LOCUS       NM_001393836            2375 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus sprouty RTK signaling antagonist 2 (Spry2),
            transcript variant 1, mRNA.
ACCESSION   NM_001393836 XM_006252438
VERSION     NM_001393836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Locatelli,C., Lemonidis,K., Salaun,C., Tomkinson,N.C.O. and
            Chamberlain,L.H.
  TITLE     Identification of key features required for efficient S-acylation
            and plasma membrane targeting of sprouty-2
  JOURNAL   J Cell Sci 133 (21) (2020)
   PUBMED   33037124
  REMARK    GeneRIF: Identification of key features required for efficient
            S-acylation and plasma membrane targeting of sprouty-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Walker,D.J. and Land,S.C.
  TITLE     Regulation of vascular signalling by nuclear Sprouty2 in fetal lung
            epithelial cells: Implications for co-ordinated airway and vascular
            branching in lung development
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 224, 105-114 (2018)
   PUBMED   29409968
  REMARK    GeneRIF: nuclear Spry2 acts as a molecular link which co-ordinates
            airway and vascular growth of the cardiopulmonary system.
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Dow,A.L., Lin,T.V., Chartoff,E.H., Potter,D., McPhie,D.L., Van't
            Veer,A.V., Knoll,A.T., Lee,K.N., Neve,R.L., Patel,T.B., Ongur,D.,
            Cohen,B.M. and Carlezon,W.A. Jr.
  TITLE     Sprouty2 in the dorsal hippocampus regulates neurogenesis and
            stress responsiveness in rats
  JOURNAL   PLoS One 10 (3), e0120693 (2015)
   PUBMED   25822989
  REMARK    GeneRIF: SPRY2 negatively regulates fibroblast growth factor-2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Yim,D.G., Ghosh,S., Guy,G.R. and Virshup,D.M.
  TITLE     Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling
  JOURNAL   Oncogene 34 (4), 474-484 (2015)
   PUBMED   24469046
  REMARK    GeneRIF: CK1 activity and binding are necessary for SPRY2
            inhibition of FGF-stimulated neurite outgrowth in PC12 cells
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Friedmacher,F., Gosemann,J.H., Fujiwara,N., Alvarez,L.A.,
            Corcionivoschi,N. and Puri,P.
  TITLE     Spatiotemporal alterations in Sprouty-2 expression and tyrosine
            phosphorylation in nitrofen-induced pulmonary hypoplasia
  JOURNAL   J Pediatr Surg 48 (11), 2219-2225 (2013)
   PUBMED   24210189
  REMARK    GeneRIF: Spry2 mRNA, protein, and tyrosination on D18 and D21 were
            significantly decreased in hypoplastic lungs with and without
            congenital diaphragmatic hernia.
REFERENCE   6  (bases 1 to 2375)
  AUTHORS   Ozaki,K., Miyazaki,S., Tanimura,S. and Kohno,M.
  TITLE     Efficient suppression of FGF-2-induced ERK activation by the
            cooperative interaction among mammalian Sprouty isoforms
  JOURNAL   J Cell Sci 118 (Pt 24), 5861-5871 (2005)
   PUBMED   16339969
REFERENCE   7  (bases 1 to 2375)
  AUTHORS   Shim,K., Minowada,G., Coling,D.E. and Martin,G.R.
  TITLE     Sprouty2, a mouse deafness gene, regulates cell fate decisions in
            the auditory sensory epithelium by antagonizing FGF signaling
  JOURNAL   Dev Cell 8 (4), 553-564 (2005)
   PUBMED   15809037
REFERENCE   8  (bases 1 to 2375)
  AUTHORS   Gross,I., Bassit,B., Benezra,M. and Licht,J.D.
  TITLE     Mammalian sprouty proteins inhibit cell growth and differentiation
            by preventing ras activation
  JOURNAL   J Biol Chem 276 (49), 46460-46468 (2001)
   PUBMED   11585837
REFERENCE   9  (bases 1 to 2375)
  AUTHORS   Mailleux,A.A., Tefft,D., Ndiaye,D., Itoh,N., Thiery,J.P.,
            Warburton,D. and Bellusci,S.
  TITLE     Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic
            lung growth and morphogenesis
  JOURNAL   Mech Dev 102 (1-2), 81-94 (2001)
   PUBMED   11287183
REFERENCE   10 (bases 1 to 2375)
  AUTHORS   Tefft,J.D., Lee,M., Smith,S., Leinwand,M., Zhao,J., Bringas,P. Jr.,
            Crowe,D.L. and Warburton,D.
  TITLE     Conserved function of mSpry-2, a murine homolog of Drosophila
            sprouty, which negatively modulates respiratory organogenesis
  JOURNAL   Curr Biol 9 (4), 219-222 (1999)
   PUBMED   10074434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 18, 2021 this sequence version replaced XM_006252438.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1539074.1,
                                           SRR26643293.60898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               JAXUCZ010000015.1  89111402-89111926   c
            526-2375            JAXUCZ010000015.1  89106809-89108658   c
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q22"
     gene            1..2375
                     /gene="Spry2"
                     /note="sprouty RTK signaling antagonist 2"
                     /db_xref="GeneID:306141"
                     /db_xref="RGD:1311472"
     exon            1..525
                     /gene="Spry2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..2375
                     /gene="Spry2"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1521
                     /gene="Spry2"
                     /note="sprouty 2; sprouty homolog 2"
                     /codon_start=1
                     /product="protein sprouty homolog 2"
                     /protein_id="NP_001380765.1"
                     /db_xref="GeneID:306141"
                     /db_xref="RGD:1311472"
                     /translation="MEARAQSGSGSQPLLQSPHDSGRQRGEPDPRDALTQQVHVLSLD
                     QIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPTQVHSS
                     RAALSRSVSTVSSGSRSSTRTSTSSSSSEQRLLGSSFSPGPAVDGIIRVQPKSELKSG
                     ELKPLSRDDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCV
                     CCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLK
                     LCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT"
ORIGIN      
        1 gcgccgcagc gccagcggag gagaggggcc ggcggagcgc gcagcgccca ggcccccgcg
       61 cgcgcccggc ccggcccgcg gccccgcgcc tgcctccgct cggaagcagc cccgggcccc
      121 caggacttgg cgagctggcc ttaggttctt tgtaaggccg tgctcgcctc gctttctctc
      181 atcgaccagg aaaaaaaaaa gagagactcg ccaacgttgg cgcttcggcc tcttgttcat
      241 tgagaaaaaa aaagggaaag aaaaaaaaaa ggcagaggaa atactccgcg tgcgcttctg
      301 gaacggaggt catctctcta gctcggaatc cgggagggtt ccaacggtgg aggatttggc
      361 ttccaaattt tcccgtggtt ttaatcctcc caccgactgc ttggaagttg gactgaagca
      421 gagtttggag agaaggaaaa agtttgcatc gggactggat ttatttgcac atcgctggaa
      481 gaagagaatc caagggagag gggttggtgc aaagccgcga tcacggagtt cagatgtgtt
      541 ctaagcctgc tggagtgaac acaccgccaa gatctgatgg aggccagagc tcagagcggc
      601 agcgggtcgc agcctttgct gcagtcaccc catgacagtg gcaggcagcg tggggagccg
      661 gaccccagag atgcccttac ccagcaggta catgtcttgt ctctggatca gatcagagcc
      721 atccgaaaca ccaatgagta cacagagggg cctactgtgg tcccaagacc tgggctcaag
      781 cctgctcctc gcccctccac ccagcacaaa catgaaagac tccacggtct gcccgagcac
      841 cgccagcctc ccaggctcca gcccacgcag gtccattctt cccgggccgc tctgtccagg
      901 tccgtcagca ccgtcagctc agggtctcgg agcagtacaa ggacaagtac cagcagcagc
      961 tcttcggaac agagactgtt aggatcatcc ttctcccctg ggcctgctgt tgatgggata
     1021 atccgagtgc agcctaaatc tgagctcaaa tccggtgagc ttaagccact gagcagagac
     1081 gatttgggtc tgcatgcata caggtgtgag gactgtggca agtgcaagtg taaggagtgc
     1141 acctacccga ggcccctgcc atcggactgg atctgtgaca agcagtgcct ttgctcagcc
     1201 cagaacgtca ttgactatgg gacttgtgtg tgctgtgtga aaggtctctt ctatcactgc
     1261 tccaatgacg acgaggacaa ttgtgctgac aacccgtgtt cttgcagcca gtctcactgt
     1321 tgtacgcgat ggtcagcgat gggtgtcatg tccctctttc tgccttgttt atggtgttac
     1381 cttccagcca agggttgcct taaattgtgc caggggtgtt atgaccgagt gaacaggcct
     1441 ggatgtcgtt gtaaaaactc aaatacagtt tgctgcaaag ttcccactgt ccccccaagg
     1501 aactttgaaa agccgacata gcgttattaa tcaggaatac tgcagtaatg aggattgttg
     1561 ccccaccccc acccccttct ttttaacaca catacacaac ctactaaaca gttgtaatcg
     1621 tggcactgtt catagagggt tagggaattt gtggtttgca gtgagatgct tttctttctt
     1681 ttttcctttt tttttttcct ctgtccatgt gccatttttt aactgatacg cttgctagag
     1741 agttcagcta gtcggaacgc cagggaaagg cgacagaagt tggtggcccc acgttattgc
     1801 ataagctaaa gcagcaaaca cccccaggcg aagttttctc ttgtttgtga atagcccttg
     1861 cagagtttgt aaatcagcag atggctcccc gacccctcct tgttttctcc agagataatg
     1921 tgctatattt ttgtatatac gataatattt gcaactgtga aaaaaaacca agttgtgcta
     1981 tactcccgtg gcacagtcac aaaatattat actaatatgc tgtacattcg gaagaatgtg
     2041 acgatcggta tgttttagat tgtattttgc cttacaggaa gcctttattg taagacgctg
     2101 acttcccttt ggacttgatg tatattgtac agttacagta aaattcaacc tttattttct
     2161 aattttttca acatattgtt tagtgtaaag aatatttatt tgaagtttta ttattttata
     2221 aaaaaagaat atttatttta agaggcatca taaattttgc cccttttatg aggatgtgag
     2281 ggttgctgca aaggagaggt tacagatgct atgttcaata taaaatagaa aatatattaa
     2341 cgtttgaaat taaactgacc ttgttttgtc ttgtt
//
