LOCUS       NM_001191975            3671 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus SLIT-ROBO Rho GTPase activating protein 3
            (Srgap3), mRNA.
ACCESSION   NM_001191975 XM_575637
VERSION     NM_001191975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3671)
  AUTHORS   Lu,H., Jiao,Q., Wang,Y., Yang,Z., Feng,M., Wang,L., Chen,X., Jin,W.
            and Liu,Y.
  TITLE     The mental retardation-associated protein srGAP3 regulates
            survival, proliferation, and differentiation of rat embryonic
            neural stem/progenitor cells
  JOURNAL   Stem Cells Dev 22 (11), 1709-1716 (2013)
   PUBMED   23311320
  REMARK    GeneRIF: results provide strong evidence that srGAP3 is involved in
            the regulation of biological behavior and the morphological
            features in neural stem cells/neural progenitor cells in vitro
REFERENCE   2  (bases 1 to 3671)
  AUTHORS   Yao,Q., Jin,W.L., Wang,Y. and Ju,G.
  TITLE     Regulated shuttling of Slit-Robo-GTPase activating proteins between
            nucleus and cytoplasm during brain development
  JOURNAL   Cell Mol Neurobiol 28 (2), 205-221 (2008)
   PUBMED   17710530
  REMARK    GeneRIF: results suggest that srGAPs are not only involved in the
            regulation of the Slit-Robo signal transduction, but also in
            neuronal development and that the translocation of srGAPs is
            important for their functions
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575637.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000004.1  147625448-147625514 c
            68-260              JAXUCZ010000004.1  147510595-147510787 c
            261-423             JAXUCZ010000004.1  147497151-147497313 c
            424-486             JAXUCZ010000004.1  147467876-147467938 c
            487-672             JAXUCZ010000004.1  147454126-147454311 c
            673-801             JAXUCZ010000004.1  147449740-147449868 c
            802-1023            JAXUCZ010000004.1  147448227-147448448 c
            1024-1125           JAXUCZ010000004.1  147446322-147446423 c
            1126-1323           JAXUCZ010000004.1  147444094-147444291 c
            1324-1408           JAXUCZ010000004.1  147440098-147440182 c
            1409-1436           JAXUCZ010000004.1  147434137-147434164 c
            1437-1539           JAXUCZ010000004.1  147428935-147429037 c
            1540-1600           JAXUCZ010000004.1  147423979-147424039 c
            1601-1678           JAXUCZ010000004.1  147421754-147421831 c
            1679-1813           JAXUCZ010000004.1  147415862-147415996 c
            1814-1919           JAXUCZ010000004.1  147412998-147413103 c
            1920-2147           JAXUCZ010000004.1  147412568-147412795 c
            2148-2227           JAXUCZ010000004.1  147408852-147408931 c
            2228-2408           JAXUCZ010000004.1  147404563-147404743 c
            2409-2558           JAXUCZ010000004.1  147403199-147403348 c
            2559-2886           JAXUCZ010000004.1  147400722-147401049 c
            2887-3671           JAXUCZ010000004.1  147395880-147396664 c
FEATURES             Location/Qualifiers
     source          1..3671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3671
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /note="SLIT-ROBO Rho GTPase activating protein 3"
                     /db_xref="GeneID:500287"
                     /db_xref="RGD:1563152"
     CDS             1..3300
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 3"
                     /protein_id="NP_001178904.1"
                     /db_xref="GeneID:500287"
                     /db_xref="RGD:1563152"
                     /translation="MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQ
                     LLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLV
                     LHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNEL
                     YTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKI
                     EKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHAS
                     LARTFRTYLSAEYNLETSRHEGLDIIENAVDNLDSRSDKHTVMDMCSQVFCPPLKFEF
                     QPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLT
                     VEDFDVSDAFQHSRSTESIKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGS
                     NLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSM
                     EAFIKDSGQAIPLVVESCIRFINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVD
                     DQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPADRVHPIQQILITLP
                     RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHVNEV
                     IKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGTIDEVDHDNGTEPHTS
                     DEEVEQIEAIAKFDYVGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYI
                     VVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRL
                     RSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLSRGRIESPEKRRM
                     ATFGSAGSINYPDKKALTEGLSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTAL
                     HELRELERQNTVKQAPDVVLDTLEPLKNPPGPISSEPASPLHTIVIRDPDAAMRRSSS
                     SSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMF
                     PNSSSDKSGTM"
     exon            1..67
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            68..260
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            261..423
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            424..486
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            487..672
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            673..801
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1023
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1125
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1323
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1408
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1436
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1539
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1600
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1678
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1813
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1919
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2147
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2227
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2408
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2558
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2886
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3671
                     /gene="Srgap3"
                     /gene_synonym="RGD1563152"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcatctc aaactaagtt caagaaagac aaagagatca ttgctgaata tgaagcccaa
       61 ataaaagaga tccgcacgca gctggtggag cagttcaaat gcctggagca gcagtcagag
      121 tcgcggctgc agctgctgca agacttgcag gagttcttcc gcaggaaagc tgagatcgag
      181 ctggagtatt cccgcagcct ggagaagctg gccgagcgct tctcctccaa gattcgaagc
      241 tcccgggagc accagttcaa gaaggatcaa tacctcctct cacctgtgaa ctgttggtat
      301 ctggtactgc atcagactcg gcgggagagc cgagatcacg ccaccctcaa tgacatcttc
      361 atgaacaatg tcatcgtccg cctctcccag atcagtgaag atgtcatcag actcttcaaa
      421 aagagcaaag agattggcct gcagatgcat gaggagctgc tgaaggtgac caatgagctc
      481 tacacagtca tgaaaaccta ccacatgtac catgcagaga gcatcagtgc agaaagcaag
      541 ctgaaggagg ccgagaagca ggaggagaaa cagtttaaca agtcaggaga cctgagcatg
      601 aaccttctcc ggcacgagga cagaccccag cgccgcagct ccgtgaagaa gattgagaag
      661 atgaaggaga agaggcaggc caagtattct gagaacaagc tcaagtgcac aaaggcccga
      721 aatgactacc tgctgaatct ggcagccacc aacgcagcta tcagcaaata ctacatccac
      781 gatgtctctg atctcatcga ttgctgtgat ttgggctttc acgccagcct ggcccgcacc
      841 tttcggacct acctctcagc agaatataac ctggagacct ctcgccacga gggcctggac
      901 atcatagaga atgcagtgga caacctggac tcccggagtg acaagcacac agtcatggac
      961 atgtgcagcc aggtcttctg ccctccactc aagtttgagt tccagcccca catgggggat
     1021 gaggtctgcc aggtcagtgc acagcagcct gtccagacgg agctgcttat gcggtaccac
     1081 cagctgcagt ccaggctggc cactctcaag attgagaacg aagaggttag gaaaaccctg
     1141 gatgccacca tgcagacctt acaggacatg ctgaccgtgg aggactttga tgtctctgac
     1201 gccttccaac acagccgatc tacagagtcc ataaagtcag ctgcttctga gacctacatg
     1261 agcaaaatca acatcgccaa aaggagagcc aaccagcagg agacagaaat gttttatttt
     1321 acaaaattta aagaatatgt gaatggcagt aacctcatca ccaagctgca agccaagcat
     1381 gacttactca agcagaccct gggtgaaggg gagagagcag agtgcggcac aaccaggccc
     1441 ccctgtcttc cccctaaacc acagaaaatg aggagaccta ggcctctttc agtgtatagc
     1501 cataaactct ttaacggcag tatggaagcg ttcattaagg attcaggaca agctatacca
     1561 cttgtagtcg agagctgtat tcgattcatc aatttatatg gactccagca gcaggggatc
     1621 ttcagagttc cagggtctca ggttgaagtc aatgacatca agaattcctt tgagagaggt
     1681 gaagaccccc tcgtggatga ccaaaatgag cgagatatca attcagttgc tggtgtttta
     1741 aaactgtatt tccgaggact ggaaaaccca ctctttccta aggaaaggtt tcaagatttg
     1801 atatctacta ttaaactgga gaacccagct gacagggtgc acccaatcca gcagatcctc
     1861 atcaccctgc cccgcgtggt cattgtggtc atgagatacc tctttgcttt cctcaatcac
     1921 ctttcccagt acagtgatga gaacatgatg gatccctaca acttggccat ctgcttcggg
     1981 cccaccctca tgcacatccc tgatgggcag gaccctgtat cctgccaggc acatgtcaat
     2041 gaagtcatca aaaccatcat catccaccat gaagccatct tccccagccc gagggagcta
     2101 gagggacccg tatacgaaaa atgcatggct ggaggggaag agtactgtga cagcccacac
     2161 agtgagccgg ggaccattga tgaagttgac catgacaatg gcacggagcc tcataccagc
     2221 gatgaagaag tggaacagat cgaggccatc gccaagtttg actatgtggg gcggtcccct
     2281 cgtgaactat ctttcaaaaa aggggcctca ctactcctgt accaccgtgc ctccgaggac
     2341 tggtgggagg gccgtcacaa tggcgtagat ggactcatcc ctcatcagta catagttgta
     2401 caggacatgg atgatgcctt ctccgatagc ctgagccaaa aggctgacag cgaggccagc
     2461 agtgggccac tgctggatga caaggcctcc tccaagaatg acctccagtc ccccacagag
     2521 cacatctctg attacggctt tgggggggtg atgggccgag tgagactacg gtccgacgga
     2581 gcagccatcc ccaggcgccg aagtgggggc gacacacaca gcccaccccg gggcttgggt
     2641 cccagcatag atacgccacc ccgagctgct gcctgtccca gcagccccca caaaatcccc
     2701 ctcagccggg gacggattga gagccctgag aagaggagga tggcgacgtt cggaagcgct
     2761 ggcagcatca actaccctga caagaaggcg ctgacagaag ggctctccat gaggtcaact
     2821 tgcggctcca ctcgacacag cagcctaggg gaccacaagt ccctagaggc tgaggccctc
     2881 gcagaagaca tcgagaagac catgagcacg gctcttcatg agttgcggga acttgagaga
     2941 cagaacactg tcaagcaggc accagatgtg gtgctggaca ccctggagcc cctaaagaat
     3001 ccaccaggcc ccatcagctc agagcctgcc agccccctgc acaccattgt catccgagac
     3061 cccgatgctg ccatgcgtcg aagcagcagc tcgtctacag agatgatgac caccttcaag
     3121 ccagccctgt cggctcgcct ggctggtgcc cagctgcgtc caccccccat gcgtccagtc
     3181 agacctgtgg tccagcaccg gtccagcagc agcagcagct caggtgtggg cagcccggca
     3241 gtgacaccta ccgagaagat gttccctaat agctcctcag acaagtccgg cactatgtga
     3301 cctgcaggat cggtgacatc gccgtggccc actgcagcac accgaggcct agggtggcct
     3361 ccgtggcttc cacttgcttc ccagggatct cctggccttg gagggcagat cctagaaggt
     3421 cagcctggga gggtgtatgt ctgtggagag cagaggccca ggcgttagct gcaactccta
     3481 ctcagccatg tgaatgccac agacctcttg tgagcagaca gacatgccaa ggaatgctgg
     3541 agcaagatca gtcccaagga cggtgtttcc tgagattgag gcagatgctt accagcgtct
     3601 catattttca ctggaaaact attctctcga tattctctac atacgtatat atgtgtgtgt
     3661 ataccaatac a
//
