LOCUS       NM_022711               5388 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus steroid 5 alpha-reductase 2 (Srd5a2), mRNA.
ACCESSION   NM_022711 XM_003750114
VERSION     NM_022711.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5388)
  AUTHORS   Ha,M., Guan,X., Wei,L., Li,P., Yang,M. and Liu,C.
  TITLE     Di-(2-ethylhexyl) phthalate inhibits testosterone level through
            disturbed hypothalamic-pituitary-testis axis and ERK-mediated
            5alpha-Reductase 2
  JOURNAL   Sci Total Environ 563-564, 566-575 (2016)
   PUBMED   27155079
  REMARK    GeneRIF: Taken together, DEHP-disturbed HPT axis and induced
            5alpha-Reductase 2 contribute to the reduction of serum
            testosterone level. The activated ERK pathway is required to
            modulate expressions of 5alpha-Reductase 2 and SRB1.
REFERENCE   2  (bases 1 to 5388)
  AUTHORS   Coronel,M.F., Sanchez Granel,M.L., Raggio,M.C., Adler,N.S., De
            Nicola,A.F., Labombarda,F. and Gonzalez,S.L.
  TITLE     Temporal changes in the expression of the translocator protein TSPO
            and the steroidogenic enzyme 5alpha-reductase in the dorsal spinal
            cord of animals with neuropathic pain: Effects of progesterone
            administration
  JOURNAL   Neurosci Lett 624, 23-28 (2016)
   PUBMED   27150077
  REMARK    GeneRIF: Results suggest that in the acute phase after spinal cord
            injury, the increased expression of 18kDa translocator protein and
            5alpha-reductase may represent a protective endogenous response
            against tissue injury.
REFERENCE   3  (bases 1 to 5388)
  AUTHORS   Castelli,M.P., Casti,A., Casu,A., Frau,R., Bortolato,M., Spiga,S.
            and Ennas,M.G.
  TITLE     Regional distribution of 5alpha-reductase type 2 in the adult rat
            brain: an immunohistochemical analysis
  JOURNAL   Psychoneuroendocrinology 38 (2), 281-293 (2013)
   PUBMED   22776423
  REMARK    GeneRIF: findings show that, in the adult brain, 5alphaR2 is
            distributed in critical regions for behavioral regulation,
            suggesting that the functional role of this isoform is present
            throughout the entire lifespan of the individual
REFERENCE   4  (bases 1 to 5388)
  AUTHORS   Sanchez,P., Torres,J.M., Castro,B., Olmo,A., del Moral,R.G. and
            Ortega,E.
  TITLE     Expression of steroid 5alpha-reductase isozymes in prostate of
            adult rats after environmental stress
  JOURNAL   FEBS J 280 (1), 93-101 (2013)
   PUBMED   23122426
  REMARK    GeneRIF: Changes in the expression of steroid 5-alpha reductase
            isoenzymes in the prostate in response to environmental stress.
REFERENCE   5  (bases 1 to 5388)
  AUTHORS   Castro,B., Sanchez,P., Torres,J.M., Preda,O., del Moral,R.G. and
            Ortega,E.
  TITLE     Bisphenol A exposure during adulthood alters expression of
            aromatase and 5alpha-reductase isozymes in rat prostate
  JOURNAL   PLoS One 8 (2), e55905 (2013)
   PUBMED   23405234
  REMARK    GeneRIF: Low Srd5a2 expression is associated with benign prostatic
            hypertrophy.
REFERENCE   6  (bases 1 to 5388)
  AUTHORS   Tian,H. and Russell,D.W.
  TITLE     Expression and regulation of steroid 5 alpha-reductase in the
            genital tubercle of the fetal rat
  JOURNAL   Dev Dyn 209 (1), 117-126 (1997)
   PUBMED   9142501
REFERENCE   7  (bases 1 to 5388)
  AUTHORS   Azzolina,B., Ellsworth,K., Andersson,S., Geissler,W., Bull,H.G. and
            Harris,G.S.
  TITLE     Inhibition of rat alpha-reductases by finasteride: evidence for
            isozyme differences in the mechanism of inhibition
  JOURNAL   J Steroid Biochem Mol Biol 61 (1-2), 55-64 (1997)
   PUBMED   9328210
REFERENCE   8  (bases 1 to 5388)
  AUTHORS   Span,P.N., Smals,A.G., Sweep,C.G. and Benraad,T.J.
  TITLE     Rat steroid 5 alpha-reductase kinetic characteristics: extreme
            pH-dependency of the type II isozyme in prostate and epididymis
            homogenates
  JOURNAL   J Steroid Biochem Mol Biol 54 (3-4), 185-192 (1995)
   PUBMED   7662592
REFERENCE   9  (bases 1 to 5388)
  AUTHORS   Normington,K. and Russell,D.W.
  TITLE     Tissue distribution and kinetic characteristics of rat steroid 5
            alpha-reductase isozymes. Evidence for distinct physiological
            functions
  JOURNAL   J Biol Chem 267 (27), 19548-19554 (1992)
   PUBMED   1527072
REFERENCE   10 (bases 1 to 5388)
  AUTHORS   Andersson,S., Berman,D.M., Jenkins,E.P. and Russell,D.W.
  TITLE     Deletion of steroid 5 alpha-reductase 2 gene in male
            pseudohermaphroditism
  JOURNAL   Nature 354 (6349), 159-161 (1991)
   PUBMED   1944596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 30, 2020 this sequence version replaced NM_022711.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M95058.1, SRR26643297.21648.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000006.1  27178089-27178402
            315-478             JAXUCZ010000006.1  27201113-27201276
            479-580             JAXUCZ010000006.1  27205492-27205593
            581-731             JAXUCZ010000006.1  27208912-27209062
            732-5388            JAXUCZ010000006.1  27212932-27217588
FEATURES             Location/Qualifiers
     source          1..5388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q13"
     gene            1..5388
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /note="steroid 5 alpha-reductase 2"
                     /db_xref="GeneID:64677"
                     /db_xref="RGD:621480"
     exon            1..314
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..798
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /EC_number="1.3.1.22"
                     /function="catalyzes the reduction of delta 4,5 double
                     bonds in steroid"
                     /note="SR type 2; 5 alpha-SR2; steroid-5-alpha-reductase,
                     alpha polypeptide 2 (3-oxo-5 alpha-steroid delta
                     4-dehydrogenase alpha 2)"
                     /codon_start=1
                     /product="3-oxo-5-alpha-steroid 4-dehydrogenase 2"
                     /protein_id="NP_073202.1"
                     /db_xref="GeneID:64677"
                     /db_xref="RGD:621480"
                     /translation="MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGV
                     PFLPARIAWFLQELPSFVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLT
                     RGRPFPAVLFLRATAFCIGNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGIN
                     IHSDYTLRQLRKPGEVIYRIPRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAF
                     FTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF"
     exon            315..478
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..580
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..731
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..5388
                     /gene="Srd5a2"
                     /gene_synonym="S5AR 2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggcagc taccaactgt gaccacaggc gagatgcaga ttgtctgcca tcaggtcccg
       61 gtgctggcag gtagcgccac attggccact atggggaccc tgatcctgtg cttagggaaa
      121 cctgccagtt acgggaaaca cacagagagt gtgtcgtcgg gagttccctt cctgccggca
      181 cgcattgcct ggttcctgca ggagttgcct tcctttgtgg tgtcggtagg gatgctcgct
      241 tggcagccgc gctccctctt cggaccgccc gggaatgtcc tgctggctct cttctctgca
      301 cattacttcc acaggacatt tatttactcg ttgctcacaa gagggaggcc tttcccagcg
      361 gtgctgtttt tgagagccac tgccttctgc atagggaacg gactccttca agcctactac
      421 ctggtttact gcgcagaata ccctgaggag tggtacacag atgtgcggtt tagctttggt
      481 gtcttcctgt ttattctggg gatgggaatc aacatccaca gtgactacac cctgcgccag
      541 ctcaggaagc ctggagaagt catctatagg attcctcgag gtggcttgtt tacgtatgtc
      601 tctggagcca atttcctggg cgagattatt gaatggattg gctacgcctt ggccacgtgg
      661 tccgtcccag ccttcgcttt cgcctttttc acactttgtt tcctggggat gcaagccttt
      721 taccaccaca ggttctacct taagatgttt aaggattacc ccaaatctag gaaagctctc
      781 attccattca tcttttaaag aaccccaatt ttaaagagca aagtttctgt ggaggaactg
      841 ctcagctgct gaaactataa actgtaaact ataacagtgt cttgctcaca tgtatatatg
      901 gtgatgtatg tgttaaaagg tctcttgtta ttccagttgc ttgaggcatg cagggtcatg
      961 cctgcttagc ctatactcct ttctgcccag ggagctctaa cccaatttcc ttttggagct
     1021 tcacagaggc cattttattc ttagctatac catctagaag cttcttgttt cccacggtat
     1081 gatctgaaga ggtaattgtt ttcttattcc atgtcacttt ggggaagttc tgcagtcaaa
     1141 accctttgga ctgacataat gaataatgaa attatagcaa ttgcaggaaa gtgggtagaa
     1201 ctggaaatta ttatattaag caacctaatc ctgactcaga aagacaaata ctgcatgttt
     1261 gtttcatgtg caggttctag attttaatat atatctaact gttcatatgt gtgtgttggg
     1321 ggtcatatag ttcattgatt tggaaaggag atcatgagaa gagaaaatgg gtcttgctgg
     1381 gaggaaaaaa agagggaaat aaaatttgtg tggcagagag aggctactgc aggaggaagg
     1441 ggagcatcag gagaaatgta ggagagaagg ggaggaggat tggcaaaaat aaagcatgta
     1501 tgaaaatgtc cataatgaaa ccaattactt tgtatgttgg ttttaaaaaa caaccagcca
     1561 gccagtcaat aaaccatcca tccaggcagt caatcaacca gctggccagc cagccagccg
     1621 gccagccaac ctaccaacca accaactatc caaccaacca gccaaccaac taaccaacca
     1681 accaacaaat caaccaacca accaaacagc cagccaccaa ccaaccaacc aacaaatcaa
     1741 ccaaccaacc aaacagccag ccaccaatca accaacaacc aaccaaccaa ccaaccagct
     1801 aaccaaccaa caaatcaacc aaccaaccaa ccaaccaatc aaccagccac caaccaatca
     1861 accaaccaat caaccaacca accagccaat caaccagcca ccaaccaacc aaccaataag
     1921 acaagcaagc aagcaagcaa gcaagcaagc aagcaagcaa gcaagcaacc aaccaaccaa
     1981 ccaaccaacc aaccaaccaa aatgaatgtc agggctgagg gcagtgctca aaaaagtaat
     2041 taaaagattt acatttttaa gtgccataga cctagagcat gcatacatga aagcctggtc
     2101 tcagctttct ctgctttagt taattaggaa gacataaaaa aggagagttt taataatgaa
     2161 attccctttt attgacccaa gtccaaatgt acacagtgtc ttagtcagtg aacaccagat
     2221 cttccagtct cacaattaga actatcatag tcatccacaa tactgctatg gacttccttg
     2281 attgtcaggt tttactgaac acaaagaaaa agatatagcc atgagtggct cctaagagaa
     2341 taaataattg tgttgcaaca gacagtgtaa actcctatca ggaacacttc taagtatgag
     2401 aaattcatat gtaaggcagt agactgttca acttgaagag atgtttatga tgatgtaaac
     2461 gtatcagaag ccctgagaaa gtttcttctg gaatttcttc cttatgatcc ttgagatgta
     2521 tcttagatga tctgtagtag ctcgagcatc agacctcagg tcccaatggc acaagtggag
     2581 atctgcaaca tctgcccaga tgctcatcgg agcagaaagc gcctttcatt ccattcagac
     2641 agggtttcac acttagtttt attttatttt atcttgaatt ccaagcctca aattgtaaaa
     2701 attaggtttt ggttctacat aaaccaaaac cctggcattc tgcagggatg gaagtgattc
     2761 tccatcttcc tgacaccgcg ttcctcatgt tgtggtgact ccaaaccgta aaaacgactt
     2821 ttgttgatac ttcagaatta taaatttttt tttactgtta tgagtcatag agtaaatctc
     2881 tgtgttttcc catggtatta ggtagtccct gggaaagtgt catttgaccc acaaaggtgt
     2941 catgacccac aggttgagaa gacatgcttt aaaagattgg aaggagagaa ttaagagata
     3001 gaagataatg ggagggtgaa tataatcaac ttactatcac aaataagaaa atctagtgag
     3061 atgatgaata taagtcagtg cttctcaatc ttcctaatgc tgcgtccctt taatccagtt
     3121 cctcatgtta tggtgacccc taccccaact ataaaattat tttattgcct cttcatagct
     3181 gtaatttgct actgttatga attataatgt aaatatctga tatgtaggat atatgatatg
     3241 tgagagccac aggctgagaa ctgctgatat atgctgacct cagcatcccc agcctggttc
     3301 ctgtgtgaga acttgggact gggtagcaca tgaacactta agggtacagt ctctggtgaa
     3361 gggatagctc ccctaaagag gctggaatgt gggttctgta aggaagggat taagcactct
     3421 gaatcagaat tgttgaattc ttatctcctc agccccaggt aggtaggttc aacaccactg
     3481 gaaatatgct tgagaaactg tgctccagtt ttatcatttg gtacagaaat ggagtgttag
     3541 ttaacaccag gatcctgaga gatttgaagt aggatatgta atgaagatat ggattgtagt
     3601 gttacaagca ggtgcttctt attgttcatc aaatgcctct caagtcatga ctgccatgaa
     3661 taaaataaaa aaaaaatcca gatcttctgt agcatcacag tgtatctatt gagtggtgtt
     3721 ctcacccctt ccctccctct atcttaattt cttgtcttgc tgttttcttt cttgttacct
     3781 tccttcattt tgccaatctg aaatcaggtg ctatgaatag gaaataaagg atgaccagca
     3841 gattctaaat tatagttgag ttccaggaag tacaagaaag gtgtgagaca ataggccaag
     3901 gccagttgtg tcctcttttc agtgatgcct aggaggaaaa atacagtgtc aagaagttct
     3961 tactaaaaca actgtgacaa atcatcttat atagacaaaa ggtttaattt tggctcatag
     4021 cccaggaata gctttgggcc tgtagcaggc agcacattgt ggtgggagca tatagtggaa
     4081 cataggtgtt tacctcctgg ccaaaagaga gggaggcaga ggggaggaga gacagccaga
     4141 ggcaccagag ttctacagtc cccctttgag ggcatgccta ccctcctcag tgacccaaag
     4201 acatcccact aggcctcagc ctatagagtt cttccacctc ccagtggtgc caaactggga
     4261 actcacccta aggtgtaggc ctttggggaa ctcccaagat gcagactagg taagctttca
     4321 caagagtggt gaattctcct gaaagcagag atttctgggg gctctctgtg attgaaaacc
     4381 acgttcctcc tatcttttat ttcagagctg aagatgaagc tcagtagagt gctcacctag
     4441 tatatgtgag accctggatt ctgcatgcag cacaaggtgt gcttgcccca gcacttgaga
     4501 ggtcccagaa gcgcaatgtc aacttctgct acacagggag ggatttaggg accagattga
     4561 gatacataag actttgtatt aaaatgtttt aaaactagat ttttatttta cttacatgaa
     4621 gatggtctag gcaatccttt acatgttaaa aatgctcgat aaatggcttg ggctgacaaa
     4681 actgcctttt agcaattgca tatttttgcc acaagagggc actatctaga attttattcg
     4741 ggtgacttct gatttagtca atttaccaat gtgttttatt ttaatcccac aaaatcttat
     4801 ttgtacttca aattaattca attaaccaca aactttcatt taaagcttta aactttatta
     4861 ttattgggtg tgtgagtgca tcacagacat tcttaattta aataagttat ttacctataa
     4921 tacggatctt cccttgacat ttgagggatt ctcagttatc taaaggcatt gttttaaaac
     4981 tcagtgttct tgttgaaggc cgataaataa atatatacat aatatacaaa ctatattata
     5041 tatcatatca catataattt ataatatatt ccataaacat attattttat aatatacaat
     5101 gtttatatga tttatattat aatatattag agtaaatata ttataatata taattattat
     5161 atactactta tatatcatat gtaattatgt ataatatatg ttatatatga tatgtgatag
     5221 atgttattac atatctataa catataatgc atataataaa aatataacta caatatacca
     5281 tatattatgt taaatatatt acataatata tttaaaaata tatatgtgca tttgctaaca
     5341 taatgtataa aatatacata tataaatatg agcatgcaat aaaataaa
//
