LOCUS       NP_001101713             466 aa            linear   ROD 02-JUN-2024
DEFINITION  sushi repeat-containing protein SRPX2 precursor [Rattus
            norvegicus].
ACCESSION   NP_001101713 XP_001067991 XP_228444
VERSION     NP_001101713.1
DBSOURCE    REFSEQ: accession NM_001108243.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Anwer,M., Lara-Valderrabano,L., Karttunen,J., Ndode-Ekane,X.E.,
            Puhakka,N. and Pitkanen,A.
  TITLE     Acute Downregulation of Novel Hypothalamic Protein Sushi
            Repeat-Containing Protein X-Linked 2 after Experimental Traumatic
            Brain Injury
  JOURNAL   J Neurotrauma 37 (7), 924-938 (2020)
   PUBMED   31650880
  REMARK    GeneRIF: Acute Downregulation of Novel Hypothalamic Protein Sushi
            Repeat-Containing Protein X-Linked 2 after Experimental Traumatic
            Brain Injury.
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Sia,G.M., Clem,R.L. and Huganir,R.L.
  TITLE     The human language-associated gene SRPX2 regulates synapse
            formation and vocalization in mice
  JOURNAL   Science 342 (6161), 987-991 (2013)
   PUBMED   24179158
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Tanaka,K., Arao,T., Tamura,D., Aomatsu,K., Furuta,K., Matsumoto,K.,
            Kaneda,H., Kudo,K., Fujita,Y., Kimura,H., Yanagihara,K., Yamada,Y.,
            Okamoto,I., Nakagawa,K. and Nishio,K.
  TITLE     SRPX2 is a novel chondroitin sulfate proteoglycan that is
            overexpressed in gastrointestinal cancer
  JOURNAL   PLoS One 7 (1), e27922 (2012)
   PUBMED   22242148
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Miljkovic-Licina,M., Hammel,P., Garrido-Urbani,S., Bradfield,P.F.,
            Szepetowski,P. and Imhof,B.A.
  TITLE     Sushi repeat protein X-linked 2, a novel mediator of angiogenesis
  JOURNAL   FASEB J 23 (12), 4105-4116 (2009)
   PUBMED   19667118
REFERENCE   6  (residues 1 to 466)
  AUTHORS   Tanaka,K., Arao,T., Maegawa,M., Matsumoto,K., Kaneda,H., Kudo,K.,
            Fujita,Y., Yokote,H., Yanagihara,K., Yamada,Y., Okamoto,I.,
            Nakagawa,K. and Nishio,K.
  TITLE     SRPX2 is overexpressed in gastric cancer and promotes cellular
            migration and adhesion
  JOURNAL   Int J Cancer 124 (5), 1072-1080 (2009)
   PUBMED   19065654
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Royer-Zemmour,B., Ponsole-Lenfant,M., Gara,H., Roll,P., Leveque,C.,
            Massacrier,A., Ferracci,G., Cillario,J., Robaglia-Schlupp,A.,
            Vincentelli,R., Cau,P. and Szepetowski,P.
  TITLE     Epileptic and developmental disorders of the speech cortex:
            ligand/receptor interaction of wild-type and mutant SRPX2 with the
            plasminogen activator receptor uPAR
  JOURNAL   Hum Mol Genet 17 (23), 3617-3630 (2008)
   PUBMED   18718938
REFERENCE   8  (residues 1 to 466)
  AUTHORS   Kurosawa,H., Goi,K., Inukai,T., Inaba,T., Chang,K.S., Shinjyo,T.,
            Rakestraw,K.M., Naeve,C.W. and Look,A.T.
  TITLE     Two candidate downstream target genes for E2A-HLF
  JOURNAL   Blood 93 (1), 321-332 (1999)
   PUBMED   9864177
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001067991.1, XP_228444.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     Protein         1..466
                     /product="sushi repeat-containing protein SRPX2 precursor"
                     /note="sushi repeat-containing protein SRPX2"
                     /calculated_mol_wt=50393
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2478
     mat_peptide     25..466
                     /product="Sushi repeat-containing protein SRPX2.
                     /evidence=ECO:0000255. /id=PRO_0000425275"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DF94.1)"
                     /calculated_mol_wt=50393
     Region          73..115
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Region          123..178
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(133,151)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Region          178..260
                     /region_name="HYR"
                     /note="HYR domain; pfam02494"
                     /db_xref="CDD:460572"
     Region          265..320
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(275,294)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Region          335..454
                     /region_name="DUF4174"
                     /note="Domain of unknown function (DUF4174); pfam13778"
                     /db_xref="CDD:463980"
     CDS             1..466
                     /gene="Srpx2"
                     /gene_synonym="RGD1562444"
                     /coded_by="NM_001108243.2:262..1662"
                     /db_xref="GeneID:317181"
                     /db_xref="RGD:1562444"
ORIGIN      
        1 mktgsltqrg alllllllap avtptwyags gyspdesyne vyaeevpdtr aldyrvprwc
       61 ytlniqdgea tcysprggny hsslgtrcel scdrgfrlig rksvqclpsr rwsgtaycrq
      121 mrchtlpfit sgtytctngm lldsrcdysc ssgyhlegdr sricmedgrw sggepvcvdi
      181 dppkircphs rekiaepekl tarvywdppl vkdsadgtit rvtlrgpepg shfpegehvi
      241 rytaydrayn rasckfivkv qvrrcpilkp pqhgyltcss agdnygaice yhcdggyerq
      301 gtpsrvcqss rqwsgsppvc tpmkinvnvn saaglldqfy ekqrllivsa pdpsnryykm
      361 qismlqqstc gldlrhvtii elvgqppqev grireqqlsa giieelrqfq rltrsyfnmv
      421 lidkqgidre rymepvtpee iftfiddyll snqelarrae qrdvce
//
