LOCUS       NM_022524               1825 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sushi-repeat-containing protein, X-linked (Srpx),
            mRNA.
ACCESSION   NM_022524
VERSION     NM_022524.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Tambe,Y., Yamamoto,A., Isono,T., Chano,T., Fukuda,M. and Inoue,H.
  TITLE     The drs tumor suppressor is involved in the maturation process of
            autophagy induced by low serum
  JOURNAL   Cancer Lett 283 (1), 74-83 (2009)
   PUBMED   19368996
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Tambe,Y., Yoshioka-Yamashita,A., Mukaisho,K., Haraguchi,S.,
            Chano,T., Isono,T., Kawai,T., Suzuki,Y., Kushima,R., Hattori,T.,
            Goto,M., Yamada,S., Kiso,M., Saga,Y. and Inoue,H.
  TITLE     Tumor prone phenotype of mice deficient in a novel
            apoptosis-inducing gene, drs
  JOURNAL   Carcinogenesis 28 (4), 777-784 (2007)
   PUBMED   17088259
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Kawai,T., Suzuki,Y., Yamashita,A. and Inoue,H.
  TITLE     Isolation of a novel mouse variant of the drs tumor suppressor gene
  JOURNAL   Cancer Lett 183 (1), 79-86 (2002)
   PUBMED   12049817
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Pan,J., Nakanishi,K., Yutsudo,M., Inoue,H., Li,Q., Oka,K.,
            Yoshioka,N. and Hakura,A.
  TITLE     Isolation of a novel gene down-regulated by v-src
  JOURNAL   FEBS Lett 383 (1-2), 21-25 (1996)
   PUBMED   8612783
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022524.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78359.1, SRR26643298.31087.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000021.1  15349604-15349764
            162-221             JAXUCZ010000021.1  15392207-15392266
            222-413             JAXUCZ010000021.1  15396723-15396914
            414-590             JAXUCZ010000021.1  15398891-15399067
            591-717             JAXUCZ010000021.1  15407821-15407947
            718-839             JAXUCZ010000021.1  15411258-15411379
            840-1019            JAXUCZ010000021.1  15412010-15412189
            1020-1153           JAXUCZ010000021.1  15413859-15413992
            1154-1275           JAXUCZ010000021.1  15416006-15416127
            1276-1825           JAXUCZ010000021.1  15419837-15420386
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1825
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /note="sushi-repeat-containing protein, X-linked"
                     /db_xref="GeneID:64316"
                     /db_xref="RGD:70950"
     exon            1..161
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1459
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /note="sushi repeat-containing protein SRPX;
                     down-regulated by v-src; sushi-repeat-containing protein,
                     X chromosome"
                     /codon_start=1
                     /product="sushi repeat-containing protein SRPX precursor"
                     /protein_id="NP_071969.1"
                     /db_xref="GeneID:64316"
                     /db_xref="RGD:70950"
                     /translation="MGSPGLRPTLLLPQVLLLLLALLHVPPSQGFPGSGDSPLEDDGV
                     WSSHSLYKDTPWCSPIKVKYGDVYCRAPPGGYYKTALGTRCDIRCRKGYELHGSSQLV
                     CQSNRRWSDKVICKQKRCPTLTMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVT
                     CMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTD
                     VILRGLPPGSNFPEGDHKIEYTVYDRAENKGTCKFRVKVRVRRCGKLNAPENGYMKCS
                     SDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPSCAAMNVNVGVRTAAALLD
                     QFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIRA
                     KIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSLVTPMALFNLIDTFPLRKE
                     EMILQAEMGQSCNT"
     exon            162..221
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            222..413
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            414..590
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            591..717
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            718..839
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1019
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1153
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1275
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1825
                     /gene="Srpx"
                     /gene_synonym="Drs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttggcctc ctccagcccc ttagtgctgc gcagcctgcc cggcggggga agcgccggct
       61 cgccatgggg agcccgggac tccggcccac gctgctgctg cctcaagtac tgttgctgtt
      121 gctggcgctg ctgcacgtcc cgccgagcca gggcttccca ggctctggag actcaccact
      181 agaagacgat ggagtctggt cttcacactc tctctataaa gacactccgt ggtgctctcc
      241 catcaaggtg aaatatgggg atgtgtactg cagggctcct cctgggggat attacaaaac
      301 agccctgggg accaggtgtg acattcgctg caggaagggc tacgagcttc atggctcttc
      361 ccagctcgtc tgccagtcaa acaggcgctg gtcggataag gtcatctgca aacaaaagcg
      421 atgtcctacc ctcaccatgc cagcaaatgg agggtttaag tgtgtcgatg gcgcctactt
      481 taactctcgg tgtgagtact attgctcacc aggatataca ttgaaagggg aacggacagt
      541 cacatgtatg gacaacaagg cctggagtgg ccgaccagcc tcctgtgtag atatggaacc
      601 tcctagaatc aagtgcccaa gtgtgaaaga acggatagct gagcctaata agctgacagt
      661 ccgcgtgtcc tgggaaaccc cagagggaag agatacagca gatgggattc ttactgatgt
      721 tattctgaga ggtcttcctc caggctcgaa ttttccagaa ggagaccaca agattgagta
      781 cactgtctat gacagagccg agaacaaggg aacttgcaag ttccgagtta aagtaagagt
      841 cagacgttgt ggcaagctca atgccccaga gaatggttac atgaagtgtt ccagcgatgg
      901 tgacaattat ggagccacct gtgagttctc ctgtatcggt ggctatgagc ttcagggtag
      961 tcctgcccga gtatgccaat ccaatctggc ttggtctggt acagagccta gctgtgcagc
     1021 gatgaatgtc aatgttggtg tcagaaccgc agctgcactt ttggatcagt tttatgagaa
     1081 aagacgactc ctcattgtgt ctacacccac agctcgaaac ctcctctaca gactgcagct
     1141 gggaatgcta cagcaagcac agtgtggtct ggatctccga catatcaccg tggtggagct
     1201 ggtcggagtc ttcccaaccc tcatcggcag gatcagagca aagattatgc ccccagccct
     1261 agctctgcag ctcaggttgt tgcttcgaat cccactctac tccttcagca tggttttagt
     1321 ggataagcat ggcatggata aagaacgtta tgtctcctta gtgacaccca tggctctctt
     1381 caacctcatt gacactttcc ccctgagaaa agaagagatg atccttcagg ctgagatggg
     1441 ccagtcttgc aacacctgat gtgctgttcc atttcctggt gctttctcac ctcttatcat
     1501 agagtatatc atgtagtata ctacagtgcc tgtgggaagg ccttaaaaat acctttgatg
     1561 tacagatttt catttgtaat ttttaaagtc tattttatta tgtgcttcct ttgctcttaa
     1621 acattggcac aatgcctttt aaactttgaa atgttaaaaa aaagtacgaa tatatctatt
     1681 ctaactctcc ctttagtcca ttgtggctga tgaaattaga agtgacagcc acgcccatgc
     1741 tttcagaata ttattcagtg tgaaacacat tttccttttc tcttattgtt tatataagtc
     1801 ttttgttaat aaaatatttt gaagc
//
