LOCUS       NM_001410274            8418 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus spectrin, beta, non-erythrocytic 1 (Sptbn1),
            mRNA.
ACCESSION   NM_001410274
VERSION     NM_001410274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8418)
  AUTHORS   Sidenstein,S.C., D'Este,E., Bohm,M.J., Danzl,J.G., Belov,V.N. and
            Hell,S.W.
  TITLE     Multicolour Multilevel STED nanoscopy of Actin/Spectrin
            Organization at Synapses
  JOURNAL   Sci Rep 6, 26725 (2016)
   PUBMED   27220554
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8418)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8418)
  AUTHORS   Forster,F., Paster,W., Supper,V., Schatzlmaier,P., Sunzenauer,S.,
            Ostler,N., Saliba,A., Eckerstorfer,P., Britzen-Laurent,N.,
            Schutz,G., Schmid,J.A., Zlabinger,G.J., Naschberger,E., Sturzl,M.
            and Stockinger,H.
  TITLE     Guanylate binding protein 1-mediated interaction of T cell antigen
            receptor signaling with the cytoskeleton
  JOURNAL   J Immunol 192 (2), 771-781 (2014)
   PUBMED   24337748
REFERENCE   4  (bases 1 to 8418)
  AUTHORS   Xu,K., Zhong,G. and Zhuang,X.
  TITLE     Actin, spectrin, and associated proteins form a periodic
            cytoskeletal structure in axons
  JOURNAL   Science 339 (6118), 452-456 (2013)
   PUBMED   23239625
  REMARK    GeneRIF: study of the organization of actin, spectrin and
            associated proteins in neurons; spectrin exhibited periodic
            structures alternating with those of actin and adducin; the
            distance between adjacent actin-adducin rings was comparable to the
            length of a spectrin tetramer
REFERENCE   5  (bases 1 to 8418)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 8418)
  AUTHORS   Mohler,P.J., Yoon,W. and Bennett,V.
  TITLE     Ankyrin-B targets beta2-spectrin to an intracellular compartment in
            neonatal cardiomyocytes
  JOURNAL   J Biol Chem 279 (38), 40185-40193 (2004)
   PUBMED   15262991
REFERENCE   7  (bases 1 to 8418)
  AUTHORS   Tang,Y., Katuri,V., Dillner,A., Mishra,B., Deng,C.X. and Mishra,L.
  TITLE     Disruption of transforming growth factor-beta signaling in ELF
            beta-spectrin-deficient mice
  JOURNAL   Science 299 (5606), 574-577 (2003)
   PUBMED   12543979
REFERENCE   8  (bases 1 to 8418)
  AUTHORS   Hayes,N.V., Scott,C., Heerkens,E., Ohanian,V., Maggs,A.M.,
            Pinder,J.C., Kordeli,E. and Baines,A.J.
  TITLE     Identification of a novel C-terminal variant of beta II spectrin:
            two isoforms of beta II spectrin have distinct intracellular
            locations and activities
  JOURNAL   J Cell Sci 113 (Pt 11), 2023-2034 (2000)
   PUBMED   10806113
REFERENCE   9  (bases 1 to 8418)
  AUTHORS   Page,L.J., Sowerby,P.J., Lui,W.W. and Robinson,M.S.
  TITLE     Gamma-synergin: an EH domain-containing protein that interacts with
            gamma-adaptin
  JOURNAL   J Cell Biol 146 (5), 993-1004 (1999)
   PUBMED   10477754
REFERENCE   10 (bases 1 to 8418)
  AUTHORS   Scoles,D.R., Huynh,D.P., Morcos,P.A., Coulsell,E.R., Robinson,N.G.,
            Tamanoi,F. and Pulst,S.M.
  TITLE     Neurofibromatosis 2 tumour suppressor schwannomin interacts with
            betaII-spectrin
  JOURNAL   Nat Genet 18 (4), 354-359 (1998)
   PUBMED   9537418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1 and AY238344.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.47759.1,
                                           SRR26643287.31028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000014.1  108217656-108217836 c
            182-373             JAXUCZ010000014.1  108173144-108173335 c
            374-525             JAXUCZ010000014.1  108106998-108107149 c
            526-699             JAXUCZ010000014.1  108099836-108100009 c
            700-791             JAXUCZ010000014.1  108097214-108097305 c
            792-872             JAXUCZ010000014.1  108094926-108095006 c
            873-988             JAXUCZ010000014.1  108094529-108094644 c
            989-1101            JAXUCZ010000014.1  108091571-108091683 c
            1102-1289           JAXUCZ010000014.1  108090739-108090926 c
            1290-1407           JAXUCZ010000014.1  108089012-108089129 c
            1408-1566           JAXUCZ010000014.1  108087832-108087990 c
            1567-1869           JAXUCZ010000014.1  108086901-108087203 c
            1870-2023           JAXUCZ010000014.1  108085278-108085431 c
            2024-2894           AY238344.1         1924-2794
            2895-3032           JAXUCZ010000014.1  108083566-108083703 c
            3033-3789           JAXUCZ010000014.1  108082084-108082840 c
            3790-3992           JAXUCZ010000014.1  108080994-108081196 c
            3993-4083           JAXUCZ010000014.1  108075248-108075338 c
            4084-4230           JAXUCZ010000014.1  108067932-108068078 c
            4231-4494           JAXUCZ010000014.1  108066752-108067015 c
            4495-4719           JAXUCZ010000014.1  108064496-108064720 c
            4720-4809           JAXUCZ010000014.1  108064039-108064128 c
            4810-5091           JAXUCZ010000014.1  108063593-108063874 c
            5092-5222           JAXUCZ010000014.1  108062741-108062871 c
            5223-5427           JAXUCZ010000014.1  108061296-108061500 c
            5428-5802           JAXUCZ010000014.1  108060631-108061005 c
            5803-6047           JAXUCZ010000014.1  108057583-108057827 c
            6048-6186           JAXUCZ010000014.1  108056655-108056793 c
            6187-6271           JAXUCZ010000014.1  108055665-108055749 c
            6272-6468           JAXUCZ010000014.1  108053658-108053854 c
            6469-6578           JAXUCZ010000014.1  108052843-108052952 c
            6579-6642           JAXUCZ010000014.1  108052234-108052297 c
            6643-6881           JAXUCZ010000014.1  108047648-108047886 c
            6882-7055           JAXUCZ010000014.1  108046516-108046689 c
            7056-7098           JAXUCZ010000014.1  108044798-108044840 c
            7099-8418           JAXUCZ010000014.1  108042629-108043948 c
FEATURES             Location/Qualifiers
     source          1..8418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..8418
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /note="spectrin, beta, non-erythrocytic 1"
                     /db_xref="GeneID:305614"
                     /db_xref="RGD:727922"
     exon            1..181
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..373
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..7317
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /note="bSPII-; cytoskeleton protein; non-erythroid
                     spectrin beta; beta II spectrin-like (short form);
                     spectrin beta chain, brain 1; short form of beta II
                     spectrin; spectrin beta 2"
                     /codon_start=1
                     /product="spectrin beta chain, non-erythrocytic 1"
                     /protein_id="NP_001397203.1"
                     /db_xref="GeneID:305614"
                     /db_xref="RGD:727922"
                     /translation="MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSR
                     IKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPK
                     PTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ
                     DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPD
                     LIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHY
                     FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSL
                     VGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDI
                     NKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF
                     GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAESYHDIKRITARKDNVIR
                     LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYGKHLLGVEDL
                     LQKHALVEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELC
                     QLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA
                     FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERISYIREQWANLEQLSAIRKKRL
                     EEASLLHQFQADADDIDAWMLDILKIVSSNDVGHDEYSTQSLVKKHKDVAEEISNYRP
                     TIDTLHEQAGALPQAHAESPDVKGRLAGIEERYKEVAELTRLRKQALQDTLALYKMFS
                     EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ
                     LMHSGHPSEKEIRAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIR
                     EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQA
                     QAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE
                     DMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA
                     LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGA
                     EAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE
                     AASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM
                     AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD
                     ANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEI
                     EELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV
                     EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNII
                     TDSSSLNAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHKAQQYYFDAAEAEAWMSE
                     QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESER
                     ISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHEL
                     GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHMADDLINSGHSDAATIAEWKDGLN
                     EAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETL
                     QRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDAC
                     EGRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA
                     EIDARNDSFTACIELGKALLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLI
                     LEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS
                     ALERLTTLELLEVRRQQEEEERKRRPPSPEPSAKVSEEAESQQWDTSKGDQVSQNGLP
                     AEQGSPRMAGTMETSEMVNGAAEQRTSSKESSPVPSPTSDRKAKSALPAQSAATLPAR
                     TLETPAAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKSAASGVPY
                     HSEVPVSLKEAICEVALDYKKKKHVFKLRLSDGNEYLFQAKDDDEMNTWIQAITSAIS
                     SDKHDTSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK"
     exon            374..525
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..699
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..791
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..872
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..988
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1101
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1289
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1407
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1566
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1869
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2023
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2894
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3032
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3789
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..3992
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4083
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4230
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4494
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4719
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4809
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..5091
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            5092..5222
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            5223..5427
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..5802
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            5803..6047
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6048..6186
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6187..6271
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6272..6468
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6469..6578
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6579..6642
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6643..6881
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            6882..7055
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            7056..7098
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            7099..8418
                     /gene="Sptbn1"
                     /gene_synonym="Spnb1; Spnb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcctc tccgcccgga gcgagcgcgc agccccgcgc agcagcgccc accggtcccg
       61 tcctgtgagc cccggcccca gccgccgcca gccccgcgga gtcgcctccc cggcccaccc
      121 gcccggccgc cgaggagcgg gaggaggacg ggaccccggc gcccccaccc cacccccgga
      181 gaactcagaa gtaactgatg tggacaagca gctgagacag ccaagatgac gaccacggtg
      241 gccacagact atgacaacat tgagatccag cagcagtaca gcgatgtgaa caaccgctgg
      301 gacgtggatg actgggacaa tgagaacagc tctgcacggc tctttgagcg ctcccgcatc
      361 aaggccctgg cagatgagcg tgaagctgta cagaagaaga ccttcaccaa gtgggtcaac
      421 tcccaccttg cccgagtgtc ctgccgaatc acagacctgt acactgacct tcgagatgga
      481 cggatgctca tcaaactact ggaggtcctc tctggagaga ggctgcctaa acccactaag
      541 ggacggatgc gcatccactg tctggagaat gtcgacaagg ctcttcagtt cctgaaggag
      601 cagagagtcc atctcgagaa catgggctcc catgatattg tggatggaaa ccaccggctg
      661 accctcggcc tcatctggac cattatcctg cgcttccaga tccaggatat cagtgtggag
      721 actgaagata acaaagagaa aaagtctgct aaggatgcat tgctgctgtg gtgccagatg
      781 aagacagctg ggtaccctaa tgtcaacatt cacaatttca ccactagctg gagggatggc
      841 atggccttca atgcactgat acacaaacac cggcctgacc tgatagattt tgataaactg
      901 aagaaatcga atgcacacta caatctgcag aatgcattta acctggcaga gcagcacctt
      961 ggccttacta aactgttaga ccctgaagat atcagcgtgg accaccctga tgagaagtcc
     1021 atcatcacgt atgtggtcac ttactaccac tacttctcca agatgaaggc cttggctgtc
     1081 gaaggaaagc gcattgggaa ggtgcttgat aatgctatag aaacagagaa aatgattgag
     1141 aagtatgagt cgcttgcttc tgaccttctg gagtggattg aacaaaccat catcattcta
     1201 aacaaccgca aatttgctaa ttcactggtt ggggtccagc agcagcttca ggcattcaac
     1261 acgtaccgca cagtggagaa accacctaag tttactgaga aggggaattt ggaggtgctg
     1321 cttttcacaa ttcagagcaa gatgagagct aataatcaga aggtctacat gccccgagaa
     1381 gggaagctca tctctgatat caacaaggcc tgggaaagac tggaaaaagc agaacatgag
     1441 agagaactgg ctctgcggaa tgagctcata cggcaggaaa aactggaaca acttgcccgc
     1501 agattcgatc gcaaggcagc tatgagagag acatggctga gcgaaaacca gcgtcttgtc
     1561 tctcaggaca actttggatt tgaccttcct gcagttgagg ccgccaccaa aaaacatgag
     1621 gccatcgaga ctgacattgc ggcgtatgaa gagcgagtgc aggctgtggt ggctgtggcc
     1681 agggagcttg aagcagagag ctatcatgac atcaagcgca tcacagcgag gaaggacaat
     1741 gtcatccgcc tctgggagta cttgctggaa ctgctcaggg ccaggaggca gcgtcttgag
     1801 atgaacctgg gactgcaaaa gatattccag gaaatgcttt atattatgga ctggatggat
     1861 gaaatgaagg tgctattgct gtctcaggac tatggcaaac acttgctcgg tgttgaagac
     1921 ttgttacaga agcatgccct ggttgaagca gacattgcaa tccaagcaga acgtgtgaga
     1981 ggtgtgaatg cctctgccca gaagttcgca acagatgggg aaggctacaa gccatgcgac
     2041 ccccaggtaa tccgagaccg tgtggcccac atggaattct gctatcaaga actctgtcag
     2101 ctggcagctg agcgtagggc tcgcctggaa gagtctcgtc gcctctggaa gttcttctgg
     2161 gagatggcgg aggaggaagg ctggatacgg gagaaggaga agatcctgtc ctctgatgac
     2221 tatgggaaag acctgactag tgtcatgcgc ctgctgagca agcacagggc ttttgaggat
     2281 gagatgagtg gccgtagtgg ccattttgag caggccatta aagaaggtga agacatgatt
     2341 gcagaggaac actttggatc agaaaagatc cgtgagagaa tcagttacat tcgagagcag
     2401 tgggccaacc tggagcagct ctcagccatt aggaagaagc gcctagagga ggcctcattg
     2461 ctgcaccagt tccaggctga tgctgatgac atcgacgctt ggatgttaga tatactcaag
     2521 attgtgtcca gcaacgatgt gggccatgat gagtattcca cacagtctct ggtcaagaag
     2581 cataaagatg tggcagaaga gatctccaac tacagaccca ctattgacac actgcatgag
     2641 caagccggtg ctcttcctca agcacacgca gagtctccag atgtgaaggg ccggctggca
     2701 ggaattgagg agcgttacaa ggaggtggca gagttaacac ggctaaggaa gcaggcactg
     2761 caggacaccc tggctctgta caagatgttc agtgaggctg atgcctgtga gctctggatc
     2821 gacgagaagg agcagtggct caacaacatg cagatcccag agaagctgga ggacctggaa
     2881 gtcatccagc acagatttga gagcctagaa ccagaaatga acaaccaggc ttcccgggtt
     2941 gctgtggtga accagattgc acggcagctg atgcacagtg gccatcccag cgaaaaggaa
     3001 atcagagctc agcaggacaa actcaacacg aggtggagtc agttcagaga actggtggac
     3061 aggaagaagg atgctcttct gtccgccctg agcatccaga actaccacct cgagtgcaat
     3121 gaaaccaaat cctggatccg ggagaagacc aaggtcatcg agtctaccca agaccttggc
     3181 aatgacctgg caggtgtcat ggccctgcag cgcaagctga ccggcatgga acgagacttg
     3241 gtagccatcg aggcgaagct gagtgacctg cagaaggaag ccgagaagct tgagtccgag
     3301 caccctgacc aggctcaagc catcctgtct cgactggctg agatcagtga cgtgtgggag
     3361 gagatgaaga caaccctgaa gaaccgagaa gcctcgctgg gagaggccag caagctgcag
     3421 cagttcctgc gggacttgga tgacttccag tcttggctct ccaggaccca gactgctatt
     3481 gcctcagagg acatgcccaa taccctgact gaggcagaga agcttctcac acagcatgag
     3541 aacatcaaaa acgagattga caattacgag gaagactacc agaagatgcg ggacatgggc
     3601 gagatggtca cgcagggaca gactgatgcc cagtacatgt ttctgcggca gcggttgcag
     3661 gccttggaca caggctggaa cgagctccac aaaatgtggg agaacaggca aaatctcctc
     3721 tcccagtccc atgcctacca gcagttcctt agggacacga aacaggctga agctttcctt
     3781 aataaccagg agtatgtttt ggctcatact gaaatgccca ccaccctgga aggagctgaa
     3841 gcagccatta agaagcagga ggacttcatg accaccatgg atgccaatga ggagaagatc
     3901 aatgctgttg tggagactgg ccggaggctg gtgagcgatg ggaatatcaa ctccgaccgc
     3961 atccaggaga aggtggactc tattgatgac aggcacagaa agaatcgaga agcagccagt
     4021 gaacttttga tgaggttaaa ggacaaccgt gatctacaga agttcctgca agattgtcaa
     4081 gagctgtccc tctggatcaa tgaaaagatg cttacagctc aggacatgtc ttatgatgaa
     4141 gccagaaacc tgcacagtaa atggttaaag catcaagcat ttatggcaga acttgcatcc
     4201 aacaaagaat ggcttgacaa aattgagaag gaaggaatgc agcttatttc agaaaagcca
     4261 gaaacagagg ctgtggtgaa ggagaaactc actggtttac ataaaatgtg ggaagtcctt
     4321 gaatccacaa cccagaccaa ggcccagagg ctcttcgatg cgaacaaggc tgagctcttc
     4381 acgcagagct gtgcagacct cgacaaatgg ctgcatggcc tggagagcca gattcaatct
     4441 gacgactatg gcaaagacct caccagtgtc aacattctgc tgaaaaagca acagatgctg
     4501 gagaatcaga tggaagtgag gaagaaggag atcgaggaac tgcaaagcca agcccaggca
     4561 ctgagtcagg aggggaagag cacagatgag gtggacagca aacgcctcac tgtgcagacc
     4621 aagttcatgg agcttctgga gcccttgaat gaaaggaagc ataatctgct ggcttccaag
     4681 gagatccacc agttcaacag ggatgtagag gacgagattc tgtgggttgg cgagaggatg
     4741 cctttggcaa cttccacaga tcatggccac aaccttcaaa ctgtgcagct gttaataaag
     4801 aaaaaccaga ccctccagaa agaaatccag ggacaccagc ctcgtattga tgacatcttt
     4861 gagaggagcc aaaacatcat cacagatagc agcagcctca atgccgaggc tatcagacag
     4921 aggctcgccg atctgaagca gctgtggggg ctcctcattg aggaaactga gaaacgccat
     4981 agacggctcg aggaggcaca caaggcccag caatactact ttgatgcagc tgaagcagag
     5041 gcatggatga gtgaacagga actgtacatg atgtctgagg aaaaggccaa ggatgagcag
     5101 agtgctgtct ccatgttgaa aaagcaccag attttggaac aggctgttga ggactatgca
     5161 gagacagtgc accagctctc caagaccagc cgggcactgg tggctgacag ccatcccgaa
     5221 agtgagcgta ttagcatgcg gcagtcaaag gtcgacaagc tgtatgctgg cctgaaggac
     5281 cttgctgagg agaggagagg gaaacttgat gagaggcaca ggctattcca gctcaacagg
     5341 gaggtagatg acctggaaca gtggatcgcc gagagggaag tggttgcagg ctcccatgag
     5401 ttgggacagg actatgagca tgtcacgatg ttacaagaac ggttccgaga atttgctcga
     5461 gacacaggaa acattgggca ggagcgtgta gatacagtta accacatggc agatgacctc
     5521 atcaattctg gacattcaga tgctgcgact attgctgagt ggaaagatgg tctcaatgaa
     5581 gcctgggctg acctcctgga gctcattgac acgagaacac agattcttgc tgcctcttac
     5641 gaacttcata agttttacca tgatgccaag gagatctttg gccgcatcca ggacaaacac
     5701 aagaaactcc ctgaggagct tggaagagat cagaacaccg tggagacttt acagagaatg
     5761 cacaccacct ttgaacatga catccaagct ctgggcactc aggtgaggca gctgcaggag
     5821 gatgcagccc gcctccaagc agcctatgca ggggacaagg ctgacgacat ccaaaagcgt
     5881 gagaacgagg tcctggaagc ctggaagtcc ctgctggatg cttgtgaggg tcgcagggtg
     5941 cggctagtag acacgggaga caagttccgc ttcttcagca tggtgcgtga cctcatgctc
     6001 tggatggaag atgtcatccg gcaaatcgag gcccaggaga aaccccggga tgtgtcatct
     6061 gttgaactgt taatgaataa tcatcaaggc atcaaagctg aaatcgatgc tcgtaatgac
     6121 agttttacag cttgcattga acttgggaaa gccctgctgg caaggaaaca ctatgcttct
     6181 gaggagatca aggaaaagtt actgcagttg acggagaaaa gaaaagaaat gatcgacaag
     6241 tgggaagacc gatgggagtg gttaagactg attttggagg tccatcagtt ctcaagagat
     6301 gccagtgtgg ctgaggcttg gctgctggga caggagccat acctatccag ccgcgaaatc
     6361 ggccagagtg tggatgaagt ggagaagctt attaagcgcc atgaggcatt tgaaaaatct
     6421 gcagcgacct gggatgagag attctctgcc ctggaaaggt tgacaacatt ggagctactg
     6481 gaagtgcgca gacagcaaga ggaagaagaa agaaagaggc gaccaccgtc tccggagcca
     6541 agcgcgaagg tttcagagga ggctgagtcc cagcaatggg acacttcaaa aggagaccaa
     6601 gtttcccaga atggtttgcc ggctgagcag ggatctccac ggatggcagg aaccatggaa
     6661 acaagtgaaa tggtcaacgg tgctgctgag cagaggacaa gctccaaaga atccagtcct
     6721 gttccttctc ccacctcgga ccgcaaggcc aaatctgcac ttccagccca gagtgctgcc
     6781 accctgccag ccaggaccct ggagacgcct gcggcccaga tggaaggctt cctcaatcgg
     6841 aagcacgagt gggaggccca caataagaaa gcctcaagca ggtcctggca caatgtttat
     6901 tgtgtcataa ataaccaaga aatgggcttc tacaaagatg ccaagagtgc tgcttctggc
     6961 gtcccctacc acagtgaggt ccctgtgagt ttgaaagagg ccatctgcga agtggccctt
     7021 gattacaaga agaagaagca tgtgttcaag ctaagactaa gtgatggcaa cgagtacctc
     7081 ttccaagcca aagatgatga tgaaatgaac acatggatcc aggctatcac ctctgccatc
     7141 tcctctgaca agcacgacac gtctgccagc acccagagta cgccagcatc cagccgagcg
     7201 cagaccttac ccaccagcgt cgtcaccatc accagcgagt ccagtcctgg caagagggag
     7261 aaggacaaag agaaagacaa agagaagcgg ttcagccttt tcggcaagaa gaagtgaact
     7321 tccctgttgt ccttcccttc tcttaccttt agtaagagtc cagcatgcaa gctcagacca
     7381 acacattact ctgtgcctaa tgttcctcca tgtagttgat tttctttctt tttttttttt
     7441 taataaattt tttaatttat agagtatttc tgagggttgg gggaaacata actaaacact
     7501 ttatctccaa gttaaaaaag tttgaggtac agagggaagg ccagattttt taatgaaatt
     7561 atatagatta gatctcagta tttaaactgt tcctcaattt tgtgaggctg tgttggaaat
     7621 aacccgcctc tgatgctgtt ggtatgcaag gcagcggtgc ttacacaata tttcctgtgc
     7681 tctccagaga cgatggactg atttcctgac actactctcc cttcacttcc gtggttaccc
     7741 tgagtcttga cttacaagtg cccacgatgg gtgtagcctt tattaaacag atcgtgtatt
     7801 ctgatctctc gctgcagcca cagtgcagct ccctataaac ctgcagccca aaccatttgt
     7861 atcaggcatc acctactaac acagacgtgc gcggcttttc tgcatcaatt gctgtgacgg
     7921 ttcagaatgt tggtatacaa gaaggaatag aaaactgata aggttttaaa taatctgtaa
     7981 tttcaatctt tttttcctga aatacattat attgtatgtt tgaaataatt ctagtacaaa
     8041 gtataataaa actagatgta taataaaccc tttaaatcat tgctaagtgt ataagtggaa
     8101 ctgaagcatt tattggacaa agtaatgtta ctctaatggt tacttgctcg ctcctgcgtg
     8161 gccacactgt tataatttgc ttcattacct tgctatttga tacatagtgt gcatttctct
     8221 gtcactgtaa ctattgtaat gacaaatttt catcttactg cacaatcaaa gtgtcattga
     8281 ttaggaatga cctccagagt ctgagcctgg acagggagtg ggcgctcagg cctggtgctc
     8341 tgttgtacga cctgtacctc tcaacttttg ccccgtctgt taaatatatg ctatgtcatt
     8401 aaatgctttt aaatctaa
//
