LOCUS       NM_001108840            2517 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus signal recognition particle 68 (Srp68), mRNA.
ACCESSION   NM_001108840 XM_001081741 XM_003750963 XM_343986
VERSION     NM_001108840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Becker,M.M., Lapouge,K., Segnitz,B., Wild,K. and Sinning,I.
  TITLE     Structures of human SRP72 complexes provide insights into SRP RNA
            remodeling and ribosome interaction
  JOURNAL   Nucleic Acids Res 45 (1), 470-481 (2017)
   PUBMED   27899666
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Yoshida,M., Kabe,Y., Wada,T., Asai,A. and Handa,H.
  TITLE     A new mechanism of
            6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,
            1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by
            target screening with drug-immobilized affinity beads
  JOURNAL   Mol Pharmacol 73 (3), 987-994 (2008)
   PUBMED   18089836
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Menichelli,E., Isel,C., Oubridge,C. and Nagai,K.
  TITLE     Protein-induced conformational changes of RNA during the assembly
            of human signal recognition particle
  JOURNAL   J Mol Biol 367 (1), 187-203 (2007)
   PUBMED   17254600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_003750963.2, XM_001081741.1, XM_343986.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2517
                     /gene="Srp68"
                     /note="signal recognition particle 68"
                     /db_xref="GeneID:363707"
                     /db_xref="RGD:1305376"
     exon            1..290
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1987
                     /gene="Srp68"
                     /note="signal recognition particle 68 kDa protein; signal
                     recognition particle subunit SRP68-like"
                     /codon_start=1
                     /product="signal recognition particle subunit SRP68"
                     /protein_id="NP_001102310.1"
                     /db_xref="GeneID:363707"
                     /db_xref="RGD:1305376"
                     /translation="MAAEKQIPGGGSGGGGSGGGGGGGGSGGGRSAGGDENKENERPS
                     AGSKANKEFGDSLSLEILQVIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMG
                     NRHKFTGKKVTEELLTDSRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRK
                     AVKHAEELERLCESSRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNRCKTIYE
                     KLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEK
                     LEALITQTRAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKER
                     LFESMLSECRDALQAVREELKPDQKQRDYTVDGESGKVSNLQYLHSYLTYIKLSTAIR
                     RNENMAKGLHRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDRTFQ
                     KEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYASEVSSHGGAFKNSLKD
                     LPDVQELITQVRSEKCSLQAAAILDANESHQTDTASQVKDNTPLVERFETFCLDPSLV
                     TKQASLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFR
                     S"
     exon            291..357
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            358..471
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            472..667
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            668..750
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            751..860
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            861..943
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1084
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1183
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1248
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1405
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1500
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1630
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1706
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1759
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2517
                     /gene="Srp68"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggagtcc gtcagtgtac catcaacccg gccaggaagg tgccgctctc tcccgctgct
       61 ggtcgtctcg cctcctccat cccatcctgc tttgcggctc aggggcaaga tggctgctga
      121 gaagcagatc ccgggtggtg gtagtggtgg tggtgggagc ggcggcggcg gcggcggcgg
      181 agggagcgga ggtggacgca gtgccggagg agacgagaat aaagaaaacg aacgcccttc
      241 agccggatcg aaggcaaaca aagagttcgg ggatagcctg agtttggaga ttctgcaggt
      301 tattaaggag tcgcagcagc agcatggcct acggcacgga gacttccagc ggtacagggg
      361 ctactgttct cgaagacaaa ggcgcctccg gaaaacactc aactttaaga tggggaacag
      421 acacaaattc accgggaaga aagtgacaga ggagctcctg actgacagca gatacctgct
      481 gctggttctg atggatgcag aaagagcctg gagctacgcc atgcagctca aacaggaagc
      541 caacaccgag ccccgaaaac ggtttcactt gctgtctcgc cttcgaaaag ccgtgaagca
      601 cgccgaggaa ctggagcgct tgtgtgagag cagccgtgtg gatgctaaga ccaagctaga
      661 ggctcaggcc tatacagctt acctctcggg gatgctgcgc tttgaacacc aggagtggaa
      721 agctgccatt gaggctttca acagatgcaa aactatctat gagaagctag ccagcgcgtt
      781 cacagaggag caggctgtgc tgtacaacca gcgcgtagag gagatctcgc ccaacatccg
      841 ctactgtgca tataacattg gggaccagtc agccatcaat gaactcatgc agatgagact
      901 gaggtctggg ggcacagagg ggctccttgc tgaaaaactt gaggccttga tcactcagac
      961 tcgagccaag caggcagcga ccatgagtga ggtggagtgg aggggcagga cggttcccgt
     1021 gaagatcgac aaagtgagga tcttcttact gggactggct gacaatgaag ccgccattgt
     1081 gcaggctgaa agtgaagaaa cgaaggagcg tctgttcgag tcgatgctca gtgagtgccg
     1141 agacgccctc caggccgtga gggaggagct caagcctgat cagaaacaga gagattacac
     1201 cgtcgatgga gagtcaggga aggtatcgaa tctccagtac ctgcacagct acctgaccta
     1261 catcaagctg tccacagcga tcaggagaaa tgagaacatg gctaaagggc tgcacagggc
     1321 tctgctgcag cagcagccgg aagatgacag caagcgctct ccccggcctc aggacctcat
     1381 ccggctctac gacatcattc tgcagaatct ggtggaattg ctgcagcttc ctggcttaga
     1441 agaagacaga accttccaga aagagatagg cctcaagacc ctggtgttca aagcttacag
     1501 gtgtttcttc atcgctcagt cctacgtgct ggtgaagaag tggagcgaag ccctcgtcct
     1561 gtatgacaga gttctcaaat atgcaagtga agtgagttct catgggggag ccttcaagaa
     1621 cagcctgaag gacctgcctg atgtgcaaga gctcatcact caggtgcggt cagagaagtg
     1681 ctcgctgcag gccgcagcta tcctggatgc aaatgagtcc catcaaactg acacggcctc
     1741 ccaagtcaag gacaatacgc ctctcgttga acggtttgag accttttgcc tggacccttc
     1801 ccttgtcacc aagcaggcca gcctcgtgca cttccccccc ggattccagc ccatcccctg
     1861 caagcctctg ttctttgacc tggccctcaa ccacgtggcc ttcccacctc ttgaggacaa
     1921 attggagcag aagaccaaga gcggcctcac aggctacatc aagggcatct ttggtttcag
     1981 gagctaacca ggctcttcct caggggcagg gaggtcctga cttgctctgc attaaaacag
     2041 acccagcaag ttccatggca ttaaatccag ttctgcattg cctggggcag agctcagtac
     2101 cctcggccct gtgaccattc atcttgtgtg tttgtgactt actttggtag cctgtcatct
     2161 tctgggccca gagtcagggt ctctgtgtcc cctgtgcctc ctggggactg ctgctgtcct
     2221 gcccttgtaa gccatggctg gtcacttttg gtcagtacgt gttcggggtc cacaccaggc
     2281 ctggggggct tggcagtgtt tgtcatgtgt cctcagtccc agggatttga aacgactcct
     2341 tgctgtgagc gtccagagtc tcctgaactt tgtcagtgac tgaaacatga gcagtgtcac
     2401 ccagagctgt ggtcagcctt accccttctc cgagaacaag cagagtgctc tatttttaac
     2461 tatgttacac tcgtaaatga cgaaaccaaa tcttctatta aaaggcaaag atgatgg
//
