LOCUS       NM_001047913            1623 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus sulfide quinone oxidoreductase (Sqor), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001047913 XM_001077275 XM_001077299 XM_001077317 XM_001077335
            XM_342606
VERSION     NM_001047913.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Augustyn,K.D., Jackson,M.R. and Jorns,M.S.
  TITLE     Use of Tissue Metabolite Analysis and Enzyme Kinetics To
            Discriminate between Alternate Pathways for Hydrogen Sulfide
            Metabolism
  JOURNAL   Biochemistry 56 (7), 986-996 (2017)
   PUBMED   28107627
  REMARK    GeneRIF: The role of Sqor in hydrogen sulfide metabolism in the
            heart and liver
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Ackermann,M., Kubitza,M., Hauska,G. and Pina,A.L.
  TITLE     The vertebrate homologue of sulfide-quinone reductase in mammalian
            mitochondria
  JOURNAL   Cell Tissue Res 358 (3), 779-792 (2014)
   PUBMED   25130143
  REMARK    GeneRIF: The present report demonstrates the presence and specific
            localization of SQRDL in various mammalian tissues.
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Jackson,M.R., Melideo,S.L. and Jorns,M.S.
  TITLE     Human sulfide:quinone oxidoreductase catalyzes the first step in
            hydrogen sulfide metabolism and produces a sulfane sulfur
            metabolite
  JOURNAL   Biochemistry 51 (34), 6804-6815 (2012)
   PUBMED   22852582
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Ackermann,M., Kubitza,M., Maier,K., Brawanski,A., Hauska,G. and
            Pina,A.L.
  TITLE     The vertebrate homolog of sulfide-quinone reductase is expressed in
            mitochondria of neuronal tissues
  JOURNAL   Neuroscience 199, 1-12 (2011)
   PUBMED   22067608
  REMARK    GeneRIF: we demonstrated that the SQRDL protein is expressed in
            neurons, oligodendrocytes, and endothelial cells
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1623)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158559.1.
            
            On Oct 21, 2008 this sequence version replaced NM_001047913.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1623
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /note="sulfide quinone oxidoreductase"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
     exon            1..18
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            19..269
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1388
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /EC_number="1.8.5.8"
                     /codon_start=1
                     /product="sulfide:quinone oxidoreductase, mitochondrial"
                     /protein_id="NP_001041378.2"
                     /db_xref="GeneID:691966"
                     /db_xref="RGD:1564504"
                     /translation="MAPLVAVVSSPRARLFACFLRLGTQQAGPLQLHTGACCTAKNHY
                     EVLVLGGGSGGITMATRMKRRVGAENVAIVEPSERHFYQPIWTLVGAGAKELSSSDRS
                     TLSVIPSGVQWIQDRVAELNPDQNCIRTDNGKEISYRYLIIALGIQLDYEKIKGLPEG
                     FAYPKIGSNYSVKTVEKTWKALQDFKEGNALFTFPNTPVKCAGAPQKIMYLSEAYFRK
                     TGKRSKANIIFNTALGTIFGVKKYADALQEIIRERNVSVNYKHNLIEVRADKQEAVFE
                     NLDKPGETHVIHYEMLHVTPPMSSPDVLKRSPVADSAGWVDVDKETLQHKKYPNVFGI
                     GDCTNLPTSKTAAAVAAQSGILDRTISLIMKNQTPTKKYDGYTSCPLVTGYNRVILAE
                     FDYTAQPLETFPFDQSKERISMYLMKADMMPFLYWNMMLRGYWGGPAFLRKLFHLGLS
                     "
     exon            270..440
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            441..494
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            495..689
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            690..899
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1083
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1151
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1330
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1599
                     /gene="Sqor"
                     /gene_synonym="Cc2-17; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagccatgg cacaacagcc tgatctaccc tggtgatggc cccactggtt gctgttgtat
       61 ccagtccacg tgcccggctc tttgcttgtt tccttaggct gggcactcag caggctggac
      121 ccctccaatt gcatacggga gcctgctgca cagccaagaa ccactatgag gtgctggtac
      181 ttggtggggg aagtggtggg atcaccatgg ccactcgcat gaagaggaga gttggagcgg
      241 agaatgtggc cattgttgaa cccagtgaga ggcatttcta ccagccaatc tggacactag
      301 tgggtgctgg tgccaaagag ctgtcctcat cggaccgttc tacactgagt gtgattccat
      361 ccggtgtgca gtggattcaa gatagagtgg cggaactgaa cccagatcag aactgtatcc
      421 gcacagacaa tggcaaggag atctcctaca gatatcttat catcgctctt ggaatccagc
      481 tggactatga gaagattaaa ggactacctg aaggctttgc ttatccaaaa atagggtcca
      541 attactcagt taagacagtg gagaagacat ggaaggccct gcaggacttc aaggaaggca
      601 atgccctttt caccttccca aacactccag tgaagtgtgc tggtgccccc cagaagatca
      661 tgtacctatc ggaagcctac ttcagaaaga ctggaaagcg atccaaggct aatatcatct
      721 tcaacacagc ccttggaaca atttttggag ttaagaagta cgcagatgct ttgcaggaga
      781 tcattcggga gaggaacgtt tctgtcaact ataagcacaa tcttattgag gtccgagctg
      841 acaaacagga ggctgttttt gagaacctgg acaagcctgg ggagacacat gtgattcatt
      901 atgaaatgct tcacgtcacg ccacccatga gctcgccaga tgtcctcaag aggagtcctg
      961 tggccgattc tgctggctgg gtggacgtgg ataaggagac tctgcagcat aagaaatacc
     1021 cgaatgtgtt tggcatcggg gactgcacca acctcccaac ttcaaagacg gctgctgcag
     1081 tagctgccca atctggaatc cttgatagaa caatttctct gattatgaag aatcaaacac
     1141 ccacaaaaaa gtatgatggc tatacctcgt gcccactggt gactggttac aaccgtgtga
     1201 ttcttgctga gtttgactac acagctcagc ctctggaaac cttccccttt gatcagagta
     1261 aagaacgaat ttccatgtac ctcatgaagg ctgacatgat gccgttcctg tattggaata
     1321 tgatgctaag aggctactgg ggaggtccag ccttcttgcg aaagctgttt catctgggcc
     1381 tgagttaaag atggctcagc acttgctctt tttggatgat gtctggacca aaatcacagt
     1441 tactgattga catgacagat ccaaaggact cagaatctta ccctttaagg agtttcttac
     1501 tggacatgat gacctttcta gacctctgaa tagctatcat gtgaacaacc cagaatgagt
     1561 ctttggaaac atccaaaata aaattctatt ttataaataa aaaaaaaaaa aaaaaaaaaa
     1621 aaa
//
