LOCUS       NM_001011961            2241 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus src-related kinase lacking C-terminal regulatory
            tyrosine and N-terminal myristylation sites (Srms), mRNA.
ACCESSION   NM_001011961 XM_230959
VERSION     NM_001011961.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Goel RK, Paczkowska M, Reimand J, Napper S and Lukong KE.
  TITLE     Phosphoproteomics Analysis Identifies Novel Candidate Substrates of
            the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking
            C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites
            (SRMS)
  JOURNAL   Mol Cell Proteomics 17 (5), 925-947 (2018)
   PUBMED   29496907
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Fan G, Aleem S, Yang M, Miller WT and Tonks NK.
  TITLE     Protein-tyrosine Phosphatase and Kinase Specificity in Regulation
            of SRC and Breast Tumor Kinase
  JOURNAL   J Biol Chem 290 (26), 15934-15947 (2015)
   PUBMED   25897081
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Goel RK, Miah S, Black K, Kalra N, Dai C and Lukong KE.
  TITLE     The unique N-terminal region of SRMS regulates enzymatic activity
            and phosphorylation of its novel substrate docking protein 1
  JOURNAL   FEBS J 280 (18), 4539-4559 (2013)
   PUBMED   23822091
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090006.1.
            
            On Feb 11, 2005 this sequence version replaced XM_230959.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2241
                     /gene="Srms"
                     /note="src-related kinase lacking C-terminal regulatory
                     tyrosine and N-terminal myristylation sites"
                     /db_xref="GeneID:296472"
                     /db_xref="RGD:1306602"
     exon            1..495
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1618
                     /gene="Srms"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="tyrosine-protein kinase Srms"
                     /protein_id="NP_001011961.1"
                     /db_xref="GeneID:296472"
                     /db_xref="RGD:1306602"
                     /translation="MRLRPQPGPLGMEPFLRKRLTFLSFFWDKIWPAGESEEDIPRIQ
                     GQDDNPVPEQPAAVEPCSFPAPRARLFRALYDFTARCAEELSVSRGDRLYALKEEGEY
                     IFAQRLSGPPSTGLVPVTYLAKATPETPSDQPWYFNGISRTQAQQLLLSPANAPGAFL
                     IRPSESSIGGYSLSVRAQAKVCHYRICMAPSGGLYLQEGRLFPSLDALLAYYKTNWKL
                     IQNPLLQPCVPQMPLAQDEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSTPVAVKVIK
                     SADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSPEG
                     KALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKD
                     DVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHET
                     LQQISRGYRLPRPAVCPAEVYMLMVECWKGSPEERPTFATLREKLNAINRRLHLGLT"
     exon            496..617
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     exon            618..784
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     exon            785..926
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1085
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1267
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1424
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..2214
                     /gene="Srms"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttgcacc ctgggctcct ggagcatggc tgtagtgctc agtctcctca gcggcagcac
       61 ggagatccca gagtactgac tcagagtctg ctccatgcgc cttcgtccgc aaccaggccc
      121 cctaggcatg gagcccttcc tccggaagcg gctcactttc ttgtcctttt tctgggataa
      181 gatatggcca gcgggtgagt cggaggaaga catccccagg atccagggac aggacgacaa
      241 cccagtgccg gagcaaccag ctgccgttga accttgtagc ttcccagccc cacgcgcccg
      301 actcttccgc gcgctctacg acttcactgc tcgatgtgca gaggaactga gcgtcagccg
      361 cggggacaga ctctacgccc tcaaggagga gggggagtac atttttgccc aaaggctctc
      421 tgggccaccc agcaccggac tagttccagt cacctacctt gccaaggcta ccccggagac
      481 gccctcagac caaccttggt acttcaatgg gatcagcagg actcaggccc agcagttgct
      541 cttgtctcct gccaacgcac caggggcctt cctcatccgg cccagcgaaa gcagcatcgg
      601 gggatattct ctgtcagtca gggctcaggc caaagtctgc cactatcgaa tctgcatggc
      661 acctagcggc ggcctctacc tgcaggaggg tcgactcttc cccagcctgg atgcattgct
      721 agcttactac aagaccaact ggaagctgat ccagaaccct ctgttgcagc cctgtgtacc
      781 ccagatgccc ttggctcagg acgagtggga acggccacgt tcagaatttg tccttcggag
      841 aaaactgggt gaaggcttct tcggggaggt gtgggaaggc ttgtggctgg gctctacacc
      901 tgtggcggtg aaggtaatca aatcagctga catgaagctg gcagacctca ccaaggagat
      961 tgaggcactg aagagcctga ggcatgagcg gctaatccga ctgcacgcta tatgctccct
     1021 gggtgaaccc gtgtacatcg ttactgaact catgggcaag ggcaacttgc aggtctacct
     1081 gggcagccct gagggaaagg ccctgagcct gcctcatcta ctgggatttg cctgccaggt
     1141 agctgagggc atgagctacc tggaggagcg gcgtgttgtc caccgcgact tggctgccag
     1201 gaacgtgctg gtgggggatg acctcacctg caaggtagct gattttggcc tggccagact
     1261 gctcaaggac gacgtctact ccccaagcag tggctccaag atccccgtca agtggacggc
     1321 acctgaggct gctaattacc gtgtcttttc ccaaaagtca gatgtttggt cctttggcat
     1381 cctgctgtat gaggtcttca cttatggcca gtgtccctat gagggaatga ccaaccacga
     1441 gacgctacag cagattagtc gtggataccg gctgccacgc ccagctgtct gcccagcaga
     1501 ggtctacatg ctcatggtgg agtgctggaa gggcagccct gaggagcgtc ccacctttgc
     1561 cacactgagg gagaagctga atgctataaa cagacgcctc cacctgggcc tcacgtgacc
     1621 aggtctctcc agacccttgg gcagcagcta gggctgccac ttcctgaagg ctgtctccca
     1681 aggaaatatt tgtcactcat acccgggaga tgctatacaa ctgagaatga cagcagcctc
     1741 tgggctccca cactggggct ccttcactga cacagtctgg tactcacatg tgcacactag
     1801 agagacacat gtacctacat gtgcacacca gacggactcg tgcagactga gcctggtcat
     1861 gagcactcac tcagatatga aggtcgatgt gctcctcctg gcatagtccc caaagtgttg
     1921 ataaagtata gaagaggagc cgcacggacg tgctggacag acaagtaccc acagagccag
     1981 cagtttcctc cttgccctca acgctgctcc cttctagaat caaggatgaa aagcccactt
     2041 tccccaggtc ttactgtgga ttaagtagcc aacaccaggg ctggctgtat gccaatacat
     2101 gctatgttct cttaggaaac agcagcagca tctgccccta cccagtgccc cacgggtact
     2161 agtaaacctt aggaacacaa agtcagcttc aataaacatg ttctgtcggt ttcaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa a
//
