LOCUS       NM_031977               2001 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SRC proto-oncogene, non-receptor tyrosine kinase
            (Src), mRNA.
ACCESSION   NM_031977
VERSION     NM_031977.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2001)
  AUTHORS   Storman,E.M., Liu,N.J. and Gintzler,A.R.
  TITLE     Relevance of c-Src and protein phosphatase 2A to aromatase
            activity: Evidence of an acute self-regulating oestrogenic
            signalling complex in rat central nervous system
  JOURNAL   J Neuroendocrinol 34 (4), e13089 (2022)
   PUBMED   35043508
  REMARK    GeneRIF: Relevance of c-Src and protein phosphatase 2A to aromatase
            activity: Evidence of an acute self-regulating oestrogenic
            signalling complex in rat central nervous system.
REFERENCE   2  (bases 1 to 2001)
  AUTHORS   Yang,Q., Zhang,C., Xie,H., Tang,L., Liu,D., Qiu,Q., Luo,D., Liu,K.,
            Xu,J.Y., Tian,H., Lu,L., Xu,G.T. and Zhang,J.
  TITLE     Silencing Nogo-B improves the integrity of blood-retinal barrier in
            diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways
  JOURNAL   Biochem Biophys Res Commun 581, 96-102 (2021)
   PUBMED   34662809
  REMARK    GeneRIF: Silencing Nogo-B improves the integrity of blood-retinal
            barrier in diabetic retinopathy via regulating Src, PI3K/Akt and
            ERK pathways.
REFERENCE   3  (bases 1 to 2001)
  AUTHORS   Liu,T., Li,T., Chen,X., Zhang,K., Li,M., Yao,W., Zhang,C. and
            Wan,L.
  TITLE     A network-based analysis and experimental validation of traditional
            Chinese medicine Yuanhu Zhitong Formula in treating neuropathic
            pain
  JOURNAL   J Ethnopharmacol 274, 114037 (2021)
   PUBMED   33746000
REFERENCE   4  (bases 1 to 2001)
  AUTHORS   Lundby,A., Franciosa,G., Emdal,K.B., Refsgaard,J.C., Gnosa,S.P.,
            Bekker-Jensen,D.B., Secher,A., Maurya,S.R., Paul,I., Mendez,B.L.,
            Kelstrup,C.D., Francavilla,C., Kveiborg,M., Montoya,G., Jensen,L.J.
            and Olsen,J.V.
  TITLE     Oncogenic Mutations Rewire Signaling Pathways by Switching Protein
            Recruitment to Phosphotyrosine Sites
  JOURNAL   Cell 179 (2), 543-560 (2019)
   PUBMED   31585087
REFERENCE   5  (bases 1 to 2001)
  AUTHORS   Zhang,L., Aalkjaer,C. and Matchkov,V.V.
  TITLE     The Na,K-ATPase-Dependent Src Kinase Signaling Changes with
            Mesenteric Artery Diameter
  JOURNAL   Int J Mol Sci 19 (9), 2489 (2018)
   PUBMED   30142894
  REMARK    GeneRIF: The Na,K-ATPase-dependent Src kinase signaling changes
            with mesenteric artery diameter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2001)
  AUTHORS   Alai,M., Mui,A.L., Cutler,R.L., Bustelo,X.R., Barbacid,M. and
            Krystal,G.
  TITLE     Steel factor stimulates the tyrosine phosphorylation of the
            proto-oncogene product, p95vav, in human hemopoietic cells
  JOURNAL   J Biol Chem 267 (25), 18021-18025 (1992)
   PUBMED   1381360
REFERENCE   7  (bases 1 to 2001)
  AUTHORS   Cartwright,C.A., Simantov,R., Cowan,W.M., Hunter,T. and Eckhart,W.
  TITLE     pp60c-src expression in the developing rat brain
  JOURNAL   Proc Natl Acad Sci U S A 85 (10), 3348-3352 (1988)
   PUBMED   2453056
REFERENCE   8  (bases 1 to 2001)
  AUTHORS   Claycomb,W.C. and Lanson,N.A. Jr.
  TITLE     Proto-oncogene expression in proliferating and differentiating
            cardiac and skeletal muscle
  JOURNAL   Biochem J 247 (3), 701-706 (1987)
   PUBMED   2447874
REFERENCE   9  (bases 1 to 2001)
  AUTHORS   Bolen,J.B., Veillette,A., Schwartz,A.M., DeSeau,V. and Rosen,N.
  TITLE     Activation of pp60c-src protein kinase activity in human colon
            carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 84 (8), 2251-2255 (1987)
   PUBMED   2436227
REFERENCE   10 (bases 1 to 2001)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF157016.1.
            
            [WARNING] On Jul 17, 2024 this sequence was replaced by
            NM_031977.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF157016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2001
                     /gene="Src"
                     /note="SRC proto-oncogene, non-receptor tyrosine kinase"
                     /db_xref="GeneID:83805"
                     /db_xref="RGD:620795"
     CDS             1..1629
                     /gene="Src"
                     /EC_number="2.7.10.2"
                     /note="tyrosine protein kinase c-src; c-Src; p60-Src;
                     pp60c-src; proto-oncogene c-Src; tyrosine protein kinase
                     pp60-c-src; v-src sarcoma (Schmidt-Ruppin A-2) viral
                     oncogene homolog; v-src avian sarcoma (Schmidt-Ruppin A-2)
                     viral oncogene homolog; Rous sarcoma oncogene"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase Src"
                     /protein_id="NP_114183.1"
                     /db_xref="GeneID:83805"
                     /db_xref="RGD:620795"
                     /translation="MGSNKSKPKDASQRRRSLEPAENVHGAGGAFPASQTPSKPASAD
                     GHRGPNAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETD
                     LSFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFG
                     KITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDS
                     GGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESL
                     RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL
                     YAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYV
                     HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI
                     KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW
                     RKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL"
     exon            1..250
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            251..350
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            351..368
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            369..467
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            468..571
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            722..877
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1057
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1134
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1288
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1420
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..2001
                     /gene="Src"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcagca acaagagcaa gcccaaggac gccagccaga ggcgccgcag cctggagccc
       61 gcggagaacg tgcatggggc aggtggcgcc ttccctgcct cacagacacc aagcaagcct
      121 gcctccgccg atggccaccg cgggcccaat gccgcctttg tgccccccgc ggccgccgag
      181 cccaagctct tcggaggctt caactcctcg gacactgtca cctccccaca aagggcgggg
      241 cctctggcag gtggggtgac tacctttgtg gccctctatg actatgagtc acggacagag
      301 actgacctgt ccttcaagaa aggggagcgg ctgcagattg tcaataacac gaggaaggtg
      361 gatgtcagag agggagactg gtggctggca cactcgctga gcaccggaca gaccggttac
      421 atccccagta actatgtggc gccctccgac tccatccagg ctgaggagtg gtactttggc
      481 aagatcacta gacgggaatc agagcggcta cttctcaacg ccgagaaccc cagagggacc
      541 ttcctcgtga gggagagtga gaccacaaaa ggtgcctact gcctctctgt atccgacttt
      601 gacaatgcca agggcctaaa tgtgaaacac tacaagatcc ggaaactgga cagtggcgga
      661 ttctacatca cctcccgcac gcaattcaac agcctgcagc agcttgtggc ttactactcc
      721 aaacatgctg atggcctgtg tcaccgtctc actaccgtgt gtcccacatc caagcctcag
      781 acccagggcc tggccaagga tgcgtgggag atcccccggg agtccctgcg gctggaggtc
      841 aagctgggcc agggttgctt cggagaggtg tggatgggga cctggaacgg caccacgagg
      901 gttgccatca aaaccctgaa gccaggcacc atgtctccag aggccttcct gcaggaggcc
      961 caagtcatga agaaactgag gcatgagaag ctggtgcagc tgtatgccgt ggtgtcagaa
     1021 gaacccattt acattgtgac agagtacatg aacaagggga gtctgctgga ctttctcaag
     1081 ggggaaacgg gcaaatactt gcggctaccc cagctggtgg acatgtctgc tcagattgct
     1141 tcaggcatgg cctatgtgga gcggatgaac tatgtgcacc gggacctccg agccgccaat
     1201 atcctggttg gcgagaacct ggtgtgcaaa gtggccgact ttgggctggc ccggctcata
     1261 gaggacaacg aatacacagc tcggcaaggt gccaaattcc ccatcaagtg gaccgcccct
     1321 gaagcggctc tgtatggcag gttcaccatc aagtcggacg tgtggtcctt tggaatcctg
     1381 ctgactgagc tcaccactaa gggcagagtg ccctatcctg ggatggtgaa ccgagaggtg
     1441 ctggaccagg tagagcgggg ctaccggatg ccttgtcccc ccgagtgccc tgagtccctg
     1501 catgacctca tgtgccagtg ctggcggaag gagcctgagg agcggcccac cttcgagtac
     1561 ctgcaggcct tcctggagga ctactttacg tccacggagc cgcagtacca gcccggggag
     1621 aacctatagg aactgtgtgc acagaactgt cacctctagg cttttgggtg tcgcctccct
     1681 tcatcctctc tctggggctg agttcctctg caatgcccct tttggagcat ggaagggctt
     1741 cagggacggg gcagcctgga aggacaggtt gaggctggta cagcgactgt cccacgcctg
     1801 ccatggccac aggctctctg tgcattctct ctggagtcgg cctgcttcat actgggtgac
     1861 gagccgagct gggggcggtt ttccaacctc aacccactct acccacctgg ctcctcccca
     1921 ctttctaaac cctgggtctg tttcaagctg gccaaagagc ctttccaaag aggaataagg
     1981 cccagccctt ggcctatatg t
//
