LOCUS       NM_001009660            1255 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus splA/ryanodine receptor domain and SOCS box
            containing 2 (Spsb2), transcript variant 1, mRNA.
ACCESSION   NM_001009660 XM_216270
VERSION     NM_001009660.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1255)
  AUTHORS   Nishiya,T., Matsumoto,K., Maekawa,S., Kajita,E., Horinouchi,T.,
            Fujimuro,M., Ogasawara,K., Uehara,T. and Miwa,S.
  TITLE     Regulation of inducible nitric-oxide synthase by the SPRY domain-
            and SOCS box-containing proteins
  JOURNAL   J Biol Chem 286 (11), 9009-9019 (2011)
   PUBMED   21199876
REFERENCE   2  (bases 1 to 1255)
  AUTHORS   Kuang,Z., Lewis,R.S., Curtis,J.M., Zhan,Y., Saunders,B.M.,
            Babon,J.J., Kolesnik,T.B., Low,A., Masters,S.L., Willson,T.A.,
            Kedzierski,L., Yao,S., Handman,E., Norton,R.S. and Nicholson,S.E.
  TITLE     The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for
            proteasomal degradation
  JOURNAL   J Cell Biol 190 (1), 129-141 (2010)
   PUBMED   20603330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 31, 2021 this sequence version replaced NM_001009660.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088189.1, SRR26643289.14073.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000004.1  159299874-159300037
            165-907             JAXUCZ010000004.1  159300232-159300974
            908-1255            JAXUCZ010000004.1  159301221-159301568
FEATURES             Location/Qualifiers
     source          1..1255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1255
                     /gene="Spsb2"
                     /gene_synonym="Grcc9"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 2"
                     /db_xref="GeneID:297592"
                     /db_xref="RGD:1310854"
     exon            1..164
                     /gene="Spsb2"
                     /gene_synonym="Grcc9"
                     /inference="alignment:Splign:2.1.0"
     exon            165..907
                     /gene="Spsb2"
                     /gene_synonym="Grcc9"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1038
                     /gene="Spsb2"
                     /gene_synonym="Grcc9"
                     /note="gene rich cluster, C9 gene protein; SPRY
                     domain-containing SOCS box protein 2-like; SSB-2; SPRY
                     domain-containing SOCS box protein SSB-2"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 2"
                     /protein_id="NP_001009660.1"
                     /db_xref="GeneID:297592"
                     /db_xref="RGD:1310854"
                     /translation="MGQTALARGSSSTPSSHALYSDLSPPEGLEELLSAPPPDLGAQR
                     HHGWNPKDCSENIDVKEGGLCFERRPVAQSTDGVRGKRGYSRGLHAWEISWPLEQRGT
                     HAVVGVATALAPLQADHYAALLGSNSESWGWDIGRGKLYHQSKGLEAPQYPAGPQGEQ
                     LVVPERLLVVLDMEEGTLGYSIGGTYLGPAFRGLKGRTLYPSVSAVWGQCQVRIRYLG
                     ERRAEEPQSLLHLSRLCVRHALGDTRLGQISSLPLPPAMKRYLLYK"
     exon            908..1255
                     /gene="Spsb2"
                     /gene_synonym="Grcc9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggcgtc ctacggcccc gctggagccg gaagcggttg ctggtcaggg gcgcttccac
       61 ccttccctat ctgtgcttcc actgaggtct ctgaggggta gggggagccc agtgaggtgc
      121 gggatagggg ccgggcctta gagacctcaa ggggacggtc cacggggacg atccggagct
      181 caactttcaa aagacagacg ccccaacaag cctgttttga gaagttcttc agctgctcac
      241 ctcatgggcc agacggccct ggcaaggggc agcagcagca cccctagctc gcacgctctg
      301 tactctgact tatctcctcc cgagggcttg gaggagctcc tgtccgcacc ccctcctgac
      361 ctaggggccc aacgacacca cggctggaac cccaaggatt gctccgagaa catcgatgtc
      421 aaggaagggg gactgtgctt tgagcggcgc cctgtggccc agagcactga tggagtccgg
      481 ggaaagaggg gctattcgag aggcctgcat gcctgggaga tcagctggcc cctggagcaa
      541 aggggaacac acgccgtggt gggcgtggcc accgccctcg ccccgctgca ggctgaccac
      601 tacgcggcgc ttttgggcag caacagcgag tcctggggct gggatattgg gaggggaaaa
      661 ttgtatcatc agagtaaggg ccttgaggcc ccccagtacc cagccggacc tcagggtgag
      721 cagctagtgg tgccagagag actgttggtg gttctggaca tggaggaggg aactctgggc
      781 tactctattg ggggcacgta cctgggacca gccttccgtg gactgaaggg gaggaccctt
      841 tatccctctg taagtgctgt ttggggacag tgccaggtcc gcatccgcta cctgggcgaa
      901 agaagagcgg aggaaccaca atcccttctg cacctgagcc gcctgtgtgt gcgccatgct
      961 ctgggggaca cccggctggg tcaaatatcc agtctgccat tgccccctgc catgaaacgc
     1021 tatctactct acaaatgacc ctgtggcaca gggtgtgctg gcaccctacc gtggggacag
     1081 gtggagaggc actgctggcc tagacaactt aaaagctgga gctgagggaa ggaggctgga
     1141 ccccttcact accccttttc acaggaacaa gacatagaaa tgatactata ggctgtggca
     1201 gctttggaca aaaggttttt gaagtaaaaa aaaaatgaga tatattgtca cagaa
//
