LOCUS       NM_001271299            2255 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus serine palmitoyltransferase, small subunit B
            (Sptssb), transcript variant 1, mRNA.
ACCESSION   NM_001271299 XM_002725981
VERSION     NM_001271299.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Zhao L, Spassieva S, Gable K, Gupta SD, Shi LY, Wang J, Bielawski
            J, Hicks WL, Krebs MP, Naggert J, Hannun YA, Dunn TM and Nishina
            PM.
  TITLE     Elevation of 20-carbon long chain bases due to a mutation in serine
            palmitoyltransferase small subunit b results in neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 112 (42), 12962-12967 (2015)
   PUBMED   26438849
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F,
            Brown RH Jr, Harmon JM and Dunn TM.
  TITLE     Identification of small subunits of mammalian serine
            palmitoyltransferase that confer distinct acyl-CoA substrate
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8186-8191 (2009)
   PUBMED   19416851
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9931]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087706.1 and FM125939.1.
            
            On Sep 15, 2012 this sequence version replaced XM_002725981.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            genome assembly.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM125939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               BC087706.1         1-483
            484-900             FM125939.1         1-417
            901-2255            BC087706.1         806-2160
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..2255
                     /gene="Sptssb"
                     /note="serine palmitoyltransferase, small subunit B"
                     /db_xref="GeneID:100362555"
                     /db_xref="RGD:2324614"
     exon            1..537
                     /gene="Sptssb"
                     /inference="alignment:Splign:2.1.0"
     exon            538..632
                     /gene="Sptssb"
                     /inference="alignment:Splign:2.1.0"
     exon            633..2232
                     /gene="Sptssb"
                     /inference="alignment:Splign:2.1.0"
     CDS             662..892
                     /gene="Sptssb"
                     /note="androgen down regulated in mouse prostate"
                     /codon_start=1
                     /product="serine palmitoyltransferase small subunit B"
                     /protein_id="NP_001258228.1"
                     /db_xref="GeneID:100362555"
                     /db_xref="RGD:2324614"
                     /translation="MDFKRVKEYFAWLYYQYQIITCCAVMEPWEQSMLNTIILTIVAM
                     VVYTAYVFIPIHIRLAWEFFSKICGYDSSISN"
ORIGIN      
        1 ctctgcctag gctccgggtt ttactgcagc aatcggaggt gacagcgcca cctcggtctc
       61 ctccgtagct ctcagagccc ctgcttcccc cagtaactgg gaaagcgccc cctcttgaga
      121 agctaatttc tgaagaagtg cgaacaggct acagaaaaaa aaaaaaaaag attttgaaaa
      181 tgtagaagtc accgggatgc attcctcctc ggagaagagc ccaatctccc agaactgagt
      241 atcagcgcat aggaagttag gaccttagag cgaaggggga ggggagtggt gcagcccgca
      301 ttctcttctg gaaggagtca ctgcaagccc tgcggttgga cataagtttg cgtaagagtg
      361 ttttcctttt gtcaattatt aatcaccgga atcagtttgg cagaactgga gttttagcag
      421 tagtgcagag ggcggggccc gaacacctaa ctctgggagc ctcggctgcg cccagcacag
      481 tggcaagcta acagaagctg gggagaagcc agagcatcta agctcactca gcaaaagatg
      541 aagaaataga gcccaaggaa gagagataac ctacatcaga tcattccgag gaaaagcgtc
      601 accgtgcacc aagcctagac cctccaggac aggcagactt tccacagctc gaggaagagc
      661 catggatttc aagcgtgtga aggagtattt tgcctggctc tactatcaat accaaatcat
      721 tacctgctgt gctgtcatgg agccttggga acaatccatg ctcaacacca tcatactaac
      781 cattgttgct atggtggtat acactgccta tgtcttcatc cccatccaca tccgactggc
      841 ttgggaattt ttctccaaaa tatgtggata tgacagttca atatctaact gatatcatcg
      901 gaattctgtg aaatggcgta atgtattcac attgcttaca acttactgac ttgggtgact
      961 gtgttatcgt tcacctgtga cctgaccagc actctttcta tgcactgtca cacacatcct
     1021 gcctggagta caagataggt gtcttcccgc ttgcttttga acatgcagca ttgtgcatca
     1081 gatgatagga aaggccatga gtttaacccc atagcccaca tttgctcaac tcaactctgt
     1141 ggctgtagat ttcttttgaa atccggatgc tttgaaataa aacttttctg gaagataggc
     1201 ttataagaga catgatggag tcatatttac actactcttt tcatattatt ccacatgaaa
     1261 ggatatgtta caaaagtatt cttcataggc tactgtcaaa agtaccctgc acttgtttac
     1321 aatttattaa gaggtgggaa taaaatagat gaacctgtaa agtcttattt tctggtagat
     1381 agctaacacc taaaattcat ttttttcttc ctttttaaat tttcattttc tttgcttcac
     1441 ctaaaattct tttactttac agtaataggc tagagacaat tgtcctcttt cggattttgt
     1501 ttcagcaatg tttcaaatgc tcctgaaatc tggctttatc gcagctttaa aggaatgttg
     1561 attttcaggt aaacaaacaa ctactgtact agagaataat ttaagtttca gaaacaaagc
     1621 ataatcaagg caaattcgca tattgtgact cttgatcatg gcccacctta catgatgctg
     1681 gagataaaag aagagagatc gttgttttgc tgtgcgtttg gtgagaggaa ggaaaactgc
     1741 acgtcctgga ccacaggaag aaaggctgat aaatagactg gaagtaatag ccaagcagca
     1801 ggaagtcaac agctccagtt aaaggctttg atacagcagc gcctttgcac agcagaaaca
     1861 agatatatta aatttctctc aaaatggtta tcttcaaagt aaacgtaaga gtttaattat
     1921 agtgctgagt caaacataca agccaaagac caagccttgc agcttttctt tcttcccagt
     1981 aaagattaac attagtgatt ctggagggtt aaaaaaaata aataaataat aaacatgttt
     2041 tgggcaatat tggcaccttt gttttaggag gaaaatattc caaggagtca tacaaagaaa
     2101 gatatttggc atgcaaaatc agcctgcatg tctatttaaa aaacaaaatg tacattttaa
     2161 acagaaacca gatatgaaat atatacttgt tgatttttgc aaaataaaat taagtttact
     2221 tttataagca aaaaaaaaaa aaaaaaaaaa aaaaa
//
