LOCUS       NM_001393740            7017 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SRC kinase signaling inhibitor 1 (Srcin1),
            transcript variant 1, mRNA.
ACCESSION   NM_001393740
VERSION     NM_001393740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7017)
  AUTHORS   Wang,W., Zhu,X., Du,X., Xu,A., Yuan,X., Zhan,Y., Liu,M. and Wang,S.
  TITLE     MiR-150 promotes angiogensis and proliferation of endothelial
            progenitor cells in deep venous thrombosis by targeting SRCIN1
  JOURNAL   Microvasc Res 123, 35-41 (2019)
   PUBMED   30315850
  REMARK    GeneRIF: Upregulation of miR-150 promoted angiogenesis and
            proliferation of endothelial progenitor cells by targeting SRCIN1
            in vitro and thrombus resolution in vivo.
REFERENCE   2  (bases 1 to 7017)
  AUTHORS   Li,M.Y., Miao,W.Y., Wu,Q.Z., He,S.J., Yan,G., Yang,Y., Liu,J.J.,
            Taketo,M.M. and Yu,X.
  TITLE     A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes
            in Stabilizing Spines and Functional Synapses in the Neocortex
  JOURNAL   Neuron 94 (6), 1155-1172 (2017)
   PUBMED   28641114
  REMARK    GeneRIF: Study demonstrates a critical role of presynaptic
            cadherin/catenin/p140Cap cell adhesion complexes in stabilizing
            functional synapses and spines in the developing neocortex.
REFERENCE   3  (bases 1 to 7017)
  AUTHORS   Repetto,D., Camera,P., Melani,R., Morello,N., Russo,I.,
            Calcagno,E., Tomasoni,R., Bianchi,F., Berto,G., Giustetto,M.,
            Berardi,N., Pizzorusso,T., Matteoli,M., Di Stefano,P., Missler,M.,
            Turco,E., Di Cunto,F. and Defilippi,P.
  TITLE     p140Cap regulates memory and synaptic plasticity through
            Src-mediated and citron-N-mediated actin reorganization
  JOURNAL   J Neurosci 34 (4), 1542-1553 (2014)
   PUBMED   24453341
  REMARK    GeneRIF: we here demonstrate that p140Cap is a key element for both
            learning and synaptic plasticity
REFERENCE   4  (bases 1 to 7017)
  AUTHORS   Yamauchi,M., Sudo,K., Ito,H., Iwamoto,I., Morishita,R., Murai,T.,
            Kajita,K., Ishizuka,T. and Nagata,K.
  TITLE     Localization of multidomain adaptor proteins, p140Cap and vinexin,
            in the pancreatic islet of a spontaneous diabetes mellitus model,
            Otsuka Long-Evans Tokushima Fatty rats
  JOURNAL   Med Mol Morphol 46 (1), 41-48 (2013)
   PUBMED   23325552
  REMARK    GeneRIF: Possible involvement of p140Cap in insulin secretion; the
            reduction of p140Cap might be related to abnormal insulin secretion
            in diabetes mellitus.
REFERENCE   5  (bases 1 to 7017)
  AUTHORS   Damiano,L., Le Devedec,S.E., Di Stefano,P., Repetto,D., Lalai,R.,
            Truong,H., Xiong,J.L., Danen,E.H., Yan,K., Verbeek,F.J., De
            Luca,E., Attanasio,F., Buccione,R., Turco,E., van de Water,B. and
            Defilippi,P.
  TITLE     p140Cap suppresses the invasive properties of highly metastatic
            MTLn3-EGFR cells via impaired cortactin phosphorylation
  JOURNAL   Oncogene 31 (5), 624-633 (2012)
   PUBMED   21725361
  REMARK    GeneRIF: Data show that p140Cap suppresses the invasive properties
            of highly metastatic breast carcinoma cells by inhibiting
            cortactin-dependent cell motility.
REFERENCE   6  (bases 1 to 7017)
  AUTHORS   Di Stefano,P., Damiano,L., Cabodi,S., Aramu,S., Tordella,L.,
            Praduroux,A., Piva,R., Cavallo,F., Forni,G., Silengo,L., Tarone,G.,
            Turco,E. and Defilippi,P.
  TITLE     p140Cap protein suppresses tumour cell properties, regulating Csk
            and Src kinase activity
  JOURNAL   EMBO J 26 (12), 2843-2855 (2007)
   PUBMED   17525734
REFERENCE   7  (bases 1 to 7017)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 7017)
  AUTHORS   Di Stefano,P., Cabodi,S., Boeri Erba,E., Margaria,V., Bergatto,E.,
            Giuffrida,M.G., Silengo,L., Tarone,G., Turco,E. and Defilippi,P.
  TITLE     P130Cas-associated protein (p140Cap) as a new
            tyrosine-phosphorylated protein involved in cell spreading
  JOURNAL   Mol Biol Cell 15 (2), 787-800 (2004)
   PUBMED   14657239
REFERENCE   9  (bases 1 to 7017)
  AUTHORS   Singh,D. and Lampe,P.D.
  TITLE     Identification of connexin-43 interacting proteins
  JOURNAL   Cell Commun Adhes 10 (4-6), 215-220 (2003)
   PUBMED   14681019
REFERENCE   10 (bases 1 to 7017)
  AUTHORS   Chin,L.S., Nugent,R.D., Raynor,M.C., Vavalle,J.P. and Li,L.
  TITLE     SNIP, a novel SNAP-25-interacting protein implicated in regulated
            exocytosis
  JOURNAL   J Biol Chem 275 (2), 1191-1200 (2000)
   PUBMED   10625663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001393740.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JACYVU010000220.1  39394582-39394740   c
            160-461             JACYVU010000220.1  39371083-39371384   c
            462-560             JACYVU010000220.1  39368251-39368349   c
            561-584             JACYVU010000220.1  39361719-39361742   c
            585-780             JACYVU010000220.1  39355803-39355998   c
            781-979             JACYVU010000220.1  39355045-39355243   c
            980-1073            JACYVU010000220.1  39354399-39354492   c
            1074-1933           JACYVU010000220.1  39353144-39354003   c
            1934-2026           JACYVU010000220.1  39352618-39352710   c
            2027-2070           JACYVU010000220.1  39352351-39352394   c
            2071-2261           JACYVU010000220.1  39351914-39352104   c
            2262-2437           JACYVU010000220.1  39350609-39350784   c
            2438-2568           JACYVU010000220.1  39345520-39345650   c
            2569-2716           JACYVU010000220.1  39345271-39345418   c
            2717-2963           JACYVU010000220.1  39344761-39345007   c
            2964-3198           JACYVU010000220.1  39344088-39344322   c
            3199-3353           JACYVU010000220.1  39341947-39342101   c
            3354-3506           JACYVU010000220.1  39341582-39341734   c
            3507-3653           JACYVU010000220.1  39337178-39337324   c
            3654-7017           JACYVU010000220.1  39327769-39331132   c
FEATURES             Location/Qualifiers
     source          1..7017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..7017
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="SRC kinase signaling inhibitor 1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
     exon            1..159
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3788
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p130Cas-associated protein; SNAP25-interacting protein"
                     /codon_start=1
                     /product="SRC kinase signaling inhibitor 1 isoform 1"
                     /protein_id="NP_001380669.1"
                     /db_xref="GeneID:56029"
                     /db_xref="RGD:708439"
                     /translation="MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRF
                     SNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQ
                     DRMREQVGGWTVDPVCLLSSLCSHLHGDSTPSGAGQPAQQPNYWSFKTRSSRHTQGAQ
                     PGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLF
                     LQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYE
                     LEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPA
                     SHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTS
                     QGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGD
                     PFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSP
                     QKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGAS
                     TAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGS
                     EPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQ
                     MQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDP
                     LQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALV
                     LKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLA
                     QIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGT
                     PLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQA
                     ELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRT
                     EKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKL
                     RRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQ
                     GPAGSPDKGKHGKQRTEYMRIQAQQQATKPSKEMSGPNETSSPVSEKPSGSRTSIPVL
                     TSFGARNSSISF"
     exon            160..461
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            462..560
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            561..584
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            585..780
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            781..979
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1073
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1933
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2026
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2070
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2261
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2437
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2568
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2716
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2963
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3198
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3353
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3506
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3653
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..7017
                     /gene="Srcin1"
                     /gene_synonym="P140; p140Cap; Snip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggccc gcgcccccgg cccgcccgcc tggcaccgcg ccccggggct ggggccgagc
       61 gaggagcccg cgaggcggcg agagggcgag cgccaggcag gccggcccgg ggcccccgcc
      121 ccccgcgccc ccgcccgatg gggaacgctc cgtcccaaga tccggagcgg agcagccccc
      181 ccatgctgtc tgccgacgat gccgaatatc ctcgggagta ccggaccctg gggggtgggg
      241 gcagcggggg cagcgggggc cggcgcttct ccaacgtggg gctggtgcac acctccgagc
      301 ggcggcacac ggtgatcgct gcccagagcc tggaggccct cagcgggctc cagaaggccg
      361 atgctgaccg caagcgagat gcgtttatgg accacctgaa gagcaagtac ccccagcatg
      421 ccctggccct tcgaggtcag caggacagga tgagagagca ggtcggcggc tggaccgtgg
      481 accctgtgtg cctcctcagc tccctctgtt cccacctcca cggcgactcc accccctcag
      541 gggctggcca gcctgcccag caaccaaact actggagttt caagacccgc agctcgcgcc
      601 atactcaggg agcccagcca gggctggcag accaggcagc caagctgtcc tacgcctcgg
      661 ctgagtcgct ggagacaatg tccgaggccg agctgcccct gggcttcagc aggatgaatc
      721 gcttccgaca gagcttgcct ctctcccgct ctgccagcca gaccaagctg cgctcaccag
      781 gagtcctgtt cctgcagttc ggggaggaga cgcgacgtgt acacatcacg catgaggtca
      841 gcagcctgga cacgctgcac gcactcatcg cgcacatgtt cccgcagaag ctcaccatgg
      901 gcatgcttaa gtcgcccaac accgccatcc tcatcaagga cgaggctcgc aacgtcttct
      961 acgagctgga agacgtccgg gatatccagg accggagtat catcaagatc tataggaagg
     1021 agccactgta tgccgctttt cctggctcgc acctcaccaa cggtgacctc cggagagaga
     1081 tggtttacgc atcgcgggag tcgtcgccca cgcggcgcct caacaacctg tcgcccgcat
     1141 cgcacctagc atctagctcc ccgcctccag ggctgccatc cgggctgcct tcgggactgc
     1201 catcgggctc gccctcgcgt tcacgcctct cgtatgctgg gggccggccg ccctcttacg
     1261 ccggcagccc ggtacaccac gcggctgagc gactgggagg cgccccgacc agccagggcg
     1321 tgagccccag ccccagcgcc atcctggagc ggcgcgacgt gaagccagat gaggatctgg
     1381 cgggcaaggc gggcggcatg gtgctggtga agggcgaggg cctctatgcc gatccctacg
     1441 ggctgctgca cgagggccgc ttgagcctgg ccgccgcagc aggagacccg ttcgcatacc
     1501 cgggcgcggg cggcttgtac aagcggggtt ctgtgcgctc gctcagcacc tactcggccg
     1561 ctgcgctgca gtccgacctg gaggactcgc tgtacaaggc gggcgccggc ggcccgctct
     1621 acggagacgg ctatggcttc cgtctgccgc cttcgtcccc gcagaaacta gccgacgtct
     1681 cagcgccctc cgggggacct ccgccaccgc acagccccta ctctgggccg cccagccgcg
     1741 gctcgccggt gcgccagtcg ttccgtaaag attctggttc ctcgtcggtc tttgctgaga
     1801 gtcctggagg caaagcccgc agcaccgggg cttccacggc cggagcacca ccttctgaac
     1861 tcttccctgg acctggagag cgctccctcg tagggttcgg gccgccggtg ccagccaagg
     1921 acacagagac cagggagcgt atggaggcca tggagaagca gattgccagc ctcactgggc
     1981 tagtacagag tgctttactg cgaggctcgg agccggagac cccaagtgag aagattgaag
     2041 gctccaatgg agcagccacc ccctcagcac cagtgtgtgg gtcaggcagt aggagtagcg
     2101 gggccactcc agtgtcgggc cctcccccac ccgcggtcag cagcacccct gcagggcagc
     2161 ccactgctgt cagccggctg caaatgcaga tgcatctgcg tggcctacag aacagcgcta
     2221 gcgacctgcg tggccagctt cagcagttgc ggaagctcca gctccagaac caggagtcgg
     2281 tgcgcgcgct gctgaagcgc accgaggcgg agctgagcat gcgcgtgtcg gaggcggcgc
     2341 ggcggcagga ggacccgctg cagcggcagc gcaccctggt ggaagaggag cgtttgcgtt
     2401 acctcaacga cgaggagctc attacacagc agctcaatga cctggagaag tcagtggaga
     2461 agatccagag ggatgtggcc cataaccacc ggctggtgcc tggtcctgag ttggaagaga
     2521 aggctctggt gctgaaacag cttggggaga cgctgacgga actcaaggct catttcccag
     2581 gcctgcagag taagatgcgg gtagtgctgc gtgtagaggt ggaggcagtc aagtttctga
     2641 aggaggaacc tcaacgcctc gacgggcttc tcaagcgctg ccgggtggtc actgacacgc
     2701 tggcccagat ccgaaggcaa gtggatgagg gtgtgtggcc tccccccaac aatctcctga
     2761 accagtcccc caagaaggtg gcagccgaaa cagacttcag caaaggcctg gattttgaga
     2821 taccaccccc gagtcctcca ctgaatctcc acgagctgag cgggcctgcg gaaggcaccc
     2881 cgcttacccc aaaaagcggc aaccctacca aaggcctgga tgctccgagc aagagaaaca
     2941 tggacaaagc tgtgtctgtc gaggctgcag agagagactg ggaagagaag cgggccgccc
     3001 tgacccagta cagcgccaag gacatcaacc ggctgctgga ggaaacccaa gctgagctgc
     3061 tcaaggctat ccccgacctg gactgtgcca gcaagaccca cccaggccct actcccactc
     3121 cagaccacaa gccccctaag gcaccccatg gtcagaaggc tgctccccgg acagagccca
     3181 gtgggagaag aggatcagat gagctcacag tgccccgata ccgcacagag aagccctcca
     3241 agtcgccccc gccaccccct ccccgccgga gcttcccttc ctcgcacggc ctgaccacca
     3301 ctcgcaccgg agaagtggtg gtcaccagta agaaagactc agtcttcatc aagaaggctg
     3361 aatctgagga gctggagatc cagaagcctc aggtgaagct gcgtcgcgct gtgtctgagg
     3421 tggtccgccc cgcgtccaca ccgcccatta tggcctcggc catcaaggat gaagacgatg
     3481 aggaacgcat cattgctgag ctggagagtg gtggtggcag tgtgccaccc atgaaggtgg
     3541 tgactcccgg agcctctcgg ctgaaggcgg cccagggtcc agcaggcagc cctgataaag
     3601 gcaaacacgg caagcaacga acggaataca tgaggatcca ggcccagcag caggccacta
     3661 aaccatctaa agagatgagc ggtccgaatg agacctcaag ccccgtctca gaaaaaccct
     3721 ctggttccag aacctccatc cctgtattga cttcctttgg ggcaaggaat tcttccatct
     3781 ccttctagaa gcccctcatg ccaccacccc agcctgcccc tcctttattc ctgccatcgt
     3841 ccctcctttc atgctctacc ctcttcactc tctcgcctga agggttgcag ggggcatggc
     3901 cctctgctct ctcatctcct cttggtgttt ttggtttttt taagcgattt ccttttaatt
     3961 atcttccttt tcctttttct ttttttaaag agtaaaagag aaagctaaaa accaaacaca
     4021 ccaacgtccc ctcacttcct gttccccagc gggcctctgc tccgcccact tcctgtcatt
     4081 ttcccccttc tgctccgccc acttcctgtc atcttcttcc cctctgctct ttcacccttt
     4141 ccccccaccc ccaagtccat ccaaagttcc cacctcccct aacttcccaa gaacacttgg
     4201 aacaaactct gagccacgga gacttggagc ggagcgagac cccctcccat ttactgggtt
     4261 ccttcctgga ggaacaaatg gacaaggact gactcagcgt caggctggac aatggacaag
     4321 ggagaccctg gccttggaga cgccccactg tctgtccagc cttcgaagag acagaactct
     4381 gctgctggcc tgtggttttt ctttcgaacc agggtgggcc tggaagcagg cctagctgga
     4441 ggggattccc agagaagagg ccaaggctgg gtgtgaggag ggaagggggt gggggggaca
     4501 ctaggtgcca ggggagaagc tggctcactg ctgctcagtg tccggctggt gctagcaaca
     4561 aatagaagga ggtccccaag acacctgtta tggagggtgc ttctggggac agcctgcccc
     4621 tggggttctg ccttgggaga gggcaaccct gagaggggca actggtactt ttagttccct
     4681 aatttagcac tttaaatgcc attaacttat tttgtggggg tggggtgggg aagatggaag
     4741 ggcctagaac tatgtttgga gggtgggaag ggtctgcttt gagggataca gggagaaggg
     4801 ttgggtgggt gcagtaaagt ctctgacccc tagggggagc aacttgacct tcagccagcc
     4861 tctatgattc gagggttttc agggaagggg tgagatgtga cttgcctgta gggatctggt
     4921 gaccactcgt caggtgtttg agggtcccca aggcagaaga gccagctagt actccagtct
     4981 ggataccttg caggggtcct gcacagggca gactgacttt tgcgtgggtc caggagtcaa
     5041 agggagaggc tgacttggtt ctggcctggc ccccagcaag tacagagggg ccagagcgaa
     5101 aaggattacg gagagggctg gaagggtgga gggggtcccc tttggagcac aaagcagagt
     5161 aagcacagag atgtggtctt gggactagtc ccacagtaag cacagagagg aaccattgaa
     5221 gggacagaac cccaagaccc tggagcccag caggggagag ccagtggcag ctgttgacgg
     5281 tttggggagg gagggaaaac tgggttgtgt ttcttttctt tgatttcgtt cgtttttatt
     5341 tctttctctt tgttttattg gtttgctctt gttttctagc tttgaatcat ttttgtacta
     5401 aggcaagcaa gcctttttga aaaataacaa aagaagaaga aaaaaaaatc cctcccagaa
     5461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaac aaaaaacaaa ataaaaaaaa ccaaaaaaag
     5521 ccctaaaaaa tagaaaaaaa aggacctcac aatgatgcaa ttacttttaa ttgcaagtaa
     5581 ctctttacat ttaagtgaag tgtcttaaca ttttatattg ttttaaaaat atatttacat
     5641 attatatata tataatatac gtaatataaa tatatataaa tatttaaaaa agaaaaaaaa
     5701 aaaaaagaaa accacagcac actctccctg gccgctgtct ggcaagggag gggctgggga
     5761 caggcgtatg gcctggtgtc catagtcccc gtgaagcagt ttggtttgat ttggctgtac
     5821 agagacccct ggcttgggag gggaggggga gggcccctcc actccatttc tctttgcttg
     5881 ctactctttg cttgccccca cacccgctca gccctgtgac ctgagtctgc gcccctccgt
     5941 cattgtcctg agttgagtgt ccttcgtgga gagaggggat gccggaggaa gtgaccatcc
     6001 acgtaggggc tgccccacga gctcaggcaa ggcccgtggg atttgcgtag ttctagttct
     6061 tcgatttggt tcctgcgcac gtgtgtcctg gaaggcattt gtgtgggttt gtgtgcacgt
     6121 gtgtgtgcac gctggcacaa gcctacataa cttgtgtgtg cacatgcatg gattgtgtgt
     6181 gcataggcca aacttaatat tgtatgtgga agccttgtac atgtatgtga acatcacctg
     6241 cctggacatc acagcatgat tgtgtgagga gagccttggg agtaagaaca tgtgtaatgt
     6301 gtgtgtggac gtgcctggct gttcttgtga ggcccacata tggatgggta cagtaacctt
     6361 agctgtgggt atggttgtgc aggcaggtgt gtgagagggc ctctgtgtgt gtgtgagtac
     6421 tcgtgtgcat gtgtgtgcgc gcgcgttcca tcatccctgc accactcgcc cggctcccct
     6481 cccaagctcc gcccccaccc gccttctcaa agcccacagc acgtcaatcc ccgccccctg
     6541 gcccccaggc ccccagctgc atgcgcctcg ccgctgtcca tcagtgtgtg cttgacaaga
     6601 gaaactgcca catcggggac cctgtacctg gtcccctcac ccctgcccgc tgtgctgtgt
     6661 tactcgcatg ggggggttct ctctgccccc ttccacaata tactgtttcc ctaggggcct
     6721 cggggccaag gctttgagtg aggtcccaag tggggtcccc caaggccagc ccggctccac
     6781 acccacccgt ccaccccgta gggcctgtgt tggtgtagaa gtgatggctt ctgtggatat
     6841 tgtgacctct gtcagtgtaa cttgacaatt tttaaatgga aagggttgct gtgttttctg
     6901 tctctttttt aatgtccttc ttttcttccc tacctcccgc tctcttccct ttccttttgg
     6961 tttttctagc cgagtgttgg ggctttaata aaacttgttt cctttttctc tccggga
//
