LOCUS       NM_001412515            5882 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus splicing regulatory glutamic acid and lysine rich
            protein 1 (Srek1), transcript variant 1, mRNA.
ACCESSION   NM_001412515 XM_006231892
VERSION     NM_001412515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5882)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 5882)
  AUTHORS   Li,J., Hawkins,I.C., Harvey,C.D., Jennings,J.L., Link,A.J. and
            Patton,J.G.
  TITLE     Regulation of alternative splicing by SRrp86 and its interacting
            proteins
  JOURNAL   Mol Cell Biol 23 (21), 7437-7447 (2003)
   PUBMED   14559993
REFERENCE   3  (bases 1 to 5882)
  AUTHORS   Barnard,D.C., Li,J., Peng,R. and Patton,J.G.
  TITLE     Regulation of alternative splicing by SRrp86 through coactivation
            and repression of specific SR proteins
  JOURNAL   RNA 8 (4), 526-533 (2002)
   PUBMED   11991645
REFERENCE   4  (bases 1 to 5882)
  AUTHORS   Barnard,D.C. and Patton,J.G.
  TITLE     Identification and characterization of a novel serine-arginine-rich
            splicing regulatory protein
  JOURNAL   Mol Cell Biol 20 (9), 3049-3057 (2000)
   PUBMED   10757789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced XM_006231892.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.6782.1,
                                           SRR26643295.7851.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000002.1  36618642-36618878   c
            238-371             JAXUCZ010000002.1  36611629-36611762   c
            372-496             JAXUCZ010000002.1  36606227-36606351   c
            497-661             JAXUCZ010000002.1  36603454-36603618   c
            662-840             JAXUCZ010000002.1  36602877-36603055   c
            841-971             JAXUCZ010000002.1  36601605-36601735   c
            972-1086            JAXUCZ010000002.1  36600638-36600752   c
            1087-1206           JAXUCZ010000002.1  36596133-36596252   c
            1207-1515           JAXUCZ010000002.1  36595499-36595807   c
            1516-1611           JAXUCZ010000002.1  36591745-36591840   c
            1612-1756           JAXUCZ010000002.1  36588469-36588613   c
            1757-5882           JAXUCZ010000002.1  36583412-36587537   c
FEATURES             Location/Qualifiers
     source          1..5882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..5882
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /note="splicing regulatory glutamic acid and lysine rich
                     protein 1"
                     /db_xref="GeneID:56763"
                     /db_xref="RGD:621696"
     exon            1..237
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1909
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SR-related protein of 86 kDa;
                     serine/arginine-rich-splicing regulatory protein 86;
                     splicing regulatory glutamine/lysine-rich protein 1;
                     splicing regulatory glutamic acid/lysine-rich protein 1;
                     serine/arginine-rich splicing factor 12; splicing factor,
                     arginine/serine-rich 12"
                     /codon_start=1
                     /product="splicing regulatory glutamine/lysine-rich
                     protein 1 isoform 1"
                     /protein_id="NP_001399444.1"
                     /db_xref="GeneID:56763"
                     /db_xref="RGD:621696"
                     /translation="MNSGGGFGLGLGFGLFPTTVIQVTNLSSAVTSEQMRTLFSFLGE
                     IEELRLYPPDNTPLAFSSKVCYIKFREPSSVGVAQHLTNTVFIDRALIVVPCAEGKIP
                     EEAKALSLLAPAPTMTSLVPGAGLLPIPTSSPLTAVSSLGVSLSSLGAIPAAALDPNI
                     TALGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMA
                     GDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAK
                     ELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS
                     KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSRSRDKRKDTREKVKERVK
                     EREREKEKEREKEREKDKERGKNKDKDREKEKDHEKERDKEKEKEQDKDKEREKDRSK
                     EADEKRKKEKKSRTPPRSYNSSRRSRSASRERRRRRSRSSSRSPRTSKTIKRKSSRSP
                     SPRGRNKKEKKREKERDHISDRRERERSTSTKKSSSDRDGKEKVEKTNTPVKEKEHSK
                     EADSTVSTDADEKDAARTEEESKAQHNGNCQPHEERLCSTADAV"
     exon            238..371
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            372..496
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            497..661
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            662..840
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            841..971
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1086
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1206
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1515
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1611
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1756
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..5882
                     /gene="Srek1"
                     /gene_synonym="Sfrs12; Srrp86; Srsf12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttcgctt cccaggctcg gtcgctgacg cgtcgtggac gttggggagc gggaaggcag
       61 ccgcagcagg gccgggatga acagcggcgg cggcttcggt ttgggcttag gcttcggcct
      121 tttccctacg acggtgattc aggtgacgaa cctctcctcg gcggtgacca gcgagcagat
      181 gcggacgctc ttttccttcc taggagaaat cgaggagcta cgactctatc ccccagacaa
      241 tacacctctt gctttttcct ccaaagtatg ttatattaag tttcgtgagc catcaagtgt
      301 tggtgtggcc cagcatctaa ctaacacggt ttttattgac agagctctga tagtagttcc
      361 ttgtgcagaa ggtaaaatcc cagaagaagc caaagccctt tctttactgg ctcctgctcc
      421 aaccatgaca agcctggtgc ctggtgcagg gctgcttccc ataccaacct ccagtccact
      481 gacggcagtg agtagtcttg gcgtttcact tagcagtttg ggagccatac cggcagcagc
      541 actggaccca aacatcacag cacttggaga gataccacag ccaccactta tgggaaatgt
      601 ggatccttct aaaattgacg agattaggag aacagtttat gttggaaatt tgaattcaca
      661 gacaacgaca gctgatcaac tacttgaatt ttttaaacaa gttggagaag tgaagtttgt
      721 tcggatggca ggtgatgaga ctcagccaac tcggtttgct tttgtggaat ttgcagacca
      781 aaattctgta ccaagggccc ttgcttttaa tggagttatg tttggagaca ggccgctgaa
      841 aataaatcac tccaacaatg caatagtaaa acctcctgag atgacacctc aggctgcagc
      901 taaggagtta gaagaagtaa tgaagcgagt gcgggaggct cagtcattta tctcagcagc
      961 cattgaacca gagtctggaa agagcaatga aaggaaaggc ggtcgatctc gttctcacac
     1021 tcgctcaaag tccaggtcta gctcaaagtc ccattctaga aggaagagat cgcagtcaaa
     1081 gcacaggagt agatcccata acaggtcacg ttcaagacag aaagatagac gtagatccaa
     1141 gagcccacat aagaaacgct ctaagtctag ggagaggcgg aagtcaagga gccggtcgcg
     1201 gtcacgggac aagagaaaag atacccggga aaaggtgaag gaaagagtga aggagagaga
     1261 aagggaaaag gaaaaggaaa gggaaaagga gcgtgaaaaa gacaaggaac ggggtaaaaa
     1321 caaagataaa gaccgtgaga aggaaaagga ccatgaaaag gagcgagaca aagaaaagga
     1381 gaaggaacaa gataaagaca aggaacggga aaaagacaga tccaaagagg cagatgaaaa
     1441 acggaagaag gagaagaagt ctagaacacc gccccgaagc tacaattcct caagacgatc
     1501 ccgtagtgcc agcagggaaa ggcggaggag gagaagcagg agttcttcta gatcgccaag
     1561 aacatcaaag accataaaaa gaaagtcttc taggtctccg tctcccaggg gccggaataa
     1621 gaaagagaaa aagagagaga aagaacggga ccacatcagt gacaggagag aaagagagcg
     1681 ttccacctcc acaaaaaaga gttctagtga ccgagacggg aaggagaagg tggagaagac
     1741 taacacacca gttaaggaga aggaacacag taaagaggca gattcaactg tgagcaccga
     1801 tgcggatgag aaggacgctg ccaggactga ggaggaaagt aaagcacagc acaatgggaa
     1861 ttgccagccc cacgaagagc gcctgtgcag cacggccgac gctgtgtagg ccgcccgctt
     1921 tgtctcctcc acggcaggct cgacccagag ctttcagttc caaacaaggt gtaaacggag
     1981 aaggaacgtt acccatgtat ggtagccaaa gctttcccag ctttgaggtg acattgcgga
     2041 catcttgtac tgagcatgga catcatgaaa taccagatgc tacccaaact gaccatcttc
     2101 tgaagtctcc atttccatgg tggcggccac gcttgtcatg tggtgggtgc atcagtgttt
     2161 gccagaaaag cagagatcca gagggaagtt ctccacggag atgagcagtg gaggctctta
     2221 aaaataatgc tagttattca attttgtatt gttttacttt tttttaaaaa aaaattttca
     2281 atatatacag tttgatgatg tgcttgaaat ttgtgcaaat atacatacac tcttgtaaag
     2341 tgcaaagtat gtaagacgtt ttaacattta cttcacaggg gttacagtga ttgtggtaaa
     2401 tcctcaccat tgggttttct tttgctcact gttttggaca tcagtttttc tttaaaacgg
     2461 ttttacaggt taacattgct taagtaagtg ataaaaacca ctgacaatgc atgctactgt
     2521 tcttcagaag agcaactgtg tcgaatacta acgacgtatt cagtgtttag aatcatcgtc
     2581 tgccataaaa aaaacatttc ttaacttcct taacatttcc aagctcatga gtaatactgc
     2641 agcgtgtctt gtcagctgga ggcggcaaag atgcccttat caaaaggaag cagctttcag
     2701 agatgggcga ttggagcaca agctgaagct ctagtgcctt ctgcaatgtg tgctgtactg
     2761 ttttctaggg ttttatatgt gctagtcatt cttaattcat atggaatcta gatggctgta
     2821 ttctagtcat atccattgaa gtgtgcaagt ggtgtgtcag aagcacttct taattcagat
     2881 aagaaaagga agccctgttt acaagatgtg tggaagttca aacaacaatg tagtttgggg
     2941 accaccagtt ttatactgtg atgattaaac aggagacctg ctcttacatg gccagaggaa
     3001 acctatgagt tgatttcatt ggatgatagc cttaatatta ccttgcagtc attttctcct
     3061 aatgatgcag aaattgtacg taaaggaagg actaggagca tatggagagg taactttgtg
     3121 tttaatgata tgcgtgcctg agtgtaagag acgaggtcat ccgtcagtct gaggctcacc
     3181 tttttgcaga aggtatgcaa gtagtaaaac gacatctgtg ttaatgtttt ccccaaaact
     3241 atacattcta gttactgcac tgttcatcat tgctcatttc cagaacaaca gaatcctgct
     3301 tttaatttgc aaaggttatt tgaaaatcaa gtgtaattat tttaacagaa cctaatacaa
     3361 tcaaatactc agttgcctta cctcatgaag ttactttccc agctttcaaa agccaagtag
     3421 cactttagtt ccttggtttc aacttgagtc tttttcacat taatagtgtg gaatctgtaa
     3481 tctgaagact agaaaggccc tttctgcaaa tcataaagcc tggttcgatt atgaagctgc
     3541 ttaatcatct tcgggtgttc agaattagcg tgtgtgtgtg tgtgtgtttg cttttttttt
     3601 gtcactgtgt acattaaact tttggaaaat gctttactat gtaaagtata gatggccatt
     3661 ttaatcactt agccacatac ggttggctgg taaacagctt attctgatac agaaatactt
     3721 ggacacctgt ggagagattg tgaaggagtg tctcacttca accgctgtct tatttatgaa
     3781 atgtaagtag aatagagcaa atgttggaat ctttgttatt ttttagtacc atttctctaa
     3841 taaagttgag tattttagcg gaaagagtct tcagttatct ccgctccggc tttgtttgcc
     3901 atgtggagtg tgccgacaaa gcctgtgcgg caagcctctg cagtgtgtct gaaacagccc
     3961 tctcctttcc tctcgggacg gctggcaaga tgctttcgtg gtggaaattc acacttaatt
     4021 cctactgctg attacctttc attcagatat ttattttgct cagataatca ttaatgtaga
     4081 aaacggtttt taactcggaa tgagcaggga tacaagagaa agtgaagtca gacgctgtgg
     4141 ctttggcctg gcaggtgtgt aggagtgagg cacgtgggga ggcaggcaca cctggtctgt
     4201 tttgattcct ttactggttt tcacctgagg tagatgctgt caggagaacc ggggtgagac
     4261 cagagctgtc cccactgaca gccgagtgtg gtcggtctcc tcctctttct agacagagga
     4321 tgctctctgt cacactgtgg atagcttctg tgtgcacact gagcagcaca aacctggtgg
     4381 ctttacagct aaggaccgaa gggggtttaa tgaactccca gtgactgttg ctgtagttgc
     4441 tgtttccatc ttaatcgagt tagctaggac taaagacact atccagcctg tgagcttctc
     4501 catggttaga actcagtgtc taatatgtat ttatctttat gtcagagact taaattttga
     4561 tatactcaat tacaaatttt aagaaaagtt tataatcaag atggtttatt tattttttgg
     4621 tcaagaaaaa attaagatac taatattgtc atctttttgt gctttcattt taaaattcag
     4681 aaaagatcca accttttatc tagacccgtc ttaacctatg aaattattta aactgaaggg
     4741 ctgtgaggct catcgtcaga ctttaacgta tcttcagttt acagtgcatc acagatagag
     4801 tagaattcag ttcagtcagt tgagtcagca gctagaatca gtgtttgggg gatgcattgg
     4861 atcacagggc gtctctgagc cctggagaag agggcttgat tgagtgggct ataaactgag
     4921 ccacgactct tcactgtgtg tgcttcccaa gtgaaggttt cctcatgttt atttgctaaa
     4981 aggcacttac ttaagttatt ttcaaattcc cgtatttaat gctcttcaaa gggctttatt
     5041 cctacttctg gaagcagaaa tctaataaaa atataacaga atgaccttgt aaaataaaac
     5101 tcatttcctc cttagtttgt aggtcagcct ttgaattcct tttgtctttc actttctctt
     5161 aaatgatttc acctgaggac cgagtgataa ctcaaaggct aaagctgctt acgtacgcct
     5221 tgtggtccat aatcaggttc agtttacatt ccagactaaa acatgcgtat agcttctgga
     5281 attgatttgt ttatatcttt ctttccttct tccttgctgc tgaggatgga gcccggactt
     5341 cacacctgac cgtgctctat cactgcattg cagcccaact cagaacactg tattttaaaa
     5401 gtaggttttt aatcttgcct gatatttaaa tttatgggca gctaacattt tagtttggag
     5461 aattgccagt ttgggagaga tgacatttaa attccagggt cgaaatggag tagtggtctc
     5521 tcttcttgat gattattatt tttttttttt ttgacattcc tgactatgaa agttcagatt
     5581 catcaaactc ataccgagag agttgtagaa ttctacaagt aaatggtacc cagtaggcaa
     5641 caccttattg gggaagagcc cagggaactg acttccatac aagattaagt atactaggtg
     5701 gctgtgtagg tcgattttgt agcttgatag aacggtactg taaatcatca gaaggagcgc
     5761 gaatgcaagc gtaacgacac tgcctggtgt gagtctgagt aactcttacg tggtgttcgt
     5821 gaagaggaac cgctattatg ttgctatatt tttaataaag tgaaactctt gaaatccttc
     5881 ca
//
