LOCUS       NM_001033694            5012 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sterol regulatory element binding transcription
            factor 2 (Srebf2), mRNA.
ACCESSION   NM_001033694 XM_216989
VERSION     NM_001033694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5012)
  AUTHORS   Ou-Yang,Y.N., Deng,F.F., Wang,Y.J., Chen,M., Yang,P.F., Yang,Z. and
            Tian,Z.
  TITLE     High-salt diet induces dyslipidemia through the SREBP2/PCSK9
            pathway in dahl salt-sensitive rats
  JOURNAL   Biochimie 216, 34-45 (2024)
   PUBMED   37844755
  REMARK    GeneRIF: High-salt diet induces dyslipidemia through the
            SREBP2/PCSK9 pathway in dahl salt-sensitive rats.
REFERENCE   2  (bases 1 to 5012)
  AUTHORS   Veitch,Z., Zer,A., Loong,H., Salah,S., Masood,M., Gupta,A.,
            Bradbury,P.A., Hogg,D., Wong,A., Kandel,R., Charames,G.S. and Abdul
            Razak,A.R.
  TITLE     A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS)
  JOURNAL   Sci Rep 9 (1), 7390 (2019)
   PUBMED   31089155
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5012)
  AUTHORS   Danielli,M., Marrone,J., Capiglioni,A.M. and Marinelli,R.A.
  TITLE     Mitochondrial aquaporin-8 is involved in SREBP-controlled
            hepatocyte cholesterol biosynthesis
  JOURNAL   Free Radic Biol Med 131, 370-375 (2019)
   PUBMED   30579780
  REMARK    GeneRIF: Mitochondrial AQP8 is involved in SREBP2-controlled
            hepatocyte cholesterol biosynthesis.
REFERENCE   4  (bases 1 to 5012)
  AUTHORS   Li,Y. and Wu,S.
  TITLE     Epigallocatechin gallate suppresses hepatic cholesterol synthesis
            by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway
  JOURNAL   Mol Cell Biochem 448 (1-2), 175-185 (2018)
   PUBMED   29446047
  REMARK    GeneRIF: EGCG can alleviate liver injury and oxidative stress in
            hyperlipidemic rats. EGCG can activate SIRT1, activate FOXO1
            protein, regulate SREBP-2 protein, and inhibit hepatic cholesterol
            synthesis.
REFERENCE   5  (bases 1 to 5012)
  AUTHORS   Mohamed,A., Viveiros,A., Williams,K. and Posse de Chaves,E.
  TITLE     Abeta inhibits SREBP-2 activation through Akt inhibition
  JOURNAL   J Lipid Res 59 (1), 1-13 (2018)
   PUBMED   29122977
  REMARK    GeneRIF: identification of SREBP-2 as an indirect target of Akt in
            neurons, which may play a role in the cross-talk between
            Alzheimer's disease and diabetes
REFERENCE   6  (bases 1 to 5012)
  AUTHORS   Repa,J.J., Liang,G., Ou,J., Bashmakov,Y., Lobaccaro,J.M.,
            Shimomura,I., Shan,B., Brown,M.S., Goldstein,J.L. and
            Mangelsdorf,D.J.
  TITLE     Regulation of mouse sterol regulatory element-binding protein-1c
            gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
  JOURNAL   Genes Dev 14 (22), 2819-2830 (2000)
   PUBMED   11090130
REFERENCE   7  (bases 1 to 5012)
  AUTHORS   Wu,J., Zhu,Y.H. and Patel,S.B.
  TITLE     Cyclosporin-induced dyslipoproteinemia is associated with selective
            activation of SREBP-2
  JOURNAL   Am J Physiol 277 (6), E1087-E1094 (1999)
   PUBMED   10600799
REFERENCE   8  (bases 1 to 5012)
  AUTHORS   Boizard,M., Le Liepvre,X., Lemarchand,P., Foufelle,F., Ferre,P. and
            Dugail,I.
  TITLE     Obesity-related overexpression of fatty-acid synthase gene in
            adipose tissue involves sterol regulatory element-binding protein
            transcription factors
  JOURNAL   J Biol Chem 273 (44), 29164-29171 (1998)
   PUBMED   9786926
REFERENCE   9  (bases 1 to 5012)
  AUTHORS   Sakai,J., Nohturfft,A., Cheng,D., Ho,Y.K., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Identification of complexes between the COOH-terminal domains of
            sterol regulatory element-binding proteins (SREBPs) and SREBP
            cleavage-activating protein
  JOURNAL   J Biol Chem 272 (32), 20213-20221 (1997)
   PUBMED   9242699
REFERENCE   10 (bases 1 to 5012)
  AUTHORS   Ryan,J.F. and Booth,C.M.
  TITLE     Endometriosis of the ureter
  JOURNAL   Br J Urol 69 (4), 430-431 (1992)
   PUBMED   1581819
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033694.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101902.1, SRR26360194.205046.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000007.1  115543307-115543534
            229-654             JAXUCZ010000007.1  115563888-115564313
            655-836             JAXUCZ010000007.1  115565231-115565412
            837-983             JAXUCZ010000007.1  115566933-115567079
            984-1205            JAXUCZ010000007.1  115569032-115569253
            1206-1320           JAXUCZ010000007.1  115571393-115571507
            1321-1502           JAXUCZ010000007.1  115571641-115571822
            1503-1695           JAXUCZ010000007.1  115574408-115574600
            1696-1877           JAXUCZ010000007.1  115575103-115575284
            1878-2154           JAXUCZ010000007.1  115577840-115578116
            2155-2324           JAXUCZ010000007.1  115580911-115581080
            2325-2493           JAXUCZ010000007.1  115587912-115588080
            2494-2611           JAXUCZ010000007.1  115589915-115590032
            2612-2721           JAXUCZ010000007.1  115590813-115590922
            2722-2854           JAXUCZ010000007.1  115591940-115592072
            2855-3023           JAXUCZ010000007.1  115593455-115593623
            3024-3209           JAXUCZ010000007.1  115595437-115595622
            3210-3321           JAXUCZ010000007.1  115598898-115599009
            3322-5012           JAXUCZ010000007.1  115599255-115600945
FEATURES             Location/Qualifiers
     source          1..5012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..5012
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /note="sterol regulatory element binding transcription
                     factor 2"
                     /db_xref="GeneID:300095"
                     /db_xref="RGD:1307751"
     exon            1..228
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..3542
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /note="sterol regulatory element binding factor 2"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 2"
                     /protein_id="NP_001028866.2"
                     /db_xref="GeneID:300095"
                     /db_xref="RGD:1307751"
                     /translation="MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSD
                     LFSEQLCSSFPGGGGGSGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTS
                     PQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQP
                     LIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPA
                     TVQTVATPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTA
                     ALQVPTLVGSNGAILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRY
                     RSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQK
                     NKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLL
                     DDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNPDQHPYSG
                     SGRNVLSLESGSGGWFDWMMPTLLLWLLNGVIVLSVFVKLLVHGEPVIRPHSRSSVTF
                     WRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLR
                     LVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSD
                     VHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCG
                     PEHSAVPDSLRWLCHPLGQKFFMERSWSIKSAAKDSLYCAQRNPADPIAQVHQAFCKH
                     LLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLHSFVDSVGFVASPFSSSSVL
                     RSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKALEVTESPLVKAVFY
                     ACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVVQLFTCDLLL
                     SLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEAT
                     VRLMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLACRHLPLSFL
                     SSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS"
     exon            229..654
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..836
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..983
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1205
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1320
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1502
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1695
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1877
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2154
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2324
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2493
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2611
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2721
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2854
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3023
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3209
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3321
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..5012
                     /gene="Srebf2"
                     /gene_synonym="Srebf2_retired; SREBP-2; SREBP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaaacatg gcggcggttg gcaccgggcg gtgaggcggt accaggtggg ggctgtcggg
       61 tgtcatgggc ggtggcggcg gtaccgcctc cgcgtctccc tgagctggac ctcacggggg
      121 actctgcgcc gaactgggcg atggatgaga acagcgagct gggcggtctg gagaccatgg
      181 agaccctcac ggagctgggc gatgagctga ctctcgggga catcgacgag atgctacagt
      241 ttgtcagcaa tcaagtggga gagttctctg acttgttttc agagcaacta tgtagctcct
      301 tccctggagg tggtggcggc agtggcagtg gtggcaccag caacaacagc agtggcagag
      361 gcaccagtgg tggagctgca gatcccgcag tacagcggtc attcagccag gtcccattgt
      421 ctaccttctc tccctcatcc acctcccctc aggctccagc cctgcaggtc aaagtctctc
      481 ctaccccacc aagggcaacc cctgttctcc agccccgacc ccagccccag cctcaacctc
      541 cagctcagct gcagcagcag acggtgatga tcaccccgac cttcagcacc gctccacaga
      601 ccaggatcat ccagcagcct ttgatatacc agaatgccgc aaccagcttt caagtcctgc
      661 agcctcaagt gcaaagcctc gtgacatcct cgcaggtaca gccagttacc atccagcagc
      721 aggtgcagac ggtacaggcc cagcgggtgt tgactcagac agccaatggc acactgcaga
      781 cccttgcccc agccacagtg cagacagtcg ctacaccaca ggtgcagcag gtcccggtcc
      841 tggttcagcc tcagattatt aagacagatt cccttgtttt gaccacgctg aaaacagatg
      901 gcagccctgt catggccgcc gtccagaacc cggccctcac tgccctcacc gcccccatcc
      961 agacggccgc ccttcaagta ccaaccctgg tgggcagcaa cggggccatt ctgaccacaa
     1021 tgccggtaat gatgggccaa gagaaagtcc ccattaagca agtgcctggg ggtgtaaagc
     1081 agctcgagcc tcccaaagaa ggagagaggc ggacaacaca caatatcatt gagaagcggt
     1141 accggtcctc catcaacgac aaaatcatag agttgaaaga cttggtcatg gggacagatg
     1201 ccaagatgca caagtctggc gttctgagga aggccattga ttacatcaag tacctgcagc
     1261 aggtcaacca caagctgcgc caggagaaca tggtgctgaa gctggcaaat cagaaaaaca
     1321 agctcctgaa gggcatcgac ttgggcagtc tggtggacag tgatgtggac ttgaagatcg
     1381 atgacttcaa tcagaatgtc cttctgatgt ctcccccggc ctcggactct gggtcccagg
     1441 ctggcttctc cccctattcc attgactctg agccgggcag ccctctgctg gatgatgcaa
     1501 aggtcaagga tgaaccggac tctccccctg tggcactggg catggtggac cgatctcgaa
     1561 ttctcttatg tgtcctcacc ttcctgggtc tctcctttaa ccccttgact tcattgctgc
     1621 agtggggagg ggcccacaac cctgaccaac acccgtactc aggctctggc cgcaatgtac
     1681 tgtcactgga gtcaggttct ggaggctggt ttgactggat gatgccgact ctactgctgt
     1741 ggctgctaaa cggtgtgatt gtcttgagcg tcttcgtgaa gctgttggtc catggggagc
     1801 cagtgatccg cccacactca cgctcctcgg tcaccttctg gagacaccgg aagcaggcag
     1861 acctagacct cgccaaaggt gactttgcag ctgctgctgc caacctacag acctgcttat
     1921 ccgttttggg ccgggcgctg cccacctccc gcctggactt ggcctgcagc ctctcctgga
     1981 acgtgatccg ctacagcctg cagaagctgc gcctggtacg ctggttactc aaaaaggtct
     2041 tccagcgctg gcgggctacc cccgccactg cagccggctt tgaggatgaa gctaagagca
     2101 gtgcgaggga tgcggccctg gcctaccaca ggctgcacca gctgcacatc acagggaagc
     2161 ttccagcagg atctgcctgt tccgatgtgc acatggctct gtgtgctgtg aacctcgccg
     2221 agtgtgcaga ggagaaaatc ccaccaagca cacttgtcga gatccacctg accgctgcca
     2281 tggggctcaa gacccgatgc gggggcaagc tgggcttctt ggctagctac ttcttaaatc
     2341 gtgcccagag tctgtgtggc ccagagcata gcgctgtccc cgactccctg cgctggctgt
     2401 gccatcccct gggccagaag tttttcatgg agcgaagctg gtcgatcaag tcagcagcca
     2461 aggacagcct gtactgcgcc cagaggaacc cagctgaccc cattgcccag gtacaccagg
     2521 ctttctgcaa acacctgctg gaaagagctg tggaggcctt ggtgaagcct caggccaaga
     2581 agaaggcagg tgaccgggaa gaagagagct gtgaattttc cagtgctcta gagtttttga
     2641 aattacttca ctcttttgtg gactctgtgg gatttgtggc ctcaccattc tccagcagtt
     2701 ctgtgctcag gtcagccctt ggtcccgatg tcgtctgtcg gtggtggacg tccgcgatca
     2761 ccgtggccat cagctggctc cagggcgatg atgcagctgt gcgctcgcat ttcactgaag
     2821 tagagcgggt ccccaaggcc ctggaagtga ctgagagtcc cttggtgaag gccgtcttct
     2881 atgcctgtag agccatgcat gcctcactct ctggaaaggc cgatgggcaa cagaactcct
     2941 tctgtcattg tgagagggcc agtggtcacc tgtggagcag tctcaatgtc agcggcacta
     3001 cttctgaccc ttcacttaac catgtggtcc agctgttcac ctgtgatctg ctactgtcac
     3061 tgaggacaac actctggcaa aagcaggcca gcgccagcca gctcctgggc gagacctacc
     3121 acgcgtcagg cactgagctg gccggcttcc agcgggacct gggcagcctt cgaaggctgg
     3181 cccacagttt ccgcccagca taccgcaagg tgttcctgca tgaagcaact gttcgactaa
     3241 tggcgggagc cagccccacc cgtacacacc agctgctgga gcacagccta cggcgccgca
     3301 ccactcagaa caccaaacac ggagaagtag acacctggcc tggccagcga gaacgagcca
     3361 ctgccatcct gctggcctgc cgccatcttc ccctctcctt cctatcttcc ccgggccagc
     3421 gggcagtgct gctggctgaa gctgcccgca ccctggagaa ggtgggtgac cgccgttcct
     3481 gcagtgactg ccagcagatg attgtcaagc tgggcggtgg cactgccatc gctgcttcct
     3541 gacccccgtc ggggcttggt ctgctgcttc ttcccgcctt tgtctctgtc tccccatctg
     3601 tttttctccc tcctccaaga gctgtgggga caaaggcaag actggttttc tgagctgtta
     3661 cctgccaagg cttttggatc atttcgggcc agtaggacca tgagccaggc tccttaaaac
     3721 tgctgtggta aatccatggt ctaagcccag gtgggctgag aagaaagatg gcctgagcag
     3781 gattggggtg atctccttac tggaaagcag cgtaggatgc tgccaagtcc ccctcccagc
     3841 cctctggaga ctgtctcctt tctgcctctg ggttttttgt ttttgttttt ttttgttttt
     3901 ttttttttgt tgttgttgtt gttgttgttg ttatgttttg tttctgtttg tttttttgtt
     3961 tttttaatca ggctttctct gggaactagg tctctgcacc agagagcatt ttgcattctg
     4021 gacttacctg acgcgcccct ttttatacag atgtttttat atgtgtgtgc ttgggcctgc
     4081 catgatacag ggcaaagttg ctgtggcatc tccgttcctc tccctgggtc tgcactccct
     4141 cccctgtgcc tgactaagcc tttcattgtt tttttttttt ttttcatcat tataaggttc
     4201 agccagggaa gggagggagc ccagtcctgg ggaggtgggt gggaggcagg ggcaggtcta
     4261 gggatgggtg aaaaataatg tcggcattgt tttttaattt tttaaaaaat aaatggtatc
     4321 ttatttaatt gtcctgttcc ttcccactcc tctaccccct gagatggccg cctgagctca
     4381 gggtaggccc acggggctgg acaggatgaa gccaccattg ggcctgaggt ccaggggtct
     4441 tcagcatgat tatttgttct tcctccccca ccctaactcc tacctcccat agagtgtatt
     4501 tttaccccta attcctgtct gaataagcca gggcggcaga cactggtccc acacctttcc
     4561 cagccacaag cctctcattt tcagggtagg cagcaggact caggtctctt gccttgagat
     4621 cgggggagtc ctagaaagaa gagtggtcct gcttttgtgg actgcttggc tcagggcttc
     4681 ctgagagact tgaaaggaat tgtccctcct tgtgcttctc atcccttcaa gctggttgaa
     4741 gcagagagta ggtaggggca ggcccttcct gtgcttggac cccacctact ctaccttcct
     4801 tccacctgtc cccagccggc actataattt atggcccctg ccgtggggca gcctagccct
     4861 cgtgtcttgt gtatatactg tgccttttct ccttgtgggg gggtggtgtt gtttttcact
     4921 gaacagggga tacacctatg tcttgtcgat gttgaaacat gcaccatgtg ctggacatag
     4981 gttttcaata aacacagatt ggtaccacct aa
//
