagggagag tagtagtgac tgagcaggac
     1741 ctggggcggt ggctcggctg ttaagagcac ttacgtggtg ttatgacaca gtcatccctg
     1801 ttccagatga cctgataccc tcttctagcc tctgtggaca cagacattac acatgtgaga
     1861 aaagcacttt tttctttttt ctttttgaga cactgggttt ttctgtgtag ctctggctat
     1921 cctggaactc actctacaga accaggctag ccttgaactc agagatctgc ctctaccacc
     1981 tcctaagtgc gggtgtacta ctgttaccca gggacatttt ttttttcaga gctgactgaa
     2041 cccagggcct tgtgcttgct aggcaagcgc tctaccacta agctaaatcc ccaacccctg
     2101 actttttttt tttaaaaggt gacaaggttt cttcagcccc ggtgctagga ctgtgtctcc
     2161 actggtcagt tcattcctta gatttcaggg gtgcaagtgg acccagctct caatgggagg
     2221 aactataaag aacgtggggc catctttcat cacagatgaa tcttggtgga caagagacag
     2281 aatttctcac tcccacacat aagcactccc gttcacaagt ttattgataa gcacacagag
     2341 gggccaagtc agcctttaag taaggttctt aaaacctaga agaagtcgtg gcacggtgcc
     2401 ttctagagct gggtacccca ctccaaggat gattcataag cagaatgagg tggataacgg
     2461 ggcattcaga ggggcttccg caaacccaga gtccacaagg caacggaagc agcagggtga
     2521 ggtggcactt gctacgcttg tcattttcaa gcctctgtct tcccagctca atagtgaggt
     2581 caccagcttc cccacccact gagtgtccca gagaatgaga ttgaaaggaa taaagtgtat
     2641 tgtggtgctg gattgattct taggaccaaa cagagaccag ggagagaaag cactttagca
     2701 ggtcaaccag gactcatact gtctgggtct tagttacctt ccagtttgta atcatatctc
     2761 tggggtgggc tggatgaaga tatatgggaa ccctttggtc tctgcaactt ttctgtgaat
     2821 ctaaagtcat tctaaaataa aagtttattt aattaaaaca cacacacaat gcaatggc
//
