LOCUS       NM_001399182            4247 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SprT-like N-terminal domain (Sprtn), mRNA.
ACCESSION   NM_001399182 XM_006255808
VERSION     NM_001399182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4247)
  AUTHORS   Davis,E.J., Lachaud,C., Appleton,P., Macartney,T.J., Nathke,I. and
            Rouse,J.
  TITLE     DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA
            damage
  JOURNAL   Nat Struct Mol Biol 19 (11), 1093-1100 (2012)
   PUBMED   23042607
REFERENCE   2  (bases 1 to 4247)
  AUTHORS   Mosbech,A., Gibbs-Seymour,I., Kagias,K., Thorslund,T., Beli,P.,
            Povlsen,L., Nielsen,S.V., Smedegaard,S., Sedgwick,G., Lukas,C.,
            Hartmann-Petersen,R., Lukas,J., Choudhary,C., Pocock,R.,
            Bekker-Jensen,S. and Mailand,N.
  TITLE     DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes
            ubiquitin-dependent responses to replication blocks
  JOURNAL   Nat Struct Mol Biol 19 (11), 1084-1092 (2012)
   PUBMED   23042605
REFERENCE   3  (bases 1 to 4247)
  AUTHORS   Ghosal,G., Leung,J.W., Nair,B.C., Fong,K.W. and Chen,J.
  TITLE     Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124
            is a regulator of translesion synthesis
  JOURNAL   J Biol Chem 287 (41), 34225-34233 (2012)
   PUBMED   22902628
REFERENCE   4  (bases 1 to 4247)
  AUTHORS   Machida,Y., Kim,M.S. and Machida,Y.J.
  TITLE     Spartan/C1orf124 is important to prevent UV-induced mutagenesis
  JOURNAL   Cell Cycle 11 (18), 3395-3402 (2012)
   PUBMED   22894931
REFERENCE   5  (bases 1 to 4247)
  AUTHORS   Centore,R.C., Yazinski,S.A., Tse,A. and Zou,L.
  TITLE     Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator
            of UV-induced DNA damage response
  JOURNAL   Mol Cell 46 (5), 625-635 (2012)
   PUBMED   22681887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006255808.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.80570.1,
                                           SRR26643294.59959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               JAXUCZ010000019.1  69754989-69755473
            486-585             JAXUCZ010000019.1  69756074-69756173
            586-714             JAXUCZ010000019.1  69756893-69757021
            715-982             JAXUCZ010000019.1  69758113-69758380
            983-4247            JAXUCZ010000019.1  69758976-69762240
FEATURES             Location/Qualifiers
     source          1..4247
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4247
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /note="SprT-like N-terminal domain"
                     /db_xref="GeneID:292101"
                     /db_xref="RGD:1559496"
     exon            1..485
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1755
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /note="spartan; protein with SprT-like domain at the N
                     terminus; sprT-like domain-containing protein Spartan"
                     /codon_start=1
                     /product="DNA-dependent metalloprotease SPRTN"
                     /protein_id="NP_001386111.1"
                     /db_xref="GeneID:292101"
                     /db_xref="RGD:1559496"
                     /translation="MDEDLVVALRLQEEWDVQAARRAAAREPLSLVDASWELVDPTPD
                     LQALFLQFNDRFFWGQLEAVEVKWSVRMTLCAGICTYEGRGGMCSIRLSEPLLKLRPR
                     KDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINQLTGANITVYHTFHDEVD
                     EYRRHWWRCNGPCQHKQPYYGYVKRATNRAPSAHDYWWADHQKTCGGTYIKIKEPENY
                     AKKGRGKTKAGKQPTSAVENKDKLCRGEAQPLIPFSGKGYVLGDTSTCPSAGKLNTSH
                     MVNDTKGLSGQDHSASGLKLDSNVEVKCEQNGLPNKKPHLVTPLPTASHQSVLSSYFP
                     RVSVANQKAFRNVNGSPVKSGTIDGTKHSASAGAQRKVPPSRASLRNSSKVTAPASAT
                     VTSAAGTSAAISREESGSEDQFLNKRPRLEDRTALNNIKEQTQSGGDLEDSSRPTAIS
                     TPRSSGGQRRLVNCPVCQGVVLESQINEHLDRCLEGSKTNLRPRRV"
     exon            486..585
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /inference="alignment:Splign:2.1.0"
     exon            586..714
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /inference="alignment:Splign:2.1.0"
     exon            715..982
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /inference="alignment:Splign:2.1.0"
     exon            983..4247
                     /gene="Sprtn"
                     /gene_synonym="RGD1559496"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggagggt cgggcacgga ccagacttga cgtgaggcgc tggacctcgg cggcggtctg
       61 gagacaactg gcttcctgaa gccgtcccta ccccgagccc agcgttccta agtctgtgtc
      121 cgcggggcag agccgagcca ccttcggtta ggcgttcgag gcgagcccgc gcgccctgac
      181 agcggggccg ggaggtctcg cgagatccgt acgcctcacg agcccgaccg gcgtcttggg
      241 agcggctgaa gtgagagtat cgggatggac gaggatctgg tggtcgcgct gcggctgcag
      301 gaggagtggg acgtgcaggc ggcgcggcgc gcggcggcgc gggagcccct atcgttggtg
      361 gacgcgtcct gggagctggt ggaccccacc ccggacctgc aggcgctctt cctgcagttt
      421 aacgatcgct tcttctgggg tcagctggag gccgtggagg tgaagtggag tgtgcgcatg
      481 acactgtgtg ctggcatctg cacctatgaa gggagaggag gcatgtgctc catccgtctc
      541 agtgaaccct tgttaaaact cagaccaaga aaggaccttg tagagactct cttgcacgaa
      601 atgatccatg cttacttatt tgtcactaat aatgacaaag accgagaagg acacggccca
      661 gagttctgta aacacatgca tcgaatcaac cagctgacag gagccaacat aacggtctac
      721 cacactttcc acgatgaggt ggatgagtat cgccggcact ggtggcgctg caatggaccc
      781 tgccagcaca aacagcccta ctatggctat gtgaagcgtg ccaccaacag ggctccctct
      841 gctcatgact actggtgggc tgaccaccag aaaacttgtg gaggcactta cataaaaatc
      901 aaggagccag agaactatgc aaagaaaggc agaggaaaga caaaagcagg caagcagccc
      961 acatcggcag tggagaataa agataaactg tgcagaggag aggcccagcc gctcatccca
     1021 ttcagtggca aagggtatgt tcttggagac acaagcactt gcccttcagc tgggaagctg
     1081 aacacctcac acatggttaa tgacaccaaa ggtctctcag gtcaagacca ttcagcgagt
     1141 ggcctgaagc tcgattccaa cgttgaggtg aaatgtgaac agaacggtct tccaaataag
     1201 aagcctcatc ttgtcacccc tcttcccact gctagtcacc aaagtgtcct gagcagctac
     1261 ttccccagag tctctgttgc caaccaaaag gctttcagaa atgtaaatgg atccccagtg
     1321 aagagtggaa ccatcgatgg caccaagcac tctgcctcag caggcgctca gagaaaggtt
     1381 ccaccttcta gggcatccct gagaaattcc tccaaagtca cggcaccagc atcagcaacc
     1441 gtgacatctg cagctgggac ttccgcagcc atatcccgag aggagagtgg gtctgaagac
     1501 caattcctga acaagcgacc caggttggag gacaggactg ctttgaataa tatcaaggag
     1561 caaacacaga gtggtggtga ccttgaggat agctcacggc ccacagccat cagcacgcct
     1621 cggagctcag gcggtcagcg gcggctggtc aactgtccag tgtgtcaggg cgtagttttg
     1681 gagtcgcaga ttaatgagca cttggaccgc tgcctggaag gcagcaaaac caacctccga
     1741 cctcgaagag tgtgaggtgg agtgggtccc acaccgcctg atggctcatg gtgccgtcac
     1801 ccagcagttg aaggacgtgt gggtcacagt gtgacttact gcaccagcag tgtcatgtct
     1861 tacatacaca caacaaacag ctgtgcttta agtctgcatt tccatccaga cgtgtccctg
     1921 tgaccccaga tgctcaggga agtgaggcag gagcatcact gcagcccacg gccttggtag
     1981 tgtagggagc ctgtctcagg agcttacttg tcagcgtgct gggtccacac atgccttacc
     2041 aagacatggc cctgtttgtt ctgtatttgt gtatggcttt gtgtactttg gggttttttt
     2101 gtttgttcat aaggttttcg agtactattt ttatttatat attctcaaga tggtcttatc
     2161 aggagtcctg acagctgaat acttttaatg ttaagccccg ttctctaaac tgatgttaat
     2221 ctttttgagg tctgacactt tgttcagata gtatgaaaca gtagttgtcc taaaagcatc
     2281 cagatttttt tttaatccta acatatgttt tctatatttt aaaagatttt actttctaca
     2341 taaaggtggt tgcaagtttt aaagacttct atattcataa tttatatttt aaatatagta
     2401 tgtatattta tgtatataat ctgtcctgct tttactaaaa gtggcagatt ttaaagactc
     2461 atatttaaaa gaatttttat agctcctggc aactcatgtt aaaatcccag tacttgggag
     2521 gctgaggcag ggcggtggct gtggggtttg gagccagcct gggcctggct ctagcgtggg
     2581 ctgtggtgag tctggttggt ttttctcttt ccttgttcca tctttattca ccgagcggtg
     2641 gctgcagaat tgagagtaga gtggatactg gatggacagt accgttgttt agaatgttaa
     2701 agccgtcact tggttctgcg gcctatttga tggggactta agtgaacggt ttaaacttgg
     2761 tgctaaaacg taactgatgt agaacctctc acaaagctgc ctgactcctt ggagagcaga
     2821 aaaggcctgg gcagcactgt gaactgtaca gcaaagtgca aacaaaagat ggtcatatcc
     2881 tctgagcact gtgaggtgct gtctttccgc gtttgggcag agacacacag acactgctca
     2941 gtttgtttgt ctcatgtctg tccctccacc ttgctacaag gtgcacaaag cttgtgaggt
     3001 caggtgaacc tggcttgtct ggtgttcccc tgtataactt cccccattcc cacctccccc
     3061 aggggcctgg gacagggcct gccttcctta ttagagagtg ggaaggtggt atctttgtta
     3121 ttgtgtaggc ttattttcat tcctctgtag aacttaaaga taactagaag tttccccctc
     3181 accccagtat tattgaacca ttggaagtgt cctggtgcag ggctaagcga caacacccac
     3241 tcaggagtgg actgtcacag ggtgtctgtg gtcagcttta tctgagtcct ctcctcccaa
     3301 cagtgtgcca ttgtcagcct ctccgcattc ctgacaggat ctttagcctg tcagatcgga
     3361 taccaagttt tgatatttct taaagcatga agttaaattt ttgttaatgt ttataggtaa
     3421 gtagctattg aggctttttg tttggatata tgccatattt tcaccaattt aacaggttat
     3481 agacaaatat ttttgtgcca aactgcatag ctgtgtttat gaagtaagtc agatggtagt
     3541 tcgtgccttt caggagcgac ctcctcagtg agggaaacat gcaggttaat attagttagt
     3601 gcttatggcg gtgcggggtc agggtctcac tccggcactg gtttttaccg agttgagtta
     3661 gcttgttaag gagggggggg gggatctcag gcggggagag aactgggcac atctgtggaa
     3721 acccaagatg ttgagcagga tgggatgtga ggtctgagcc agcggcagga gggagagcgt
     3781 agacagacag gctagccagg ttgagggtgt ccgccaacca gctctgcagt gacggtgtgc
     3841 acattagaaa gtgggaatgg gaggaacccg tgcctgttac aggagatttg ccggaagagt
     3901 aattatcctt tatctgtcat tttatcaatg aaatgtgaat tttgtattct ccctttggaa
     3961 gcaaatttct gaccccacag tggagctaaa gttggttcag ctccacatcg tagggcccac
     4021 agccataggt cctgtttctg tacaatttgt gctttcatcc cagttgcacg atggctaaag
     4081 gcaatgtgag aaacctttgt ttggctttgg ccgactgggc acacatcctg actgggacct
     4141 ctgaggcaaa tgggaaaaca ctaaaacctc attctctctt gttccaaaac tctagttttt
     4201 ttcaaaactt tacagatttt aaaaaataaa cgatgttttg atgtaaa
//
