LOCUS       NM_001100845            8736 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus spectrin, beta, non-erythrocytic 4 (Sptbn4),
            mRNA.
ACCESSION   NM_001100845 XM_001072073 XM_218364
VERSION     NM_001100845.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8736)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   2  (bases 1 to 8736)
  AUTHORS   Sohn,P.D., Tracy,T.E., Son,H.I., Zhou,Y., Leite,R.E., Miller,B.L.,
            Seeley,W.W., Grinberg,L.T. and Gan,L.
  TITLE     Acetylated tau destabilizes the cytoskeleton in the axon initial
            segment and is mislocalized to the somatodendritic compartment
  JOURNAL   Mol Neurodegener 11 (1), 47 (2016)
   PUBMED   27356871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8736)
  AUTHORS   van Beuningen,S.F.B., Will,L., Harterink,M., Chazeau,A., van
            Battum,E.Y., Frias,C.P., Franker,M.A.M., Katrukha,E.A., Stucchi,R.,
            Vocking,K., Antunes,A.T., Slenders,L., Doulkeridou,S., Sillevis
            Smitt,P., Altelaar,A.F.M., Post,J.A., Akhmanova,A.,
            Pasterkamp,R.J., Kapitein,L.C., de Graaff,E. and Hoogenraad,C.C.
  TITLE     TRIM46 Controls Neuronal Polarity and Axon Specification by Driving
            the Formation of Parallel Microtubule Arrays
  JOURNAL   Neuron 88 (6), 1208-1226 (2015)
   PUBMED   26671463
REFERENCE   4  (bases 1 to 8736)
  AUTHORS   Glynn,P., Musa,H., Wu,X., Unudurthi,S.D., Little,S., Qian,L.,
            Wright,P.J., Radwanski,P.B., Gyorke,S., Mohler,P.J. and Hund,T.J.
  TITLE     Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates
            Late Current, Arrhythmia, and Cardiac Function In Vivo
  JOURNAL   Circulation 132 (7), 567-577 (2015)
   PUBMED   26187182
REFERENCE   5  (bases 1 to 8736)
  AUTHORS   Xu,K., Zhong,G. and Zhuang,X.
  TITLE     Actin, spectrin, and associated proteins form a periodic
            cytoskeletal structure in axons
  JOURNAL   Science 339 (6118), 452-456 (2013)
   PUBMED   23239625
  REMARK    GeneRIF: study of the organization of actin, spectrin and
            associated proteins in neurons; spectrin exhibited periodic
            structures alternating with those of actin and adducin; the
            distance between adjacent actin-adducin rings was comparable to the
            length of a spectrin tetramer
REFERENCE   6  (bases 1 to 8736)
  AUTHORS   Lacas-Gervais,S., Guo,J., Strenzke,N., Scarfone,E., Kolpe,M.,
            Jahkel,M., De Camilli,P., Moser,T., Rasband,M.N. and Solimena,M.
  TITLE     BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon
            initial segments
  JOURNAL   J Cell Biol 166 (7), 983-990 (2004)
   PUBMED   15381686
REFERENCE   7  (bases 1 to 8736)
  AUTHORS   Komada,M. and Soriano,P.
  TITLE     [Beta]IV-spectrin regulates sodium channel clustering through
            ankyrin-G at axon initial segments and nodes of Ranvier
  JOURNAL   J Cell Biol 156 (2), 337-348 (2002)
   PUBMED   11807096
REFERENCE   8  (bases 1 to 8736)
  AUTHORS   Tse,W.T., Tang,J., Jin,O., Korsgren,C., John,K.M., Kung,A.L.,
            Gwynn,B., Peters,L.L. and Lux,S.E.
  TITLE     A new spectrin, beta IV, has a major truncated isoform that
            associates with promyelocytic leukemia protein nuclear bodies and
            the nuclear matrix
  JOURNAL   J Biol Chem 276 (26), 23974-23985 (2001)
   PUBMED   11294830
REFERENCE   9  (bases 1 to 8736)
  AUTHORS   Berghs,S., Aggujaro,D., Dirkx,R. Jr., Maksimova,E., Stabach,P.,
            Hermel,J.M., Zhang,J.P., Philbrick,W., Slepnev,V., Ort,T. and
            Solimena,M.
  TITLE     betaIV spectrin, a new spectrin localized at axon initial segments
            and nodes of ranvier in the central and peripheral nervous system
  JOURNAL   J Cell Biol 151 (5), 985-1002 (2000)
   PUBMED   11086001
REFERENCE   10 (bases 1 to 8736)
  AUTHORS   Bronson,R.T., Sweet,H.O., Spencer,C.A. and Davisson,M.T.
  TITLE     Genetic and age related models of neurodegeneration in mice:
            dystrophic axons
  JOURNAL   J Neurogenet 8 (2), 71-83 (1992)
   PUBMED   1634998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BE107551.1.
            
            On Sep 11, 2014 this sequence version replaced NM_001100845.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000001.1  91864722-91864840   c
            120-306             JAXUCZ010000001.1  91860971-91861157   c
            307-458             JAXUCZ010000001.1  91854056-91854207   c
            459-632             JAXUCZ010000001.1  91852868-91853041   c
            633-933             BE107551.1         161-461
            934-1034            JAXUCZ010000001.1  91838471-91838571   c
            1035-1222           JAXUCZ010000001.1  91838070-91838257   c
            1223-1340           JAXUCZ010000001.1  91837856-91837973   c
            1341-1499           JAXUCZ010000001.1  91837420-91837578   c
            1500-1802           JAXUCZ010000001.1  91835889-91836191   c
            1803-1953           JAXUCZ010000001.1  91834140-91834290   c
            1954-2887           JAXUCZ010000001.1  91830198-91831131   c
            2888-3025           JAXUCZ010000001.1  91828694-91828831   c
            3026-3776           JAXUCZ010000001.1  91824733-91825483   c
            3777-3979           JAXUCZ010000001.1  91823116-91823318   c
            3980-4070           JAXUCZ010000001.1  91818455-91818545   c
            4071-4217           JAXUCZ010000001.1  91815123-91815269   c
            4218-4481           JAXUCZ010000001.1  91812561-91812824   c
            4482-4706           JAXUCZ010000001.1  91796883-91797107   c
            4707-4796           JAXUCZ010000001.1  91795807-91795896   c
            4797-5075           JAXUCZ010000001.1  91793645-91793923   c
            5076-5206           JAXUCZ010000001.1  91793423-91793553   c
            5207-5411           JAXUCZ010000001.1  91792217-91792421   c
            5412-5792           JAXUCZ010000001.1  91791020-91791400   c
            5793-6037           JAXUCZ010000001.1  91789504-91789748   c
            6038-6176           JAXUCZ010000001.1  91788449-91788587   c
            6177-6261           JAXUCZ010000001.1  91788265-91788349   c
            6262-6458           JAXUCZ010000001.1  91787439-91787635   c
            6459-7078           JAXUCZ010000001.1  91785973-91786592   c
            7079-7151           JAXUCZ010000001.1  91784452-91784524   c
            7152-7444           JAXUCZ010000001.1  91783613-91783905   c
            7445-7618           JAXUCZ010000001.1  91781866-91782039   c
            7619-7661           JAXUCZ010000001.1  91781677-91781719   c
            7662-8736           JAXUCZ010000001.1  91778380-91779454   c
FEATURES             Location/Qualifiers
     source          1..8736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..8736
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /note="spectrin, beta, non-erythrocytic 4"
                     /db_xref="GeneID:308458"
                     /db_xref="RGD:1304682"
     exon            1..119
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            120..306
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..7820
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /note="spectrin beta 4; spectrin beta chain, brain 3"
                     /codon_start=1
                     /product="spectrin beta chain, non-erythrocytic 4"
                     /protein_id="NP_001094315.2"
                     /db_xref="GeneID:308458"
                     /db_xref="RGD:1304682"
                     /translation="MAQVPGEVDNMEGPAASNNNNPAARWESPDRGWDREPPAAANAA
                     ASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYADLRDGFVLTRLLEV
                     LSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWT
                     IILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNA
                     LIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIIT
                     YVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLIS
                     NQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPR
                     EGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQ
                     RLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDARRVA
                     AQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSRECGQ
                     HLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVH
                     GCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAG
                     GAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGAEPLHLAGL
                     AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFG
                     HDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAE
                     QLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEV
                     VQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELV
                     EQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQAL
                     EPRQAALLEEAALLAERFPAQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQR
                     FLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIV
                     AASEALLASDGAELGPGLALDEWLPHLEVGWHKLLGLWEERREALVQAHVYQLFLRDL
                     CQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVAVQAAEGLL
                     RQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHELDGWIHEK
                     MLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR
                     KKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGG
                     DLATVNSQLKKLQSMESQVEEWCREVGELQAQTAALPLEQASKELVGERQSAVGERLV
                     RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMLTERGTGLQAVQQHIKK
                     NQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREATERRQ
                     QTLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN
                     YEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVSLEQQYWLY
                     QLSRQVDELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGTAGRERLAAVN
                     QMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAREL
                     QGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV
                     YAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDLLSWMDGIA
                     GQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTACQELGRSLLLNKSAMADEIQ
                     AQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGS
                     SVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGD
                     PTELAAKAAPLLRPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDR
                     LPETSGKVEPAAPTAAALDTTDTPGTPAVTEQVRPRPERQELADRAEELPRRRRSERQ
                     ESTDQPEEAARRRRPERQESADHEGPHSLTLGRYEQMERRRERRERRIERQESSEQET
                     PTRGELVKGKATLADIVEQLQEKEAGPGLPAAVPSLPQPRELPPGRLPNGLEPPERTP
                     RPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFL
                     LRKRELDANRKSSNRSWVNLYCVLSKGELGFYKDSKGPASGGTHGGEPLLSLHKATSE
                     VASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIARWGQTLPT
                     TSSTDEGNPKREGGERRASGRRK"
     exon            307..458
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            459..632
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..724
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..805
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            806..921
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1034
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1222
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1340
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1499
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1802
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1953
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2887
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3025
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3776
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3979
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4070
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4217
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..4481
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..4706
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4707..4796
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..5075
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5206
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5207..5411
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5412..5792
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            5793..6037
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            6038..6176
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            6177..6261
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            6262..6458
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            6459..7078
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            7079..7151
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            7152..7444
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            7445..7618
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            7619..7661
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            7662..8736
                     /gene="Sptbn4"
                     /gene_synonym="Spnb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgagcgg cgggccggcg gggccgaata gagccgggcc cggcccggcg acgaacgccc
       61 gcagggaggg cggtgctgcg cggcgagcat ccgggaccgc atcggcggcc ggcgcccagg
      121 ccctgccttc cccaatggca caagtaccag gggaagtgga caacatggag ggcccggcag
      181 cctccaacaa caacaaccct gcagcccgct gggagagccc agatcggggc tgggaccggg
      241 agcctccggc agccgccaac gctgccgctt cgctcttcga gtgttctagg atcaaggcct
      301 tagcagatga acgagaggct gtgcagaaga aaaccttcac caagtgggtg aattcgcacc
      361 tcgctcgcgt gggctgccac atcggagacc tgtatgcaga cctgagggat ggctttgtcc
      421 tcacccggct cctggaagtg ctgtcggggg agcagctgcc gagacccact cgcggccgca
      481 tgcggatcca ctcgctggag aacgtggaca aggctctgca gttcctgaag gagcagcgcg
      541 tgcacctgga gaacgtgggg tcacatgaca tcgtggatgg gaaccaccga ctgacgctgg
      601 ggctggtctg gaccatcatc ctgcgcttcc agattcaagt catcaagatt gagacagaag
      661 acaacagaga gacccgctcg gccaaggacg ctctgctctt gtggtgccag atgaagacag
      721 ctggttaccc tgaggtaaac atccagaatt tcactactag ctggagagat ggcctggcct
      781 tcaatgccct catccatcgc cacaggcctg atcttgtgga cctcagcaaa cttaccaagt
      841 ccaacgccaa ctacaacctg cagagagctt tccgcacagc cgagcagcac ctggggctag
      901 cacgtctgct ggaccccgaa gacgtgaaca tggaggctcc agatgagaag tccatcatca
      961 cctacgtggt ctccttctac cactacttct ccaagatgaa ggctctggct gtggagggaa
     1021 aacggattgg gaaggtcctg gaccaggtgt tggaggtgga caagatcata gagcgctacg
     1081 aggagctggc ggcggagctg ctggcctgga tccaccgcac cgtggacctc atcagcaacc
     1141 aaaagtttgc caactcactg agtggggtgc agcagcagct gcaggctttc actgcctact
     1201 gtaccctgga gaagccggtc aagtttcagg agaaggggaa cctggaggtg ctactcttca
     1261 gcatccaaag caaactgcgc gcccacaacc ggcgcctctt tgtgcctcgg gaaggctgtg
     1321 gcatctggga tattgacaag gcatggggtg agctggagaa ggcagagcat gagcgagagg
     1381 cagccctcag agctgagctc atccgacagg agaagttgga actcttggct caaagatttg
     1441 accacaaggt ggccatgagg gagagctggc taaatgagaa ccagcgcctg gtctctcagg
     1501 acaacttcgg atatgagctg ccggcagtgg aggcagccat gaagaagcac gaagccatcg
     1561 aggctgacat cgcggcctac gaggagcggg ttcagggtgt ggcggagcta gcccaggcat
     1621 tggcagctga aggctactat gatgcccggc gagtggcagc ccagcgtgac agcgtcctcc
     1681 gccagtgggc cctgctgact gggctggtag gtgcccggcg gacccggctt gagcagaatc
     1741 tggccctgca gaaggtcttc caggagatgg tctacatggt ggactggatg gaggaaatgc
     1801 agactcagct gctgtctcgg gaatgtgggc agcacctggt ggaggctgat gacctgctgc
     1861 agaagcatgg gctactggag ggcgacatcg cagcccagag cgagcgggtg gaggccctca
     1921 atgctgcagc cctgagattc tcccagttgc agggctacca accctgcgac cctcaggtca
     1981 tttgcaaccg tgtgaaccac gtgcacggtt gtctgtcgga gctgcaggag caggcggcgc
     2041 ggcggcgcgc ggagctggaa gcctctcgga gcctgtgggc gctgctgcag gagctggagg
     2101 aggcggagag ctgggcacgg gacaaggagc gcctcctaga ggccacgagc ggcagtggtg
     2161 gcgcggcggg cacggcggga ggcgcgcacg acctgtccag caccgctcgc ctgctggcgc
     2221 agcacaagat cttgcagggc gaactgggcg gccggcgggc gctactgcag caggcgctgc
     2281 gacgtggaga ggagctggct gcggcgggcg gctccgtggg ccccggcgcc gagcccttgc
     2341 acttggctgg tctggcggag cgcgcggcta gcgctcggcg ccgctggcag cgactggaag
     2401 aggcggctgc gcgccgggaa cggaggctgc aggaggcacg ggcgttgcac cagtttggcg
     2461 ccgacctgga cgggctcctg gactggcttc gcgacgcgta tcgtctggca gccgccggag
     2521 atttcggtca cgacgaagcg tccagccgtc gcctggcgcg ccagcaccga gctctcaccg
     2581 gggaggtgga agcgcaccgt ggccctgtgg gtggcctgag gcgtcagctg gcaacactgg
     2641 gaggagccag tggcgccggg ccgctggtgg tggcgctgca ggtgcgcgtg gtggaagcag
     2701 aacagttgtt cgcggaggtg accgaggtgg ccgcgctgag acgacagtgg cttcgggacg
     2761 cgctcgcggt gtaccgcatg tttggagagg tgcatgcctg cgagttgtgg atcggagaga
     2821 aagagcagtg gctgctggcc atgcgtgtgc ccgactccct cgacgacgtt gaggtggtgc
     2881 agcaccgatt tgaaagtctg gaccaggaaa tgaacagcct aatgggccga gtcttggatg
     2941 tgaaccaaac agttcaggag ttggtggaag gaggtcaccc cagctccgat gaggtgcgct
     3001 cctgtcagga ccatctcaac agcaggtgga accgcatcgt ggagctggta gaacagcgca
     3061 aagaggagat gagcgccgtg ctgctggtgg agaaccatgt actggaggtg gccgaggtgc
     3121 gcgcccaggt gcgagagaag cggagggcgg tggagagcgc gccccgggcg ggcggagccc
     3181 tgcagtggcg cctgagtggc ctggaggcgg ccctacaggc tctggagccg cgacaggccg
     3241 cacttctgga ggaggcggcg ttgttggcgg aacgcttccc ggcacaggcg acgcgcctgc
     3301 accagggcgc cgaggagctg ggagcggagt ggggtgcact ggctggagcg gctcaggctt
     3361 gcggagaggc ggtggcggcg gcaggtcgcc tgcaacgttt cctgcgcgat ttggatactt
     3421 tcctggactg gctggtgcgt gcgcaggagg cagcgggcgc cgtcgagggg cctctgccgc
     3481 gtagcctgga ggaggcggac gggctgctgg cgcgccatgc cgcactcaag gaggaggtgg
     3541 atcagcgcga ggaggactac gcgcgcatcg tagctgccag tgaggcgttg ctggcgtccg
     3601 acggtgccga gctgggcccc ggtctggcgc tagacgaatg gctgccgcat ctcgaggttg
     3661 gctggcacaa actgctcggc ttgtgggagg agcgcaggga ggctctggtc caggcgcacg
     3721 tctatcagct cttcctgaga gacctgtgcc aggcgctcgc ggtgctgcgc aaccaggagg
     3781 tggcgctgtc tggcgctgaa ctcccttgca cagtggagtc ggtagaggag gccatgaaaa
     3841 ggcaccggga tttcctcacc acgatggagc tgaaccagca aaagatgcag gtggcggttc
     3901 aagctgcaga gggcctgctg cggcaaggca acgcctacgg ggagcaggcg caggaggcag
     3961 tggcccggct gctagagaag agccaagaaa atcagctgag ggcccagcag tggatgcaaa
     4021 aactcctgga ccagcttgtg ctgcagcact ttcttagaga ttgtcatgag ctggatggct
     4081 ggatccacga gaaaatgctg atggctcgtg atggcacccg agaagacagc cacaagctgc
     4141 acaagagatg gctccggcac caggcgttca tggctgagct ggctcagaat aaggagtggc
     4201 tggagaagat agaaagggag ggccagcaac tgatgcagga gaaaccggag ctggcagctt
     4261 ctgtgcgcaa gaaattaggt gagatccggc agtgctgggc agagctggag agcaccacac
     4321 aggccaaggc gcgccagctc ttcgaggcca gcaaggcgga ccagctggtg cagagcttcg
     4381 cagagctgga caagaggctg ctccacatgg aaagccagtt gcaggacgta gaccccggtg
     4441 gagacctggc caccgtcaac agccagctca agaagttaca gtctatggag tctcaggtgg
     4501 aggagtggtg tcgagaggtg ggcgagctgc aggcgcagac agcggcgctt ccactggagc
     4561 aggcgagcaa ggagttggtg ggcgagcggc agagcgcggt gggagagcgc ctggtgcgcc
     4621 tgctggagcc tttgcaggag cgtcgccgct tgctgctggc atccaaggag ctgcatcagg
     4681 tggcacacga cctggatgac gaactggcgt gggttcaaga gcggctgccg ctggccatgc
     4741 tgacagagcg aggcactggc ttgcaggctg tccagcagca catcaaaaag aaccagggcc
     4801 tgaggcggga gatccaggct cacgggccgc gcttggagga ggtgctggag cgcgcgggcg
     4861 tgctggcctc gttgcgcagc ccggaggctg aggcggtgcg ccgcggccag gagcagctgc
     4921 agagcgcctg gaccggactg cgggaagcca ctgaacggcg gcagcagacg ctggacgccg
     4981 ccttccaggt ggaacagtac tactttgacg tggctgaggt ggaggcatgg ctgggcgagc
     5041 aggagctgct catgatgagt gaggacaagg gcaaggatga acaaagcact ctgcagctgc
     5101 tcaagaagca tctgcaactg gagcagggag tggagaacta tgaagaaagc attgcccagc
     5161 tgtcacgcca gtgccgggcg ctactggaaa tgggacaccc agacagtgag cagatcagcc
     5221 gtcgacagtc ccaggtggat cgcctctatg tggcgctcaa ggagctgggt gaagagcgca
     5281 gggtgagcct ggaacagcag tactggctat accagctcag ccgccaggtg gacgagctgg
     5341 aacactggat agccgagaag gaggtggtag ctggttcacc agagctgggc caggactttg
     5401 aacatgtgtc ggtgctacag gagaaattct cagagttcgc cagtgagaca ggaaccgcag
     5461 ggcgggagcg gctggcagca gtaaaccaga tggtggacga gctgattgag tgtggccaca
     5521 cagcagcggc caccatggct gagtggaagg acgggctgaa cgaggcctgg gctgaactgc
     5581 tggagctcat gggcactcgg gcccagctgc ttgctgcctc tcgggagctg cataagttct
     5641 tcagtgatgc ccgagagctt caagggcaga tcgaggagaa gcggaggagg ctgccccgcc
     5701 tgacggcacc acctgagccc agacccagcg ctagctccat gcagcggacc ctgcgagcct
     5761 ttgagcacga cctgcagctc ctcgtgtcgc aggtgcggca gctgcaggaa ggggcggccc
     5821 agttgcggac tgtgtacgcg ggcgagcacg cagaggccat cgccagccgt gagcaggagg
     5881 tgttgcaggg ctggaaggag ctgctggcag cctgtgagga tgctcgtctg cacgtcagct
     5941 ccacggctga cgccctgcgc ttccacagcc aggcccgaga cttgctctcc tggatggacg
     6001 gcatcgcggg ccagatcggg gcagctgaca aacccaggga tgtatcatcc gtggaggtgc
     6061 ttatgaacta ccaccagggc ctgaagacag aattggaggc tcgtgtgcct gagctgacag
     6121 cctgccagga gctggggcgt tctctattac tcaacaaaag tgccatggct gatgagatcc
     6181 aggcacagtt ggacaagctg ggaagccgga aggaggaggt gtcggagaag tgggaccggc
     6241 actgggagtg gctgcaacag atgctggagg tacaccagtt tgctcaggag gccgtggtgg
     6301 ctgacgcctg gctgacagct caggagccgc tcctgcagag ccgggagctg ggcagcagtg
     6361 tggatgaggt ggagcagctt atccggcgac acgaggcctt ccgaaaagcg gctgcggcgt
     6421 gggaggagag gttcagctct ctgcggcgct tgaccacgat cgagaaactc aaggcagaac
     6481 agagtaagca gccacccacc ccattgctgg ggcgcaagtt ctttggggac cccacagagc
     6541 tggcggccaa ggcagcaccc ttgctgcgtc cagggggcta tgacaggggc ctggagcctt
     6601 tggcccgcag ggcctcggac acgctgtcag cggaggtgcg gacccgggtt ggttatgtgc
     6661 gccaggagct caagcccgag cgtctccagc cgcgcattga ccggctgccg gagacctcgg
     6721 ggaaggtaga acccgcggcc ccaacagccg cagcgttgga cacgacggac acccctggaa
     6781 ctccggcggt gacggagcag gtccggcccc ggccggagcg ccaggagtta gcggatcgtg
     6841 cggaggagct gccacggaga cgaagatcag aacgccagga gtccacggat caacccgagg
     6901 aggcagcgcg gaggcggcgg cctgagcgcc aggagtccgc ggaccacgag gggcctcaca
     6961 gccttactct gggtcgctat gagcaaatgg agaggcggag ggagcggcgg gagcggcgga
     7021 tagaacgaca ggagtctagc gagcaggaga ctcccaccag aggagagctg gtcaaaggga
     7081 aggccaccct ggctgacatc gtggagcagc ttcaggagaa agaggcaggc ccagggctcc
     7141 ctgctgcggt gccgtcgctg cctcagcctc gggagcttcc ccctggtcgc ctgcccaacg
     7201 ggcttgagcc gcccgagcgg acacctcggc ccgatcggcc gcgggcacgg gaccggccca
     7261 agccccgccg gcggccacgg cctcgagagg gtggtgaggg cgggggaagc cggcgctcgc
     7321 gctccgcccc tgctcaggga ggctccgccc ccgcgcctcc acctccgccc actcacacag
     7381 tgcagcacga gggcttcctg ctgcgcaagc gcgagctcga cgctaaccgc aagtcgtcca
     7441 accggtcgtg ggtgaacctg tactgtgtgc tcagcaaggg ggagctgggc ttctacaagg
     7501 actccaaagg cccagcatca gggggcacgc atggcgggga gccactgctc agcctgcaca
     7561 aagccaccag cgaggtggct agtgactaca agaaaaagaa gcatgtcttc aagctccaaa
     7621 cccaggatgg cagcgagttc ttgctccagg ctaaagatga ggaggagatg aacggctggc
     7681 tggaggctgt ggctaactcc gtggcagaac acgccgagat cgcccgatgg ggccagacac
     7741 tacctaccac atcatccaca gacgagggca accccaagcg tgagggcggg gagcgtaggg
     7801 ccagcgggcg ccggaagtga tcccaggtac ccttccccct ccccccttgg agtctgacaa
     7861 gtctccttgc ccctcctgtc tgcactgtgg acacaaagac accttctcat ccgcaagggc
     7921 aggaagatgg ctgcggatgt gccacggtgg gcctgaaata gaagggactt ctgcactcca
     7981 agaagtggtg gtaggggatt gctgtcccta ttagccatat ctcggtccct tcctgctcgt
     8041 caaccccacc ccaggtgctg gggctccatt ctttttatgc aataactgag cttgatgggg
     8101 acgggcaggg agccagttga gccaagcccc ctgcctaatc gtcagatcct gccccaagaa
     8161 actggagtgg cgagggatct aggaggtggt gatttgttgg cctcctctcc gccctaagga
     8221 tggacaacgg gggcgctggt gaggtcccct ggaccatcca gggtgctagg gggtggggag
     8281 gggacacact ccctccctgc ctttacctca cttccaatgc tgccttgatc tgtctgggaa
     8341 gagggaggaa aggggccctt agcccctgta ctccgccatc tcagagccat gcggttaatt
     8401 cttgacttag tttatttttg caaaaaccta gacctccctc tcctttcccc cgccccgcat
     8461 ccgcgaaggc ttttaatagg aggggagtca aagttcaaaa ctgtcttcct ctcccctccc
     8521 cgattccagc tgtaaatgcc acttcccgag gggagggggg tggggaagcc ctccccctgc
     8581 atgcttctgg ctggagcacc tccctgggag tcgggagatc agggttacag gcaacctcag
     8641 tggctgcttg gagacgccgc cagggcctgg ggtgcggggc ggtgtggcag gcgcacactg
     8701 tatgtaccta taataaaccc ttttggcttt gatggt
//
