LOCUS       NM_001025726            2374 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus SRSF protein kinase 1 (Srpk1), mRNA.
ACCESSION   NM_001025726 XM_342104
VERSION     NM_001025726.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2374)
  AUTHORS   Li Z, Li A, Yan L, Yang T, Xu W and Fan P.
  TITLE     Downregulation of long noncoding RNA DLEU1 attenuates
            hypersensitivity in chronic constriction injury-induced neuropathic
            pain in rats by targeting miR-133a-3p/SRPK1 axis
  JOURNAL   Mol Med 26 (1), 104 (2020)
   PUBMED   33167866
  REMARK    GeneRIF: Downregulation of long noncoding RNA DLEU1 attenuates
            hypersensitivity in chronic constriction injury-induced neuropathic
            pain in rats by targeting miR-133a-3p/SRPK1 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2374)
  AUTHORS   Li XG and Wang YB.
  TITLE     SRPK1 gene silencing promotes vascular smooth muscle cell
            proliferation and vascular remodeling via inhibition of the
            PI3K/Akt signaling pathway in a rat model of intracranial aneurysms
  JOURNAL   CNS Neurosci Ther 25 (2), 233-244 (2019)
   PUBMED   30101479
  REMARK    GeneRIF: The vascular walls in Intracranial aneurysm rat models
            produced high levels of SRPK1 expression and an activated PI3 K/Akt
            signaling pathway
REFERENCE   3  (bases 1 to 2374)
  AUTHORS   Sridhara SC, Carvalho S, Grosso AR, Gallego-Paez LM, Carmo-Fonseca
            M and de Almeida SF.
  TITLE     Transcription Dynamics Prevent RNA-Mediated Genomic Instability
            through SRPK2-Dependent DDX23 Phosphorylation
  JOURNAL   Cell Rep 18 (2), 334-343 (2017)
   PUBMED   28076779
REFERENCE   4  (bases 1 to 2374)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2374)
  AUTHORS   Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M,
            Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K,
            Onogi H, Hagiwara M and Watanabe M.
  TITLE     Inhibition of hepatitis C virus replication by a specific inhibitor
            of serine-arginine-rich protein kinase
  JOURNAL   Antimicrob Agents Chemother 54 (8), 3179-3186 (2010)
   PUBMED   20498328
REFERENCE   6  (bases 1 to 2374)
  AUTHORS   Kamachi M, Le TM, Kim SJ, Geiger ME, Anderson P and Utz PJ.
  TITLE     Human autoimmune sera as molecular probes for the identification of
            an autoantigen kinase signaling pathway
  JOURNAL   J Exp Med 196 (9), 1213-1225 (2002)
   PUBMED   12417631
REFERENCE   7  (bases 1 to 2374)
  AUTHORS   Nikolakaki E, Kohen R, Hartmann AM, Stamm S, Georgatsou E and
            Giannakouros T.
  TITLE     Cloning and characterization of an alternatively spliced form of SR
            protein kinase 1 that interacts specifically with scaffold
            attachment factor-B
  JOURNAL   J Biol Chem 276 (43), 40175-40182 (2001)
   PUBMED   11509566
REFERENCE   8  (bases 1 to 2374)
  AUTHORS   Kuroyanagi N, Onogi H, Wakabayashi T and Hagiwara M.
  TITLE     Novel SR-protein-specific kinase, SRPK2, disassembles nuclear
            speckles
  JOURNAL   Biochem Biophys Res Commun 242 (2), 357-364 (1998)
   PUBMED   9446799
REFERENCE   9  (bases 1 to 2374)
  AUTHORS   Tronchere H, Wang J and Fu XD.
  TITLE     A protein related to splicing factor U2AF35 that interacts with
            U2AF65 and SR proteins in splicing of pre-mRNA
  JOURNAL   Nature 388 (6640), 397-400 (1997)
   PUBMED   9237760
REFERENCE   10 (bases 1 to 2374)
  AUTHORS   Gui JF, Lane WS and Fu XD.
  TITLE     A serine kinase regulates intracellular localization of splicing
            factors in the cell cycle
  JOURNAL   Nature 369 (6482), 678-682 (1994)
   PUBMED   8208298
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099089.1.
            
            On Jul 22, 2005 this sequence version replaced XM_342104.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099089.1, SRR8487230.22788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2374
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2374
                     /gene="Srpk1"
                     /note="SRSF protein kinase 1"
                     /db_xref="GeneID:361811"
                     /db_xref="RGD:1308272"
     exon            1..90
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2045
                     /gene="Srpk1"
                     /EC_number="2.7.11.1"
                     /note="serine/arginine-rich protein specific kinase 1;
                     serine/threonine-protein kinase SRPK1; SFRS protein kinase
                     1"
                     /codon_start=1
                     /product="SRSF protein kinase 1"
                     /protein_id="NP_001020897.1"
                     /db_xref="GeneID:361811"
                     /db_xref="RGD:1308272"
                     /translation="MERKVLALQARKKRTKAKKDKAQRKPETQHRGSAPHSESDIPEQ
                     EEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQG
                     KKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTH
                     ICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPEN
                     ILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQK
                     RQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLTENPPNKMTQEKLEESS
                     SIGQDQTLTEHGGEGGAPEINCNGVIGIVNYTANSNNETLRLKEDLHNANDCDGRTLK
                     QEPSFLSSPNGDSSPSPETDSCTPSGSEVPETMACQASVERSLTLTQQDITHLQERIR
                     AHTPSGDEQEREHNGALDSKGKFSAGNFLINPLEPKNAEKLKVKIADLGNACWVHKHF
                     TEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHI
                     ALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAA
                     GFTDFLLPMLELMPEKRATAAECLRHPWLNS"
     exon            91..151
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..270
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..379
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..467
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..555
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..662
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..828
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..854
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1068
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1488
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1589
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1697
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1767
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1860
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2296
                     /gene="Srpk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggattag ggccgcggcg ggagcccgag tcggcgtcac tcgagtgcgc aggcgcctgg
       61 cggttaccgg tctcgccatg gagcggaaag tgctcgcgct ccaggcccga aagaaaagga
      121 ccaaggccaa gaaggacaaa gcccaaagga agcctgaaac ccagcaccga ggctctgcac
      181 cccactccga gagcgacatc cccgagcagg aggaggagat tctggggtct gatgatgatg
      241 aacaggaaga ccctaacgac tactgtaaag gaggttatca tcttgtgaaa attggagatc
      301 tatttaacgg gcgataccat gtgattcgaa aattaggctg gggacacttt tccacagtat
      361 ggttatcatg ggatattcag ggaaagaagt ttgtagcaat gaaagtagtt aaaagtgccg
      421 aacattacac agagacagca ctggatgaga tccggctcct gaaatcggtt cgcaattcag
      481 acccgaatga tccaaatgga gaaatggtcg ttcaactact agatgacttt aaaatatcag
      541 gcgttaatgg aacacatatc tgcatggtgt ttgaagtttt aggacatcat ctactcaagt
      601 ggatcatcaa gtccaactat caggggcttc cgctgccttg tgtcaaaaaa attattcagc
      661 aagtgctcca gggtctggat tacttacaca ccaagtgccg gatcatccac actgacatca
      721 agccggaaaa catcctgttg tccgtgaacg agcagtacat tcggaggctg gctgcagagg
      781 ccacagagtg gcaacggtct ggagctcccc caccatcggg gtctgcagtc agcactgctc
      841 cacagcctaa gccagctgac aaaatgtcaa agaataagaa gaagaaattg aagaagaagc
      901 agaagcgcca ggcagaatta ctagagaagc gaatgcagga aattgaggaa atggagaaag
      961 agtcgggccc tgggcaaaaa agacctaaca agcaagaaga atcagagagt cctgttgaaa
     1021 gacccttgac agagaaccca cctaataaaa tgacccaaga gaaacttgaa gagtcgagtt
     1081 ccattggcca ggatcagaca ctcacggagc atggtggaga gggtggtgcg ccagaaatta
     1141 attgcaatgg agtgattgga atcgttaatt acactgcaaa cagtaacaat gaaaccttga
     1201 ggcttaaaga ggacctacat aatgccaatg actgtgatgg ccgcactctg aagcaggaac
     1261 ctagcttcct aagctctcca aatggagaca gtagtccgtc tccagaaaca gactcttgca
     1321 caccttcggg ctcggaggtg cccgagacca tggcgtgcca ggcctctgta gagcggtcac
     1381 tcaccctcac ccaacaggac atcacccacc tgcaggagcg catccgggca catacgcctt
     1441 ctggggatga gcaggagcgg gaacacaatg gagcgctgga cagcaaagga aaattctctg
     1501 ctggaaattt tcttattaat cccctggagc caaaaaatgc agaaaagctc aaagtgaaga
     1561 ttgctgatct tgggaatgcc tgctgggtgc acaagcattt caccgaagac atccagaccc
     1621 ggcagtaccg gtctttggag gtcctgatag gatctggcta caacacccct gctgacatct
     1681 ggagcacagc atgcatggcc tttgaactag ccacagggga ctatctgttt gagcctcatt
     1741 cgggggagga ttacacgcga gatgaagacc acatcgccct gatcatagag ctcctgggga
     1801 aggtgcctcg caagctcatt gtagcaggga aatactccaa ggaatttttc accaaaaaag
     1861 gtgacctgaa acacatcacc aagttgaagc cttggggtct tctggaggtt ctggtggaga
     1921 agtatgagtg gcctcaggag gaggctgctg gcttcacaga tttcctgctg cccatgttgg
     1981 agctcatgcc tgagaagaga gccactgccg ctgagtgtct ccggcatcct tggctgaact
     2041 cctaagccag ccctgcccgc ccgccactgc agcaggctca tcagactgac cctccctccg
     2101 gccctcccct ctgaggcttc cctctctttt ttccagggca aagctctttc tttcaagggt
     2161 ttctattttt tttaatccaa catgttcatt tgggtttgct tccttgatcc tgtgggaatc
     2221 ccacagccat tgggcatcct aggtgaattt ggccttggtt gggctctgcc aaagactaaa
     2281 agtgtgaaca gcctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
