LOCUS       NM_001109552            5086 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine and arginine rich splicing factor 1
            (Srsf1), mRNA.
ACCESSION   NM_001109552 XM_001072402
VERSION     NM_001109552.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5086)
  AUTHORS   Xie,Z.W., Chen,Y.X., Long,C.F., Qi,Y.X. and Yao,Q.P.
  TITLE     Cyclic stretch induces VEGFA alternative splicing via
            Serine/Arginine-Rich Splicing Factor 1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 64 (7), 43-50 (2018)
   PUBMED   29974845
  REMARK    GeneRIF: present results suggested that pathologically high cyclic
            stretch induces the shuttling of SRSF1 which results in the
            secretive pattern splicing of VEGFA and finally contributes to the
            proliferation of vascular smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5086)
  AUTHORS   Xie,N., Chen,M., Dai,R., Zhang,Y., Zhao,H., Song,Z., Zhang,L.,
            Li,Z., Feng,Y., Gao,H., Wang,L., Zhang,T., Xiao,R.P., Wu,J. and
            Cao,C.M.
  TITLE     SRSF1 promotes vascular smooth muscle cell proliferation through a
            Delta133p53/EGR1/KLF5 pathway
  JOURNAL   Nat Commun 8, 16016 (2017)
   PUBMED   28799539
  REMARK    GeneRIF: SRSF1 promotes vascular smooth muscle cell (VSMC)
            proliferation and injury-induced neointima formation. SRSF1 favors
            the induction of a truncated p53 isoform, Delta133p53, which has an
            equal proliferative effect and in turn transcriptionally activates
            Kruppel-like factor 5 (KLF5) via the Delta133p53-EGR1 complex,
            resulting in an accelerated cell-cycle progression and increased
            VSMC proliferation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5086)
  AUTHORS   Yao,J., Qin,X., Zhu,J. and Sheng,H.
  TITLE     Dyrk1A-ASF-CaMKIIdelta Signaling Is Involved in Valsartan
            Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats
  JOURNAL   Cardiology 133 (3), 198-204 (2016)
   PUBMED   26619200
REFERENCE   4  (bases 1 to 5086)
  AUTHORS   He,J., Yao,J., Sheng,H. and Zhu,J.
  TITLE     Involvement of the dual-specificity tyrosine
            phosphorylation-regulated kinase 1A-alternative splicing
            factor-calcium/calmodulin-dependent protein kinase IIdelta
            signaling pathway in myocardial infarction-induced heart failure of
            rats
  JOURNAL   J Card Fail 21 (9), 751-760 (2015)
   PUBMED   26067684
REFERENCE   5  (bases 1 to 5086)
  AUTHORS   Maertens,G.N., Cook,N.J., Wang,W., Hare,S., Gupta,S.S., Oztop,I.,
            Lee,K., Pye,V.E., Cosnefroy,O., Snijders,A.P., KewalRamani,V.N.,
            Fassati,A., Engelman,A. and Cherepanov,P.
  TITLE     Structural basis for nuclear import of splicing factors by human
            Transportin 3
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2728-2733 (2014)
   PUBMED   24449914
REFERENCE   6  (bases 1 to 5086)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 5086)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   8  (bases 1 to 5086)
  AUTHORS   Labourier,E., Rossi,F., Gallouzi,I.E., Allemand,E., Divita,G. and
            Tazi,J.
  TITLE     Interaction between the N-terminal domain of human DNA
            topoisomerase I and the arginine-serine domain of its substrate
            determines phosphorylation of SF2/ASF splicing factor
  JOURNAL   Nucleic Acids Res 26 (12), 2955-2962 (1998)
   PUBMED   9611241
REFERENCE   9  (bases 1 to 5086)
  AUTHORS   Sarkissian,M., Winne,A. and Lafyatis,R.
  TITLE     The mammalian homolog of suppressor-of-white-apricot regulates
            alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS
  JOURNAL   J Biol Chem 271 (49), 31106-31114 (1996)
   PUBMED   8940107
REFERENCE   10 (bases 1 to 5086)
  AUTHORS   Griffin,E.E. and Miller,L.L.
  TITLE     Effects of hypophysectomy of liver donor on net synthesis of
            specific plasma proteins by the isolated perfused rat liver.
            Modulation of synthesis of albumin, fibrinogen, alpha 1-acid
            glycoprotein, alpha 2-(acute phase)-globulin, and haptoglobin by
            insulin, cortisol, triiodothyronine, and growth hormone
  JOURNAL   J Biol Chem 249 (16), 5062-5069 (1974)
   PUBMED   4211972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1, FM051934.1 and FM055064.1.
            
            On Sep 11, 2010 this sequence version replaced NM_001109552.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2846044.1,
                                           SRR26360172.1301466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000010.1  73336498-73336523
            27-581              FM051934.1         6-560
            582-697             FM055064.1         535-650
            698-5086            JAXUCZ010000010.1  73338161-73342549
FEATURES             Location/Qualifiers
     source          1..5086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5086
                     /gene="Srsf1"
                     /gene_synonym="Sfrs1"
                     /note="serine and arginine rich splicing factor 1"
                     /db_xref="GeneID:689890"
                     /db_xref="RGD:1587490"
     exon            1..318
                     /gene="Srsf1"
                     /gene_synonym="Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..871
                     /gene="Srsf1"
                     /gene_synonym="Sfrs1"
                     /note="splicing factor, arginine/serine-rich 1B"
                     /codon_start=1
                     /product="serine/arginine-rich splicing factor 1"
                     /protein_id="NP_001103022.1"
                     /db_xref="GeneID:689890"
                     /db_xref="RGD:1587490"
                     /translation="MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRD
                     IDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGG
                     GGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVV
                     EFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSR
                     SNSRSRSYSPRRSRGSPRYSPRHSRSRSRT"
     exon            319..503
                     /gene="Srsf1"
                     /gene_synonym="Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..676
                     /gene="Srsf1"
                     /gene_synonym="Sfrs1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..5086
                     /gene="Srsf1"
                     /gene_synonym="Sfrs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagctgata aaggcgccat tttggaccgg ccgcgggaga cgtggtgccg ctgagggctc
       61 gctctgccgt acgctaggct tggtgggaag gcctcttttc gagtccgcgc ttttcgtcgc
      121 cgccatgtca ggaggtggtg tgattcgtgg cccggcaggg aacaacgact gccgcatcta
      181 cgtgggtaac ctacctccag acatccgaac caaggacatt gaggacgtgt tttacaaata
      241 cggcgctatc cgcgacatcg acctgaagaa ccgccgcggg ggaccgccct tcgccttcgt
      301 tgagttcgag gacccgcgag acgcggaaga tgcggtgtac ggtcgcgacg gctacgatta
      361 cgacggctac cgtctgcggg tagagtttcc ccgaagcggc cgtgggaccg gccgaggcgg
      421 cggcgggggt ggaggcggcg gagccccgag aggccgctat ggcccgccat ccaggcggtc
      481 tgaaaacaga gtggttgttt ctggactgcc tccgagtgga agctggcagg acttaaagga
      541 tcacatgcgt gaagcaggtg atgtatgtta tgctgatgtt taccgagatg gcactggtgt
      601 cgtggagttt gtacggaaag aagatatgac gtatgcagtt cgaaaactgg ataacactaa
      661 gtttagatct catgagggag aaactgccta catccgggtt aaagttgatg ggcccagaag
      721 tccaagttat ggaagatctc gatctcgaag ccgtagtcgt agcagaagcc gtagcagaag
      781 caacagcagg agtcgcagtt actccccaag gagaagcaga ggatcaccac gctattctcc
      841 ccgtcatagc agatctcgct ctcgtacata agatgattgg tgacactttt tgtagaaccc
      901 atgttgtata cagttttcct ttactcagta caatcttttc atttttttta attcaaactg
      961 ttttgttcag aatgggctaa agtgttgaat tgcattcttg tgtaatatcc ccttgctcct
     1021 aacatctaca ttcccctcat gtctttggta acttgtattt taagtgatgt catagacagg
     1081 attgtttaaa tttagttaat ttccatgctc ttcagactgt gatattatgt aaatgtctat
     1141 tctgctctgg tttgtgtgaa atgggatgtt gggggtgttt gtggttatct tacttgggga
     1201 agttcttatg tttatcttgc ttttcatgtg tctttctgta gacatatctg aagagatgga
     1261 ttaagaatgc tttggattaa ggattgtgga gcacatttca atcattttag gattgtcaaa
     1321 aggaggattg aggaggatca gatcaataat ggaggcaatg gtatgactcc aagtgctatt
     1381 gtcacagatg aaattggcag tattgacctt atactaaaag gcgagggtta aaattttatc
     1441 taccttaaaa gacttgcaaa catcttatgc agttatcttc agctacaatt gctttgcttt
     1501 ttaaaacctt ggcaattgtg gcaaaattgc ccgttttgta acagttattt gctcccttcc
     1561 cccctttttg ttttaatagg gactaatgtg ggaagaatgg ctaatttgtc acagtgctta
     1621 gttacaactg ttaatgtgtg gcctgctgtt ggtgtacatg tgggtacagg gtgtctattt
     1681 ccaaacagag tataatatca atactgctaa atctgcatgt cctctgtgtg actgatagag
     1741 cgttgttatt tcatttttta aagacaaaaa tgacagcaaa atatagaatt ccaacatatt
     1801 aatgtagata atctagttgg gaatactttt gtctcacttt cccttttaat attcataatt
     1861 gactcatgtt tagaacactt taatttacaa gctaaattgc agatgggagc aatagattta
     1921 gtttagattt aggtgggtag taataccagt aaacttcaat tacataactt tgcaaccaca
     1981 aaacctgtga tacctgtaca gtaacaaatg ttggcattat cagttgaact gtaaatataa
     2041 agtgcttctt ccagttagtc tctgtagtga ttaagtttct aaaatttatc tgaacaccat
     2101 acagaaaact tgttttgggg aatttgatag ttattgatgt acatctgtaa actgatgaca
     2161 gacataactc atcattcccc agaaactttt tttggttaca gtatctaaca ttttgcctcc
     2221 tcttttttgg ttttgctggt tataaaggtt tggattggag agggctcact ggatcccaat
     2281 ccttggagct ggatcattgg attcaaatca taatgtggat aggataggga ggatgaatta
     2341 ccaggattca tggagcggga tcagattacc aggaacatag gagtggattc cttcctgccc
     2401 caaccaaacc gcattcgtgt ggattttttt tcattcaact taattggcta ttccaaagaa
     2461 tttttttcct atttttgacg attggagccc ttaagatgca cgatggaatt gtgttttgca
     2521 ttttttggta aaaggagcaa agcgaggacc tggagatata cgctggagca atctccttgg
     2581 aaggattcag cacgagtaga tggtaaacat ttaaagggga aaaggggggg tttgctttaa
     2641 atagtaaatc agtaagtcac ttctaaattt aaagaaaaca aaattggagt tgaagaataa
     2701 gtaggtttcc aattggctat tgccattttt ctttgaaaaa ataaacattt tttaaaaaac
     2761 gatgcatggt tgtccttttt cctcttcatg taaaattttg actgggtaac tagtgtatca
     2821 gttaattaat ttgatgagat tctgattctg tttatgtgtt agtaaattaa agatttaatc
     2881 taataaatga taactgtctc tgttgtggaa gtcttaagag cgtaataaac cgagtgtaag
     2941 gcagttatga tgtaacaatt gtctaggggg taatggtctg gaaagtaatc tttcatagtt
     3001 tgctaaagga tgattcagaa cttgctattt attttggtat tgctttagac aaaaataggc
     3061 ctttatacaa agttggttaa taactagtaa attttagctt tgagatagcc attgaactca
     3121 aattcagtat taacattagc agaagtatta gaatacaata cagatttttt ttttttttga
     3181 attttggaca aatttaactg tttattgggt gaatcaatac attgtaaatc ttttcagcca
     3241 tatactccct gagtattctg tccccaaact gttctgtatt aagtcagcaa ttatagttta
     3301 gtctactagt gtatctctac tgatacccct tgaagctgaa tcttcatctt tctaggattg
     3361 aagagtggaa attttattta aaatcccaag cttgtgattt ttcttcctgg ttagaatgaa
     3421 taaaccactc tttcagtacc acaatagaaa tatctagata aaagctattt ttaactttcc
     3481 ttgagttgca ggctgaatat gagattattc agatgtaatg taaaatttag gggagactag
     3541 gagttttgat agtaaacgaa acaggtttca agaaatttgc atgagaatct caacctgttc
     3601 attttaatga ccctataagc caattctatg atcaaaacta ggatttcact ttaggtaaag
     3661 caaattagta gactcattaa ggtaaagttg ctgtgttaca gaattcaaag tataactaaa
     3721 ggatgaggaa ttagcatagt taaacatgct ataattggaa atttatagtg tttttaaata
     3781 cattgcatga tcagaggaaa atgttctttt cctccataga gcctcattct gctctggtct
     3841 agactttcgt agatgtcagg gtgggctcaa aactccaaaa atatatccag tttcccagat
     3901 tctgggatta gacatgaacc accacaccag cttgctaaaa tagtatttat aagttaaagt
     3961 gagctagata aaagcaaatg tgggtttatt ttgaatgctt tggaaaccag accaagaatg
     4021 gcctgtttta agtagttcag ccatagattg aaatgtaaaa acaatctttg ccttactgta
     4081 ggcttgtgtt tgaacactag agagcacagt gtttgtaaag ggtatagtag gttttaagac
     4141 ttaggaaata gggctatacc catactgaca attttttttg gaactacaaa tactactttg
     4201 atttccaccc ctccccttct ctgttccctt aggatattgt agggaaccta tgattagttt
     4261 ttctaaccaa gaaagcactt aaatctcttt aagcaagtac tttcataaca tctgattgag
     4321 taaccccaac ttgctgttca gctcatccta ctggagacaa aggtaagaaa cattttctga
     4381 tacctggttt gggatctgga ttttaagaac taaagtttgt aatgaataat tatttgctcc
     4441 tgacttgcaa tgttactttc ctcctcccaa ctttatattt ttaattttga gtgtataaat
     4501 atacccatct caattctgga gttgaatatg atattctaag atctgtttct tagttttgtc
     4561 tgtgagccat gcttttgtag ggctggtgct attgtcagct ttctgtggtc aaggtcaatc
     4621 aacttttggt gtttgccttt tttgctttgt atatgaaatt tgtagtgaaa ttacaaatga
     4681 aataaattat atgtatttaa atagtattaa aaggagagaa gtattagact gttgtaataa
     4741 ccacttgtgg cttatttcca tcatgatttg aagacagatt gacaacccac aatacctgaa
     4801 taccacagat ttttattgag ccaattgaat gtaaaatctg gccagaatag atgcctttat
     4861 tgtgtaattc gtgtaacagt cacataggca ttgttgaagg tgttttatat atatataaag
     4921 tttatgtgat aagatcttca tgtaaagtct gaacaaccat gaatcccaaa tacatctcta
     4981 gtttgggtgg gcaaggagtt gtagaattgt actagtactg cagaggatta atgttgctat
     5041 gtgtaatttt gggagtgaat aaaaagctgt tactttggaa ccttta
//
