LOCUS       NM_171983               7868 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus spectrin, alpha, non-erythrocytic 1 (Sptan1),
            mRNA.
ACCESSION   NM_171983 XM_346647
VERSION     NM_171983.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7868)
  AUTHORS   Emtage,J.A., Shipman,M.L. and Corbit,L.H.
  TITLE     The role of dorsomedial striatum adenosine 2A receptors in the loss
            of goal-directed behaviour
  JOURNAL   Psychopharmacology (Berl) 240 (3), 547-559 (2023)
   PUBMED   36129491
  REMARK    GeneRIF: The role of dorsomedial striatum adenosine 2A receptors in
            the loss of goal-directed behaviour.
REFERENCE   2  (bases 1 to 7868)
  AUTHORS   Houy,S., Nicolas,G., Momboisse,F., Malacombe,M., Bader,M.F.,
            Vitale,N., Lecomte,M.C., Ory,S. and Gasman,S.
  TITLE     alphaII-spectrin controls calcium-regulated exocytosis in
            neuroendocrine chromaffin cells through neuronal Wiskott-Aldrich
            Syndrome protein interaction
  JOURNAL   IUBMB Life 72 (4), 544-552 (2020)
   PUBMED   31859439
  REMARK    GeneRIF: alphaII-spectrin controls calcium-regulated exocytosis in
            neuroendocrine chromaffin cells through neuronal Wiskott-Aldrich
            Syndrome protein interaction.
REFERENCE   3  (bases 1 to 7868)
  AUTHORS   Garcia-Caballero,A., Zhang,F.X., Hodgkinson,V., Huang,J., Chen,L.,
            Souza,I.A., Cain,S., Kass,J., Alles,S., Snutch,T.P. and
            Zamponi,G.W.
  TITLE     T-type calcium channels functionally interact with spectrin
            (alpha/beta) and ankyrin B
  JOURNAL   Mol Brain 11 (1), 24 (2018)
   PUBMED   29720258
  REMARK    GeneRIF: These findings reveal spectrin (alpha/beta) / ankyrin B
            cytoskeletal and signaling proteins as key regulators of T-type
            calcium channels expressed in the nervous system.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7868)
  AUTHORS   Wang,Y., Ji,T., Nelson,A.D., Glanowska,K., Murphy,G.G.,
            Jenkins,P.M. and Parent,J.M.
  TITLE     Critical roles of alphaII spectrin in brain development and
            epileptic encephalopathy
  JOURNAL   J Clin Invest 128 (2), 760-773 (2018)
   PUBMED   29337302
  REMARK    GeneRIF: alphaII spectrin has a role in critical aspects of
            dendritic and axonal development and synaptogenesis, and there is a
            dominant-negative mechanism of SPTAN1 mutations in epileptic
            encephalopathy
REFERENCE   5  (bases 1 to 7868)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7868)
  AUTHORS   Kontrogianni-Konstantopoulos,A., Frye,C.S., Benz,E.J. Jr. and
            Huang,S.C.
  TITLE     The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog
            mediate fodrin-actin complex formation
  JOURNAL   J Biol Chem 276 (23), 20679-20687 (2001)
   PUBMED   11274145
REFERENCE   7  (bases 1 to 7868)
  AUTHORS   Tamura,Y., Ozkan,E.D., Bole,D.G. and Ueda,T.
  TITLE     IPF, a vesicular uptake inhibitory protein factor, can reduce the
            Ca(2+)-dependent, evoked release of glutamate, GABA and serotonin
  JOURNAL   J Neurochem 76 (4), 1153-1164 (2001)
   PUBMED   11181835
REFERENCE   8  (bases 1 to 7868)
  AUTHORS   Ozkan,E.D., Lee,F.S. and Ueda,T.
  TITLE     A protein factor that inhibits ATP-dependent glutamate and
            gamma-aminobutyric acid accumulation into synaptic vesicles:
            purification and initial characterization
  JOURNAL   Proc Natl Acad Sci U S A 94 (8), 4137-4142 (1997)
   PUBMED   9108118
REFERENCE   9  (bases 1 to 7868)
  AUTHORS   Hong,W.J. and Doyle,D.
  TITLE     Cloning and analysis of cDNA clones for rat kidney alpha-spectrin
  JOURNAL   J Biol Chem 264 (22), 12758-12764 (1989)
   PUBMED   2753883
REFERENCE   10 (bases 1 to 7868)
  AUTHORS   Leto,T.L., Fortugno-Erikson,D., Barton,D., Yang-Feng,T.L.,
            Francke,U., Harris,A.S., Morrow,J.S., Marchesi,V.T. and Benz,E.J.
            Jr.
  TITLE     Comparison of nonerythroid alpha-spectrin genes reveals strict
            homology among diverse species
  JOURNAL   Mol Cell Biol 8 (1), 1-9 (1988)
   PUBMED   3336352
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_171983.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X90845.1, SRR26643429.10986.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000003.1  33639069-33639173
            106-345             JAXUCZ010000003.1  33651975-33652214
            346-471             JAXUCZ010000003.1  33653483-33653608
            472-612             JAXUCZ010000003.1  33657104-33657244
            613-759             JAXUCZ010000003.1  33657486-33657632
            760-893             JAXUCZ010000003.1  33659862-33659995
            894-1038            JAXUCZ010000003.1  33660092-33660236
            1039-1193           JAXUCZ010000003.1  33660473-33660627
            1194-1329           JAXUCZ010000003.1  33662121-33662256
            1330-1431           JAXUCZ010000003.1  33665092-33665193
            1432-1569           JAXUCZ010000003.1  33666011-33666148
            1570-1680           JAXUCZ010000003.1  33667123-33667233
            1681-1758           JAXUCZ010000003.1  33668067-33668144
            1759-1914           JAXUCZ010000003.1  33668255-33668410
            1915-2119           JAXUCZ010000003.1  33668613-33668817
            2120-2301           JAXUCZ010000003.1  33669555-33669736
            2302-2545           JAXUCZ010000003.1  33670056-33670299
            2546-2668           JAXUCZ010000003.1  33670466-33670588
            2669-2886           JAXUCZ010000003.1  33670781-33670998
            2887-2979           JAXUCZ010000003.1  33672309-33672401
            2980-3114           JAXUCZ010000003.1  33673464-33673598
            3115-3263           JAXUCZ010000003.1  33674076-33674224
            3264-3323           JAXUCZ010000003.1  33675260-33675319
            3324-3522           JAXUCZ010000003.1  33676403-33676601
            3523-3627           JAXUCZ010000003.1  33677773-33677877
            3628-3651           JAXUCZ010000003.1  33678171-33678194
            3652-3687           JAXUCZ010000003.1  33678906-33678941
            3688-3735           JAXUCZ010000003.1  33680056-33680103
            3736-3827           JAXUCZ010000003.1  33681082-33681173
            3828-3972           JAXUCZ010000003.1  33681430-33681574
            3973-4154           JAXUCZ010000003.1  33681659-33681840
            4155-4254           JAXUCZ010000003.1  33684092-33684191
            4255-4452           JAXUCZ010000003.1  33684300-33684497
            4453-4599           JAXUCZ010000003.1  33684581-33684727
            4600-4703           JAXUCZ010000003.1  33686737-33686840
            4704-4866           JAXUCZ010000003.1  33686962-33687124
            4867-4998           JAXUCZ010000003.1  33688857-33688988
            4999-5136           JAXUCZ010000003.1  33689187-33689324
            5137-5241           JAXUCZ010000003.1  33690419-33690523
            5242-5450           JAXUCZ010000003.1  33692332-33692540
            5451-5571           JAXUCZ010000003.1  33693931-33694051
            5572-5693           JAXUCZ010000003.1  33694415-33694536
            5694-5826           JAXUCZ010000003.1  33694921-33695053
            5827-5925           JAXUCZ010000003.1  33696096-33696194
            5926-6085           JAXUCZ010000003.1  33697357-33697516
            6086-6162           JAXUCZ010000003.1  33697990-33698066
            6163-6372           JAXUCZ010000003.1  33698543-33698752
            6373-6669           JAXUCZ010000003.1  33699106-33699402
            6670-6782           JAXUCZ010000003.1  33699536-33699648
            6783-6800           JAXUCZ010000003.1  33699999-33700016
            6801-6855           JAXUCZ010000003.1  33702060-33702114
            6856-7052           JAXUCZ010000003.1  33702436-33702632
            7053-7106           JAXUCZ010000003.1  33702754-33702807
            7107-7253           JAXUCZ010000003.1  33702888-33703034
            7254-7401           JAXUCZ010000003.1  33703111-33703258
            7402-7868           JAXUCZ010000003.1  33703423-33703889
FEATURES             Location/Qualifiers
     source          1..7868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..7868
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /note="spectrin, alpha, non-erythrocytic 1"
                     /db_xref="GeneID:64159"
                     /db_xref="RGD:621714"
     exon            1..105
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            106..345
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..7527
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /note="alpha-spectrin 2; inhibitory protein factor;
                     spectrin alpha chain, brain; alpha II spectrin; fodrin
                     alpha chain; spectrin, non-erythroid alpha chain;
                     noerythroid alpha-spectrin 2; nonerythroid alpha-spectrin
                     2; a--fodrin; brain alpha-spectrin; alpha-fodrin"
                     /codon_start=1
                     /product="spectrin alpha chain, non-erythrocytic 1"
                     /protein_id="NP_741984.3"
                     /db_xref="GeneID:64159"
                     /db_xref="RGD:621714"
                     /translation="MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY
                     RFQFFQRDAEELEKWIQEKLQVASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL
                     DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED
                     VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAAKLIQE
                     QHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIKEKEQ
                     LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSANQIQV
                     KREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELAND
                     VAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLSILSEERA
                     ALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK
                     HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHRR
                     AQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN
                     QSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQ
                     FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ
                     ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET
                     WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF
                     AAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG
                     STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPMDDETGKELV
                     LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA
                     SRENLLEEQGSIALRQGQIDNQTRITKEAGSVSLRMKQVEELYQSLLELGEKRKGMLE
                     KSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESR
                     LKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHTVAT
                     FNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG
                     HDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQA
                     WTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL
                     ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQ
                     RRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI
                     NVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQT
                     LQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVI
                     DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK
                     DFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT
                     SSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKK
                     LLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQ
                     QRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD
                     TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKV
                     SDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT
                     KQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKAIEARHASLMKRWTQLLANSAT
                     RKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA
                     HDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE
                     LELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT
                     KRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH
                     NLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEE
                     GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKP
                     YVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN"
     exon            346..471
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..612
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..759
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..893
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1038
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1193
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1329
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1431
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1569
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1680
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1758
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1914
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2119
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2301
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2545
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2668
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2886
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2979
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3114
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3263
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3323
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3522
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3627
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3651
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3687
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3735
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3827
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3972
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3973..4154
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..4254
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4452
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4599
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4703
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4866
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4867..4998
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5136
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5137..5241
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5242..5450
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5451..5571
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5572..5693
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5694..5826
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5827..5925
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5926..6085
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6086..6162
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6163..6372
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6373..6669
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6670..6782
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6783..6800
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6801..6855
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6856..7052
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7106
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7107..7253
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7254..7401
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7402..7868
                     /gene="Sptan1"
                     /gene_synonym="A2a; IPF; Spna2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatccgctg cggagcgaac ggcgtgaggc aggggccgcg gcggcgcatc tttttcctca
       61 gcagccctca gcgcggcgac ccacgcccct cacccctagg aaccgaaaat ggatccaagt
      121 ggggtcaaag tgctggaaac agccgaggac atccaggaga gacgacagca ggttctggat
      181 cggtaccacc gcttcaagga gctctctacc ttgcggcggc agaaactgga ggattcctat
      241 cgcttccagt tttttcagag agatgctgag gagctggaga agtggattca ggagaagctt
      301 caagttgcct ctgatgagaa ctacaaagac cccaccaact tgcagggaaa gctccagaaa
      361 caccaagcct ttgaagctga agtacaggcc aactcaggag ccattgtgaa gctggatgag
      421 acaggaaact tgatgatttc tgaagggcac tttgcatctg agaccatccg gacacgttta
      481 atggagctgc accgccagtg ggagttgctt ttggagaaga tgcgggagaa aggaatcaaa
      541 ctgctgcagg cacagaagct ggtgcagtat ttgcgggagt gtgaggatgt aatggactgg
      601 atcaatgaca aggaagcaat tgtgacgtct gaggagctgg gccaggattt ggagcatgta
      661 gaggtactac agaagaagtt tgaagagttt caaactgatc tggctgctca tgaagaaaga
      721 gttaatgaag taaaccagtt tgctgccaaa cttatccagg agcagcaccc ggaagaggag
      781 ctgatcaaga ccaagcagga ggaggtgaat gcagcttggc agcgactgaa aggcctggct
      841 cttcaaaggc aggggaagct ctttggtgct gccgaggttc agcgctttaa cagggatgta
      901 gatgagacca ttggttggat taaggagaaa gagcagttaa tggcctctga tgactttggc
      961 agagacttag caagtgttca agctctgctt cggaagcatg agggtctgga gagagatctt
     1021 gctgctctag aggacaaggt gaaagccctg tgtgccgagg ctgaccgcct gcaacagtca
     1081 caccctctga gtgccaacca gatccaggtg aagcgagagg aactaattac caactgggag
     1141 cagatccgaa ctctggccgc agagagacat gcacggcttg atgactcata caggcttcag
     1201 cgctttcttg ctgacttccg tgacctcacg agctgggtga ctgaaatgaa agccctcatc
     1261 aatgcagatg aactggccaa tgacgtggct ggtgctgagg ccctgctgga caggcatcaa
     1321 gagcacaagg gtgaaatcga tgctcatgaa gatagcttta agtctgcaga tgagtctggg
     1381 caggccctac tcgctgctgg tcactatgcc tcagatgaag tgagggagaa gctgagcatc
     1441 ctctctgagg agagagctgc cctgctggag ctgtgggagc ttcggaggca acagtatgag
     1501 cagtgcatgg acttgcagct cttctaccga gacactgagc aggtggacaa ctggatgagc
     1561 aaacaggagg cattcctgct aaatgaagat ttgggtgact ccttagacag tgtggaagct
     1621 cttttgaaga agcatgagga ctttgagaaa tctctcagtg cccaggaaga aaaaatcaca
     1681 gcacttgatg agtttgcaac caagcttatt cagaacaacc actacgcaat ggaagatgta
     1741 gccactcgac gagatgctct cctgagccgc cgcaatgccc tccatgagcg agccatgcat
     1801 cgccgggcac agctggccga ttccttccac ctgcagcagt tcttccgcga ttccgatgag
     1861 ctcaaaagtt gggtcaatga gaagatgaaa acggccactg atgaagctta caaagatccg
     1921 tccaacctgc aagggaaagt ccaaaagcac caggcttttg aggctgagct ctcagccaac
     1981 cagagccgta ttgatgccct agagaaagct gggcaaaaac taatagatgt gaaccactat
     2041 gccaaggaag aagtagcagc tcggatgaat gaggtcatca gtttgtggaa gaaacttcta
     2101 gaggccacag aactgaaagg agtcaagctc cgagaagcca accagcagca acaatttaat
     2161 cgaaatgttg aggacattga gttgtggctg tatgaagttg aaggtcactt ggcttcagat
     2221 gattatggta aagacctcac taatgtccag aacctccaga agaagcatgc tctgctagag
     2281 gcagatgttg ctgctcacca ggatcgaatt gacggcatca caattcaggc ccgccagttc
     2341 caagatgctg gccatttcga tgccgaaaac attaaaaaga agcaagaggc ccttgtagct
     2401 cgctatgagg ctctcaagga acccatggtg gcccggaagc agaagctggc agattctctt
     2461 cgtctgcagc agctcttccg agatgtggag gatgaggaaa cctggattcg agaaaaggag
     2521 cctattgctg cgtccactaa cagaggcaaa gatcttattg gagtccagaa tctgctaaag
     2581 aagcaccaag ctttacaggc agaaattgct ggccatgaac ctcgcatcaa agcagtgaca
     2641 caaaagggca atgccatggt ggaggaaggc cattttgctg ctgaggatgt gaaggccaaa
     2701 ctgagtgagc tcaaccagaa gtgggaggca ctgaaagcca aagcctccca gcggaggcag
     2761 gatctggagg actcactaca ggcccagcag tactttgccg acgccaatga agctgagtcc
     2821 tggatgcggg agaaggagcc cattgtgggc agtaccgact atgggaagga tgaagactct
     2881 gctgaggctc tgctcaagaa gcatgaagct ttgatgtccg atctcagtgc ctacggcagc
     2941 agcattcaag ctttgcgaga gcaggctcag tcatgccggc aacaagtggc ccccatggat
     3001 gatgagactg gcaaggagct ggtcttggct ctctatgact atcaagagaa gagccctcgt
     3061 gaggtcacca tgaagaaagg ggatatcctc accttgctca acagcacaaa caaggactgg
     3121 tggaaagtgg aagtgaatga ccgtcagggt tttgtgccag ctgcgtatgt gaagaagctg
     3181 gaccccgccc agtcagcctc aagggagaac ctcctggaag aacagggcag cattgctctg
     3241 cggcaggggc agatcgacaa ccagacacgc ataactaagg aggccggcag tgtatctctg
     3301 cgtatgaaac aggtggaaga actgtatcag tctctgctgg agctgggtga gaagagaaaa
     3361 ggcatgttgg agaagagttg caagaagttc atgttgttcc gggaagcgaa cgagctacag
     3421 cagtggatca acgagaagga agctgctcta acgagtgaag aggttggcgc tgacttggag
     3481 caggtcgagg tgctgcagaa gaagttcgat gacttccaga aggatctgaa agccaatgag
     3541 tcccggctga aggacattaa caaagtggcc gaggacctgg agtctgaagg tctcatggcg
     3601 gaagaagtgc aggccgtgca gcagcaggag gtgtatggta tgatgcccag ggatgaagca
     3661 gattccaaga ccgcctcccc atggaagtct gctcgactga tggtccacac agtggccacc
     3721 ttcaactcca tcaaggagct gaatgagcgc tggcggtccc tgcaacagct ggctgaggaa
     3781 cgtagccagc tcctgggcag tgcacacgaa gtacagaggt tccacaggga tgcggatgaa
     3841 accaaagaat ggattgagga gaagaaccag gctctgaaca cagacaacta tggccatgat
     3901 ctagctagcg tccaggccct gcagcgcaaa cacgaaggct tcgagaggga ccttgcagct
     3961 cttggtgaca aggtgaattc ccttggggaa acagcccaga ggctgatcca gtcccaccct
     4021 gaatctgcag aggacttaaa ggaaaagtgc acagagttaa accaggcctg gaccagccta
     4081 gggaagcgtg cagaccagcg caaggccaaa ctgggtgact cccatgacct gcagcgcttc
     4141 cttagcgatt tccgggacct catgtcttgg atcaatggaa tacgagggtt ggtatcttca
     4201 gatgaactgg ccaaggatgt cactggagct gaggctttgc tggagcgaca ccaggaacac
     4261 cggacagaaa ttgatgccag ggctggcact ttccaggcat ttgagcagtt tgggcagcag
     4321 ctgttggctc atgggcacta tgccagccca gagatcaagg agaaacttga tattcttgac
     4381 caggagcgca cagacctgga gaaggcctgg gttcagcgca gaatgatgct ggaccactgc
     4441 ctggagttgc agctgttcca tcgagactgt gagcaagcag agaactggat ggctgcccgg
     4501 gaagccttcc taaacacaga agacaaagga gactcgctgg acagtgtgga ggctctgatc
     4561 aaaaaacatg aagacttcga caaagctatc aatgtccagg aggagaagat agctgccctg
     4621 caggcctttg ccgaccagct cattgctgtg gaccactatg ccaagggaga cattgcaaac
     4681 cgacgcaatg aggtcctgga caggtggcgc cgcctaaaag cccagatgat tgagaaaagg
     4741 tcaaagctcg gagaatctca aacacttcag cagttcagcc gggatgtaga tgagattgaa
     4801 gcctggatca gtgagaagtt acaaacagcc agcgatgagt catacaagga ccccaccaac
     4861 atccagagca agcaccagaa gcaccaagcc tttgaggcag aactgcacgc caatgctgac
     4921 cgaatccgtg gagttattga catgggcaac tccctcattg agcgtggggc ctgtgctggc
     4981 agtgaggatg ctgtcaaggc ccgcctggct gcccttgcag accagtggca gttcctggtg
     5041 cagaagtcag ctgagaagag ccagaagctg aaagaggcca ataagcagca gaacttcaac
     5101 accgggatca aagactttga cttctggctt tctgaggtgg aggctctcct ggcatctgaa
     5161 gactacggca aagacctggc ttccgtgaac aacctgctca aaaagcatca gctgctggag
     5221 gcagacatat cggcccacga ggatcgtctg aaggacctga acagccaggc tgacagcctg
     5281 atgactagca gtgccttcga cacctcccaa gtgaaagaga agcgggacac catcaatgga
     5341 cgctttcaga agatcaagag catggcaacc tcccgaagag caaaactgag cgagtcccat
     5401 cgcctgcacc agtttttccg agacatggat gacgaggagt cctggatcaa ggagaagaag
     5461 ttgttagtga gctctgagga ctatggcaga gacctcactg gtgttcaaaa tctgaggaag
     5521 aaacacaagc ggctagaagc cgaactggcc gcacacgaac cagccattca gggtgtcctg
     5581 gacacgggga agaagctgtc tgatgacaac accatcgggc aggaggagat ccagcagcgt
     5641 ctcgcacagt ttgtggagca ctggaaggaa ctgaaacagc tagcagctgc acggggccag
     5701 cggctggagg agtccttgga gtatcagcag tttgtggcca acgtggagga ggaggaggct
     5761 tggatcaatg agaagatgac cctggtggcc agcgaagact acggggacac tcttgctgcc
     5821 atccagggct tactgaagaa acatgaagct tttgagacag acttcactgt ccacaaggat
     5881 cgagtgaatg atgtctgtac taatggacaa gacctcatta agaagaacaa tcaccatgag
     5941 gagaacatct cttcaaagat gaagggtctg aatggtaaag tgtctgacct ggagaaagca
     6001 gcagctcaga ggaaagcgaa gctggatgag aactcggcct tccttcagtt caattggaag
     6061 gctgacgtgg tggagtcctg gattggtgaa aaggagaaca gcttgaaaac agatgattat
     6121 ggccgagatc tgtcttctgt ccaaactctg ctcaccaagc aggagacatt tgatgctggc
     6181 ctgcaggcct tccagcagga gggcattgcc aatatcactg ccctcaaaga ccagctgcta
     6241 gctgccaagc acattcagtc gaaggccatc gaggcccgac atgcctccct catgaagagg
     6301 tggacccagc tgttggccaa ttcagctacc cgcaagaaga agttgctaga ggcccagagt
     6361 catttccgaa aggtagaaga cctcttcctg acctttgcca aaaaggcatc ggctttcaac
     6421 agctggtttg agaatgcaga agaggacctc acagacccag tgcgctgcaa ctctctggaa
     6481 gaaatcaaag ccctccgaga ggctcatgat gccttccgct catcgctcag ctctgcgcag
     6541 gccgacttca accagctagc cgagctggac cgtcagatca agagtttccg agtggcctcc
     6601 aatccctaca cctggttcac catggaggcc ctggaagaga cgtggaggaa cctacagaag
     6661 atcattaagg agcgagaact ggagctgcag aaggaacagc ggcggcagga ggagaatgac
     6721 aagctacgcc aagagtttgc ccagcatgcc aacgcgttcc accagtggat ccaggaaaca
     6781 agaacgtatc tcctcgacgg gtcctgcatg gtcgaagagt cgggaactct ggaatctcag
     6841 cttgaagcta ccaaacgcaa gcaccaggag attcgggcca tgagaagtca gctgaagaag
     6901 attgaggacc tgggggctgc catggaggaa gccctcatcc tggacaacaa gtacactgag
     6961 cacagcactg tgggcctggc ccagcagtgg gaccagttag accagctggg catgcgcatg
     7021 cagcacaacc tggagcagca gatccaggcc aggaacacaa caggagtcac tgaggaggcc
     7081 ctcaaggagt tcagcatgat gttcaaacac ttcgacaagg acaagtctgg ccggctgaat
     7141 catcaagagt tcaaatcctg ccttcgttct ctgggttacg acctgccaat ggttgaggaa
     7201 ggagagcctg atcctgagtt tgaggccata ctggacactg ttgatcccaa cagggacggc
     7261 cacgtctccc tgcaagagta catggctttc atgatcagcc gtgaaaccga gaatgtcaag
     7321 tccagtgaag agatcgagag tgctttccgg gccctcagct ccgagggcaa gccttatgtg
     7381 accaaggagg agctctacca gaacctgacc cgggaacaag ctgactactg tgtctcccac
     7441 atgaagccct atgtggatgg caagggccgc gaacttccaa ctgccttcga ctacgtggag
     7501 ttcacccgct ctctctttgt gaattgatca atcctcttgg cttccagaca gcctgaccca
     7561 catgcttgcc ctgctatctg tcacctttgc tgcatgtcac tccctctgct ttcaaggaca
     7621 atattccaga cagcgctact ttccagtgta accatagcct gcttagcttg gggtaagact
     7681 tagtagaaaa tggtgcttca gtaaaccgct tacttccagt cacaatcacc ttgttgctgt
     7741 gggacccgac cctgtttgag ccggctgccc tcattcccac ttaaatcaaa gcagctggct
     7801 agtccccctg tttccttccc aaatcctgtt ttcatgtaca agacaaaata aaggactcaa
     7861 ttctccct
//
