LOCUS       NM_001009720            1901 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serine and arginine rich splicing factor 2
            (Srsf2), mRNA.
ACCESSION   NM_001009720
VERSION     NM_001009720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Kiefer,K.C., Cremer,S., Pardali,E., Assmus,B., Abou-El-Ardat,K.,
            Kirschbaum,K., Dorsheimer,L., Rasper,T., Berkowitsch,A., Serve,H.,
            Dimmeler,S., Zeiher,A.M. and Rieger,M.A.
  TITLE     Full spectrum of clonal haematopoiesis-driver mutations in chronic
            heart failure and their associations with mortality
  JOURNAL   ESC Heart Fail 8 (3), 1873-1884 (2021)
   PUBMED   33779075
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Zhang,C., Shen,L., Yuan,W., Liu,Y., Guo,R., Luo,Y., Zhan,Z.,
            Xie,Z., Wu,G., Wu,W. and Feng,Y.
  TITLE     Loss of SRSF2 triggers hepatic progenitor cell activation and tumor
            development in mice
  JOURNAL   Commun Biol 3 (1), 210 (2020)
   PUBMED   32372053
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Wang,P., Guo,L., Li,K., Ning,S., Shi,W., Liu,Z. and Chen,Y.
  TITLE     Serine/arginine rich splicing factor 2 expression and clinic
            pathological features indicating a prognostic factor in human
            hepatocellular carcinoma patients
  JOURNAL   Cancer Biomark 21 (3), 681-687 (2018)
   PUBMED   29278882
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Luo,C., Cheng,Y., Liu,Y., Chen,L., Liu,L., Wei,N., Xie,Z., Wu,W.
            and Feng,Y.
  TITLE     SRSF2 Regulates Alternative Splicing to Drive Hepatocellular
            Carcinoma Development
  JOURNAL   Cancer Res 77 (5), 1168-1178 (2017)
   PUBMED   28082404
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Derlig,K., Giessl,A., Brandstatter,J.H., Enz,R. and Dahlhaus,R.
  TITLE     Special characteristics of the transcription and splicing machinery
            in photoreceptor cells of the mammalian retina
  JOURNAL   Cell Tissue Res 362 (2), 281-294 (2015)
   PUBMED   26013685
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Xu,G.M. and Arnaout,M.A.
  TITLE     WAC, a novel WW domain-containing adapter with a coiled-coil
            region, is colocalized with splicing factor SC35
  JOURNAL   Genomics 79 (1), 87-94 (2002)
   PUBMED   11827461
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Muralikrishna,B., Dhawan,J., Rangaraj,N. and Parnaik,V.K.
  TITLE     Distinct changes in intranuclear lamin A/C organization during
            myoblast differentiation
  JOURNAL   J Cell Sci 114 (Pt 22), 4001-4011 (2001)
   PUBMED   11739632
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Berke,J.D., Sgambato,V., Zhu,P.P., Lavoie,B., Vincent,M., Krause,M.
            and Hyman,S.E.
  TITLE     Dopamine and glutamate induce distinct striatal splice forms of
            Ania-6, an RNA polymerase II-associated cyclin
  JOURNAL   Neuron 32 (2), 277-287 (2001)
   PUBMED   11683997
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Potter,G.B., Beaudoin,G.M. 3rd, DeRenzo,C.L., Zarach,J.M.,
            Chen,S.H. and Thompson,C.C.
  TITLE     The hairless gene mutated in congenital hair loss disorders encodes
            a novel nuclear receptor corepressor
  JOURNAL   Genes Dev 15 (20), 2687-2701 (2001)
   PUBMED   11641275
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Sahlas,D.J., Milankov,K., Park,P.C. and De Boni,U.
  TITLE     Distribution of snRNPs, splicing factor SC-35 and actin in
            interphase nuclei: immunocytochemical evidence for differential
            distribution during changes in functional states
  JOURNAL   J Cell Sci 105 (Pt 2), 347-357 (1993)
   PUBMED   8408269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 11, 2010 this sequence version replaced NM_001009720.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058508.1, SRR26643287.26220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               JAXUCZ010000010.1  102553617-102554141 c
            526-836             JAXUCZ010000010.1  102553072-102553382 c
            837-1901            JAXUCZ010000010.1  102550962-102552026 c
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..1901
                     /gene="Srsf2"
                     /gene_synonym="Sfrs2"
                     /note="serine and arginine rich splicing factor 2"
                     /db_xref="GeneID:494445"
                     /db_xref="RGD:1359422"
     exon            1..525
                     /gene="Srsf2"
                     /gene_synonym="Sfrs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..829
                     /gene="Srsf2"
                     /gene_synonym="Sfrs2"
                     /note="SC-35; splicing factor SC35; splicing component, 35
                     kDa; splicing factor, arginine/serine-rich 2"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 2"
                     /protein_id="NP_001009720.1"
                     /db_xref="GeneID:494445"
                     /db_xref="RGD:1359422"
                     /translation="MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVY
                     IPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSR
                     RGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRST
                     SKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGA
                     VSS"
     exon            526..836
                     /gene="Srsf2"
                     /gene_synonym="Sfrs2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1901
                     /gene="Srsf2"
                     /gene_synonym="Sfrs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagttgctgc ttacgagtcc ttcccgcgag ggtgctacgc ggcggccttg cggctcttgg
       61 ctgatccacg aggattgtag ctgccgaaag ccagagagaa gccgcgtttc ctgagagcga
      121 gggcctgtcc ggggcgttgg ggtctcggcg ccgcttcgca gccatgagct acggccgccc
      181 gcctcccgat gtggagggca tgacctccct caaggtggac aacctgacct accgcacctc
      241 acccgacacc ctgaggcgcg tcttcgagaa gtacgggcgc gtcggcgacg tgtacatccc
      301 gcgggaccgc tacaccaagg agtcccgtgg cttcgctttc gtccggttcc acgacaagcg
      361 tgacgccgaa gacgccatgg acgccatgga tggggccgtg ctcgatggcc gcgagctgcg
      421 ggtgcagatg gcgcgctacg gccgtcctcc cgactcgcac cacagccgcc ggggaccgcc
      481 accccgtagg tacggcggcg gcggctacgg gcgacggagc cgcagtcctc ggcgccgccg
      541 gcgcagccga tcccggagcc ggagccgttc caggtcccga agccgctctc gctacagccg
      601 ctccaagtct cggtcccgca ctcgttctcg ctcgaggtcg acctccaagt ccagatctgc
      661 ccgaagatcc aagtccaagt cctcgtcggt ctccagatcc cgctcgaggt ccaggtccag
      721 gtcgcgatcc agaagtcctc cgcctgtgtc gaagagagag tccaagtcta ggtcgcggtc
      781 caagagccca cccaagtctc cagaagaaga gggagcggtt tcatcttaag agaatgatgg
      841 atcggcaagc cgcttaacag aggactttgg gggaaaggac cacaaactca gtccatcggt
      901 ccgtggaaga gtccttggaa caagcaactg gctattaaaa aggttatttt gtaacatttg
      961 tctaactttt tacttgtttt aatctgcctc aggtggcaaa cttcatttta tgtgccattt
     1021 tgttgctgtt attcaaattt cttgtaattt agtgaggtga gcgacttcag atttcattat
     1081 tggattggat atttgaggta aaatttcatt tttgtttata gtgctgactt tttttgtttg
     1141 aaattaaaca gattggtaac ctaatttgtg gcctcctgac ttaataaaga aacgtgtgca
     1201 gccattacat acagcctaaa gctgtcagca gattgactca acattgcctt cactccttaa
     1261 aaattagaaa cctatgaaag ttggtgtaat ttgctcatat atgttattta ccttcaggtc
     1321 taaatgataa tctgaaccca aatttgtata aagacttttc aggtgaaaag acttattttt
     1381 tttttaaagg attgtttacc cgacacaatt ctaatctctt ctcttatgta tttttgtgca
     1441 ctaggcgcag ttgtgtagca gttgagtaat gctggttagc tgttaaggtg gcgtgttgca
     1501 gtgcagagtg cttggctgtt tcctgttttc tcctgattgc tcctgtgtaa agatgccttg
     1561 tcgtgcagaa acaaatggct gtccagttta ttaaaatgcc tgacaactgc acttccagtc
     1621 acccgggcct tgcatataaa taatggagca tacagtgagc acatctagct gatgataaat
     1681 acacccccct tccctcaaaa aaaaaaagcg caaaatggta aatctgatac ttgtgttgtg
     1741 aacttaaaaa aaaaacagaa aatgttaagg aagcaaatgg tttgtaactt tgtaagtact
     1801 taaaacatgg tgtatctttt gcttatgaat attctgtact ataaccattg tttctgtagt
     1861 ttgattaaag tgttttcttg gtgttagctt ttttgagaat a
//
