LOCUS       NM_001109302            4104 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serum response factor (Srf), mRNA.
ACCESSION   NM_001109302 XM_001063545 XM_576514
VERSION     NM_001109302.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4104)
  AUTHORS   Gao,L., Zhang,C., Zhu,Y., Zhang,N., Zhang,C., Zhou,S., Feng,G.,
            Huang,F. and Zhang,L.
  TITLE     Serum response factor promoting axonal regeneration by activating
            the Ras-Raf-Cofilin signaling pathway after the spinal cord injury
  JOURNAL   CNS Neurosci Ther 30 (2), e14585 (2024)
   PUBMED   38421133
  REMARK    GeneRIF: Serum response factor promoting axonal regeneration by
            activating the Ras-Raf-Cofilin signaling pathway after the spinal
            cord injury.
REFERENCE   2  (bases 1 to 4104)
  AUTHORS   Ihara,D., Miyata,T., Fukuchi,M., Tsuda,M. and Tabuchi,A.
  TITLE     SRF and SRF Cofactor mRNA Expression Is Differentially Regulated by
            BDNF Stimulation in Cortical Neurons
  JOURNAL   Biol Pharm Bull 46 (4), 636-639 (2023)
   PUBMED   36801840
  REMARK    GeneRIF: SRF and SRF Cofactor mRNA Expression Is Differentially
            Regulated by BDNF Stimulation in Cortical Neurons.
REFERENCE   3  (bases 1 to 4104)
  AUTHORS   Rauschner,M., Reime,S., Riemann,A. and Thews,O.
  TITLE     Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in
            Experimental Tumours In Vivo
  JOURNAL   Adv Exp Med Biol 1395, 243-248 (2022)
   PUBMED   36527644
  REMARK    GeneRIF: Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and
            in Experimental Tumours In Vivo.
REFERENCE   4  (bases 1 to 4104)
  AUTHORS   Zhao,L., Li,C., Guan,C., Song,N., Luan,H., Luo,C., Jiang,W., Bu,Q.,
            Wang,Y., Che,L. and Xu,Y.
  TITLE     Serum response factor, a novel early diagnostic biomarker of acute
            kidney injury
  JOURNAL   Aging (Albany NY) 13 (2), 2885-2894 (2021)
   PUBMED   33406503
  REMARK    GeneRIF: Serum response factor, a novel early diagnostic biomarker
            of acute kidney injury.
REFERENCE   5  (bases 1 to 4104)
  AUTHORS   Zhao,L., Li,C., Zhou,B., Luo,C., Wang,Y., Che,L., Zhao,J. and Xu,Y.
  TITLE     Crucial role of serum response factor in renal tubular epithelial
            cell epithelial-mesenchymal transition in hyperuricemic nephropathy
  JOURNAL   Aging (Albany NY) 11 (22), 10597-10609 (2019)
   PUBMED   31774735
  REMARK    GeneRIF: Crucial role of serum response factor in renal tubular
            epithelial cell epithelial-mesenchymal transition in hyperuricemic
            nephropathy.
REFERENCE   6  (bases 1 to 4104)
  AUTHORS   Chen,C.Y. and Schwartz,R.J.
  TITLE     Recruitment of the tinman homolog Nkx-2.5 by serum response factor
            activates cardiac alpha-actin gene transcription
  JOURNAL   Mol Cell Biol 16 (11), 6372-6384 (1996)
   PUBMED   8887666
REFERENCE   7  (bases 1 to 4104)
  AUTHORS   Chen,C.Y., Croissant,J., Majesky,M., Topouzis,S., McQuinn,T.,
            Frankovsky,M.J. and Schwartz,R.J.
  TITLE     Activation of the cardiac alpha-actin promoter depends upon serum
            response factor, Tinman homologue, Nkx-2.5, and intact serum
            response elements
  JOURNAL   Dev Genet 19 (2), 119-130 (1996)
   PUBMED   8900044
REFERENCE   8  (bases 1 to 4104)
  AUTHORS   Latinkic,B.V., O'Brien,T.P. and Lau,L.F.
  TITLE     Promoter function and structure of the growth factor-inducible
            immediate early gene cyr61
  JOURNAL   Nucleic Acids Res 19 (12), 3261-3267 (1991)
   PUBMED   2062642
REFERENCE   9  (bases 1 to 4104)
  AUTHORS   Schroter,H., Mueller,C.G., Meese,K. and Nordheim,A.
  TITLE     Synergism in ternary complex formation between the dimeric
            glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum
            response element
  JOURNAL   EMBO J 9 (4), 1123-1130 (1990)
   PUBMED   2108863
REFERENCE   10 (bases 1 to 4104)
  AUTHORS   Norman,C., Runswick,M., Pollock,R. and Treisman,R.
  TITLE     Isolation and properties of cDNA clones encoding SRF, a
            transcription factor that binds to the c-fos serum response element
  JOURNAL   Cell 55 (6), 989-1003 (1988)
   PUBMED   3203386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001109302.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.31809.1,
                                           SRR26643288.36760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-829               JAXUCZ010000009.1  21924076-21924904
            830-1096            JAXUCZ010000009.1  21926454-21926720
            1097-1358           JAXUCZ010000009.1  21928440-21928701
            1359-1478           JAXUCZ010000009.1  21929208-21929327
            1479-1670           JAXUCZ010000009.1  21930205-21930396
            1671-1747           JAXUCZ010000009.1  21930737-21930813
            1748-4104           JAXUCZ010000009.1  21930981-21933337
FEATURES             Location/Qualifiers
     source          1..4104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..4104
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /note="serum response factor"
                     /db_xref="GeneID:501099"
                     /db_xref="RGD:1559787"
     exon            1..829
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1843
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /note="serum response factor (c-fos serum response
                     element-binding transcription factor)"
                     /codon_start=1
                     /product="serum response factor"
                     /protein_id="NP_001102772.1"
                     /db_xref="GeneID:501099"
                     /db_xref="RGD:1559787"
                     /translation="MLPSQAGAAAALGRGSALGGSLNRTPTGRPGGSGGTRGANGGRV
                     PGNGAGLGPGRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEME
                     LGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKR
                     KTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSP
                     DSPPRSDPSTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQ
                     TAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQ
                     LPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMT
                     SSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGV
                     PQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE"
     exon            830..1096
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1358
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1478
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1670
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1747
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..4104
                     /gene="Srf"
                     /gene_synonym="RGD1559787"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccagcgcg tggtcccggc cccctccacc cgcggtctcg gccgcggcca gcagcccctg
       61 ccccgcgggg gacgctgacg gccgcagggc gcgcctcccc ggcacacgga cagggggcgc
      121 tgcgcgcggc ctggggcaac cccggccata ggggcaggaa agtgagggcc caggtcggcc
      181 cgggcgtgca ggggccccgg gttcgcagct gcggcagcga cagcggcttt agcagcagcg
      241 ggagtgccgg gtggaaccgg gaagccgatg gcggcggcgg ccccgattcc tcgctgactt
      301 gcctgtccgc cctcctgcac tcagcgccat gttaccgagc caagctgggg ccgcggcggc
      361 tctgggccgg ggctcggccc tggggggcag cctgaacagg accccgacgg ggcggccggg
      421 cggcagcggt gggactcgcg gggcgaacgg gggccgggtc cccgggaacg gcgcggggct
      481 cggcccgggt cgtctggagc gggaggctgc agcagcagca gcgcccaccg ccggggccct
      541 ctacagcggc agcgagggcg actctgagtc cggcgaggag gaggagctgg gcgccgagcg
      601 gcgcggcctc aagcggagtc tgagcgagat ggagctcggt gtggtggtcg gtgggcctga
      661 ggcggcggcg gcggccgccg gaggctacgg accggtgagc ggcgcggtga gcggggccaa
      721 gccggggaag aagacccggg gccgcgtgaa gatcaagatg gagttcatcg acaacaagct
      781 gcggcgttac acgaccttca gcaagaggaa gacgggcatc atgaagaagg cttatgagct
      841 gtccacgctg acagggacac aggtgctgtt gctggtggcc agtgagacag gccatgtgta
      901 tacctttgcc acccgcaaac tgcagcccat gatcaccagt gagaccggca aggcgctgat
      961 tcagacctgc ctcaactcgc cagactctcc accccgctca gaccccagca cagaccagag
     1021 aatgagtgcc actggctttg aagagccaga tctcacctac caggtgtcgg aatctgacag
     1081 cagtggggaa accaaggaca cactgaagcc agcattcaca gtcaccaacc tgccgggtac
     1141 cacctccaca atccaaacag cacccagcac ctctaccacc atgcaagtca gcagcggccc
     1201 ctccttcccc atcaccaact acctggcacc agtgtctgct agtgtcagcc ccagtgctgt
     1261 cagcagtgcc aacgggactg tgctcaagag tacaggcagc ggccctgtct cctctggggg
     1321 ccttatgcag ctgcctacca gcttcactct catgcctggt ggggcagtgg cccagcaggt
     1381 ccctgtgcag gccattcatg tgcaccaggc cccacagcaa gcgtctccct ctcgtgacag
     1441 cagcacagac ctcacgcaga cctcctccag cgggacagtg acgttgcccg ccaccatcat
     1501 gacgtcgtct gtacccacaa ctgtgggtgg ccacatgatg taccctagtc cccatgcagt
     1561 gatgtatgcc cccacctcgg gcctggctga tggcagcctc accgtgctca atgccttctc
     1621 tcaggcacca tccaccatgc aggtgtccca cagccaggtc caggagccag gtggtgtccc
     1681 tcaggtgttc ctcacagcac cgtctgggac cgtgcagatc cctgtctctg ccgttcagct
     1741 tcaccagatg gctgtgatag gacagcaagc tgggagcagc agcaacctca ccgagctaca
     1801 ggtggtgaac ttggacgcca cccacagcac caagagtgaa tgatccgccc gccaccctgg
     1861 acagatggcc caagggacgg caccacttat ttattgttgc cttttcacgg tttctttaca
     1921 cacacattga ctggccgaag gagggaggcg gggagaagga gtgggcagcc acaggacaat
     1981 gccctctcac tccagccaaa gacacggcct gcctgccctt ccctgtcttc ccagctcccc
     2041 tcctgctcta cctgtcatgc tgttgatggt ggggctttcc tccctcctca gaccccttgc
     2101 cagcctggct caatgtttgc tctgagtatt agcttaccca atgggaccgt gcccacctcc
     2161 cactcacagg ccttctgtgg gactgggcac agcggtcccc tctgaggaag tgttggggcc
     2221 ctctctccag cctctttggc gacctctggt tagctctgtg tctgccacgg cctgggacaa
     2281 aagagccctg cccctgcccc tcagggagcc agctgggaga gatggggact tcttccctca
     2341 caccgcctcc ctctgcccct ttcagctcct gaaacagctg ggcctgtgca ctgggcaggt
     2401 tattggggcc gcctgccctg ccttgcctct ctgttcccat ggacctccag gggctcttgg
     2461 gttgaaggga accactatta gcgttctctt cctccccttg gtcttccccc ttctcccagc
     2521 tgctttactt aaaagttgat tttgaacttt ttatttgagg agatgaagtg aaaacaaatc
     2581 tataaatata tatttttaaa atatttaact tttttttaat ggcgtttttc tcatccccct
     2641 ccctgcccaa actccccttt cctggggatg cttttgggct ccctagaact gtctgggccc
     2701 ctggggacag ccaccccttg agctggggtc cccagtgtct gtgtgggaga ttctgagatt
     2761 gtaccatatc ctgggttctt tccaggagaa agctggggaa gggcccctca ggccatgcca
     2821 cgaaaggggg tgggagggtg acccacagtt ctaggcctct tttgccctct agggttgctg
     2881 tgaggaggag ggaagagggg gagcagatgt ggggagggtg gggtgggagg gtcaggtaga
     2941 gaagactggt ttcatttgtg ccacagcatg gtcattgcag cctgtgctcc cccaggctcg
     3001 cagctacctg gggcccaagt tgcagtgagc aggatggggt ttgggaggta gggagacaca
     3061 ggaatggggg tcagaagtag gagcagctct tgggctgagt gcagcaacgg ggagccagat
     3121 gtgggcagct ctcccaggga gtgagcagct actgtaactt ttttaaatta agacaaaaag
     3181 ccttgaagaa aatgacttta tttttctaag tgtaacctca gtatttatgt aatttgtaca
     3241 gggccatgcc ccaccccctt aaagtcccct tggggacctt gagggtgggc tagcataggg
     3301 gagggtgttt taccctgtgt cagagccagc ctaaaccacc tgtatccatt aaaggagctt
     3361 tttcaggggg gcagttgggg tagggagtca ctaacccctt gctactgcct tcagtaggaa
     3421 caagcctgcc tctgtggtta ggtgaagggg taggggaagg tattatgcat agcctaggta
     3481 tagtggggat gatctgctga caagtttgag agccccctta acctctaatc cccattgctg
     3541 tcttccccag ctgggatgcc acctttctgg cctttctcct ggaaatagct ggggcatttg
     3601 ggtggctttc aagactgggg catggtaaac cagggccaga gttggggagc ttgggactca
     3661 ggtctgtaac tgcccagccc ccttctctgc tcttgtttcc ctccactgcc acccactcac
     3721 ggcccctccc ccaacaccgg aggaggtgtt gattcctcct cacaaaagat agagccaggg
     3781 cgagtgaatc aggcaaagtg cttaccacaa cgtgtgctgt gtgattgtgg ccttgggaga
     3841 acctgtttgt caggactgag gtggcatttc tatgtgcagc aacccttggt gtttcccttc
     3901 ctaagtggct ctgggggtgt gtgtgtgcct gtgtctgagt gaatatatgt gtgactgtgg
     3961 agtatgtgtg gaaatatccg tggtttctac ttctcctggg atgtcgaccc aggaatagtg
     4021 gacatggtca catcctctgt acagagcttt cttttgtatt aaaaaaaaat actctttcaa
     4081 taaatgtatc atttttgtgc acag
//
