LOCUS       NM_053871               2167 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus signal recognition particle 54A (Srp54a), mRNA.
ACCESSION   NM_053871 XM_343063
VERSION     NM_053871.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Carapito,R., Konantz,M., Paillard,C., Miao,Z., Pichot,A.,
            Leduc,M.S., Yang,Y., Bergstrom,K.L., Mahoney,D.H., Shardy,D.L.,
            Alsaleh,G., Naegely,L., Kolmer,A., Paul,N., Hanauer,A., Rolli,V.,
            Muller,J.S., Alghisi,E., Sauteur,L., Macquin,C., Morlon,A.,
            Sancho,C.S., Amati-Bonneau,P., Procaccio,V., Mosca-Boidron,A.L.,
            Marle,N., Osmani,N., Lefebvre,O., Goetz,J.G., Unal,S., Akarsu,N.A.,
            Radosavljevic,M., Chenard,M.P., Rialland,F., Grain,A., Bene,M.C.,
            Eveillard,M., Vincent,M., Guy,J., Faivre,L., Thauvin-Robinet,C.,
            Thevenon,J., Myers,K., Fleming,M.D., Shimamura,A.,
            Bottollier-Lemallaz,E., Westhof,E., Lengerke,C., Isidor,B. and
            Bahram,S.
  TITLE     Mutations in signal recognition particle SRP54 cause syndromic
            neutropenia with Shwachman-Diamond-like features
  JOURNAL   J Clin Invest 127 (11), 4090-4103 (2017)
   PUBMED   28972538
REFERENCE   2  (bases 1 to 2167)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 2167)
  AUTHORS   Yoshida,M., Kabe,Y., Wada,T., Asai,A. and Handa,H.
  TITLE     A new mechanism of
            6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,
            1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by
            target screening with drug-immobilized affinity beads
  JOURNAL   Mol Pharmacol 73 (3), 987-994 (2008)
   PUBMED   18089836
REFERENCE   4  (bases 1 to 2167)
  AUTHORS   Romisch,K., Miller,F.W., Dobberstein,B. and High,S.
  TITLE     Human autoantibodies against the 54 kDa protein of the signal
            recognition particle block function at multiple stages
  JOURNAL   Arthritis Res Ther 8 (2), R39 (2006)
   PUBMED   16469117
REFERENCE   5  (bases 1 to 2167)
  AUTHORS   Politz,J.C., Yarovoi,S., Kilroy,S.M., Gowda,K., Zwieb,C. and
            Pederson,T.
  TITLE     Signal recognition particle components in the nucleolus
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 55-60 (2000)
   PUBMED   10618370
REFERENCE   6  (bases 1 to 2167)
  AUTHORS   Gowda,K., Black,S.D., Moeller,I., Sakakibara,Y., Liu,M.C. and
            Zwieb,C.
  TITLE     Protein SRP54 of human signal recognition particle: cloning,
            expression, and comparative analysis of functional sites
  JOURNAL   Gene 207 (2), 197-207 (1998)
   PUBMED   9511762
REFERENCE   7  (bases 1 to 2167)
  AUTHORS   Bacher,G., Lutcke,H., Jungnickel,B., Rapoport,T.A. and
            Dobberstein,B.
  TITLE     Regulation by the ribosome of the GTPase of the signal-recognition
            particle during protein targeting
  JOURNAL   Nature 381 (6579), 248-251 (1996)
   PUBMED   8622769
REFERENCE   8  (bases 1 to 2167)
  AUTHORS   Hauser,S., Bacher,G., Dobberstein,B. and Lutcke,H.
  TITLE     A complex of the signal sequence binding protein and the SRP RNA
            promotes translocation of nascent proteins
  JOURNAL   EMBO J 14 (22), 5485-5493 (1995)
   PUBMED   8521805
REFERENCE   9  (bases 1 to 2167)
  AUTHORS   Traianedes,K., Findlay,D.M., Martin,T.J. and Gillespie,M.T.
  TITLE     Modulation of the signal recognition particle 54-kDa subunit
            (SRP54) in rat preosteoblasts by the extracellular matrix
  JOURNAL   J Biol Chem 270 (36), 20891-20894 (1995)
   PUBMED   7673110
REFERENCE   10 (bases 1 to 2167)
  AUTHORS   Miller,J.D., Wilhelm,H., Gierasch,L., Gilmore,R. and Walter,P.
  TITLE     GTP binding and hydrolysis by the signal recognition particle
            during initiation of protein translocation
  JOURNAL   Nature 366 (6453), 351-354 (1993)
   PUBMED   8247130
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079117.1.
            
            On Apr 27, 2005 this sequence version replaced XM_343063.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079117.1, FQ211580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2167
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /note="signal recognition particle 54A"
                     /db_xref="GeneID:116650"
                     /db_xref="RGD:621390"
     exon            1..211
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            212..321
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1758
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /EC_number="3.6.5.4"
                     /note="signal recognition particle 54 kDa protein"
                     /codon_start=1
                     /product="signal recognition particle subunit SRP54"
                     /protein_id="NP_446323.1"
                     /db_xref="GeneID:116650"
                     /db_xref="RGD:621390"
                     /translation="MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADV
                     NIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQN
                     VIMFVGLQGSGKTTTCSKLAYFYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFY
                     GSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVSNAIQPDNIV
                     YVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTG
                     EHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYE
                     QFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDG
                     AKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNV
                     SQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM"
     exon            322..413
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            414..498
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            499..603
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            604..670
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            671..728
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            729..879
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1028
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1129
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1216
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1290
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1399
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1570
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1666
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..2145
                     /gene="Srp54a"
                     /gene_synonym="Srp54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcggtgg cagtcgtcgg tattccagct ggtgggagtt ggcttaaggg tgctgggctc
       61 tgggccccta gtttatgtag ctgggaagtt ggactgcgtg gtcttccctg tccttctgct
      121 tccagtgttc ctgggtttcc ttctgcggcg tggggcctcg ccaaggactc gccggccctg
      181 tggggccacg gctagagtgg tgccttttgc gagttctcac aagtacatct taaaaccttc
      241 aagatggttc tagcagatct tggaagaaaa ataacatcag cattacgctc actgagcaat
      301 gccaccatta tcaatgaaga ggtactaaat gctatgctga aggaagtgtg tacagcacta
      361 ttggaagcag atgttaatat taaactagtg aagcagctga gagaaaatgt taagtctgcg
      421 attgatcttg aggagatggc gtccggtctg aacaaaagga agatgattca gcatgctgtg
      481 tttaaagaac ttgtaaagct tgtagaccct ggagttaaag catggacacc gactaaggga
      541 aagcaaaatg tgatcatgtt tgttggattg caagggagtg gtaaaacaac aacgtgttca
      601 aagttagcat atttttacca gaggaaaggt tggaagacct gtttgatatg tgcagataca
      661 ttcagagcag gagcttttga ccagcttaaa cagaacgcca ccaaagcaag aattccgttc
      721 tatggaagct ataccgaaat ggatcctgtc atcattgctt ctgaaggagt ggagaaattc
      781 aaaaatgaaa attttgaaat tattattgtt gatacaagtg gtcgtcacaa acaagaagac
      841 tccttgtttg aagaaatgct tcaagtttct aacgctatac aacctgataa cattgtttat
      901 gtgatggacg catccattgg acaggcttgt gaggcccagg caaaggcctt caaagataaa
      961 gtagatgtag cttcagtaat agtgacgaaa cttgatggtc atgcaaaagg aggtggtgct
     1021 ctcagtgcag ttgctgccac aaaaagtcca attattttca ttggtacagg agaacatata
     1081 gatgactttg aacctttcaa aacacaacct ttcattagta aacttcttgg aatgggtgac
     1141 attgaaggac tgattgataa agtcaatgag ttgaagttgg atgataacga ggcacttata
     1201 gagaagctga agcacggtca gtttacattg cgagacatgt atgaacagtt tcagaatatt
     1261 atgaaaatgg gcccattcag tcagatcttg gggatgattc ctggttttgg cacagatttt
     1321 atgagcaaag gaaatgagca ggagtcaatg gcaaggctaa agaagctgat gacgataatg
     1381 gacagtatga atgatcaaga actggacagt acagatggtg ccaaggtttt tagtaagcaa
     1441 ccaggcagaa tccaaagagt tgcccgggga tcaggtgtgt caacaagaga tgtgcaagaa
     1501 cttctcacac agtataccaa gtttgcccag atggtcaaaa agatgggagg tatcaaaggg
     1561 ctttttaaag gtggtgatat gtcaaagaat gtgagtcagt cacagatggc aaaattaaat
     1621 caacaaatgg ccaaaatgat ggacccacga gttcttcatc acatgggtgg catggccggc
     1681 cttcagtcga tgatgcggca gtttcagcag ggtgctgctg gcaatatgaa aggcatgatg
     1741 ggattcaata acatgtaaag aagccgcctt actagagacg gacatggctg attatgttat
     1801 ccgctgagac ctcacagttt ctctcccact tgcagacggg gaagaagaat ttcttgcctg
     1861 tcttgccttc attcttctgt ctcacctttt ccttgtcttc cttcccttct catgtttggg
     1921 aggagtgact gattcttgtg gaagtcatca tttctgcttt aaatctatta gttctcaacg
     1981 tcataacact tcttaagtta aacaaatcat gatgtaaaat tttagtactt aaaggttttt
     2041 aattgtctca aaggccaagc attacattta taaacagttg cgatcagtaa attacatgat
     2101 attgaagaaa agtgctacaa aataaacttc aagtgataag ttaaaaaaaa aaaaaaaaaa
     2161 aaaaaaa
//
