LOCUS       NM_020074               1289 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serglycin (Srgn), mRNA.
ACCESSION   NM_020074
VERSION     NM_020074.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Liu,X., Huai,J., Endle,H., Schluter,L., Fan,W., Li,Y., Richers,S.,
            Yurugi,H., Rajalingam,K., Ji,H., Cheng,H., Rister,B., Horta,G.,
            Baumgart,J., Berger,H., Laube,G., Schmitt,U., Schmeisser,M.J.,
            Boeckers,T.M., Tenzer,S., Vlachos,A., Deller,T., Nitsch,R. and
            Vogt,J.
  TITLE     PRG-1 Regulates Synaptic Plasticity via Intracellular
            PP2A/beta1-Integrin Signaling
  JOURNAL   Dev Cell 38 (3), 275-290 (2016)
   PUBMED   27453502
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Trimbuch,T., Beed,P., Vogt,J., Schuchmann,S., Maier,N.,
            Kintscher,M., Breustedt,J., Schuelke,M., Streu,N., Kieselmann,O.,
            Brunk,I., Laube,G., Strauss,U., Battefeld,A., Wende,H.,
            Birchmeier,C., Wiese,S., Sendtner,M., Kawabe,H., Kishimoto-Suga,M.,
            Brose,N., Baumgart,J., Geist,B., Aoki,J., Savaskan,N.E.,
            Brauer,A.U., Chun,J., Ninnemann,O., Schmitz,D. and Nitsch,R.
  TITLE     Synaptic PRG-1 modulates excitatory transmission via lipid
            phosphate-mediated signaling
  JOURNAL   Cell 138 (6), 1222-1235 (2009)
   PUBMED   19766573
  REMARK    Erratum:[Cell. 2011 Sep 16;146(6):1043]
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Theocharis,A.D., Seidel,C., Borset,M., Dobra,K., Baykov,V.,
            Labropoulou,V., Kanakis,I., Dalas,E., Karamanos,N.K., Sundan,A. and
            Hjerpe,A.
  TITLE     Serglycin constitutively secreted by myeloma plasma cells is a
            potent inhibitor of bone mineralization in vitro
  JOURNAL   J Biol Chem 281 (46), 35116-35128 (2006)
   PUBMED   16870619
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Henningsson,F., Hergeth,S., Cortelius,R., Abrink,M. and Pejler,G.
  TITLE     A role for serglycin proteoglycan in granular retention and
            processing of mast cell secretory granule components
  JOURNAL   FEBS J 273 (21), 4901-4912 (2006)
   PUBMED   17010166
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   Lundequist,A., Abrink,M. and Pejler,G.
  TITLE     Mast cell-dependent activation of pro matrix metalloprotease 2: A
            role for serglycin proteoglycan-dependent mast cell proteases
  JOURNAL   Biol Chem 387 (10-11), 1513-1519 (2006)
   PUBMED   17081126
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Schick,B.P., Pestina,T.I., San Antonio,J.D., Stenberg,P.E. and
            Jackson,C.W.
  TITLE     Decreased serglycin proteoglycan size is associated with the
            platelet alpha granule storage defect in Wistar Furth hereditary
            macrothrombocytopenic rats. Serglycin binding affinity to type I
            collagen is unaltered
  JOURNAL   J Cell Physiol 172 (1), 87-93 (1997)
   PUBMED   9207929
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Giorda,R., Chambers,W.H., Dahl,C.A. and Trucco,M.
  TITLE     Isolation and characterization of a cDNA that encodes the core
            protein of the cytolytic granule proteoglycan in rat natural killer
            cells
  JOURNAL   Nat Immun Cell Growth Regul 9 (2), 91-102 (1990)
   PUBMED   2352541
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   Avraham,S., Stevens,R.L., Gartner,M.C., Austen,K.F., Lalley,P.A.
            and Weis,J.H.
  TITLE     Isolation of a cDNA that encodes the peptide core of the secretory
            granule proteoglycan of rat basophilic leukemia-1 cells and
            assessment of its homology to the human analogue
  JOURNAL   J Biol Chem 263 (15), 7292-7296 (1988)
   PUBMED   3366780
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Bourdon,M.A., Shiga,M. and Ruoslahti,E.
  TITLE     Identification from cDNA of the precursor form of a chondroitin
            sulfate proteoglycan core protein
  JOURNAL   J Biol Chem 261 (27), 12534-12537 (1986)
   PUBMED   2427521
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Bourdon,M.A., Oldberg,A., Pierschbacher,M. and Ruoslahti,E.
  TITLE     Molecular cloning and sequence analysis of a chondroitin sulfate
            proteoglycan cDNA
  JOURNAL   Proc Natl Acad Sci U S A 82 (5), 1321-1325 (1985)
   PUBMED   3919394
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_020074.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088144.1, FQ220127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000020.1  31000004-31000103   c
            101-245             JAXUCZ010000020.1  30990653-30990797   c
            246-1289            JAXUCZ010000020.1  30985508-30986551   c
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1289
                     /gene="Srgn"
                     /gene_synonym="Pgsg"
                     /note="serglycin"
                     /db_xref="GeneID:56782"
                     /db_xref="RGD:619969"
     exon            1..100
                     /gene="Srgn"
                     /gene_synonym="Pgsg"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..564
                     /gene="Srgn"
                     /gene_synonym="Pgsg"
                     /note="PG19 core protein; proteoglycan 10K core protein;
                     cytolytic granule proteoglycan core protein; secretory
                     granule proteoglycan core protein; chondroitin sulfate
                     proteoglycan core protein; proteoglycan peptide core
                     protein"
                     /codon_start=1
                     /product="serglycin precursor"
                     /protein_id="NP_064459.1"
                     /db_xref="GeneID:56782"
                     /db_xref="RGD:619969"
                     /translation="MRQVPVGTRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPDGI
                     FANCIEEKGPRFDLIAEESNVGPPMTDPVLMRGFPNDFFPISDDYSGSGSGSGSGSGS
                     GSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSLADMEWEYQPTDENNIVYFNYG
                     PFDRMLTEQNQEQPGDFII"
     exon            101..245
                     /gene="Srgn"
                     /gene_synonym="Pgsg"
                     /inference="alignment:Splign:2.1.0"
     exon            246..1289
                     /gene="Srgn"
                     /gene_synonym="Pgsg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgagggg ctgagctggt caggatgcgg caggttcctg tgggcaccag gcttgtcctg
       61 gctctcgcct tcgtcctggt ttggggatct tcagttcaag gttatcctgc tcggagagcc
      121 aggtaccaat gggtccgctg taaaccagat ggcatttttg caaactgcat tgaggagaaa
      181 ggaccacggt tcgacctaat agcagaggaa tccaacgttg gccccccgat gaccgatcct
      241 gttttgatga gaggattccc gaatgatttc ttccccattt ctgatgacta ttctggctcc
      301 ggctccggct ctggctctgg ctctggctcc ggctctggct ctggctctgg ctccggctca
      361 ggttccggct ccggttccgg ttctggctct ggctcgggtt ctggctccgg ctcgggctct
      421 ggctcaggaa gcggctccct agctgacatg gaatgggaat accagccaac agatgaaaac
      481 aatattgtct atttcaacta tgggcctttt gataggatgc tcaccgagca aaaccaagaa
      541 caaccaggag attttattat atgaaagtaa ccgtctgttt ctccacctcc acatgaaaca
      601 atgtgttcag tatactttgt gtaccacgtt taaatgagca gtctcaggat aaagttttac
      661 agaaaattta aaatgcttgg aaaagactct tgaatcctgt tacccctttc ctcattaatt
      721 gataaggaat tatgctttaa tgctgttatc tatcttattg ttctggaaaa tatccgcagc
      781 tatatgtgta ttgaatcata actttaaaag ccatactggt ttcgaaaact ttattttgat
      841 agcaagttga tgaacaatac ttcataccta aagtgttcca ttgtgaatta aagatatatt
      901 cctatgtgat taaaaagaaa ataaaatgaa acacagtggc ctcctaccgt ggctatgtga
      961 tgtggtttac atggtgaggg gtatatattc tgttatggcc attggatatg acggggaaga
     1021 ccaaatgttg tttatctaaa aatgttgtgg gttggggctg gggatttagc tcagtggtag
     1081 agcgcttacc taggaagcgc aaggccctgg gttcggtccc cagctccgaa aaaaagaacc
     1141 aaaaaaaaaa atgttgtggg ttgtaaagtt agaaacatta acacctcaaa taacatagag
     1201 ttgtggtctc aatgcctcat aatgttttgc cttttcctag atgcttgttc aggttcaaac
     1261 gttactccat taaagcaaac ataaccaaa
//
