LOCUS       NM_001346306            4822 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serine/arginine repetitive matrix 4 (Srrm4),
            mRNA.
ACCESSION   NM_001346306 XR_001840704 XR_001845700
VERSION     NM_001346306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4822)
  AUTHORS   Nakano,Y., Kelly,M.C., Rehman,A.U., Boger,E.T., Morell,R.J.,
            Kelley,M.W., Friedman,T.B. and Banfi,B.
  TITLE     Defects in the Alternative Splicing-Dependent Regulation of REST
            Cause Deafness
  JOURNAL   Cell 174 (3), 536-548 (2018)
   PUBMED   29961578
REFERENCE   2  (bases 1 to 4822)
  AUTHORS   Liu,B., Cheng,S., Xing,W., Pourteymoor,S. and Mohan,S.
  TITLE     RE1-Silencing Transcription Factor (Rest) is a Novel Regulator of
            Osteoblast Differentiation
  JOURNAL   J Cell Biochem 116 (9), 1932-1938 (2015)
   PUBMED   25727884
REFERENCE   3  (bases 1 to 4822)
  AUTHORS   Quesnel-Vallieres,M., Irimia,M., Cordes,S.P. and Blencowe,B.J.
  TITLE     Essential roles for the splicing regulator nSR100/SRRM4 during
            nervous system development
  JOURNAL   Genes Dev 29 (7), 746-759 (2015)
   PUBMED   25838543
REFERENCE   4  (bases 1 to 4822)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   5  (bases 1 to 4822)
  AUTHORS   Calarco,J.A., Superina,S., O'Hanlon,D., Gabut,M., Raj,B., Pan,Q.,
            Skalska,U., Clarke,L., Gelinas,D., van der Kooy,D., Zhen,M.,
            Ciruna,B. and Blencowe,B.J.
  TITLE     Regulation of vertebrate nervous system alternative splicing and
            development by an SR-related protein
  JOURNAL   Cell 138 (5), 898-910 (2009)
   PUBMED   19737518
REFERENCE   6  (bases 1 to 4822)
  AUTHORS   Deol,M.S. and Gluecksohn-Waelsch,S.
  TITLE     The role of inner hair cells in hearing
  JOURNAL   Nature 278 (5701), 250-252 (1979)
   PUBMED   423972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Oct 9, 2016 this sequence version replaced
            XR_001840704.1, XR_001845700.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1051              JAXUCZ010000012.1  45659729-45660779
            1052-1198           JAXUCZ010000012.1  45771974-45772120
            1199-1285           JAXUCZ010000012.1  45778727-45778813
            1286-1357           JAXUCZ010000012.1  45780704-45780775
            1358-1384           JAXUCZ010000012.1  45783335-45783361
            1385-1435           JAXUCZ010000012.1  45784822-45784872
            1436-1528           JAXUCZ010000012.1  45787942-45788034
            1529-1685           JAXUCZ010000012.1  45791205-45791361
            1686-1990           JAXUCZ010000012.1  45804173-45804477
            1991-2194           JAXUCZ010000012.1  45808856-45809059
            2195-2305           JAXUCZ010000012.1  45811614-45811724
            2306-2440           JAXUCZ010000012.1  45812302-45812436
            2441-4822           JAXUCZ010000012.1  45814094-45816475
FEATURES             Location/Qualifiers
     source          1..4822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4822
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /note="serine/arginine repetitive matrix 4"
                     /db_xref="GeneID:498189"
                     /db_xref="RGD:1560213"
     exon            1..1051
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     CDS             921..2729
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /codon_start=1
                     /product="serine/arginine repetitive matrix protein 4"
                     /protein_id="NP_001333235.1"
                     /db_xref="GeneID:498189"
                     /db_xref="RGD:1560213"
                     /translation="MASLQQGEKQLFEKFWKGTFKAVATPRPESIIVASITARKPMPR
                     TETQSSLLLPDQDGPSEKLGQRLATEALGTNSWGREKACRELGPARAHSASQDRDPTP
                     PPSSRGKKKKKKSTRKKRRRSPSYSPSPVKKKKKKSSKKHKRHRSFSKKRRHSSCSPK
                     SKRREEKRHKKQSRSRKSHRHRHHRCPSRSQSSELRSPSCESRHRGRSPEEGRKSRRT
                     HSRRCSKNHCKVSPEARSSHLPSQPLQRLGFLSARGVISGSGSTADLFSKSASPLAAS
                     RGRSQEYDSGNDTSSPPSTQTSSARSQGQEKGSPGGELSKSRDLNCGNTSDSGNSFTT
                     SSPQNKGAVLENVSPACRSSESRGFQSPCLQCAEVKKSSLVPSTARSSPIKECSRSSS
                     YTSTRSSSPSSRSPNPRASPGSTRSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSSRSR
                     RSPSYSRYSPSRERDPKYGEKEPQPRERARRRRRSYSPMRKRRRDSPSHLEARRITSA
                     RKRPIPYYRPSPSSSSSLSSASSWYSSSSSRSASRSYSRSRSPSRNRSSRSQTRSRTR
                     TSRSSSSRSLSLGSRSRSRNRSLSYSSAESYASTRR"
     exon            1052..1198
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1285
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1357
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1384
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1435
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1528
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1685
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1990
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2194
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2305
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2440
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..4822
                     /gene="Srrm4"
                     /gene_synonym="RGD1560213"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtggggg gtgggagagg ccgcggcccc caggcgtaaa gaaaaccata ggggcacccc
       61 cactttgcag tcctcggcag cccctcccag aagtggggta ggtgaaggca ggttggcgtg
      121 ggtggagagg tggggcattt tttagtagct ctctcaatgg aagatgcgct ccaagtcttg
      181 caaaaggata gggaggtggc ccaggcccgg gagtgcgcat gtaagggttg aggagaaggc
      241 ctgcgacgac ggaggagggg tgagggctga gagagaggat cgcctttttg gttctgttca
      301 aggtgttggg gttgcttctc agaggggtca gagccgcaac tcagtggcca cggggccttg
      361 gagacaagcg ctcacccctc cctttctcct cctcagacct gcgggctttt gttatgcaga
      421 tggcggcggg aggctgagcc agagaaggag gggttgctgg ggaaggagga gacggagaag
      481 gggagggagg aaagtacagc tcgcgcgacc agcctccctt ttcaacgtca cattgtgcaa
      541 gagacaaaac ccgggcgcgc cggagctcac acgcgcacgc acggcagacg ccccggtcgc
      601 ctcctctcgg ttctctgcgc ggtagagaaa gccggcccag ctttgctttg cggaggacgc
      661 ggagctcagc ctgctcccac cgcagctcag aaccaagcca agaggtgaac ccagccggtg
      721 gaccaccttc tttctccgct gcctgcctag accagagacg tcccattcta tcccatcccc
      781 cgctctgaac tccgatctct ccccacccca ccccttgggg gtttcacgcg gacagcgccc
      841 cggagcccag ggcgtgtcat cgggtttgga atccacgttt cagcacttcg gacagcgccc
      901 cgggctcttg ggctttcagg atggcgagcc tgcagcaagg cgagaaacag ctgtttgaga
      961 agttctggaa agggaccttc aaagcagtgg ccactccgcg tcccgagagc atcatcgtcg
     1021 ccagtatcac agcccgcaag ccgatgccaa ggacagagac acagagcagt ctcctgctcc
     1081 cagaccagga cggaccttca gagaagctgg gccaacgtct ggccactgag gcccttggta
     1141 ccaacagctg gggaagagag aaagcctgca gggagctggg tcctgccaga gcacacagtg
     1201 cctctcaaga cagagacccg acaccaccac cttcctccag ggggaaaaag aaaaagaaga
     1261 aatcgaccag gaaaaagagg aggaggtccc catcgtacag cccctctcca gtcaagaaga
     1321 agaagaagaa aagctccaag aaacataagc gacacaggtc tttctccaag aaaaggagac
     1381 acagttcctg cagccctaaa agcaaaagac gggaagagaa gaggcacaaa aaacaatctc
     1441 gaagccggaa gtctcaccga catagacatc accgatgccc ctcaaggtcc cagagctcag
     1501 aactgcgctc ccccagctgc gagagcaggc accgaggtcg gtctcctgag gaagggcgga
     1561 aatcccgccg aacacattcc cgacgctgct ccaagaacca ctgcaaggtc agcccagagg
     1621 cccggtccag ccacctgccc agccagcccc tccagaggct cggcttcctg tcagccaggg
     1681 gtgtaatctc tgggtcgggg tccacggctg atctctttag caaatcggcc agcccgctcg
     1741 ccgcctcccg agggcgctcg caggagtacg actcgggcaa tgacacgtcc tcgccgccct
     1801 ccacgcaaac cagctcggcc aggtctcagg gccaggagaa ggggagcccc ggtggggagc
     1861 tgagcaagag ccgggacctc aactgcggca acacttccga ttcagggaac tccttcacca
     1921 catcctcccc ccagaacaag ggggctgtct tagagaatgt ctctcccgcc tgcaggagca
     1981 gtgagtcaag agggtttcag tctccatgtc tccagtgcgc agaggtgaag aagtctagtt
     2041 tggtcccatc cacagcccgg agctccccca ttaaagagtg ctcccgtagc tcctcctaca
     2101 ccagtactcg gtcctccagt ccctcatcca ggtctccaaa tcccagagcc tcccccgggt
     2161 ccacccggag ccggtccacc tcctctgaaa aaaggtccta ctctcgctct cccagctatt
     2221 cttccaagtc tggcaagagg agcccaccta gcagaagctc caggtctcgt cgaagtccga
     2281 gctactcccg ctacagcccc agcagggaac gggacccaaa gtatggtgag aaggaaccac
     2341 agccccgaga acgtgcacgc aggaggcgaa ggtcctactc gcctatgagg aagcgccgga
     2401 gagactcccc aagccacttg gaggcccgga ggataaccag tgcccgcaaa cgccccatcc
     2461 cctactaccg acccagcccc tcctcctcca gcagcctcag cagcgcctcc tcctggtaca
     2521 gcagcagcag cagccgctct gctagccgca gttactcccg gagccggagt cccagtcgga
     2581 accgcagcag ccgaagccag accaggagca ggacgcggac cagccgcagc tccagctccc
     2641 gcagcctcag cctgggctcc cggagccgca gtcggaaccg gagcctgagc tacagctcag
     2701 cagaaagcta tgccagcacg aggcgttaag cgaaggccct ccgtcgagcc agctgccctc
     2761 cgggaagacc cctctgtcca ccgggaggac ccccctctgt actctgcagt ctcctttact
     2821 acctgccctt cagaccatct cctgagtgac agatacagaa tgctcctggc tcctgtcctc
     2881 tcatgtcctg ggaagatggc atgggagaca gggacttcta ttcctttgcc aagctgctag
     2941 gagcctctct accagcacca tcctggggct caccggggca gatagggagg gccaactgtg
     3001 gatccatgac tcaaaagttt gggcctggcc aagatatgga gatggctctg ttccagtcat
     3061 ctactgttca cagggcatct cctagaggcc agggttaatc caccctcacc cacaccaccc
     3121 accttcctcc cttattctgt ctcatggctg caaagtttgg aaccagtgtt gggaaaagag
     3181 gagatcaagg gtggttgaaa ttcaagataa gagctcagag cttttacctc cagctcctgg
     3241 gtcctgctag gagaggtcag acacgagcat gggaggagga tgttagtgtt ggtggcaata
     3301 ggtttcaggg aagtttggaa atggtctctc tataagtata acttcaaaga gacgggtcaa
     3361 ctgccttcct agtaggtcag catcatcaag gaaggaagcc cagcaggttc cagctttatg
     3421 gaggccctta cacagggtcc tgtgacatca caggggtact aaggagacag tggaaccgtc
     3481 cacatacctt gggctacagc cctacttccc aaatttgcct catccccagg agctggcaca
     3541 aatttgattc cacgggacca tctgttgagc attctcagtg ctgtggccag cagccagccc
     3601 ccagcgccag ccagtctgcc cttgccctcc agttggcgcc tgccagcccc ctccacattg
     3661 cccagactgc cacaccctgg attctaccca gggcatcctg gcacctgctg tcctacatga
     3721 agaccactct cttttcctct caggaatttt gccgagacag ggcactgcat tgtaaatcag
     3781 tgttgttggg gggaagactc agattcagag agtctgtgac agagggactt gaatggtccc
     3841 tgtctcaggc tcctgctagc ttctgagttt gtggtcagca tagggaagcc caattgcact
     3901 taaggagtac cacgcatagg aagggtatag aagtaccctc ccgcccaagg ctggccagca
     3961 agagtaagct gccttctgac acataaatgc caccagctgc tttgcctgca gaagatattg
     4021 ggaacaggca ggcaagagag atggtcctta aaataaaccc ttgggcatcc ccctcaccag
     4081 ctgcctggct ctctgagcca tgtgggtatc aagtttgtga tgacaacagt tgagcagagc
     4141 cagggcacat ggagaaagag cttctctccc agctttggat agtggcaagg acagacagca
     4201 ttacctatcc ttcttgcctc aagaaaaaca tatggggggg gtgggagggt gggaatttcc
     4261 atcataaaag cagtgatctc cccataccaa tctttcccag cctatcatgg tgcctggggg
     4321 tccagtgagc accagagaag ttcatcgtcc atcaggagag gaggaggatc agtgactgta
     4381 tcatggcttc tggcccagac caacactcca ctaacacaaa cttgtggatg cctatgcaga
     4441 caccacggga ggccagatgg taggtgcctg gcacaggagt aggtgccccg ggagggcatg
     4501 tgcagctact gtaaatagcc cttgtcccca cccaggatgc caaccaagtc aacgaagcct
     4561 catctttttc acggagacaa aggcttccag gagccacaaa acccttccca gcaggacagc
     4621 ttgtgaaggc aggagcctgc ccggaagaca cagactatct ccgttcaaac cactctaggg
     4681 ggaccgtttt gcccggggct cctagcaaac tttttattta ttagatttat ttatttttta
     4741 tttatttatt atttatgtga tgagctctct ttcctcacca ttagcggcat ttcattattt
     4801 atttgtgtat ttattccgag ag
//
