LOCUS       NM_175843               1991 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus sequestosome 1 (Sqstm1), transcript variant 1,
            mRNA.
ACCESSION   NM_175843
VERSION     NM_175843.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1991)
  AUTHORS   Jiang,G., Shi,L.F., Li,L.J., Duan,X.J. and Zheng,Z.F.
  TITLE     Activation of the p62-Keap1-Nrf2 pathway improves pulmonary
            arterial hypertension in MCT-induced rats by inhibiting autophagy
  JOURNAL   FASEB J 38 (3), e23452 (2024)
   PUBMED   38308640
  REMARK    GeneRIF: Activation of the p62-Keap1-Nrf2 pathway improves
            pulmonary arterial hypertension in MCT-induced rats by inhibiting
            autophagy.
REFERENCE   2  (bases 1 to 1991)
  AUTHORS   Chernyshova,E.V., Gureev,A.P., Sadovnikova,I.S., Plotnikov,E.Y.,
            Silachev,D.N., Zorov,D.B. and Popov,V.N.
  TITLE     The Relationship of p62 Gene Expression with Integrity of
            Mitochondrial DNA and the Level of Lipid Peroxidation Products in
            Skeletal Muscles of Rats of Different Ages Exposed to Different
            Feeding Protocols
  JOURNAL   Bull Exp Biol Med 175 (2), 245-248 (2023)
   PUBMED   37466855
  REMARK    GeneRIF: The Relationship of p62 Gene Expression with Integrity of
            Mitochondrial DNA and the Level of Lipid Peroxidation Products in
            Skeletal Muscles of Rats of Different Ages Exposed to Different
            Feeding Protocols.
REFERENCE   3  (bases 1 to 1991)
  AUTHORS   Zhang,X.X., Lang,Y.F., Li,X., Li,Z., Xu,Y.Q. and Chu,H.Q.
  TITLE     The protective effect of puerarin-loaded mesoporous silicon
            nanoparticles on alcoholic hepatitis through mTOR-mediated
            autophagy pathway
  JOURNAL   Biomed Microdevices 24 (4), 37 (2022)
   PUBMED   36308627
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1991)
  AUTHORS   Zeng,T., Zhang,S., He,Y., Liu,Z. and Cheng,Q.
  TITLE     MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation
            induced neuronal injury by negatively regulating SQSTM1 in vitro
  JOURNAL   Metab Brain Dis 36 (8), 2359-2368 (2021)
   PUBMED   34581931
  REMARK    GeneRIF: MiR-361-5p promotes oxygen-glucose
            deprivation/re-oxygenation induced neuronal injury by negatively
            regulating SQSTM1 in vitro.
REFERENCE   5  (bases 1 to 1991)
  AUTHORS   Babuta,M., Furi,I., Bala,S., Bukong,T.N., Lowe,P., Catalano,D.,
            Calenda,C., Kodys,K. and Szabo,G.
  TITLE     Dysregulated Autophagy and Lysosome Function Are Linked to Exosome
            Production by Micro-RNA 155 in Alcoholic Liver Disease
  JOURNAL   Hepatology 70 (6), 2123-2141 (2019)
   PUBMED   31090940
REFERENCE   6  (bases 1 to 1991)
  AUTHORS   Wooten,M.W., Seibenhener,M.L., Mamidipudi,V., Diaz-Meco,M.T.,
            Barker,P.A. and Moscat,J.
  TITLE     The atypical protein kinase C-interacting protein p62 is a scaffold
            for NF-kappaB activation by nerve growth factor
  JOURNAL   J Biol Chem 276 (11), 7709-7712 (2001)
   PUBMED   11244088
REFERENCE   7  (bases 1 to 1991)
  AUTHORS   Kuusisto,E., Suuronen,T. and Salminen,A.
  TITLE     Ubiquitin-binding protein p62 expression is induced during
            apoptosis and proteasomal inhibition in neuronal cells
  JOURNAL   Biochem Biophys Res Commun 280 (1), 223-228 (2001)
   PUBMED   11162503
REFERENCE   8  (bases 1 to 1991)
  AUTHORS   Gong,J., Xu,J., Bezanilla,M., van Huizen,R., Derin,R. and Li,M.
  TITLE     Differential stimulation of PKC phosphorylation of potassium
            channels by ZIP1 and ZIP2
  JOURNAL   Science 285 (5433), 1565-1569 (1999)
   PUBMED   10477520
REFERENCE   9  (bases 1 to 1991)
  AUTHORS   Nakaso,K., Kitayama,M., Ishii,T., Bannai,S., Yanagawa,T.,
            Kimura,K., Nakashima,K., Ohama,E. and Yamada,K.
  TITLE     Effects of kainate-mediated excitotoxicity on the expression of rat
            counterparts of A170 and MSP23 stress proteins in the brain
  JOURNAL   Brain Res Mol Brain Res 69 (2), 155-163 (1999)
   PUBMED   10366737
REFERENCE   10 (bases 1 to 1991)
  AUTHORS   Joung,I., Strominger,J.L. and Shin,J.
  TITLE     Molecular cloning of a phosphotyrosine-independent ligand of the
            p56lck SH2 domain
  JOURNAL   Proc Natl Acad Sci U S A 93 (12), 5991-5995 (1996)
   PUBMED   8650207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 19, 2021 this sequence version replaced NM_175843.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061575.1, SRR22399481.2001150.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840116
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000010.1  35037518-35037750   c
            234-329             JAXUCZ010000010.1  35035464-35035559   c
            330-556             JAXUCZ010000010.1  35034996-35035222   c
            557-698             JAXUCZ010000010.1  35034752-35034893   c
            699-779             JAXUCZ010000010.1  35033435-35033515   c
            780-1000            JAXUCZ010000010.1  35029221-35029441   c
            1001-1196           JAXUCZ010000010.1  35028823-35029018   c
            1197-1991           JAXUCZ010000010.1  35026598-35027392   c
FEATURES             Location/Qualifiers
     source          1..1991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1991
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /note="sequestosome 1"
                     /db_xref="GeneID:113894"
                     /db_xref="RGD:69287"
     exon            1..233
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1354
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxidative stress induced; protein kinase
                     C-zeta-interacting protein; ubiquitin-binding protein p62;
                     PKC-zeta-interacting protein"
                     /codon_start=1
                     /product="sequestosome-1 isoform 1"
                     /protein_id="NP_787037.2"
                     /db_xref="GeneID:113894"
                     /db_xref="RGD:69287"
                     /translation="MASLTVKAYLLGKEEAAREIRRFSFCFSPEPEAEAAAGPGPCER
                     LLSRVAVLFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKE
                     CRREHRPPCAQEARSMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHREH
                     SKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGWPGWEMGPPGNWSPRPPRAGDGRPCPT
                     AESASAPSEDPNVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPTSAESSSTG
                     TEDKSGTQPSSCSSEVSKPDGAGEGPAQSLTEQMKKIALESVGQPEELMESDNCSGGD
                     DDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPR
                     LIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL"
     exon            234..329
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..556
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..698
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..779
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1000
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1196
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1991
                     /gene="Sqstm1"
                     /gene_synonym="Osi; ZIP; ZIP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagctgt ttcctccgta cctagtctgc ggttatggct tcgctcacgg tgaaggccta
       61 tctactgggc aaggaggagg cggcccgcga gatccgccgc ttcagcttct gcttcagccc
      121 ggagccggag gcggaagccg cggctggccc ggggccctgc gagaggctgc tgagccgggt
      181 ggctgtgctg ttccccgcgc tgcggcctgg aggctttcag gcgcactacc gcgatgagga
      241 tggggacttg gtcgccttct ccagtgatga ggaactgaca atggccatgt cctatgtgaa
      301 agatgacatc ttccgcatct acattaaaga gaagaaggag tgccggcggg aacatcgccc
      361 cccatgtgct caggaggcac gaagcatggt gcaccccaac gtgatttgtg atggttgcaa
      421 tgggcctgtg gtgggaactc gctataagtg cagtgtgtgc cccgactacg acctgtgcag
      481 cgtctgcgag gggaagggcc tgcacaggga gcacagcaag ctcatctttc ccaacccctt
      541 tggccacctc tctgatagct tctctcatag ccgctggctt cggaagctga aacatgggca
      601 ctttggctgg cctggctggg agatgggccc accagggaac tggagcccac gtcctcctcg
      661 cgcaggggat ggtcgccctt gccccacagc tgagtcggct tctgctccat cagaggatcc
      721 caatgtcaat ttcctgaaga atgtggggga gagcgtggca gctgccctca gccctctagg
      781 catcgaggtt gacattgatg tggaacatgg agggaagaga agccgcctga cacccacctc
      841 tgcagaaagt tccagcacag gcacagaaga taagagtggt actcagccaa gcagctgctc
      901 ttcggaagtc agcaaacctg acggggccgg ggagggccct gctcagtctc tgacagagca
      961 gatgaagaag atagccttgg agtcggtggg acagccagag gaactgatgg agtcggataa
     1021 ctgctcagga ggggatgacg actggacgca tttgtcttct aaagaagtgg acccatccac
     1081 aggtgaactc cagtctctac agatgccaga atcggaaggg ccaagctctc tagacccctc
     1141 acaggaaggc cccacagggc tgaaggaagc tgccctgtac ccacatctcc caccagaggc
     1201 tgatccccgg ctgattgagt cactctctca gatgctgtcc atgggtttct cggatgaagg
     1261 cggctggctc accaggctcc tacagaccaa gaattatgac atcggggctg ctctggacac
     1321 gatccagtat tcaaagcacc ctccaccatt gtgacagtgc tgtggccaag tcccacaacc
     1381 cacctccctt gtcttctagt tgcatcatgt agagtagcag ggcttctaag gcccagtgtc
     1441 ttggcattct tctagaacct tcaggtggga ctgtgaggcc ttcttaggca gtaggaaagt
     1501 gcatgagaag agagtctgag tgtgcacatg ctgacccctg agcacagatc caagcagctg
     1561 tggctgggct tccgctgctt tccctcggcc tggcctttgc cagggagctg tggagtcatg
     1621 ctgcactcca cttgctcttg ccgccagcat tgcacctgca gtccatcatc cctgcctgat
     1681 aaccttctgt gttttcttta ttaaaaggga ttagtacaac tgatagttat tttcaacaaa
     1741 taaagccatt atgtttagag ggggactgtc ctcagtgagt gaaaggtggc aggctaccgg
     1801 ggcctacggc tcctgggtga tggagaactt aggtgaagcc aactgaaaga tcttatcatt
     1861 cactgtgccc ccttttaatg gccagtttag tttttgtgtc taatgttaat gcttaaagta
     1921 caaaccccct atgtagcttc ctctgacttg atttttaagt aacctgtaat aaagtggcat
     1981 atgcacttta a
//
