LOCUS       NM_053464               1293 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus spermidine synthase (Srm), mRNA.
ACCESSION   NM_053464 XM_001075160 XM_003749458
VERSION     NM_053464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Zayas-Santiago,A., Malpica-Nieves,C.J., Rios,D.S., Diaz-Garcia,A.,
            Vazquez,P.N., Santiago,J.M., Rivera-Aponte,D.E., Veh,R.W.,
            Mendez-Gonzalez,M., Eaton,M. and Skatchkov,S.N.
  TITLE     Spermidine Synthase Localization in Retinal Layers: Early Age
            Changes
  JOURNAL   Int J Mol Sci 25 (12), 6458 (2024)
   PUBMED   38928162
  REMARK    GeneRIF: Spermidine Synthase Localization in Retinal Layers: Early
            Age Changes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Lemay,S.E., Grobs,Y., Romanet,C., Martineau,S., Salem,M.,
            Shimauchi,T., Breuils-Bonnet,S., Bourgeois,A., Theberge,C.,
            Pelletier,A., Potus,F., Provencher,S., Bonnet,S. and Boucherat,O.
  TITLE     Hypusine Signaling Promotes Pulmonary Vascular Remodeling in
            Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Crit Care Med 209 (11), 1376-1391 (2024)
   PUBMED   38261723
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Wallace,H.M., Fraser,A.V. and Hughes,A.
  TITLE     A perspective of polyamine metabolism
  JOURNAL   Biochem J 376 (Pt 1), 1-14 (2003)
   PUBMED   13678416
  REMARK    Review article
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Dejima,H., Kobayashi,M., Takasaki,H., Takeda,N., Shirahata,A. and
            Samejima,K.
  TITLE     Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for
            aminopropyl transferases
  JOURNAL   Biol Pharm Bull 26 (7), 1005-1008 (2003)
   PUBMED   12843627
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Cyriac,J., Haleem,R., Cai,X. and Wang,Z.
  TITLE     Androgen regulation of spermidine synthase expression in the rat
            prostate
  JOURNAL   Prostate 50 (4), 252-261 (2002)
   PUBMED   11870804
REFERENCE   9  (bases 1 to 1293)
  AUTHORS   Shirahata,A., Takahashi,N., Beppu,T., Hosoda,H. and Samejima,K.
  TITLE     Effects of inhibitors of spermidine synthase and spermine synthase
            on polyamine synthesis in rat tissues
  JOURNAL   Biochem Pharmacol 45 (9), 1897-1903 (1993)
   PUBMED   8494549
REFERENCE   10 (bases 1 to 1293)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Apr 16, 2021 this sequence version replaced
            XM_003749458.2, NM_053464.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128733.1, AF337636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               JAXUCZ010000005.1  164309002-164309274
            274-394             JAXUCZ010000005.1  164309561-164309681
            395-487             JAXUCZ010000005.1  164309992-164310084
            488-641             JAXUCZ010000005.1  164310822-164310975
            642-725             JAXUCZ010000005.1  164311310-164311393
            726-871             JAXUCZ010000005.1  164311472-164311617
            872-994             JAXUCZ010000005.1  164311701-164311823
            995-1293            JAXUCZ010000005.1  164311905-164312203
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1293
                     /gene="Srm"
                     /note="spermidine synthase"
                     /db_xref="GeneID:84596"
                     /db_xref="RGD:620796"
     exon            1..273
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1015
                     /gene="Srm"
                     /EC_number="2.5.1.16"
                     /codon_start=1
                     /product="spermidine synthase"
                     /protein_id="NP_445916.1"
                     /db_xref="GeneID:84596"
                     /db_xref="RGD:620796"
                     /translation="MEPGPDGPAAPGPAAIREGWFRETCSLWPGQALSLQVEQLLHHR
                     RSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGG
                     GDGGVLREVVKHPSVESVVQCEIDEDVIEVSKKFLPGMAVGYSSSKLTLHVGDGFEFM
                     KQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGILCCQGECQWLHLDLIK
                     EMRHFCKSLFPVVSYAYCTIPTYPSGQIGFMLCSKNPSTNFREPVQQLTQAQVEQMQL
                     KYYNSDMHRAAFVLPEFTRKALNDIS"
     exon            274..394
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     exon            395..487
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     exon            488..641
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     exon            642..725
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     exon            726..871
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     exon            872..994
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1293
                     /gene="Srm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgggtta ggttgcggcg cgggcggcgg gcagaggtgg tcccgttgtg ctggggctcc
       61 gcgcggcctg cagtcccggg cccgcgacgc gcgccgcccg cccgccatgg agcctggccc
      121 cgacggccca gccgcgcccg gccccgccgc catccgtgag ggttggttcc gagagacctg
      181 cagcctgtgg cctggccagg ccctgtcgct gcaagtggag cagctgctgc accaccggcg
      241 ctcgcggtac caagacatcc tcgtcttccg cagtaaaacc tacggcaacg tgctggttct
      301 ggatggcgtc atccagtgta ccgagaggga cgagttctcc taccaggaga tgatagccaa
      361 cctgccgctc tgcagccacc ccaacccgcg gaaggtgctg atcatcgggg gtggagatgg
      421 gggcgtccta cgggaagtgg tgaagcaccc ctctgtggag tctgtggtcc agtgcgagat
      481 cgatgaggat gtcattgagg tctctaagaa gttcctgcct ggcatggccg ttggctactc
      541 cagctcaaag ctgactctcc acgtgggcga tggctttgag ttcatgaagc agaaccaaga
      601 tgcctttgat gtcatcatca ccgactcctc agaccccatg ggccctgctg agagcctctt
      661 caaggagtcc tattaccagc tcatgaagac agccctcaaa gaagatggca tcctctgttg
      721 ccagggcgag tgccagtggc tgcacctgga cctcatcaag gagatgaggc atttctgcaa
      781 gtctctcttc cctgtggtga gctatgccta ctgtaccatt cccacctatc ccagtggcca
      841 gatcggcttc atgctgtgta gcaaaaaccc gagcaccaac ttccgggagc ccgtgcagca
      901 gctgacacag gcccaggtag agcagatgca gctgaagtac tataactcag acatgcaccg
      961 cgcggccttc gtgctgccag agttcacccg aaaggccctg aatgacataa gctgaatcca
     1021 gtgccactgt aacaccaccc gagacctcag ttggattgga ccaaggagct tccaagctgt
     1081 ctgggaccac cagtcctgga ccagactccc agatgactct tgcccaccaa ccaagtgtta
     1141 caggccccag aatgctgcct ggcctgccct gctgggtgga ctcagtctct gtgtctgtct
     1201 atctctgtgg cgttcagccc cacgcctata ccagctctgt acagcaccac ctatgccctg
     1261 tgacccaaca aaaaacacgt gtatttataa caa
//
