LOCUS       NM_001106517            2837 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus serine palmitoyltransferase, long chain base
            subunit 3 (Sptlc3), mRNA.
ACCESSION   NM_001106517 XM_001081310 XM_230620
VERSION     NM_001106517.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2837)
  AUTHORS   Hornemann T, Penno A, Rutti MF, Ernst D, Kivrak-Pfiffner F, Rohrer
            L and von Eckardstein A.
  TITLE     The SPTLC3 subunit of serine palmitoyltransferase generates short
            chain sphingoid bases
  JOURNAL   J Biol Chem 284 (39), 26322-26330 (2009)
   PUBMED   19648650
REFERENCE   2  (bases 1 to 2837)
  AUTHORS   Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F,
            Brown RH Jr, Harmon JM and Dunn TM.
  TITLE     Identification of small subunits of mammalian serine
            palmitoyltransferase that confer distinct acyl-CoA substrate
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8186-8191 (2009)
   PUBMED   19416851
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9931]
REFERENCE   3  (bases 1 to 2837)
  AUTHORS   Hornemann T, Wei Y and von Eckardstein A.
  TITLE     Is the mammalian serine palmitoyltransferase a high-molecular-mass
            complex?
  JOURNAL   Biochem J 405 (1), 157-164 (2007)
   PUBMED   17331073
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081310.1, XM_230620.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760393
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2837
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /note="serine palmitoyltransferase, long chain base
                     subunit 3"
                     /db_xref="GeneID:296188"
                     /db_xref="RGD:1310030"
     exon            1..403
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1978
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /EC_number="2.3.1.50"
                     /codon_start=1
                     /product="serine palmitoyltransferase 3"
                     /protein_id="NP_001099987.1"
                     /db_xref="GeneID:296188"
                     /db_xref="RGD:1310030"
                     /translation="MANPRDSAVTNGTLRNPKTQPGKRQSTDCVKNGISKEAQQNRKA
                     EEDDKLVFKPYPEPPLYVFVFTYMGYGIGMLFGYLRDFMRNWGIEKCNAAVEREEQKD
                     FVPLYQDFENFYTRNLYMRIRDSWSHTVCSVPVPNFDIMEKVTDDYNWTFRHTGKVIK
                     NVINMASYNYLGLASKYNESMEKVKDTIEKYGVGVASTRNEMGSLDIHNELEDLMAKF
                     LNVEAVMVFGMGFATNSTNIPIFVGKGCLILSDEFNHTSVILGSRLSGAVIRPFKHNN
                     IQNLEKLLREAIIRGQPRTGRAWKKILILVEGVYSMEGSIVNLPQIVALKKKYKAYLY
                     MDEAHSIGCTGTMGQGIRELFGLAPEDIDIYMGTFTKSFAASGGYIAGKKEIVDYVRV
                     QSHSATYATSMSPVVAAQIIRSLKIMMGYEGNFGGVQRIQQLRENIKYFRRRLIEMGF
                     IIYGNDYSPVVPVLLYMPAKVSAFGRLLLKKKIAVVVVGFPATSLPEGRARFSLSSAH
                     TREMLDTVLEVVDKIGDLLNVKYFPYKKSGRAVLYNKENFDNEASFEEKSSEPEA"
     exon            404..589
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            590..744
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            745..893
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1018
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1112
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1218
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1438
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1565
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1701
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1831
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2837
                     /gene="Sptlc3"
                     /gene_synonym="RGD1310030"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcagcctc aaaaggcagc tagcaaggca aattctcttt gtagtttcag aacaggtttg
       61 ttgccatgga tcccacaacg cgactggagt aaactagtaa aaggtaacaa ctaaagatct
      121 agtcaataga taggctgtgg ttcttcttct ggaaaatcct gactggtagg attcctttaa
      181 aggctctgcc gcaaagtgct ttatgttatt acttcagctg cttgaaaagt gaagttccag
      241 gagaccgcag aaagagaacc tgccttggcc aaagcacttc ccactaatgg ccaacccgag
      301 ggacagtgct gttactaatg ggactctacg caatcccaag acccagccgg gaaaaagaca
      361 gagcactgat tgtgtgaaaa atggaatctc gaaagaagcc cagcaaaata ggaaggcaga
      421 ggaggacgat aaacttgtct ttaagcccta cccagagcca ccactttatg tcttcgtttt
      481 cacatacatg ggatatggaa ttggcatgct gttcggctat ctcagagact tcatgagaaa
      541 ctggggaata gaaaaatgca acgcagctgt agagcgagaa gaacaaaaag attttgtgcc
      601 gctgtatcag gactttgaga acttttatac aagaaacctt tacatgagaa tcagagacag
      661 ctggagtcac accgtctgca gtgtcccagt acctaacttt gacataatgg aaaaagtgac
      721 agatgactat aactggacat tcaggcatac tggaaaagtt atcaaaaatg ttatcaacat
      781 ggcctcctac aactaccttg gccttgcatc aaaatacaat gagtcaatgg agaaagttaa
      841 agacactata gaaaagtatg gcgtaggtgt ggccagcacc agaaatgaaa tgggttcctt
      901 ggatatacac aacgagctgg aggatctcat ggctaagttc ttgaatgtgg aagcagtgat
      961 ggtttttggg atgggattcg caaccaactc gacgaatatc cctatatttg ttggaaaggg
     1021 atgcctcatt ttaagtgacg agttcaacca cacttcagtc atcctggggt ctcgactctc
     1081 aggcgcagtc ataagaccct tcaaacacaa taatatacaa aacctagaga agctcctgag
     1141 agaagctatc atccgtggcc agcctcgcac gggaagagct tggaaaaaga ttctcatcct
     1201 ggtagaggga gtctacagca tggaaggttc cattgtgaac cttccccaga tagtggctct
     1261 aaagaagaaa tacaaggctt acctctacat ggatgaagct cacagtattg gctgtacagg
     1321 taccatgggc caaggcatcc gagagttgtt tggactggcc cctgaagata tcgacatata
     1381 catgggtaca ttcaccaaaa gcttcgcggc ttctggaggc tatatagctg gtaaaaagga
     1441 aattgtggat tatgtacggg ttcagtcgca tagtgctaca tatgctacat ccatgagtcc
     1501 tgtagtagca gcgcaaatca tcagatcatt gaagataatg atgggatatg aaggaaactt
     1561 tggaggtgtg cagagaatac agcaacttag agaaaacata aaatatttcc gacggcgact
     1621 tatagagatg ggattcatca tctatggcaa tgactactct cccgtggtcc ccgtcctcct
     1681 ctacatgcct gctaaagtgt ctgcttttgg aagacttttg cttaagaaaa agattgcggt
     1741 ggtggtcgtt ggatttccag ctacttctct gccagaaggt cgggctaggt tcagcctttc
     1801 ctcagctcat actcgggaga tgttagacac agttttggaa gttgttgata aaatcggtga
     1861 tctcctgaat gtgaaatatt tcccatacaa gaagtcagga cgggctgtac tctacaataa
     1921 ggagaatttt gacaatgaag caagctttga agagaagagc tctgaaccag aagcctaagt
     1981 ttcctggctc taaatagaac ataaagacta ccagaaagac ctccctccct ctttatctca
     2041 aaagtaatat aattgtattt taccccttct aagaacaatt ttatttttca aacaaactta
     2101 attgaagaag ggaaataatc atttatttaa tgtctcaaac ttgctgctac aaagtgaaag
     2161 aatataattc tagatttaag ttttccctct tctttgctgt aaatacacac atacgtgcaa
     2221 atggtagtaa gcctatgttt tagctgcttt tgggtcaggc cttatcaagg gctacaacta
     2281 aaatgaaagg attttgattt tttacttgat aatcttcctg tgtaccatct gcacacaaga
     2341 aaaagtgtca gagaggagct gggtccctcg ttccacctga aacagttcat atgtgtcgtg
     2401 ggaagctcca gaaaaggaga agacaatgtt gcttctgttt gtcacatttg gactttatcc
     2461 aaggacaggt gtcaaaagac acagttaatg cttgggagag aatacagaac tggctggtgg
     2521 tgagcagaga cgtctttgaa gtgagcctcc tttttcctct tgatgttctc ctacagcttt
     2581 attgttaagc tctaaggact ggaaagttca tgtctcttgt tttctaaaga ggaggaagaa
     2641 aagcaatcac aagccagttt tggacctaga ctaaaactat aaaattaaaa caacccaaat
     2701 gatgctggtg ccatgcagag ggagcctaaa aacgcttggc ctttattgct ttaaggaaca
     2761 tcttcccatt tttctattga attctgagta catagtgaaa ctcaatttcc cttacaacac
     2821 attcccaaat tgcactt
//
