LOCUS       NM_001395072            2500 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sprouty RTK signaling antagonist 1 (Spry1),
            transcript variant 1, mRNA.
ACCESSION   NM_001395072
VERSION     NM_001395072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Alakoski,T., Ulvila,J., Yrjola,R., Vainio,L., Magga,J., Szabo,Z.,
            Licht,J.D. and Kerkela,R.
  TITLE     Inhibition of cardiomyocyte Sprouty1 protects from cardiac
            ischemia-reperfusion injury
  JOURNAL   Basic Res Cardiol 114 (2), 7 (2019)
   PUBMED   30635790
  REMARK    GeneRIF: Our findings indicate that Spry1 is an important regulator
            of cardiomyocyte viability during ischemia-reperfusion injury
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Bronnum,H., Andersen,D.C., Schneider,M., Sandberg,M.B.,
            Eskildsen,T., Nielsen,S.B., Kalluri,R. and Sheikh,S.P.
  TITLE     miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of
            epicardial mesothelial cells involving Programmed Cell Death 4 and
            Sprouty-1
  JOURNAL   PLoS One 8 (2), e56280 (2013)
   PUBMED   23441172
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Henke,A., Grace,O.C., Ashley,G.R., Stewart,G.D., Riddick,A.C.,
            Yeun,H., O'Donnell,M., Anderson,R.A. and Thomson,A.A.
  TITLE     Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and
            Tsukushi in developing prostate and decreased levels of decorin in
            prostate cancer
  JOURNAL   PLoS One 7 (8), e42516 (2012)
   PUBMED   22880013
  REMARK    GeneRIF: The spatio-temporal expression of Decorin, Semaphorin6D,
            SPARC, Spry-1 and Tsukushi in developing prostate is described and
            observed similar mesenchymal expression patterns in rat and human.
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Hashimoto,S., Nakano,H., Suguta,Y., Singh,G. and Katyal,S.L.
  TITLE     Immunolocalization of sprouty-1 and sprouty-2 in developing rat
            lung
  JOURNAL   Pathobiology 79 (1), 34-44 (2012)
   PUBMED   22236546
  REMARK    GeneRIF: A comparison the distribution of Sprouty-1 and Sprouty-2
            proteins by immunohistochemistry in developing and adult rat lung.
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Tang,N., Marshall,W.F., McMahon,M., Metzger,R.J. and Martin,G.R.
  TITLE     Control of mitotic spindle angle by the RAS-regulated ERK1/2
            pathway determines lung tube shape
  JOURNAL   Science 333 (6040), 342-345 (2011)
   PUBMED   21764747
REFERENCE   6  (bases 1 to 2500)
  AUTHORS   Boros,J., Newitt,P., Wang,Q., McAvoy,J.W. and Lovicu,F.J.
  TITLE     Sef and Sprouty expression in the developing ocular lens:
            implications for regulating lens cell proliferation and
            differentiation
  JOURNAL   Semin Cell Dev Biol 17 (6), 741-752 (2006)
   PUBMED   17141539
  REMARK    GeneRIF: Expressed in the lens throughout embryogenesis, Spry1
            becomes restricted to the lens epithelium, indicating that lens
            cell proliferation and fiber differentiation may be tightly
            regulated by this negative regulatory molecule.
REFERENCE   7  (bases 1 to 2500)
  AUTHORS   Jarvis,L.A., Toering,S.J., Simon,M.A., Krasnow,M.A. and
            Smith-Bolton,R.K.
  TITLE     Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine
            phosphatases
  JOURNAL   Development 133 (6), 1133-1142 (2006)
   PUBMED   16481357
REFERENCE   8  (bases 1 to 2500)
  AUTHORS   Ozaki,K., Miyazaki,S., Tanimura,S. and Kohno,M.
  TITLE     Efficient suppression of FGF-2-induced ERK activation by the
            cooperative interaction among mammalian Sprouty isoforms
  JOURNAL   J Cell Sci 118 (Pt 24), 5861-5871 (2005)
   PUBMED   16339969
REFERENCE   9  (bases 1 to 2500)
  AUTHORS   Basson,M.A., Akbulut,S., Watson-Johnson,J., Simon,R., Carroll,T.J.,
            Shakya,R., Gross,I., Martin,G.R., Lufkin,T., McMahon,A.P.,
            Wilson,P.D., Costantini,F.D., Mason,I.J. and Licht,J.D.
  TITLE     Sprouty1 is a critical regulator of GDNF/RET-mediated kidney
            induction
  JOURNAL   Dev Cell 8 (2), 229-239 (2005)
   PUBMED   15691764
REFERENCE   10 (bases 1 to 2500)
  AUTHORS   Gross,I., Bassit,B., Benezra,M. and Licht,J.D.
  TITLE     Mammalian sprouty proteins inhibit cell growth and differentiation
            by preventing ras activation
  JOURNAL   J Biol Chem 276 (49), 46460-46468 (2001)
   PUBMED   11585837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169059.1, SRR22582419.609197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000002.1  122485347-122485499
            154-442             JAXUCZ010000002.1  122485914-122486202
            443-2500            JAXUCZ010000002.1  122487951-122490008
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..2500
                     /gene="Spry1"
                     /note="sprouty RTK signaling antagonist 1"
                     /db_xref="GeneID:294981"
                     /db_xref="RGD:1309293"
     exon            1..153
                     /gene="Spry1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..442
                     /gene="Spry1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..2500
                     /gene="Spry1"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..1439
                     /gene="Spry1"
                     /note="sprouty homolog 1, antagonist of FGF signaling"
                     /codon_start=1
                     /product="protein sprouty homolog 1"
                     /protein_id="NP_001382001.1"
                     /db_xref="GeneID:294981"
                     /db_xref="RGD:1309293"
                     /translation="MDSPSQHDSHTSLVVIQPPAVEGRQRLDYDRDTQPATILSLDQI
                     KAIRGSNEYTEGPSVARRPAPRTAPRPEKQERTHEIIPANVNSSYVHRPAGHSGNARG
                     SVLSRSTSTGSAASSGSSSSVSSEQGLLGRSPPTRPIPGHRSDRVIRTQPKQLLVDDL
                     KASLKEDPTQHKFICEQCGKCKCGECTAPRALPSCLACDRQCLCSAESMVEYGTCMCL
                     VKGIFYHCSNDDDGGSYSDNPCSCSQSHCCSRYLCMGALSLCLPCLLCYPPAKGCLKL
                     CRGCYDWTHRPGCRCRNSNTVYCKLESCPSRAQGKPS"
ORIGIN      
        1 tgctcagcac gcaggggttt gcggcggccc cgcagccaga gctctgcggg ctgaggagct
       61 gctgtgggcg gcgtgcatgt gccgggaagg ccggccccag gctctgcact aggtaagagc
      121 cttcccctcc cgccgaggac ctggcgagat cagccggcgt ggcgactgcg gggacgcgga
      181 cctgcgggaa cccgagagcc cgggacgacg ccgggccgcg cgcctgacga ccgggacggg
      241 acggtgctgt ggagcgggcg ccgcgcgcac ccggcggatg tccccgagcc gccctcggcc
      301 gccgccaacc gcggagaagc gcccctgccc gggggccgct gaggccgcag cgcgggccat
      361 gcgcgcccgg ccgccccgcc gcgcttgatg cggcgcgcgc ttcgcccgct ccgcgccccc
      421 ggccggcgcc gtggaggccg aggatttcag atgcatggca gatttccgct gactgctgga
      481 attggagatc actccacatg gattccccaa gtcagcatga cagccacact tcactagtgg
      541 tgattcagcc accggctgtg gaaggccggc agaggttaga ctatgacagg gacacccagc
      601 ctgccacgat tctgtcccta gaccagatca aagccatcag aggcagcaat gaatacacag
      661 agggaccttc ggtagcgaga agaccggctc ctcgaactgc accaagaccc gaaaagcagg
      721 aaaggactca tgaaatcata ccagccaatg tgaatagcag ctacgtgcac cgacctgccg
      781 gccactcggg caatgccaga ggctcggtgc tgagcaggtc caccagcacc ggaagcgcag
      841 ccagctcagg gagcagcagc agtgtgtctt ctgagcaggg cctgttggga agatctccgc
      901 ccaccaggcc catcccaggt cataggtcag atagggtcat ccgaacccag cccaagcagc
      961 tgcttgtgga tgacttgaag gcctccttga aagaggaccc cacccaacac aagttcatct
     1021 gcgaacagtg tggcaagtgc aaatgtggag agtgtacagc cccccgggct ctgccttcct
     1081 gtctggcctg tgatcggcag tgcctctgct ccgcggagag catggtggag tacgggacct
     1141 gcatgtgcct ggtcaagggt attttttacc actgctccaa tgatgacgat gggggctctt
     1201 actcggataa cccgtgctcc tgttcacagt cccactgctg ctccagatac ctgtgcatgg
     1261 gagccctgtc cttgtgccta ccctgcttgc tctgctaccc tcctgccaag ggctgcctga
     1321 agctgtgcag gggctgttat gactggaccc accgccctgg ctgcaggtgt agaaactcca
     1381 acactgtcta ttgtaagctg gagagctgcc cctcaagggc tcaaggcaag ccgtcatgac
     1441 ttctggaggt gggttggacc tccggaatgt ctagcttcca aactttggct gttgagaagc
     1501 gtggtattag aggcagattt tcttctttag tctctcctgt cttggatgat cctcagtagg
     1561 agtggactgt gaaactgtgt ccagcctggt cccatcccac ctcgagggtt ctgggagctg
     1621 ggagtgcctg tgggctgtgt cagctttcca gctgcatctg tgaagatgtg cgcttgccca
     1681 gacttggccg agagttgttt ggggtctggt actgtgggat catggattta gtttggttta
     1741 taaaaaaagt aaccatgtaa gtgcttaaat aagctatata ttaatctgcc tctgatgaga
     1801 gctatcttag cgtcctactc ctagccggat gggaggttct actccttaga acacagtttt
     1861 cttggcatct actcactgcc ttgtccttac agccctccgc aatctcccca caatgcactg
     1921 tgcagatggg tcatccccgc acacagctct ggattcactg tgcggtgttg gtcttcacat
     1981 cagagatgat gttggcaacc ctcctttctc ctcctccagc acccagtatc cgtgaaggcc
     2041 ttcccttcgc accccccact tcactgaggg ggcgcttgga cacggtagtt gacattccta
     2101 tctgatctgc cccggtgtct cagccgcagc tccctaaggt gcctttggct cctggctggc
     2161 cttttgactc tttaacagct gagcacttcc aacccttcct gtgttttcat tgccttaacc
     2221 acaaattgtg gtgctttttg tatattttat gtataaaaca caaagttgaa tcctggctat
     2281 ttttaagaca aaagtctgtt aaactttttt ttattgtaaa gaatatttat tatgcgaatc
     2341 tctattattt tatgatattt attgcaaaag actgttgaaa tgtactcatg tctgaatata
     2401 acatatcact acttcaagaa aaacaaggtg actcaaagac agtacacaaa gtacatatat
     2461 gttaactaca atgcagaaaa tatattaatt aatgaaacca
//
