LOCUS       NM_001108685            2232 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine and arginine rich splicing factor 4
            (Srsf4), mRNA.
ACCESSION   NM_001108685 XM_001064077 XM_001064238 XM_001064296 XM_001064400
            XM_001064463 XM_001064515 XM_001064569 XM_001064632 XM_001064687
            XM_001064748 XM_575921
VERSION     NM_001108685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   Walsh,C.M., Suchanek,A.L., Cyphert,T.J., Kohan,A.B.,
            Szeszel-Fedorowicz,W. and Salati,L.M.
  TITLE     Serine arginine splicing factor 3 is involved in enhanced splicing
            of glucose-6-phosphate dehydrogenase RNA in response to nutrients
            and hormones in liver
  JOURNAL   J Biol Chem 288 (4), 2816-2828 (2013)
   PUBMED   23233666
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2232)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2232)
  AUTHORS   Liu,J., Huang,B., Xiao,Y., Xiong,H.M., Li,J., Feng,D.Q., Chen,X.M.,
            Zhang,H.B. and Wang,X.Z.
  TITLE     Aberrant expression of splicing factors in newly diagnosed acute
            myeloid leukemia
  JOURNAL   Onkologie 35 (6), 335-340 (2012)
   PUBMED   22722453
REFERENCE   6  (bases 1 to 2232)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   7  (bases 1 to 2232)
  AUTHORS   Tsangaris,G.T., Karamessinis,P., Kolialexi,A., Garbis,S.D.,
            Antsaklis,A., Mavrou,A. and Fountoulakis,M.
  TITLE     Proteomic analysis of amniotic fluid in pregnancies with Down
            syndrome
  JOURNAL   Proteomics 6 (15), 4410-4419 (2006)
   PUBMED   16847874
REFERENCE   8  (bases 1 to 2232)
  AUTHORS   Wang,J., Gao,Q.S., Wang,Y., Lafyatis,R., Stamm,S. and Andreadis,A.
  TITLE     Tau exon 10, whose missplicing causes frontotemporal dementia, is
            regulated by an intricate interplay of cis elements and trans
            factors
  JOURNAL   J Neurochem 88 (5), 1078-1090 (2004)
   PUBMED   15009664
REFERENCE   9  (bases 1 to 2232)
  AUTHORS   Patel,N.A., Chalfant,C.E., Watson,J.E., Wyatt,J.R., Dean,N.M.,
            Eichler,D.C. and Cooper,D.R.
  TITLE     Insulin regulates alternative splicing of protein kinase C beta II
            through a phosphatidylinositol 3-kinase-dependent pathway involving
            the nuclear serine/arginine-rich splicing factor, SRp40, in
            skeletal muscle cells
  JOURNAL   J Biol Chem 276 (25), 22648-22654 (2001)
   PUBMED   11283022
REFERENCE   10 (bases 1 to 2232)
  AUTHORS   Ghigna,C., Moroni,M., Porta,C., Riva,S. and Biamonti,G.
  TITLE     Altered expression of heterogenous nuclear ribonucleoproteins and
            SR factors in human colon adenocarcinomas
  JOURNAL   Cancer Res 58 (24), 5818-5824 (1998)
   PUBMED   9865741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and BC160850.1.
            
            On Sep 15, 2010 this sequence version replaced NM_001108685.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.1707102.1,
                                           SRR22399484.402841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000005.1  149345538-149345755
            219-361             JAXUCZ010000005.1  149363060-149363202
            362-474             JAXUCZ010000005.1  149363963-149364075
            475-689             JAXUCZ010000005.1  149369341-149369555
            690-779             JAXUCZ010000005.1  149371626-149371715
            780-2203            JAXUCZ010000005.1  149371880-149373303
            2204-2232           BC160850.1         1677-1705
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2232
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /note="serine and arginine rich splicing factor 4"
                     /db_xref="GeneID:362612"
                     /db_xref="RGD:1561347"
     exon            1..218
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1578
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /note="splicing factor, arginine/serine-rich 4"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 4"
                     /protein_id="NP_001102155.1"
                     /db_xref="GeneID:362612"
                     /db_xref="RGD:1561347"
                     /translation="MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDD
                     LRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRT
                     EYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKL
                     DGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS
                     RSRSRSGSHSRSKSRSRSQSRSRSKKEKSRSPSKDNKSRSRSRSPDKSRSKSKDHAED
                     KLQNNDSAGKAKSHSPSRHDSKSRSRSQERRAEEERRSSTSRGHSQEKSLLKSRSRSR
                     SKVGSRSRSRSKSKDKRKGRKRSREESRSRSRSKSERSRKHSSKRDSKVSSSSSKKKK
                     GDTDHSRSPSRSVSKEREHATAEPGQRESRAEGESEGPNPEPRARSRSTSKSKPSLPA
                     ESRSRSKSASKTRSRSKSPSRSASRSPSRSRSRSHSRS"
     exon            219..361
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /inference="alignment:Splign:2.1.0"
     exon            362..474
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /inference="alignment:Splign:2.1.0"
     exon            475..689
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..779
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..2209
                     /gene="Srsf4"
                     /gene_synonym="RGD1561347; Sfrs4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgggctt cggctgcgtc cgtcccgccg cccgcccgtt accgccgccg ccgccgcgct
       61 ttcccttcgc cggccgccgc ctgagggggg ccggggccag ccgccgccgg aatgccgcgc
      121 gtgtacatcg gccgcctgag ctaccaggcc cgggagcgcg atgtggagcg cttctttaag
      181 ggctacggga agatcctgga ggtggatctg aagaacgggt atggttttgt ggagtttgat
      241 gatctgcgtg atgcagatga tgctgtttat gaactgaatg gcaaagacct ctgtggtgaa
      301 cgagtcattg ttgagcatgc ccgaggccca cgtcgggacg gcagttacgg ttctggacgc
      361 agtggatatg gttatcgaag aagtggccga gataaatatg gtcctcctac tcgcacagag
      421 tacagactta ttgtggagaa tctgtcaagt cgatgcagct ggcaagatct aaaggattat
      481 atgcgtcagg caggagaagt gacgtatgca gatgctcaca agggacgcaa aaacgaagga
      541 gtgattgaat ttgtgtctta ctctgatatg aaaagagctt tggaaaagtt ggatggaact
      601 gaagtcaacg gcagaaaaat cagattagtt gaagacaagc caggttctag acggcgccgg
      661 tcttactcca gaagccggag tcactcaagg tctcgctctc gaagcagaca ttctcggaag
      721 agcagaagcc gaagtggtag cagtaaaagc agccattcaa agagccgctc tcgatccagg
      781 tcgggttccc actcccgcag caagagccgc agccgcagcc agagccgcag tcgcagtaag
      841 aaggagaaaa gccggagccc cagcaaagac aacaagagcc gcagtcgcag ccgcagcccc
      901 gacaagagcc gaagcaaaag taaagaccat gcagaggaca agctccagaa caacgacagc
      961 gctggcaaag ccaagagcca cagccccagc cgccatgaca gtaaaagtcg gagcaggagc
     1021 caggagagga gagcagagga ggagaggaga agcagcacga gcaggggtca cagccaggag
     1081 aagagcctgc ttaagagccg cagccgcagc cgcagcaaag tgggcagccg cagccgcagc
     1141 cgcagcaaaa gcaaggacaa gcggaagggc cggaagagaa gcagggaaga aagtcgaagc
     1201 cggagccgca gcaagagcga gcgcagccgg aagcatagca gcaagcggga cagcaaagtc
     1261 agcagcagca gcagcaagaa gaagaaggga gacaccgacc actcccggtc accgtcccgc
     1321 tcagtgtcaa aggagcggga acatgccacg gcagagcctg gccagaggga aagccgggct
     1381 gagggtgaga gcgagggtcc caatccagag ccccgggcca ggtcaagatc cacttccaaa
     1441 tccaaaccta gtctcccggc agagtcccgc tccaggtcaa agtcagcttc aaaaacgcgc
     1501 tctcggtcca agtctccatc caggtctgct tccaggtcgc cctcccggtc tagatccagg
     1561 tcccactcaa ggtcctaact ggccatgctg cgctggaact gccgagaagt ttttgtacat
     1621 ttggtagccg tagcacagga gtgaagtaga acacccgtca ctgctgtaca ttaactcccc
     1681 aaaggtgtgt ctcagttgtt caatctcagt gcttcctcgg taccgcctcc cggcgccagg
     1741 ccttcccgct ccactgaaaa gcagctcctc aaactccctg tactcacagt aggacaccca
     1801 acgccttggc tttcaggcct ggccacggct acagggagct cggcacctgg acggcttctc
     1861 aggctggagt gatggcgtag gtaggtgtgg tgagctcagc cgtttgccct tgaattgatg
     1921 ccctttgatg tgtgccacgt agtgaaagtg caagtcttca gtctcccacc acttcggttt
     1981 cctgtttctg gacttaacaa ccttgtgaat agcacagtca agagaaatgg atacctgcat
     2041 agcccatagg aagtaacact gtagagctcc atattctggt attgtgatta tattgtttta
     2101 tattaaaaaa ggaaagaatt ttttttaatt ttatttttcc ccgtcttgca aagtatagtg
     2161 gcccctgttt ccattaaatt tgaataaaga ctatttttgc ttgacaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa aa
//
