LOCUS       NM_001014185            3513 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus serine and arginine rich splicing factor 6
            (Srsf6), mRNA.
ACCESSION   NM_001014185 XM_342569
VERSION     NM_001014185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3513)
  AUTHORS   Fernandez-Nogales,M., Cabrera,J.R., Santos-Galindo,M.,
            Hoozemans,J.J., Ferrer,I., Rozemuller,A.J., Hernandez,F., Avila,J.
            and Lucas,J.J.
  TITLE     Huntington's disease is a four-repeat tauopathy with tau nuclear
            rods
  JOURNAL   Nat Med 20 (8), 881-885 (2014)
   PUBMED   25038828
REFERENCE   2  (bases 1 to 3513)
  AUTHORS   Ni,B., Ma,H., Lin,Y., Dai,J., Guo,X., Xia,Y., Sha,J. and Hu,Z.
  TITLE     Genetic variants in Ser-Arg protein-coding genes are associated
            with the risk of nonobstructive azoospermia in Chinese men
  JOURNAL   Fertil Steril 101 (6), 1711-7 (2014)
   PUBMED   24661730
REFERENCE   3  (bases 1 to 3513)
  AUTHORS   Jensen,M.A., Wilkinson,J.E. and Krainer,A.R.
  TITLE     Splicing factor SRSF6 promotes hyperplasia of sensitized skin
  JOURNAL   Nat Struct Mol Biol 21 (2), 189-197 (2014)
   PUBMED   24440982
REFERENCE   4  (bases 1 to 3513)
  AUTHORS   Iborra,S., Hirschfeld,M., Jaeger,M., Zur Hausen,A., Braicu,I.,
            Sehouli,J., Gitsch,G. and Stickeler,E.
  TITLE     Alterations in expression pattern of splicing factors in epithelial
            ovarian cancer and its clinical impact
  JOURNAL   Int J Gynecol Cancer 23 (6), 990-996 (2013)
   PUBMED   23748175
REFERENCE   5  (bases 1 to 3513)
  AUTHORS   Nogueira,T.C., Paula,F.M., Villate,O., Colli,M.L., Moura,R.F.,
            Cunha,D.A., Marselli,L., Marchetti,P., Cnop,M., Julier,C. and
            Eizirik,D.L.
  TITLE     GLIS3, a susceptibility gene for type 1 and type 2 diabetes,
            modulates pancreatic beta cell apoptosis via regulation of a splice
            variant of the BH3-only protein Bim
  JOURNAL   PLoS Genet 9 (5), e1003532 (2013)
   PUBMED   23737756
REFERENCE   6  (bases 1 to 3513)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   7  (bases 1 to 3513)
  AUTHORS   Wang,J., Gao,Q.S., Wang,Y., Lafyatis,R., Stamm,S. and Andreadis,A.
  TITLE     Tau exon 10, whose missplicing causes frontotemporal dementia, is
            regulated by an intricate interplay of cis elements and trans
            factors
  JOURNAL   J Neurochem 88 (5), 1078-1090 (2004)
   PUBMED   15009664
REFERENCE   8  (bases 1 to 3513)
  AUTHORS   Tran,Q. and Roesser,J.R.
  TITLE     SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing
  JOURNAL   Biochemistry 42 (4), 951-957 (2003)
   PUBMED   12549914
REFERENCE   9  (bases 1 to 3513)
  AUTHORS   Patel,N.A., Chalfant,C.E., Watson,J.E., Wyatt,J.R., Dean,N.M.,
            Eichler,D.C. and Cooper,D.R.
  TITLE     Insulin regulates alternative splicing of protein kinase C beta II
            through a phosphatidylinositol 3-kinase-dependent pathway involving
            the nuclear serine/arginine-rich splicing factor, SRp40, in
            skeletal muscle cells
  JOURNAL   J Biol Chem 276 (25), 22648-22654 (2001)
   PUBMED   11283022
REFERENCE   10 (bases 1 to 3513)
  AUTHORS   Ghigna,C., Moroni,M., Porta,C., Riva,S. and Biamonti,G.
  TITLE     Altered expression of heterogenous nuclear ribonucleoproteins and
            SR factors in human colon adenocarcinomas
  JOURNAL   Cancer Res 58 (24), 5818-5824 (1998)
   PUBMED   9865741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM060375.1, FM081417.1 and JAXUCZ010000003.1.
            
            On Sep 14, 2010 this sequence version replaced NM_001014185.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1093744.1,
                                           SRR26360172.694966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               FM060375.1         1-634
            635-690             FM081417.1         159-214
            691-3120            JAXUCZ010000003.1  172011966-172014395
            3121-3512           FM081417.1         216-607
            3513-5942           JAXUCZ010000003.1  172011966-172014395
FEATURES             Location/Qualifiers
     source          1..3513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3513
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /note="serine and arginine rich splicing factor 6"
                     /db_xref="GeneID:362264"
                     /db_xref="RGD:1359241"
     exon            1..236
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1149
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /note="splicing factor, arginine/serine-rich 6;
                     pre-mRNA-splicing factor SRP55"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 6"
                     /protein_id="NP_001014207.2"
                     /db_xref="GeneID:362264"
                     /db_xref="RGD:1359241"
                     /translation="MPRVYIGRLSYNVREKDIQRFFSGYGRLLEIDLKNGYGFVEFED
                     SRDADDAVYELNSKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKY
                     GPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMK
                     RALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRS
                     ISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDKYGKSRSRS
                     RSRSPKENGKGDIKSKSRSRSQSRSHSPLPAPPSKARSMSPPPKRASRSRSRSRSRSR
                     SSSRD"
     exon            237..385
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            386..510
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            511..719
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            720..803
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            804..3513
                     /gene="Srsf6"
                     /gene_synonym="Sfrs6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgactcgg ccgcagctgc ggtgtgaggc gcgtgttcgg gccttcgccg tccccgcacc
       61 cgcaccgcag cccctgcccc gcggcccgcc gcacctcagc tagcctccgg gagaacaccc
      121 accacggcca tgccgcgcgt ctacatagga cgcctgagct acaacgtccg cgagaaggac
      181 atccagcgct ttttcagcgg ctacggccgc ctcctcgaaa tcgacctcaa aaatgggtac
      241 ggtttcgtgg agttcgagga ctcccgtgat gcggacgacg ccgtttacga gctgaacagc
      301 aaggagctgt gcggcgagcg cgtgatcgta gagcacgccc ggggcccgcg ccgggaccgc
      361 gatggctaca gctacggaag ccgcagtggt ggaggtggat acagcagtcg gagaacttct
      421 ggcagagaca aatatggacc acctgttcgt acagaataca ggcttattgt agaaaatcta
      481 tctagtcgtt gcagttggca agacttaaag gatttcatgc ggcaagcagg agaggtgact
      541 tatgcagatg ctcacaaaga acgaacaaat gagggtgtaa ttgaatttag atcctactct
      601 gacatgaagc gtgctttgga taaactggat ggcacagaaa taaatggcag gaatatacgg
      661 cttattgaag ataagccacg aacaagccat aggcgctctt actctggaag tagatccaga
      721 tcacggtcta gaagaagatc tcggagtagg agtcgcagaa gcagccgcag tagatctcga
      781 agtatctcaa aaagtcgctc gcgatctagg tctcggagca aaggtcgatc ccgatcccgc
      841 tcaaagggca ggaaatccag atcaaagagc aaatctaagc ccaagtctga tcggggttcc
      901 cattcacatt caagaagcag atctaaggat aagtatggga agtcacgaag taggtcacgt
      961 tctcggtccc ccaaagaaaa tggaaaagga gatataaagt caaaatccag atcccggagc
     1021 cagtctcgat cccattcgcc tctgcctgct ccaccctcaa aggctcggtc catgtcccct
     1081 ccgccaaaaa gagcttcaag gtcccgttct agatctcgtt ccaggtccag atcaagttcc
     1141 agagattagc cctgaactct acgttctttg cacactatga cggaactctt tcctacttgc
     1201 ctaggcagtc actcttccga gttcgtactc ggcctcttct tcaagaggat ttcctgaaaa
     1261 gggaacacag gaatttgatt tgtggccaaa tttaatgaga aaagatgagg ttctaaaatg
     1321 gtggtatgaa gccctctccc ttctttgtag aattaagata attttgattt tgtagccttt
     1381 gagctaaaat aacttttgta aagattaagc tcacttagat tttttttaaa gtattgcagc
     1441 gggatctgct gcagggttct gttgttttgt tttgcttatt tttaaattaa ctgttcaagc
     1501 ttttggatac tgcaggcttt agagggagaa cccaaatttt caattatgtt ggctttttat
     1561 aaagcttgag ttatgtaaga tttaaataaa agtttgctac caagatgatt gccttattga
     1621 ataggtcact cctaaggccc tttaagtgtt gatacctgcc attggtggag acagtgtaaa
     1681 ttctacagaa gtgtaaaaca aggcaagcct cagaccagca ataaattatt cagtttggct
     1741 aaccttattt tgtgctgtta atcaaatcta ccaaagtctt ttgtctaccc cttttataag
     1801 ttgagttaaa agtaaaaggg actttgtagt tagtgccaca tgataaataa aagaaactaa
     1861 aggattacaa tttgaactct tcaagaagta ggtcctagta cttgggatct tgttatcctg
     1921 tgctctggaa gtggtcagca taattagtgt taatgtatga tttggtggtc tttaatgttt
     1981 gaaaaacaga agtaaccttt aattagagat ttagttattt ttattcaaag ttgaaaagca
     2041 tatacactgc attttctgct gaaagatgaa tctgtttaac aggtgcttag cagactattg
     2101 ataagatttg ctggttaaaa ttcaatcagt cccctttgta ttggtggggc ttttgtggtt
     2161 agtttaaaaa acagtgacat ggttaaacta aaatgcttca tacttttaag cattaggaat
     2221 gctgtggaaa cccaagttaa aataaatagt gcaaatgtgt aggaataact agatttgcag
     2281 tttctataca tcccaaagcc cagtcagttg agactgcgat caattgttac ttaacaacct
     2341 ttccattatt cagacgtgtg taaagtcatt tcatctaagt gcttaacctc attctttagt
     2401 aaaggtgtag atggattggg tgaggtttaa ttccttcctc agctgttgta taatctagca
     2461 aaagttggat tagagattat aaggtagagt ttgtttgtag ggttaaataa tcaggacatg
     2521 caataaagtc aggctgagtg gaaaaagatt caagggccta ggtaggtgtc agtaagtggg
     2581 aatacttgga aaaacaggga aaggggaatg ttttcaagac atttatcctg ctcaaaatct
     2641 tagagactga ctttaggaat aaagtgtcag atacagctgc tgctttagtc gtcttttctt
     2701 tgatgctttg tttagatgtt tataagaaat aggtttattt ttccagtgta aatttcagaa
     2761 tttaaagaaa attgtgtctg gttatagttt actattttac ctacttaaaa acaaatgtga
     2821 tggctcttta agaattggat ttgaccaaag ttctctttgt tttcagggaa aactatataa
     2881 aagctttctg agccacagcc ttttaaaggg ggaaaggcta atagtaaaat ttgactttct
     2941 gactgcatgc aactttgagc tgggcttgcc ttctgtggta atacatgaca gaggcattag
     3001 acttttttag ctgccctaat aagtatatga tgaataaata aatgccaata cccataacaa
     3061 tttttctagt ggggacaaag gtcatttgat taatctaggt tttcataccg acccgattat
     3121 taaatgcact taaaaaaaaa ctgcatttaa agcattggcc ttagcagaat tgactgactt
     3181 agttccttac tggtgagtga attcagttcc ctaccaacta atgcgcagaa tctaagaatc
     3241 ccatcctgca cacattggtt ggagccctga gtggagtatc agcagcacca actgataaga
     3301 gcacaagaga agtggggaac atctggagtc ctgttggacg tgacagtgtt tcttgatatg
     3361 tatgccacag tgccttggtg gccagcttga gtcctaccta ctcagccttt gtccccactc
     3421 ctcctgtgtt agctttcatc ttgcatattc ttttttttct actttgttaa cctactttat
     3481 gctttatctc aataaaatgc ttaccaaggg aaa
//
