LOCUS       NM_019257               1501 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine and arginine rich splicing factor 5
            (Srsf5), transcript variant 2, mRNA.
ACCESSION   NM_019257 XM_003750191 XM_003750192 XM_008764880
VERSION     NM_019257.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Iborra,S., Hirschfeld,M., Jaeger,M., Zur Hausen,A., Braicu,I.,
            Sehouli,J., Gitsch,G. and Stickeler,E.
  TITLE     Alterations in expression pattern of splicing factors in epithelial
            ovarian cancer and its clinical impact
  JOURNAL   Int J Gynecol Cancer 23 (6), 990-996 (2013)
   PUBMED   23748175
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Walsh,C.M., Suchanek,A.L., Cyphert,T.J., Kohan,A.B.,
            Szeszel-Fedorowicz,W. and Salati,L.M.
  TITLE     Serine arginine splicing factor 3 is involved in enhanced splicing
            of glucose-6-phosphate dehydrogenase RNA in response to nutrients
            and hormones in liver
  JOURNAL   J Biol Chem 288 (4), 2816-2828 (2013)
   PUBMED   23233666
REFERENCE   4  (bases 1 to 1501)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1501)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1501)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   7  (bases 1 to 1501)
  AUTHORS   Du,K. and Taub,R.
  TITLE     Alternative splicing and structure of the human and mouse
            SFRS5/HRS/SRp40 genes
  JOURNAL   Gene 204 (1-2), 243-249 (1997)
   PUBMED   9434190
REFERENCE   8  (bases 1 to 1501)
  AUTHORS   Du,K., Peng,Y., Greenbaum,L.E., Haber,B.A. and Taub,R.
  TITLE     HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a
            possible cause of increased EIIIB expression in proliferating liver
  JOURNAL   Mol Cell Biol 17 (7), 4096-4104 (1997)
   PUBMED   9199345
REFERENCE   9  (bases 1 to 1501)
  AUTHORS   Hamil,K.G. and Hall,S.H.
  TITLE     Cloning of rat Sertoli cell follicle-stimulating hormone primary
            response complementary deoxyribonucleic acid: regulation of TSC-22
            gene expression
  JOURNAL   Endocrinology 134 (3), 1205-1212 (1994)
   PUBMED   8161377
REFERENCE   10 (bases 1 to 1501)
  AUTHORS   Diamond,R.H., Du,K., Lee,V.M., Mohn,K.L., Haber,B.A., Tewari,D.S.
            and Taub,R.
  TITLE     Novel delayed-early and highly insulin-induced growth response
            genes. Identification of HRS, a potential regulator of alternative
            pre-mRNA splicing
  JOURNAL   J Biol Chem 268 (20), 15185-15192 (1993)
   PUBMED   7686911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM081441.1, BC058479.1 and BE115959.1.
            
            On or before Aug 24, 2014 this sequence version replaced
            XM_008764880.1, XM_003750191.1, XM_003750192.1, NM_019257.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               FM081441.1         1-509
            510-1485            BC058479.1         504-1479
            1486-1501           BE115959.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1501
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /note="serine and arginine rich splicing factor 5"
                     /db_xref="GeneID:29667"
                     /db_xref="RGD:3664"
     exon            1..124
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     exon            125..269
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..953
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /note="splicing factor, arginine/serine-rich 5 (SRp40,
                     HRS); delayed-early protein HRS; pre-mRNA-splicing factor
                     SRP40; insulin-induced growth response protein CL-4"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 5"
                     /protein_id="NP_062130.2"
                     /db_xref="GeneID:29667"
                     /db_xref="RGD:3664"
                     /translation="MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEF
                     EDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAP
                     PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNA
                     IEKLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRRSKSYSRSRSRS
                     RSRSKSRSGSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN"
     exon            270..340
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     exon            341..439
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     exon            440..509
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     exon            510..583
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     exon            584..694
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1490
                     /gene="Srsf5"
                     /gene_synonym="HRS; Sfrs5; SRp40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctaagtgc gtcagttgtg gagagacgta gaggagttga gttcgtgtgt gtagggaggc
       61 agacagctcc gacgcagact acggacctct ccaggtctca gccgtcaaag accctgtccg
      121 gtaggaaaca ctagccgggg atcatgagtg gctgtcgagt gttcattggg agactaaatc
      181 ccgcagcgag ggagaaagat gtggaaagat tcttcaaggg ttacggacgg atcagagata
      241 ttgatttgaa aagaggtttt ggttttgtgg aatttgagga cccaagggat gcagatgacg
      301 ctgtttatga acttgatggg aaggaacttt gcagtgaaag ggttactatt gaacatgctc
      361 gggctcggtc tcgaggtgga agaggtagag gacgatactc cgaccgtttt agcagtcgca
      421 gacctcgaaa tgatagacga aatgctccac ctgtaagaac agaaaatcga cttatagttg
      481 agaatttatc ctcaagagtc agctggcagg atctcaaaga tttcatgaga caagctgggg
      541 aagtaacctt tgcggatgca catcgaccta aactaaatga aggggtagtt gagtttgcct
      601 cttatggtga cttaaagaat gctattgaga aactttctgg aaaggaaatt aatgggagaa
      661 aaatcaaatt aattgaaggc agcaaaagac acaggtcaag aagcaggtca cgatctcgga
      721 ccaggagttc ctctaggtcc cgtagccgat cccgttcacg caggagcaag tcttacagcc
      781 gatcaaggag caggagccgg agccggagca agtcccgttc tggtagtagg tctcccgtgc
      841 ctgagaagag ccagaaacgt ggttcttcga gtagatctaa atctccagca tctgtggatc
      901 gccagaggtc ccgatcccgg tccaggtcca gatcagttga cagtggcaat taattaaact
      961 gtaaataact tgccctgggg gccttttttt aaacaaaaca aaacaaattc ccaaaccata
     1021 cttgctaaaa attctggtaa gtatgtgctt tttctgtggg gtgggatttg gatggggttg
     1081 ggctggattt ctttgtagat gtggaccacc aaggggttgt tgaaaactaa ttgtattaaa
     1141 tgtcttttga taagccttct gctcacactt ttgtgactgt ctgaagtata tagtttgtgt
     1201 atattgatag agctctttta taactaaagc atttaatttt ttgtactaga aaaacttttg
     1261 aatattttag ttcattgttc agatatgtta acttaagatt agtttaattg ctcaattaaa
     1321 ctaatgaata gctttggaca ctttaaaaga gctctaaatt tgcttgtata taaaagctta
     1381 gtttgagttt tccttgttag ggtcaagggt gtcttcttgc ccattaacag ctgtagatag
     1441 acttaaagca gctgtttgtt actgataata aaatactaag tattataaaa aaaaaaaaaa
     1501 a
//
