LOCUS       NM_001276707            4377 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sterol regulatory element binding transcription
            factor 1 (Srebf1), transcript variant 1, mRNA.
ACCESSION   NM_001276707 XM_001075680 XM_213329
VERSION     NM_001276707.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4377)
  AUTHORS   Li,H., Liu,Y., Meng,F., Chen,J. and Han,X.
  TITLE     Adrenarche-accompanied rise of adrenal sex steroid precursors
            prevents NAFLD in Young Female rats by converting into active
            androgens and inactivating hepatic Srebf1 signaling
  JOURNAL   BMC Genomics 25 (1), 190 (2024)
   PUBMED   38369486
  REMARK    GeneRIF: Adrenarche-accompanied rise of adrenal sex steroid
            precursors prevents NAFLD in Young Female rats by converting into
            active androgens and inactivating hepatic Srebf1 signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4377)
  AUTHORS   Ma,P., Huang,J., Chen,B., Huang,M., Xiong,L., Chen,J., Huang,S. and
            Liu,Y.
  TITLE     Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis
            Via Regulating SREBP1
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 12 (2023)
   PUBMED   38079167
  REMARK    GeneRIF: Lanosterol Synthase Prevents EMT During Lens Epithelial
            Fibrosis Via Regulating SREBP1.
REFERENCE   3  (bases 1 to 4377)
  AUTHORS   Bian,C., Zhang,H., Gao,J., Wang,Y., Li,J., Guo,D., Wang,W.,
            Song,Y., Weng,Y. and Ren,H.
  TITLE     SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and
            pancreas via the AMPKalpha-mTORC1 pathway
  JOURNAL   Lab Invest 102 (5), 474-484 (2022)
   PUBMED   34923569
  REMARK    GeneRIF: SIRT6 regulates SREBP1c-induced glucolipid metabolism in
            liver and pancreas via the AMPKalpha-mTORC1 pathway.
REFERENCE   4  (bases 1 to 4377)
  AUTHORS   Yalcin,M. and Kacar,M.
  TITLE     Investigation of the hepatic mTOR/S6K1/SREBP1 signalling pathway in
            rats at different ages: from neonates to adults
  JOURNAL   Mol Biol Rep 48 (11), 7415-7422 (2021)
   PUBMED   34655015
  REMARK    GeneRIF: Investigation of the hepatic mTOR/S6K1/SREBP1 signalling
            pathway in rats at different ages: from neonates to adults.
REFERENCE   5  (bases 1 to 4377)
  AUTHORS   Kilby,E.L., Kelly,D.M. and Jones,T.H.
  TITLE     Testosterone stimulates cholesterol clearance from human
            macrophages by activating LXRalpha
  JOURNAL   Life Sci 269, 119040 (2021)
   PUBMED   33453241
REFERENCE   6  (bases 1 to 4377)
  AUTHORS   Boizard,M., Le Liepvre,X., Lemarchand,P., Foufelle,F., Ferre,P. and
            Dugail,I.
  TITLE     Obesity-related overexpression of fatty-acid synthase gene in
            adipose tissue involves sterol regulatory element-binding protein
            transcription factors
  JOURNAL   J Biol Chem 273 (44), 29164-29171 (1998)
   PUBMED   9786926
REFERENCE   7  (bases 1 to 4377)
  AUTHORS   Shimano,H., Shimomura,I., Hammer,R.E., Herz,J., Goldstein,J.L.,
            Brown,M.S. and Horton,J.D.
  TITLE     Elevated levels of SREBP-2 and cholesterol synthesis in livers of
            mice homozygous for a targeted disruption of the SREBP-1 gene
  JOURNAL   J Clin Invest 100 (8), 2115-2124 (1997)
   PUBMED   9329978
REFERENCE   8  (bases 1 to 4377)
  AUTHORS   Sawada,Y. and Noda,M.
  TITLE     An adipogenic basic helix-loop-helix-leucine zipper type
            transcription factor (ADD1) mRNA is expressed and regulated by
            retinoic acid in osteoblastic cells
  JOURNAL   Mol Endocrinol 10 (10), 1238-1248 (1996)
   PUBMED   9121491
REFERENCE   9  (bases 1 to 4377)
  AUTHORS   Kim,J.B., Spotts,G.D., Halvorsen,Y.D., Shih,H.M., Ellenberger,T.,
            Towle,H.C. and Spiegelman,B.M.
  TITLE     Dual DNA binding specificity of ADD1/SREBP1 controlled by a single
            amino acid in the basic helix-loop-helix domain
  JOURNAL   Mol Cell Biol 15 (5), 2582-2588 (1995)
   PUBMED   7739539
REFERENCE   10 (bases 1 to 4377)
  AUTHORS   Tontonoz,P., Kim,J.B., Graves,R.A. and Spiegelman,B.M.
  TITLE     ADD1: a novel helix-loop-helix transcription factor associated with
            adipocyte determination and differentiation
  JOURNAL   Mol Cell Biol 13 (8), 4753-4759 (1993)
   PUBMED   8336713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Feb 28, 2013 this sequence version replaced
            XM_213329.6, XM_001075680.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.40892.1,
                                           SRR26643297.34196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000010.1  45528994-45529164   c
            172-594             JAXUCZ010000010.1  45515178-45515600   c
            595-770             JAXUCZ010000010.1  45514726-45514901   c
            771-908             JAXUCZ010000010.1  45514514-45514651   c
            909-1130            JAXUCZ010000010.1  45514204-45514425   c
            1131-1242           JAXUCZ010000010.1  45513473-45513584   c
            1243-1457           JAXUCZ010000010.1  45512773-45512987   c
            1458-1653           JAXUCZ010000010.1  45512458-45512653   c
            1654-1832           JAXUCZ010000010.1  45512187-45512365   c
            1833-2094           JAXUCZ010000010.1  45511701-45511962   c
            2095-2261           JAXUCZ010000010.1  45511454-45511620   c
            2262-2430           JAXUCZ010000010.1  45511116-45511284   c
            2431-2533           JAXUCZ010000010.1  45510323-45510425   c
            2534-2643           JAXUCZ010000010.1  45509965-45510074   c
            2644-2776           JAXUCZ010000010.1  45509751-45509883   c
            2777-2942           JAXUCZ010000010.1  45509412-45509577   c
            2943-3143           JAXUCZ010000010.1  45508754-45508954   c
            3144-3255           JAXUCZ010000010.1  45508552-45508663   c
            3256-4377           JAXUCZ010000010.1  45507152-45508273   c
FEATURES             Location/Qualifiers
     source          1..4377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4377
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /note="sterol regulatory element binding transcription
                     factor 1"
                     /db_xref="GeneID:78968"
                     /db_xref="RGD:69423"
     exon            1..171
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..3485
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sterol regulatory element-binding protein 1;
                     adipocyte determination- and differentiation-dependent
                     factor 1"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 1
                     isoform 1 precursor"
                     /protein_id="NP_001263636.1"
                     /db_xref="GeneID:78968"
                     /db_xref="RGD:69423"
                     /translation="MDELPFGEAALEQALAEVCEMDAALLTDIEDMLQLINNQDSDFP
                     GLFDAPYAGGETGDTGPSSPGASSPESFSSPASLGSSLEAFLGGPKVTPAPLSPPPSA
                     PTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPAPQPSPGTLLPPSFPPPPVQLSPAPV
                     LGYSSLPSGFSGTLPGNTQQTPSSLPLGSTPGISPTPLHTQVQSSAAQQPPPASAAPR
                     MSTVASQIQQVPVVLQPHFIKADSLLLTAVKTDTGATMKTAGINTLAPGTAVQAGPLQ
                     TLVSGGTILATVPLVVDTDKLPIHRLAAGGKALGSAQSRGEKRTAHNAIEKRYRSSIN
                     DKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSAHKSKSLKD
                     LVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSLGSRGSSSGGSDSEP
                     DSPAFEDNQVKAQRLPSHSRGMLDRSRLALCVLVFLCLTCNPLASLFGWGILTPSDAS
                     GVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPHSG
                     PAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLPTSNLDLACSLLWNLVRHL
                     LQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLVAS
                     NLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLA
                     QSGAVPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDPLAQVTRLFCEHL
                     LERALNCIAQPSPGAADGDREFSDALGYLQLLNSCSDAVGAPACSFSVSSSMATTTGT
                     DPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPLPRAALYSFKAAR
                     ALLDHRKVESSPASLAICEKASGYLRDSLASTSTASSIDKAMQLLLCDLLLVARTSLW
                     RRQQSAASAQGAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATAR
                     LMAGASPARTHQLLDRSLRRRAGSSGKGGAAAELEPRPTWREHTEALLLASCYLPPAF
                     LSAPGQRVSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS"
     exon            172..594
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..770
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..908
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1130
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1242
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1457
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1653
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1832
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2094
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2261
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2430
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2533
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2643
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2776
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2942
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3143
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3255
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..4377
                     /gene="Srebf1"
                     /gene_synonym="ADD-1; ADD1; SREBP-1; SREBP-1c; Srebp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctccgccc gcggaacccg gtttcccagg aacttttcgt taacgtgggt ctcctccgaa
       61 gccgggtggg cgccggcgcc atggacgagc tacccttcgg tgaggcggct ctggaacagg
      121 cactggccga ggtgtgcgaa atggacgcgg cgctcttgac cgacatcgaa gacatgcttc
      181 agctcatcaa caaccaagac agtgacttcc ctggcctatt tgatgccccc tatgctgggg
      241 gtgagacagg agacacaggc cccagcagcc ctggtgccag ctctcctgag agcttctctt
      301 ctcctgcttc tctgggctcc tctctggaag ccttcctggg aggacccaag gtgacacctg
      361 cacccttgtc ccctccacca tcggcaccca ctgctgtaaa gatgtacccg tccgtgcccc
      421 ccttctcccc tgggcctgga atcaaagagg agccagtgcc actcaccatc ctgcagcccc
      481 cagcaccaca gccatcgcca gggaccctgt tgcctccgag cttccctcct ccacctgtgc
      541 agctcagccc tgctcctgtg ctggggtact caagcctgcc ttccggcttc tcaggaaccc
      601 ttcctgggaa cacccagcag acgccatcta gcctgccact gggctccacg ccaggaatct
      661 cgcccacccc cttacacacc caggtccaga gctcggccgc ccagcagccg ccgccagcct
      721 cagcagcccc tagaatgagc actgtggcct cacagatcca gcaggtcccc gttgtactgc
      781 agccacactt catcaaggca gactcgctgc tgctgacagc tgtaaagaca gacacaggag
      841 ccacaatgaa gaccgcaggc atcaacaccc tggctcctgg cacagccgtg caggcaggcc
      901 ccttgcagac cctggtgagt ggagggacca tcctggccac agtaccactg gttgtggaca
      961 cagacaaact gcccatccac cgactagcag ctggtggcaa ggccctgggc tcagctcaga
     1021 gccgtggtga gaagcgcaca gcccacaatg ccattgagaa gcgctaccgt tcctctatca
     1081 atgacaagat tgtggagctc aaggacctgg tggtgggcac tgaggcaaag ctgaataaat
     1141 ctgctgtctt gcgcaaggcc atcgactaca tccgcttctt acagcacagc aaccagaaac
     1201 tcaagcagga gaacctgacc ctgcgaagtg ctcacaaaag caaatcactg aaagacctgg
     1261 tgtcagcttg tggcagtgga ggaggcacag atgtgtctat ggagggcatg aaacctgaag
     1321 tggtagaaac gctgacccct ccaccctcag acgccggctc accctcccag agtagcccct
     1381 tgtccttggg cagcagaggc agcagcagtg gtggcagtga ctctgagccc gacagcccag
     1441 cctttgagga taaccaggtg aaagcccagc ggctgccttc acatagccga ggcatgctgg
     1501 accgctcccg cctggccctg tgtgtactgg tcttcctgtg tctgacctgc aacccattgg
     1561 cctcactgtt tggctggggc atcctcactc cctctgatgc ttcgggtgtg caccgtagtt
     1621 ctgggcgcag catgctggag gccgagagca gagatggctc taattggacc cagtggttgc
     1681 tgccacccct agtctggctg gccaatggac tactagtgtt ggcctgcttg gctcttctct
     1741 ttgtctacgg ggaacctgtg accaggccac actccggccc ggctgtacac ttctggagac
     1801 atcgcaaaca agctgacctg gatttggccc ggggagattt tgcccaggcc gctcaacagc
     1861 tgtggctggc cttgcaagcc ctgggccggc ccctgcccac ctcaaacctg gatctggcct
     1921 gcagcctgct ttggaacctc gtccgccacc tgctgcagcg tctttgggtg ggccgctggc
     1981 tggcaggcca ggctgggggc ctgcagaggg actacaggct gagaaaggat gctcgtgcca
     2041 gtgcccgaga tgcggctgtc gtctaccata agctgcacca gctgcatgcc atgggcaagt
     2101 acacaggagg ccatcttgtt gcttctaacc tggcactgag tgcccttaac ctggctgagt
     2161 gtgcaggaga tgctatatcc atggcaacac tggcagagat ctacgtggca gctgccctaa
     2221 gggtcaaaac cagcctcccc agagccttgc acttcttgac acgtttcttc ctgagtagtg
     2281 cccgccaggc ctgcctggca cagagtggtg cagtgcctct tgccatgcag tggctctgcc
     2341 accctgtagg tcaccgtttc ttcgtggatg gggactgggc tgtacacggt gccccccagg
     2401 agagtctgta cagcgtggct gggaacccag tggatccact ggcccaggtg acccgactat
     2461 tctgtgaaca tctcctggag cgagcattga actgtatcgc tcagcccagc ccaggggcag
     2521 ctgatggaga cagggagttc tcagatgctc ttggatatct acagttgcta aatagctgtt
     2581 ctgacgctgt cggagctcct gcgtgcagct tctctgtcag ttccagcatg gctaccacca
     2641 ctggcacaga cccagtggcc aagtggtggg cctcactgac agccgtggtg atccactggc
     2701 tgaggcggga tgaggaggca gctgaacgct tatacccact ggtagagcac attccccaag
     2761 tgctgcagga aactgagaga ccccttccca gggcagctct gtactccttc aaggctgccc
     2821 gggctctgct ggaccacaga aaggtggaat ccagcccagc cagcctggcc atctgtgaga
     2881 aggccagtgg gtacctgcgg gacagcttag cctctacatc aactgccagt tccattgaca
     2941 aggccatgca gctgctcctg tgtgatctac ttcttgtggc ccgcaccagc ctatggcggc
     3001 gccaacagtc agcagcttca gcccagggag ctcacggtac cagcaatgga ccccaggcct
     3061 ctgctctgga gctgcgtggt ttccaacatg acctgagcag cctgaggcgc ttggcacaga
     3121 gcttccggcc tgctatgagg agggtcttcc tacatgaggc cacagctcgg ctgatggcag
     3181 gagcaagtcc tgcccggaca caccagctcc tggaccgcag tctgcggagg cgggcaggtt
     3241 ccagtggcaa aggaggcgct gcagctgagc tggagcctcg acccacatgg cgggagcaca
     3301 cagaggcctt gctgttggcc tcctgctatc tgccccctgc cttcctgtcg gcccccgggc
     3361 agcgagtgag catgctggct gaggcagcgc gcaccgtgga gaagcttggc gatcaccggc
     3421 tcctgcttga ctgccagcag atgctcctgc gcctgggtgg cgggaccact gtcacttcca
     3481 gctagacccc aaagcttccc ccagtaccct tgaggacctt tgtccctggc tgtggtcttc
     3541 cagaggctga gcctgacaag cagtcaggat cgtgccgacc tctagtggca gatctggaga
     3601 ttgcagaggc tgcacggggc cagtgccacc ctcttgctct gtaggcatct tagtggcttt
     3661 tcctgacctt tcccttgctg ggggccatac tgtctcaagg ctctcacccc ggggaggctg
     3721 tacatagtgt agatccgctg agcccagctc ctgggcgggc tcatgtacta cttttacaaa
     3781 ctttattttc ataggttgag aaattttgta cagaaaatta aaaagtgaaa ttatttataa
     3841 cttgagtttt atttatctgg gtaggcggat gtttgcctca tctgattgcc atccttcctg
     3901 gattgtcctt cgggaagctg gacttcccat gctgtacaag tgtttgctgg cttctgcctt
     3961 gtgcggtatg ttgagccaac ctggccctct aatctcatgg ctaccctgtg gctccacctt
     4021 gaagggcctt gatggcatca gttgtttctt tgccttccag ccctccacca ggtcccaggg
     4081 taatgatatc ccgtgtgcct ggaaacagac acacagttcc ctggttctct ctgttaccag
     4141 cataggtgag ggatcatggt ccactcagga gcagaatccg ggatccctgt ttgtgtcccc
     4201 tggcccctcc ctctactccc aaccccttag ggaatctggt tggcatccat gggccacaaa
     4261 cttccaaaac aatcgtggta tctttattga cttttttttc tgaatgcaat gactgttttt
     4321 ttttttttaa ctcttaagga aaataaacat cttttagaaa cagctcgata cacacaa
//
