LOCUS       NM_198757               2052 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus serine racemase (Srr), mRNA.
ACCESSION   NM_198757 XM_220701
VERSION     NM_198757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Bean,L., Bose,P.K., Rani,A. and Kumar,A.
  TITLE     Serine racemase expression profile in the prefrontal cortex and
            hippocampal subregions during aging in male and female rats
  JOURNAL   Aging (Albany NY) 16 (10), 8402-8416 (2024)
   PUBMED   38761177
  REMARK    GeneRIF: Serine racemase expression profile in the prefrontal
            cortex and hippocampal subregions during aging in male and female
            rats.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Watanabe,A., Sasaki,T., Yukami,T., Kanki,H., Sakaguchi,M.,
            Takemori,H., Kitagawa,K. and Mochizuki,H.
  TITLE     Serine racemase inhibition induces nitric oxide-mediated
            neurovascular protection during cerebral ischemia
  JOURNAL   Neuroscience 339, 139-149 (2016)
   PUBMED   27693471
  REMARK    GeneRIF: Study to demonstrate that serine racemase inhibitor
            alleviates neuronal ischemic injury. Serine racemase inhibition
            acts on the neurovascular unit as a neuroprotectant and ameliorant
            of reductions in regional cerebral blood flow.
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Ito,T., Hayashida,M., Kobayashi,S., Muto,N., Hayashi,A.,
            Yoshimura,T. and Mori,H.
  TITLE     Serine racemase is involved in d-aspartate biosynthesis
  JOURNAL   J Biochem 160 (6), 345-353 (2016)
   PUBMED   27387750
  REMARK    GeneRIF: results indicate that SRR indeed acts as a d-Asp
            biosynthetic enzyme in some organs and/or tissues, and also provide
            evidences that there should be some additional enzyme for d-Asp
            synthesis in mammals.
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Kolodney,G., Dumin,E., Safory,H., Rosenberg,D., Mori,H.,
            Radzishevsky,I. and Wolosker,H.
  TITLE     Nuclear Compartmentalization of Serine Racemase Regulates D-Serine
            Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR
            ACTIVATION
  JOURNAL   J Biol Chem 290 (52), 31037-31050 (2015)
   PUBMED   26553873
  REMARK    GeneRIF: that nuclear translocation of SR provides a fail-safe
            mechanism to prevent or limit secondary NMDAR-mediated toxicity in
            nearby synapses.
            Erratum:[J Biol Chem. 2016 Feb 5;291(6):2630. doi:
            10.1074/jbc.A115.699496.. Radzishevisky, Inna [corrected to
            Radzishevsky, Inna]. PMID: 26851299]
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Zhang,H., Kuang,X.L., Chang,Y., Lu,J., Jiang,H. and Wu,S.
  TITLE     Reduced serine racemase expression in aging rat cerebellum is
            associated with oxidative DNA stress and hypermethylation in the
            promoter
  JOURNAL   Brain Res 1629, 221-230 (2015)
   PUBMED   26505919
  REMARK    GeneRIF: In aging cerebellum, oxidative DNA stress was associated
            with reduced serine racemase expression.
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Konno,R.
  TITLE     Rat cerebral serine racemase: amino acid deletion and truncation at
            carboxy terminus
  JOURNAL   Neurosci Lett 349 (2), 111-114 (2003)
   PUBMED   12946565
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Cook,S.P., Galve-Roperh,I., Martinez del Pozo,A. and
            Rodriguez-Crespo,I.
  TITLE     Direct calcium binding results in activation of brain serine
            racemase
  JOURNAL   J Biol Chem 277 (31), 27782-27792 (2002)
   PUBMED   12021263
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   De Miranda,J., Santoro,A., Engelender,S. and Wolosker,H.
  TITLE     Human serine racemase: moleular cloning, genomic organization and
            functional analysis
  JOURNAL   Gene 256 (1-2), 183-188 (2000)
   PUBMED   11054547
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Wolosker,H., Blackshaw,S. and Snyder,S.H.
  TITLE     Serine racemase: a glial enzyme synthesizing D-serine to regulate
            glutamate-N-methyl-D-aspartate neurotransmission
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13409-13414 (1999)
   PUBMED   10557334
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Wolosker,H., Sheth,K.N., Takahashi,M., Mothet,J.P., Brady,R.O. Jr.,
            Ferris,C.D. and Snyder,S.H.
  TITLE     Purification of serine racemase: biosynthesis of the neuromodulator
            D-serine
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 721-725 (1999)
   PUBMED   9892700
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082014.1.
            
            On Sep 16, 2004 this sequence version replaced NM_198757.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082014.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2052
                     /gene="Srr"
                     /note="serine racemase"
                     /db_xref="GeneID:303306"
                     /db_xref="RGD:735094"
     exon            1..92
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            93..318
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            319..497
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1331
                     /gene="Srr"
                     /EC_number="4.3.1.17"
                     /EC_number="5.1.1.18"
                     /EC_number="4.3.1.18"
                     /note="D-serine dehydratase; L-serine dehydratase;
                     D-serine ammonia-lyase; L-serine ammonia-lyase"
                     /codon_start=1
                     /product="serine racemase"
                     /protein_id="NP_942052.1"
                     /db_xref="GeneID:303306"
                     /db_xref="RGD:735094"
                     /translation="MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFF
                     KCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPA
                     YIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVI
                     AGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCY
                     QSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWE
                     RMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP"
     exon            498..624
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            625..728
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            729..848
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            849..923
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1133
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..2027
                     /gene="Srr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggtggcg gagacgacat gtgcgcgtgc gcagaggtgt aacgctggga aggtacgccg
       61 aggcttggag gtggaggtgc agctctcagg agtattccta aatgacctta caccctttgc
      121 tacactggtc ctgggccaag atgggccaat caaagtcctt acccagaatt ttttgaactg
      181 aaattgagag aaaaattcct cttcagtatg gaagccataa aatgtaaaac gcaggagctg
      241 tcagcagcca tgtgtcctgc catacggagc cagctggcct gctgtgagaa ggaagccaac
      301 ctgccagagg cagcagaggt ttcaaaacca tgtgtgctca gtactgcatc tcctttgctg
      361 atgttgaaaa agctcatctc aacattcaag actctgtcca cctcacacca gtgctaacaa
      421 gctccatttt gaatcaaata gcagggcgca atctcttctt caaatgtgaa ctcttccaga
      481 aaactgggtc ttttaagatt cgaggtgccc ttaacgccat cagaggctta attcctgata
      541 ctttagaagg gaagcccaaa gccgttgtta ctcacagcag tggaaaccat ggccaggctc
      601 tcacctatgc tgctaaactg gaaggaattc ctgcttacat tgtggtgccc caaacagctc
      661 ccaattgcaa gaaactggcc atccaagcct acggagcatc tatagtatac agtgaaccga
      721 gtgatgagtc cagagaaaac gtcgctcaac gaattataca agaaacagaa ggcatcttgg
      781 tccatcccaa ccaggagcct gcagtgatag cgggacaagg gacaattgcc ctagaagtgc
      841 tgaaccaggt tcccttggta gatgcgttgg tggtaccagt aggaggagga ggaatggttg
      901 ctggaatagc cattacaatt aagaccctga aacctagcgt gaaggtgtac gctgctgaac
      961 cttccaatgc agatgactgc taccagtcta agctgaaagg agagctgacc cccaatcttc
     1021 atcctccaga gaccatagca gatggcgtca agtccagcat tggcttaaat acctggccta
     1081 ttataaggga ccttgtggac gatgtcttca ctgtcacgga agatgaaatc aagtatgcaa
     1141 cccagctggt gtgggaaaga atgaaactgc tcattgagcc tactgctggc gtcggattgg
     1201 ctgcagtgct atctcagcat ttccaaactg tctctccaga agtaaagaac atctgtattg
     1261 tactcagtgg tgggaatgta gacttaacct ccctaagctg ggtgaagcag gcggaacggc
     1321 cggctcctta acagactgtt tctgttccaa tttagtctct agatgaaagt tttgttttcc
     1381 atcttcctgt ttaaactatt ttcaaaatcc caatcaagta tgttatagta taaatcctgt
     1441 acttagcaga gacacagaca gcctagtcac aacccaacaa ctccaacact ggagccttgg
     1501 ctggaggaac ccaactgagt ggccattact ccatgtctac ttcagacact gttgaagaga
     1561 tgtcactttt aacccaaagt actggctctg gtacatacgg gtcataagtc catttgggaa
     1621 acactcgctt atagagattc attaatactg tatcctgaga ttttagcttc ccatcaaaac
     1681 tgcacttcat atggccatgt gtacctacaa gaaaaacaca taattggtca aagtaaagtg
     1741 gacactttta agcagtgaac ttccagccca ccagtcccaa ggaacacctg ggaacgccag
     1801 gtcttaccca gcggctcttt gatgtgtccc cggcggcccc acttggttct cagttccaca
     1861 ggcttaaacc acagcacatc gtcttagaat ggaacagaca taacaccaaa cgtttgccca
     1921 cgtgtcagtc agggccatct tcccagcacc ctctccactc acacctacct ctgctgaaga
     1981 acatgtagcg cactactgcc gtcttagtaa aaattttgaa aggatgaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aa
//
