LOCUS       NM_212522               6810 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Rattus norvegicus spectrin, beta, erythrocytic (Sptb), transcript
            variant 1, mRNA.
ACCESSION   NM_212522 XM_234322
VERSION     NM_212522.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6810)
  AUTHORS   Nestor,M.W., Cai,X., Stone,M.R., Bloch,R.J. and Thompson,S.M.
  TITLE     The actin binding domain of betaI-spectrin regulates the
            morphological and functional dynamics of dendritic spines
  JOURNAL   PLoS One 6 (1), e16197 (2011)
   PUBMED   21297961
  REMARK    GeneRIF: suggest that betaI-spectrin is a synaptic protein that can
            modulate both the morphological and functional dynamics of
            dendritic spines, perhaps via interaction with actin and Rac3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6810)
  AUTHORS   Korsgren,C. and Lux,S.E.
  TITLE     The carboxyterminal EF domain of erythroid alpha-spectrin is
            necessary for optimal spectrin-actin binding
  JOURNAL   Blood 116 (14), 2600-2607 (2010)
   PUBMED   20585040
REFERENCE   3  (bases 1 to 6810)
  AUTHORS   Maciag,M., Plochocka,D., Adamowicz-Salach,A. and Burzynska,B.
  TITLE     Novel beta-spectrin mutations in hereditary spherocytosis
            associated with decreased levels of mRNA
  JOURNAL   Br J Haematol 146 (3), 326-332 (2009)
   PUBMED   19538529
REFERENCE   4  (bases 1 to 6810)
  AUTHORS   Robledo,R.F., Ciciotte,S.L., Gwynn,B., Sahr,K.E., Gilligan,D.M.,
            Mohandas,N. and Peters,L.L.
  TITLE     Targeted deletion of alpha-adducin results in absent beta- and
            gamma-adducin, compensated hemolytic anemia, and lethal
            hydrocephalus in mice
  JOURNAL   Blood 112 (10), 4298-4307 (2008)
   PUBMED   18723693
REFERENCE   5  (bases 1 to 6810)
  AUTHORS   An,X., Debnath,G., Guo,X., Liu,S., Lux,S.E., Baines,A., Gratzer,W.
            and Mohandas,N.
  TITLE     Identification and functional characterization of protein 4.1R and
            actin-binding sites in erythrocyte beta spectrin: regulation of the
            interactions by phosphatidylinositol-4,5-bisphosphate
  JOURNAL   Biochemistry 44 (31), 10681-10688 (2005)
   PUBMED   16060676
REFERENCE   6  (bases 1 to 6810)
  AUTHORS   Devarajan,P., Scaramuzzino,D.A. and Morrow,J.S.
  TITLE     Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase
            alpha subunit
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 2965-2969 (1994)
   PUBMED   8159688
REFERENCE   7  (bases 1 to 6810)
  AUTHORS   Garbarz,M., Tse,W.T., Gallagher,P.G., Picat,C., Lecomte,M.C.,
            Galibert,F., Dhermy,D. and Forget,B.G.
  TITLE     Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant
            in a kindred with hereditary elliptocytosis. Characterization of
            the molecular defect as exon skipping due to a splice site mutation
  JOURNAL   J Clin Invest 88 (1), 76-81 (1991)
   PUBMED   2056132
REFERENCE   8  (bases 1 to 6810)
  AUTHORS   Bodine,D.M. 4th, Birkenmeier,C.S. and Barker,J.E.
  TITLE     Spectrin deficient inherited hemolytic anemias in the mouse:
            characterization by spectrin synthesis and mRNA activity in
            reticulocytes
  JOURNAL   Cell 37 (3), 721-729 (1984)
   PUBMED   6234993
REFERENCE   9  (bases 1 to 6810)
  AUTHORS   Bennett,V. and Stenbuck,P.J.
  TITLE     The membrane attachment protein for spectrin is associated with
            band 3 in human erythrocyte membranes
  JOURNAL   Nature 280 (5722), 468-473 (1979)
   PUBMED   379653
REFERENCE   10 (bases 1 to 6810)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY238343.1.
            
            On Aug 30, 2004 this sequence version replaced XM_234322.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY238343.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..6810
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /note="spectrin, beta, erythrocytic"
                     /db_xref="GeneID:314251"
                     /db_xref="RGD:1303243"
     exon            1..92
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..294
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..6560
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythroid spectrin beta; spectrin beta 1; spectrin beta
                     chain, erythrocyte; spectrin beta chain, erythrocytic"
                     /codon_start=1
                     /product="spectrin beta chain, erythrocytic isoform 1"
                     /protein_id="NP_997687.1"
                     /db_xref="GeneID:314251"
                     /db_xref="RGD:1303243"
                     /translation="MTSATEFENVGNQPPYSRINARWDAPDDELDNDSSSARLFERSR
                     IKALADEREVVQKKTFTKWVNSHLARVSCRISDLYKDLRDGRMLIKLLEVLSGEMLPR
                     PTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQ
                     DIVVQTQEGRETRSAKDALLLWCQMKTAGYPQVNVTNFTSSWKDGLAFNALIHKHRPD
                     LIDFDKLKDSNARHNLEHAFDVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHY
                     FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSRKFANSL
                     SGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDI
                     NRAWESLEEAEYQRELALRSELIRQEKLEQLARRFDRKAAMRETWLNENQRLVTQDNF
                     GYDLAAVEAAKKKHEAIETDTAAYEERVKALEDLAQELEKENYHDQKRISARKNNILR
                     LWSYLQELLRSRRQRLEATLALQKLFQDMLHSIDWMDEIKAHILSAEFGKHLLEVEDL
                     LQKHKLMEADIAIQGDKVKTITAATLQFTEGKGYQPCDPQVIQDRVSHLEQCFSELSN
                     MAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF
                     EDELRGLDAHLKQIFQEAEDMVAQKQFGHPQIETRVKEVSAQWDHLKELAAFRKKDLQ
                     DAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKEFLEELEESRGV
                     MEHLENQAQGFPEEFRDSPDVTNRLQALRKLYQQVMAQAELRGHKLQEALDLYTVFGE
                     SDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDILDQEMKTLMAQIDGVNLAANNL
                     VESGHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETSKWIVD
                     KTKVVESTKDLGQDLAGVIAIQRKLSGLERDVLAIRDRVSALERESQYLMESHPDQKE
                     DIGQRQADVEKMWKGLQDALQGQELSLGEASKLQAFLQDLDDFKAWLSMAQKAVASED
                     MPESLPEAEQLLQQHAAIKEEIDAHKDDYHRVKASGEKVIEGQTDPDYQLLGQRLEGL
                     DTDWDALWRMWESRGNTLTQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLAAAE
                     AGIRKFEDFLVSMENNRDKVLSPVDSGNMLVSEGNLYSNKIKEKVQLIEDRHMKNNEK
                     AQEVTALLKDNLELQNFLQNCKELTLWINDKLLTSPDISYDEARNLHNKWMKHQAFMA
                     ELASHQGWLENIVAEGRQLMAEKPQFTDVVSERLEALHKLWDELQTTTKAKTEQLSAA
                     RSSDLRLQTHADLSKWISAMEDQLRSDDLGKDLTTVNRMLVKLKRVEEQVNLRKEELE
                     ELFAEAPPLGAEAGDTDMSIEKRFLDLLEPLGRRKKQLELSKAKLQISRDLEDETLWV
                     EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHAPRVEDVLHRGQELVKAAEIDC
                     QDIEERLGHLQSSWDTLREAAAGRLQRLREAHEAQQYYLDAGEAEAWISEQELYVFSD
                     EPPKDEEGAIVMLKRHLRQQRTVEEYGRNIKQLAGRAQSLLSAGHPEGEQIIRLQGQV
                     DKQYAGLKDMAEERRRKLENMYHLFQLKREADDLEQWITEKEMVASSQEMGQDFDHVT
                     MLRDKFRDFARETGAIGQERVDNVNSIIERLIDAGHSEAATIAEWKDGLNDMWADLLE
                     LIDTRMQLLAASYDLHRYFYTGTEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFE
                     RELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAAWQALLDACAGRRAQLV
                     DTADKFRFFSMVRDLLSWMESIIRQIETQERPRDVSSVELLLKYHQGIKAEINTRAKN
                     FSTCLELGESLLQRQHQASDEIREKLQQVISRRQEMNDKWEARSDRLHMLLEVCQFSR
                     DASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTL
                     ELKERQTPDRPTEEPGPQEEEGETAGEAPQVHHAATERTSPVSFMSRLSSSWESLLPE
                     PAHPF"
     exon            295..446
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..620
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..712
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..793
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..909
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1022
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1210
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1328
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1487
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1790
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1941
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2812
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2950
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3707
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3910
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4001
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4148
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4412
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4619
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4620..4709
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4988
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5119
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5324
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5325..5699
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5700..5944
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5945..6083
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6084..6168
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6169..6365
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6366..6415
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6416..6794
                     /gene="Sptb"
                     /gene_synonym="Spnb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgctg tgccaggagc cccgtgctgc cctcctcccc ctgcgccgcc gcccccgggc
       61 tcggggtggc cgccgcttca gccccagcgc agggactctt ccatgaagac tgagccaggc
      121 atagctgcta agaagagcct gctgacatga catcagccac ggagtttgaa aacgtgggca
      181 accagccacc atacagccgg attaatgccc gctgggacgc cccagatgat gaactggaca
      241 acgatagcag ctcagccagg ctctttgaga ggtcccggat caaggccttg gcagatgagc
      301 gggaagtggt tcagaagaaa acctttacga aatgggtgaa ctcccacctg gctcgagtgt
      361 cctgccgcat cagcgatctc tacaaggacc tgcgggatgg acgcatgctc atcaagctgc
      421 tggaggtgct ctccggagag atgctgccaa ggccgaccaa gggcaagatg cgcatccact
      481 gcctggagaa cgtggacaaa gccctgcagt tcctcaagga gcagcgcgtg cacctggaaa
      541 acatgggctc ccacgacatc gtggatggca accaccgcct ggtcctgggc ctcatctgga
      601 cgattatcct ccgattccag attcaagaca ttgttgtcca aactcaagaa ggtcgggaga
      661 cacgctcagc caaggatgct ctgcttctgt ggtgccagat gaagacagcc ggctaccccc
      721 aagtcaacgt aaccaacttc acctccagct ggaaggacgg cctggccttc aatgccctaa
      781 ttcataaaca ccggcctgac ctcattgact ttgacaagct aaaggactcc aatgcccggc
      841 ataacttgga gcacgcattt gatgtggccg agcgtcagct gggcatcatc ccactccttg
      901 accccgaaga tgtcttcaca gaaaacccag acgagaagtc catcatcacc tacgtggtag
      961 cattttacca ctacttctcc aagatgaagg tgctagcggt ggagggcaag agagtcggca
     1021 aggtcattga ccatgccatt gagactgaga agatgattga aaagtacagt gggctagcct
     1081 cagacctgct cacctggatt gagcaaacca ttagcgtcct gaacagccgc aagtttgcca
     1141 actcattgag tggcgtccag cagcagctac aggccttcag cacctaccgc actgtggaga
     1201 agccacccaa gtttcaagag aaggggaatc tggaagtcct cctgttcact atccaatccc
     1261 gaatgagagc caacaatcag aaagtgtaca cgccccacga tgggaagcta gtgtctgaca
     1321 tcaacagggc ctgggagagc ctagaggaag cagaatacca aagggagctg gccctgagga
     1381 gcgagctcat tcggcaggag aaactggagc agctggcgcg gcgcttcgac cgtaaggcag
     1441 ccatgagaga gacgtggctc aacgaaaacc agcgcctggt gacccaggat aacttcgggt
     1501 atgacctggc agctgtggag gccgccaaga agaagcacga agccattgag accgacacgg
     1561 ctgcctatga ggagcgggtg aaggcactgg aggacctggc ccaggagctg gagaaggaga
     1621 attaccatga ccagaagcgc atcagtgcca ggaagaacaa tatcctccgt ctgtggagct
     1681 acctgcagga gctgctgcga tcccggcgac agcggctcga ggccaccctg gcactgcaga
     1741 agctcttcca ggacatgctg cacagtatcg actggatgga tgagatcaag gcgcacatct
     1801 tgtctgctga atttgggaag cacttgttag aggttgaaga cctgctacag aaacacaagc
     1861 taatggaagc cgacattgct atccaagggg acaaagtgaa gaccatcacc gcggccaccc
     1921 tgcagttcac tgaggggaaa gggtatcagc cttgtgaccc ccaggtcatc caggaccgtg
     1981 tcagccacct agagcaatgc ttcagtgaac tgagcaacat ggcagctgga cggaaggctc
     2041 agctggagca gtctaagcga ctctggaagt tcttctggga gatggacgag gccgaaagct
     2101 ggatcaagga aaaggaacag atctactcct ccctggacta cggcaaggac ctgacgagtg
     2161 tgctcatctt acagcgcaag cacaaggcct tcgaggacga gctccgtggg ctcgatgccc
     2221 atctgaagca gatcttccag gaggctgagg acatggttgc acaaaagcag tttggacatc
     2281 cacagatcga gacccgtgtc aaagaagtat cggctcagtg ggaccacttg aaagagctgg
     2341 ctgcctttcg taagaaagac ctgcaggatg cggaaaactt cttccagttc cagggtgatg
     2401 cagacgacct gaaggcttgg ctgcaagacg ctcaccggct gctttccggt gaagatgtgg
     2461 ggcaagacga aggagccacg agggccctgg gaaagaagca caaggagttt ctagaggagc
     2521 tggaggagag ccgcggggtg atggagcact tagagaacca agcccagggc ttccccgagg
     2581 agtttcgaga ttccccagat gtgacaaacc gtctacaggc actcaggaag ctctaccagc
     2641 aggtgatggc ccaggcagaa ttgcgtggac acaagctgca ggaagccctg gacttgtaca
     2701 ctgtgtttgg agagtcagac gcctgtgagc tgtggatgac tgagaagggg aagtggctgg
     2761 accagatgga tatcccaaac acgctggagg atctggaggt tgtgcagcac aggtttgaca
     2821 tcctggacca ggagatgaag accttgatgg cgcagattga tggcgtgaac cttgcggcca
     2881 acaacctggt agagagcggc cacccacgca gtggggaggt gaaacaatat caggaccgcc
     2941 taaacaagag gtggcaggcc ttccaggcag tggtgtcaga gcagagagag gctgtggact
     3001 cggctctccg agtaaacaat tactgtgtag actgtgagga aaccagcaag tggatcgtgg
     3061 acaagacgaa ggttgtggag tctaccaagg acttggggca ggacctagca ggagtcattg
     3121 ccatccagcg gaagttgtca gggttggagc gggacgtatt ggccatccgg gatcgtgtga
     3181 gcgccttgga acgggagtcg cagtacttga tggagtcaca ccctgaccag aaagaggaca
     3241 ttggccagcg gcaagcagat gtcgagaaga tgtggaaggg cctgcaagat gccttgcaag
     3301 gtcaggagct ctccttaggt gaggccagca agctgcaggc tttcctacaa gacctggatg
     3361 acttcaaggc ctggctgtcg atggcccaaa aggcagtggc ctctgaggac atgcctgagt
     3421 cactcccaga ggctgagcaa ctcctacagc agcatgcagc cattaaagag gagattgatg
     3481 ctcacaaaga cgattaccac cgggtcaagg cctctgggga aaaagtgatc gaaggtcaaa
     3541 ctgacccaga ttaccagctt ctgggccagc gactggaggg tctagatact gactgggatg
     3601 ctctgtggcg gatgtgggag agccgaggga acaccctcac ccagtgcctg ggcttccagg
     3661 agttccagaa agatgccaag caggctgaag ccatcctcag caaccaggaa tacactctgg
     3721 ctcacctgga gcccccagac tccctagcag ctgcagaggc cggcatccga aagtttgagg
     3781 atttcttagt gtctatggaa aacaaccgag ataaagtcct gagtcctgtg gactccggaa
     3841 acatgctggt gtctgagggc aacctgtact cgaacaagat caaagagaag gtgcagctga
     3901 ttgaagacag gcacatgaag aacaatgaga aagcccagga ggttacagct ctactgaaag
     3961 acaacctgga gttgcagaac ttcctccaga actgcaagga gctcactctc tggatcaatg
     4021 acaagctgct gacgtctcca gacatctcct atgacgaagc ccgcaacctt cacaacaaat
     4081 ggatgaaaca ccaggcattt atggcagagc tggcttcaca ccaagggtgg cttgagaaca
     4141 tcgtcgcgga gggaaggcag ctgatggcag agaagcccca gttcacggat gtggtgtcag
     4201 aaaggctgga agccctgcac aagctctggg atgagctgca gaccaccaca aaggcgaaga
     4261 cggagcaact ctctgctgcc cggagctctg acctgcgctt gcaaacccac gccgacctta
     4321 gcaaatggat cagcgccatg gaggaccagc tgcgatccga cgacctgggc aaggatctga
     4381 ccactgtcaa ccggatgttg gttaagttga agcgagtgga ggaacaagtg aatttgcgga
     4441 aggaggagct ggaggaactc tttgcagagg cacccccact gggagcagag gcaggagaca
     4501 cggacatgag cattgaaaag cggttcctag accttctaga acctctgggg aggaggaaga
     4561 agcagctgga attatccaaa gccaagctac agatcagccg ggacttagag gatgagacgc
     4621 tctgggtgga agagaggctg ccgttggcgc agtcagctga ctatggcact aatctgcaaa
     4681 cagtgcagct gttcatgaag aagaaccaga ccctgcagaa tgagatccta ggccacgcac
     4741 cacgggtgga ggatgtgcta catcgagggc aggagctggt gaaggcagcc gagatcgact
     4801 gccaagacat cgaggagcgc ttggggcatc tgcagagctc gtgggacacg ctgcgggagg
     4861 cggcagctgg ccggctgcag cgcctgcggg aagctcacga ggcacagcag tactacctgg
     4921 atgcgggcga ggctgaagcg tggatcagcg agcaggagct ctacgtgttc tctgacgaac
     4981 cccctaagga cgaagagggc gccatcgtga tgctcaagcg gcaccttcgg cagcagcgca
     5041 cggtggagga atatggaagg aatatcaaac agctggctgg ccgcgcccag agcctgctgt
     5101 ctgcaggcca cccggagggg gagcagatca tcagacttca ggggcaagtg gataagcagt
     5161 atgccgggct gaaggacatg gctgaggaac ggaggcggaa gctagagaac atgtaccacc
     5221 tgttccagct gaagagagag gctgacgact tggagcagtg gattacggag aaagagatgg
     5281 tggcctcatc ccaagaaatg gggcaggact ttgaccacgt gactatgctc cgtgacaagt
     5341 tccgagactt tgcccgggag accggggcta tcgggcagga gcgagtagac aatgtgaatt
     5401 ctatcattga gcgtctcatc gatgcgggcc acagcgaggc agccaccatt gcagagtgga
     5461 aggatgggct gaatgacatg tgggcagatc tgctggagct cattgacacc cgcatgcagc
     5521 tgctggctgc ctcctacgac ctgcaccgct atttctacac gggcaccgag atcctgggcc
     5581 tcatagatga gaagcacaga gagttgccag aggacgtggg gctggacgcc agcacagctg
     5641 agtccttcca ccgggtccac actgccttcg agcgggagct ccacctcctg ggtgtgcagg
     5701 tgcagcagtt ccaggacgtg gccacccgac tgcagacagc gtatgctggg gagaaggcag
     5761 atgctatcca gagcaaggag caggaggtgt ccgcggcctg gcaggccctg ctggacgcgt
     5821 gtgctgggcg ccgagctcag ctggtagata cggcagacaa gttccgcttc ttcagcatgg
     5881 tgcgtgacct cctctcctgg atggagagca tcatccggca gatcgagacc caggagagac
     5941 ccagggatgt ctcctcggtg gaactgctct tgaagtatca ccagggcatc aaggcagaga
     6001 tcaataccag ggccaagaac ttcagcacct gcctagaact tggggagtcc ctgctacaga
     6061 ggcaacacca ggcttcagac gagatccggg agaaattaca gcaagtgata tccaggaggc
     6121 aggagatgaa tgacaagtgg gaagcccgct ctgacaggct ccacatgctg ctggaggtgt
     6181 gccagttctc gagggacgct tctgtggccg aggcatggct gattgcccag gagccctacc
     6241 tggccagccg ggactttgga catacggtgg acagcgtgga aaagctcatc aagaggcatg
     6301 aggcttttga gaagtccaca gccagctggg cagagcgctt tgctgccctg gagaagccca
     6361 ccacgcttga gcttaaggaa cgccagactc cagacagacc cacagaggaa cctgggcctc
     6421 aagaggagga aggcgagaca gctggcgagg ctccccaggt ccaccatgcg gccacggaga
     6481 gaacatcccc ggtcagtttt atgtcccgct tgtctagctc ctgggagtca ctgctgccag
     6541 agcctgctca ccccttctag gatcagccag ggcagaagga aggcgaggac agaagagggc
     6601 agggcatgct tcctggtccc taccctcatc ctgcccacag gccactctag gagcctcctt
     6661 cagattcatc tacttttcta cttagatttt aattcttaaa taattccgct ccttccaacc
     6721 cagaagccag cccaccaaca tgattctgca agtttggttt tctctagttt aataaatttt
     6781 atgggataga tacaaaaaaa aaaaaaaaaa
//
