LOCUS       NM_001106575            3648 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SRSF protein kinase 2 (Srpk2), mRNA.
ACCESSION   NM_001106575 XM_001059468 XM_238336
VERSION     NM_001106575.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3648)
  AUTHORS   Arancibia,D., Lira,M., Cruz,Y., Barrera,D.P.,
            Montenegro-Venegas,C., Godoy,J.A., Garner,C.C., Inestrosa,N.C.,
            Gundelfinger,E.D., Zamorano,P. and Torres,V.I.
  TITLE     Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the
            Active Zone Scaffolding Protein CAST1/ERC2
  JOURNAL   Cells 8 (11), 1333 (2019)
   PUBMED   31671734
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3648)
  AUTHORS   Sridhara,S.C., Carvalho,S., Grosso,A.R., Gallego-Paez,L.M.,
            Carmo-Fonseca,M. and de Almeida,S.F.
  TITLE     Transcription Dynamics Prevent RNA-Mediated Genomic Instability
            through SRPK2-Dependent DDX23 Phosphorylation
  JOURNAL   Cell Rep 18 (2), 334-343 (2017)
   PUBMED   28076779
REFERENCE   3  (bases 1 to 3648)
  AUTHORS   Lipp,J.J., Marvin,M.C., Shokat,K.M. and Guthrie,C.
  TITLE     SR protein kinases promote splicing of nonconsensus introns
  JOURNAL   Nat Struct Mol Biol 22 (8), 611-617 (2015)
   PUBMED   26167880
REFERENCE   4  (bases 1 to 3648)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3648)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3648)
  AUTHORS   Jang,S.W., Liu,X., Fu,H., Rees,H., Yepes,M., Levey,A. and Ye,K.
  TITLE     Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell
            cycle and cell death in neurons
  JOURNAL   J Biol Chem 284 (36), 24512-24525 (2009)
   PUBMED   19592491
REFERENCE   7  (bases 1 to 3648)
  AUTHORS   Jang,S.W., Yang,S.J., Ehlen,A., Dong,S., Khoury,H., Chen,J.,
            Persson,J.L. and Ye,K.
  TITLE     Serine/arginine protein-specific kinase 2 promotes leukemia cell
            proliferation by phosphorylating acinus and regulating cyclin A1
  JOURNAL   Cancer Res 68 (12), 4559-4570 (2008)
   PUBMED   18559500
REFERENCE   8  (bases 1 to 3648)
  AUTHORS   Kamachi,M., Le,T.M., Kim,S.J., Geiger,M.E., Anderson,P. and
            Utz,P.J.
  TITLE     Human autoimmune sera as molecular probes for the identification of
            an autoantigen kinase signaling pathway
  JOURNAL   J Exp Med 196 (9), 1213-1225 (2002)
   PUBMED   12417631
REFERENCE   9  (bases 1 to 3648)
  AUTHORS   Wang,H.Y., Lin,W., Dyck,J.A., Yeakley,J.M., Songyang,Z.,
            Cantley,L.C. and Fu,X.D.
  TITLE     SRPK2: a differentially expressed SR protein-specific kinase
            involved in mediating the interaction and localization of pre-mRNA
            splicing factors in mammalian cells
  JOURNAL   J Cell Biol 140 (4), 737-750 (1998)
   PUBMED   9472028
REFERENCE   10 (bases 1 to 3648)
  AUTHORS   Kuroyanagi,N., Onogi,H., Wakabayashi,T. and Hagiwara,M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161879.1.
            
            On Apr 6, 2008 this sequence version replaced NM_001106575.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3648
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3648
                     /gene="Srpk2"
                     /note="SRSF protein kinase 2"
                     /db_xref="GeneID:296753"
                     /db_xref="RGD:1305107"
     exon            1..232
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2240
                     /gene="Srpk2"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase SRPK2;
                     serine/arginine-rich protein specific kinase 2; SFRS
                     protein kinase 2"
                     /codon_start=1
                     /product="SRSF protein kinase 2"
                     /protein_id="NP_001100045.1"
                     /db_xref="GeneID:296753"
                     /db_xref="RGD:1305107"
                     /translation="MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPLPDPVPPEPE
                     EEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGK
                     RFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV
                     CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENI
                     LMCVDGAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKR
                     QAELLEKRLQEIEELEREAERKILEENTTSAEASSEQDGECQPEVKLKEAELEDTTEE
                     ETAKDNGEVEDQEEKEDTEKENTEKDEDDVEQELENIDPTWMESPKANGHIENGLFLL
                     EQQLEDEEDEEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQPKSPEFPTPL
                     FSGPLEPVASDSVLSEGSPLTEPEESSPSRDRSRTVSASSTGDLPKTKTRAADLLVNP
                     LDPQNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACM
                     AFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELR
                     HITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS"
     exon            233..384
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..493
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..581
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..669
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..776
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..942
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..968
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1215
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1683
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1784
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1892
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1962
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2055
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..3619
                     /gene="Srpk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgccgt ccctttacag caccattgaa tcccagcccg aacagaagta ctgtgaatcc
       61 tgtggcctca ttctgaacaa aagggattag ggaagaaaaa tctcttgata taaggcttgt
      121 aagcaagggc gggcaatctt ggttgtgaat attttctgat ttttccagaa atcaagcaga
      181 agattgagct gctgatgtca gttaactctg agaagtcgtc ctcttcagaa aggccggagc
      241 ctcaacagaa agctccttta gttcctcctc ctccaccacc gccaccgcca ccaccactgc
      301 cagaccccgt gcctccagag ccagaggagg agattctggg gtcagatgat gaggagcagg
      361 aggaccccgc ggattactgc aaaggtggct atcatccagt gaaaatcgga gacctcttca
      421 atggtcgcta tcatgtcatt aggaagctag gatgggggca cttttccacc gtctggctat
      481 gctgggatat gcaagggaag aggtttgtcg ccatgaaagt tgtaaaaagt gcacagcatt
      541 atacagagac agccttggat gaaattaaat tgctcaaatg tgttcgagaa agtgacccca
      601 gtgacccaaa caaagacatg gtagtccagc taatcgatga cttcaagatc tcaggcatga
      661 atgggataca tgtctgcatg gtcttcgaag tacttggtca ccatctcctc aaatggatca
      721 tcaagtccaa ctatcaaggc ctcccagtcc gctgtgtgaa gagtatcatt cgacaggtcc
      781 ttcagggctt agactatcta cacagcaagt gcaagataat ccacactgat atcaagccgg
      841 agaacatcct gatgtgtgtg gacggcgcgt acgtgcggag aatggcggcc gaggctacgg
      901 agtggcagaa agcaggtgct cctcctcctt ctgggtctgc agtgagtacg gctccacagc
      961 agaaacctat aggaaaaata tctaaaaaca aaaagaaaaa gctaaaaaag aaacagaaga
     1021 ggcaggctga gttgctggag aagcgcctgc aggagattga ggaattggag agagaagccg
     1081 aaaggaaaat cctagaagag aacaccacct ctgcagaagc ttccagtgag caagatggag
     1141 aatgccagcc tgaggtgaaa ctgaaagagg ccgagttaga ggacacaact gaggaagaga
     1201 cagcaaagga caatggtgaa gttgaagacc aggaagagaa agaagacaca gagaaggaaa
     1261 acactgagaa ggatgaagat gatgttgaac aggaacttga gaacatagac cctacgtgga
     1321 tggagtcccc taaggccaac ggccatattg aaaatggcct gtttttactg gagcagcagc
     1381 tggaggatga agaggatgag gaagatgact gtgcaaaccc cgaggagtat aacctggatg
     1441 aaccaaatgc ggagagtgat tatacgtata gcagctccta tgaacaattc aatggtgaat
     1501 tgccaaacgg acagcctaag agtccagagt ttcccacacc gctgttttct gggcccttag
     1561 aacctgtggc ctctgactct gtgctgtcag agggatcacc actcaccgag ccagaggaaa
     1621 gcagtccatc ccgtgacaga agcaggacag tttcagcctc cagtactgga gacttgccaa
     1681 aaacaaaaac ccgggcagct gacctgttgg tgaaccctct ggatccacag aatgcagata
     1741 aaattagagt aaaaattgct gacctgggaa atgcttgttg ggtgcataaa catttcacag
     1801 aggatatcca aacacgtcag tataggtcca tagaggtttt gataggagca ggctacagta
     1861 cacctgcaga catttggagt acagcatgca tggcatttga gctggcaaca ggagactatt
     1921 tgttcgaacc gcattctggg gaagactatt ccagagatga agaccacata gcccacatca
     1981 tagagctgct aggcagtatc ccaaggcact ttgctctgtc tggaaaatac tcccgggagt
     2041 tcttcaaccg cagaggagaa ctgcggcaca tcaccaagct gaagccctgg agcctctttg
     2101 atgttcttgt ggaaaagtat ggctggcccc atgaagatgc tgcacagttt acagatttcc
     2161 tgatcccaat gttagagatg gttccagaaa aacgagcctc agctggcgaa tgccttcggc
     2221 atccttggtt gaattcttag cagattctac aaatatagca ttctgagcta gcaaattttt
     2281 cccagtacat tggacctaaa cagtggctct cattctttaa caggattaca agtgagcggg
     2341 ctccacccag acctttgttt tgctttgagg tactgttgtt tgacacttcg cttcctgtgc
     2401 accacggtcc tggggaaggg tggtctttgt cttcagctaa gtagtttact cgccattttc
     2461 ttctggaaac aataacatgt ctctaagcat tgtttcttgt gttgtgtgac attcaaatgt
     2521 catttttttt ttgaacgaaa aatactttcc cctttgtgtt ttggcaggtt cgttaactat
     2581 ttatgaagac acattttagc tgagtattct ataatttaca ctcttaagaa attatcagtt
     2641 ggaaccaaga aagagcaagg gaatgtacaa tgttctcttc tggcgagggg aagtcagtcc
     2701 ccctgtatta tatgtatgta accattcatc tgcacagata gggcgaggag tcccgcgcgg
     2761 aaagccgccc gccctgagct tcttagcctc cactgcatgt ttcgggtttc ccactgcttc
     2821 aagaagttgc acaaactttt catcccgtag cagtccgagt ggctctggat taggtgccat
     2881 gccctctgtg gcccagcaag agagaaaaac attaaaattg acactataat ctagcagttc
     2941 catttgtatt ttgcatattt ttaaaactat gtttaaaaac atgtgatggc ccagtaccat
     3001 ctagtgttgc ctcttcccag cactgtaagt taaatgcgtt gtttaaattg gacaagagaa
     3061 atatgttcag tgtgtggaat gaaaaaaata atatattttc ggaaaagcat gatcagtgtt
     3121 tgtttaaaac acaaggtgtg tttctacagt ttgcagcgca gtggacagaa cacgcctcac
     3181 agcttacagg tagccgtgat catgttcatt ccaccggcag ctttacttgc tactgcggct
     3241 ccccttgcct tttcattacc gcccatgaat gagaaggtca tttccccttt gcagagcgca
     3301 tacagtttta gtttatgcat ttccttaaaa ttaactgtag aatccaggac gcagacatta
     3361 gtaggcaata ctattttaga gtgtctcata ggaggtgtat ttaacctctt ttagaagtca
     3421 gtggattgaa tgtctttttt aaaaaatttt tattcattaa ggtgcctcgt tttttcttga
     3481 ctttgtccat taacatttat ccatttgcct ttgcaataat tagattgtga aaagctaaca
     3541 agtgttgtaa caataatcct ttgtttgggg tgcttgcact tgtcttaaaa attaaagtgt
     3601 tttggggtgt ttttccagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
