LOCUS       NM_017070               2638 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus steroid 5 alpha-reductase 1 (Srd5a1), mRNA.
ACCESSION   NM_017070
VERSION     NM_017070.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2638)
  AUTHORS   Su,Y., Li,H., Chen,X., Wang,Y., Li,X., Sun,J. and Ge,R.S.
  TITLE     Ziram inhibits rat neurosteroidogenic 5alpha-reductase 1 and
            3alpha-hydroxysteroid dehydrogenase
  JOURNAL   Toxicol Mech Methods 28 (1), 38-44 (2018)
   PUBMED   28707553
  REMARK    GeneRIF: Ziram inhibited SRD5A1 and AKR1C14 activities, thus
            possibly interfering with neurosteroid production in rats.
REFERENCE   2  (bases 1 to 2638)
  AUTHORS   Wang,Y., Sun,J., Chen,L., Zhou,S., Lin,H., Wang,Y., Lin,N. and
            Ge,R.S.
  TITLE     Effects of resveratrol on rat neurosteroid synthetic enzymes
  JOURNAL   Fitoterapia 122, 61-66 (2017)
   PUBMED   28823883
REFERENCE   3  (bases 1 to 2638)
  AUTHORS   Rossetti,M.F., Varayoud,J., Moreno-Piovano,G.S., Luque,E.H. and
            Ramos,J.G.
  TITLE     Environmental enrichment attenuates the age-related decline in the
            mRNA expression of steroidogenic enzymes and reduces the
            methylation state of the steroid 5alpha-reductase type 1 gene in
            the rat hippocampus
  JOURNAL   Mol Cell Endocrinol 412, 330-338 (2015)
   PUBMED   26021641
  REMARK    GeneRIF: Exposure of middle-aged rats to environmental enrichment
            increased mRNA levels of 5al;pha-reductase-1, 3alpha-HSD and
            cytochrome P450 17alpha-hydroxylase/c17,20-lyase and decreased the
            methylation state of the 5alpha-reductase-1 gene
REFERENCE   4  (bases 1 to 2638)
  AUTHORS   Livingstone,D.E., Barat,P., Di Rollo,E.M., Rees,G.A., Weldin,B.A.,
            Rog-Zielinska,E.A., MacFarlane,D.P., Walker,B.R. and Andrew,R.
  TITLE     5alpha-Reductase type 1 deficiency or inhibition predisposes to
            insulin resistance, hepatic steatosis, and liver fibrosis in
            rodents
  JOURNAL   Diabetes 64 (2), 447-458 (2015)
   PUBMED   25239636
  REMARK    GeneRIF: The effects of deficiency or inhibition of S5AR1 on the
            risk of liver disease and insulin resistance in male rats and mice
            are reported.
REFERENCE   5  (bases 1 to 2638)
  AUTHORS   Castro,B., Sanchez,P., Torres,J.M., Preda,O., del Moral,R.G. and
            Ortega,E.
  TITLE     Bisphenol A exposure during adulthood alters expression of
            aromatase and 5alpha-reductase isozymes in rat prostate
  JOURNAL   PLoS One 8 (2), e55905 (2013)
   PUBMED   23405234
  REMARK    GeneRIF: Low Srd5a1 expression is associated with benign prostatic
            hypertrophy.
REFERENCE   6  (bases 1 to 2638)
  AUTHORS   Taylor,M.F., Bhattacharyya,A.K. and Collins,D.C.
  TITLE     Inhibition of rat steroid 5 alpha-reductase (isozyme 1) by suramin
  JOURNAL   Steroids 60 (7), 452-456 (1995)
   PUBMED   7482629
REFERENCE   7  (bases 1 to 2638)
  AUTHORS   Eicheler,W., Seitz,J., Steinhoff,M., Forssmann,W.G., Adermann,K.
            and Aumuller,G.
  TITLE     Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by
            immunohistochemistry
  JOURNAL   Exp Clin Endocrinol Diabetes 103 (2), 105-112 (1995)
   PUBMED   7553073
REFERENCE   8  (bases 1 to 2638)
  AUTHORS   Thigpen,A.E. and Russell,D.W.
  TITLE     Four-amino acid segment in steroid 5 alpha-reductase 1 confers
            sensitivity to finasteride, a competitive inhibitor
  JOURNAL   J Biol Chem 267 (12), 8577-8583 (1992)
   PUBMED   1314830
REFERENCE   9  (bases 1 to 2638)
  AUTHORS   Andersson,S. and Russell,D.W.
  TITLE     Structural and biochemical properties of cloned and expressed human
            and rat steroid 5 alpha-reductases
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3640-3644 (1990)
   PUBMED   2339109
REFERENCE   10 (bases 1 to 2638)
  AUTHORS   Andersson,S., Bishop,R.W. and Russell,D.W.
  TITLE     Expression cloning and regulation of steroid 5 alpha-reductase, an
            enzyme essential for male sexual differentiation
  JOURNAL   J Biol Chem 264 (27), 16249-16255 (1989)
   PUBMED   2476440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO394005.1, J05035.1, CV112588.1 and BC088303.1.
            
            On Oct 14, 2005 this sequence version replaced NM_017070.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            22 bp suspected to be vector contamination from the 3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05035.1, BC127454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               CO394005.1         1-147
            148-1214            J05035.1           1-1067
            1215-1915           CV112588.1         5-705
            1916-1924           J05035.1           1768-1776
            1925-2638           BC088303.1         393-1106
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2638
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /note="steroid 5 alpha-reductase 1"
                     /db_xref="GeneID:24950"
                     /db_xref="RGD:3757"
     exon            1..437
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..924
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /EC_number="1.3.1.22"
                     /note="SR type 1; steroid-5-alpha-reductase, alpha
                     polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase
                     alpha 1); steroid 5-alpha-reductase"
                     /codon_start=1
                     /product="3-oxo-5-alpha-steroid 4-dehydrogenase 1"
                     /protein_id="NP_058766.2"
                     /db_xref="GeneID:24950"
                     /db_xref="RGD:3757"
                     /translation="MELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGI
                     RVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLI
                     RGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVI
                     NIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFA
                     LFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL"
     exon            438..604
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..706
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..857
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..2614
                     /gene="Srd5a1"
                     /gene_synonym="S5AR 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcctgtgg tcctgtcccc gcccgagcag gtggctcgcc cctcccctgg gcaggtacac
       61 actgctggag aggtggcccg tctgcgccct cctcctggcc ttatatgagg ctccactcgg
      121 acacccgggc atggagtaca ctgctcgacc tcagctatgg agttggatga gctgtgcctg
      181 ctcgacatgc tggtctactt ggaaggtttc atggccttcg tgtccattgt ggggctccgg
      241 tcggttggct ctccgtacgg ccgctactcg ccgcagtggc ccggcatccg agtgcccgcg
      301 cgacctgcct ggttcataca ggagctgccc tcgatggcct ggccgctgta cgagtacatt
      361 cgtcctgcag ccgcgcgact gggcaacctg cctaaccgcg tcctgctggc tatgtttctg
      421 atccactacg tgcaaaggac gctggttttc ccggttctga tcaggggagg gaagcccacc
      481 ctcctggtca cctttgtctt ggccttcctg ttctgcacct tcaacggcta tgtacagagc
      541 agatacttga gccagtttgc ggtttatgct gaagactggg tgacccatcc ctgtttcctg
      601 acaggctttg ccctgtggtt agtgggcatg gtgataaata tccactcaga ccacatcctg
      661 aggaatctga gaaaaccagg ggaaactgga tacaagatac ccaggggagg cctgtttgaa
      721 tacgtatctg cagccaacta ttttggggag ctcgtggagt ggtgtggctt tgcactggcc
      781 agctggtccc tccagggtgt agtgtttgca ctgttcacac tcagcacact gctcaccaga
      841 gcgaagcagc accatcagtg gtaccatgag aagtttgaag attaccccaa gtcaagaaaa
      901 atactgattc catttgtgct ttagtgctct gttagcgctg ttgcctccca tgagctgagt
      961 ctgtctgtct ccctggtgac tttgctctga gcacttacga atgaattgtt ttccttaatt
     1021 ctcctgcagc ccctttctca ggaaaggctg ggggtggggg ggtgtcgtcc cctggtaaag
     1081 gacaaagcca atgataaact aatccaccac atgcagttag gggctacact gcctgctgga
     1141 tccgaagcag gtagccctga gtcattatgg cgctctctga cttcagcaat cagcagccct
     1201 tacaatcctg caaggattcc acccaagtca gcagcagtca cgggcctcct tcactgatgt
     1261 gtgttctgcc tgctcagccc ctgccacaga ggcctggagg tgtgggagtg tggcctaagc
     1321 acagtctgcc atccttgacc gcagacctct tggacccacc cccactccct ccagacactg
     1381 gtaagagaag ccttcctgca acatgtcctg tcctcaggag gtgagacagc agagtgcttc
     1441 cattcactcg atgaccccat ttttgctctt cctttgggct agaattcatt aaggtcctta
     1501 aaaacaaaac aaaacttttt cttaatagta caaaacaaaa tatcaaaaca aaatttgtta
     1561 ttttgaatgc acccaaggac caatcatgtc acacaaagaa agctcagggc tagcctgggc
     1621 tgtgtaggga gaccctgttt gggaaaaaaa aaatgaagat aacaaccagc taactgtcca
     1681 aagaagtgac cgcagtaata aaagacgccg cccacacagg caccagcttg ggagaaagat
     1741 gtgcgcctgg gattgtaaac ccactgttgc tctgggcagg ctgaggccca ctggtgaaga
     1801 gccattccca cccgacccat gcacactgcc tcggggcagc gtctgcactc acctctcacc
     1861 cgctgccacc acagctaaag aacagaacgg atagaactgt gtgctctgaa cccagtgaag
     1921 atgccgcatg aagacctgca ggcacacctg atggcgtgca cggtgcccac cactcgcctg
     1981 actcggacca tctctgtgtg cccgttgcca cctctgtgtg ccctttccag ctggctttcc
     2041 catcagggct tcctcagctc ttctgctctc agacagaaac tattctctgt tcctctggtt
     2101 cgcagaatgt ctagatttga cccagaaaac ttcatgacac agctacttca ttttaacaaa
     2161 gagcagtgtt taatggggaa ctacccttca atcctttacc ctcccctttt ctggccaagt
     2221 aactgcttga aaacctaaag cactaaacat tgtaggtctc ctctcaaaac ctcaggcctg
     2281 tctggtgtgt tctgaaacgt ttgtgtggaa ggagatattc agctgagacc ctgggaatgt
     2341 ttgctgtgaa cttgacctcc cttggagggc atggtgctag ataaacttgg aacctaggac
     2401 tccaggttgc taggcagatg ccctgacact aagccacatc acacattagc tctgtgatgc
     2461 ctctttcttt atgaaggacc aagctgccca catactaagt gagattaatt taagaggaac
     2521 cctgtcctaa cactgtatac ttcattccct acaactcaac ttacttgtat gaaccatgat
     2581 tgttaaggaa attaataaac tacatttata agtaaaaaaa aaaaaaaaaa aaaaaaaa
//
