LOCUS       NM_021864                812 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus small proline-rich protein 1A (Sprr1a), mRNA.
ACCESSION   NM_021864 XM_001056859 XM_574984
VERSION     NM_021864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Marklund,N., Fulp,C.T., Shimizu,S., Puri,R., McMillan,A.,
            Strittmatter,S.M. and McIntosh,T.K.
  TITLE     Selective temporal and regional alterations of Nogo-A and small
            proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor
            (NgR) occur following traumatic brain injury in the rat
  JOURNAL   Exp Neurol 197 (1), 70-83 (2006)
   PUBMED   16321384
  REMARK    GeneRIF: increases in Nogo-A and SPRR1A in several important brain
            regions suggest that the injured brain is capable of expressing
            proteins promoting axonal outgrowth following traumatic brain
            injury
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Tesfaigzi,Y., Wright,P.S. and Belinsky,S.A.
  TITLE     SPRR1B overexpression enhances entry of cells into the G0 phase of
            the cell cycle
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 285 (4), L889-L898 (2003)
   PUBMED   12832281
  REMARK    GeneRIF: SPRR1B expression pattern in nonsquamous tumors; findings
            indicate SPRR1B likely coupled to signals responsible for
            withdrawal from the proliferative state; overexpression for
            prolonged periods may disrupt normal progression of mitosis
            (sprr1B)
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Lee,C.H., Marekov,L.N., Kim,S., Brahim,J.S., Park,M.H. and
            Steinert,P.M.
  TITLE     Small proline-rich protein 1 is the major component of the cell
            envelope of normal human oral keratinocytes
  JOURNAL   FEBS Lett 477 (3), 268-272 (2000)
   PUBMED   10908733
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Tesfaigzi,J., Th'ng,J., Hotchkiss,J.A., Harkema,J.R. and
            Wright,P.S.
  TITLE     A small proline-rich protein, SPRR1, is upregulated early during
            tobacco smoke-induced squamous metaplasia in rat nasal epithelia
  JOURNAL   Am J Respir Cell Mol Biol 14 (5), 478-486 (1996)
   PUBMED   8624253
REFERENCE   6  (bases 1 to 812)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_574984.3, XM_001056859.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN805093.1, FN805092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                JAXUCZ010000002.1  180752597-180752625 c
            30-812              JAXUCZ010000002.1  180750709-180751491 c
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..812
                     /gene="Sprr1a"
                     /gene_synonym="Spr; Spr1a; Sprr; Sprr1; Sprr1al; Sprr1b"
                     /note="small proline-rich protein 1A"
                     /db_xref="GeneID:499660"
                     /db_xref="RGD:1593163"
     exon            1..29
                     /gene="Sprr1a"
                     /gene_synonym="Spr; Spr1a; Sprr; Sprr1; Sprr1al; Sprr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            30..812
                     /gene="Sprr1a"
                     /gene_synonym="Spr; Spr1a; Sprr; Sprr1; Sprr1al; Sprr1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..507
                     /gene="Sprr1a"
                     /gene_synonym="Spr; Spr1a; Sprr; Sprr1; Sprr1al; Sprr1b"
                     /note="small proline-rich protein 1B (cornifin)"
                     /codon_start=1
                     /product="cornifin-A"
                     /protein_id="NP_068636.1"
                     /db_xref="GeneID:499660"
                     /db_xref="RGD:1593163"
                     /translation="MSSHQQKQPCTVPPQLHQQQVKQPCQPPPQEPCAPKTKEPCHPI
                     PEPCNPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPEPCQPKVPE
                     PCHPKAPEPCHPVVPEPCQPVAPEPCQPVVPEPCPPTVTPSPYQQKTKQK"
ORIGIN      
        1 ctgagagcct gctcttctct gagtattaga accaagtact acctaatcat gagttcccac
       61 cagcagaagc agccttgcac tgtaccccct cagctgcacc agcagcaggt gaaacagcct
      121 tgccagccac caccccagga accttgtgct cccaaaacta aggagccctg tcaccctatt
      181 cctgagccct gcaaccccaa ggtgccagag ccctgccagc ctaaggtgcc agagccttgt
      241 caacctaagg tgccagagcc ttgccagcct aaggtgccag agccttgcca gcctaaggtg
      301 ccagagcctt gccagcctaa ggtgccagag ccctgccagc ctaaggtgcc agagccctgc
      361 catcccaagg cacctgagcc ctgccaccct gttgttcccg agccctgcca gcctgttgct
      421 cctgagccct gccagcctgt tgttcctgaa ccctgccccc caactgtcac tccatcacca
      481 taccagcaga agacaaagca gaagtaatat tgtccatagc caagcctgaa gatctgatca
      541 ccagatgctg aggctgcttt ccatcctgct tatgagtccc attgccttgt gctacacatg
      601 ctgtgacctc cagtcttaat cctccatcct tgcaccacct aaaaagttgt ctctcatcct
      661 catcctcaag agttctcgag ccactcaaca ttacccaaag tctcattgaa tggctaatct
      721 ttccatggct caggattcat ctgaatgggg gtggggaata agacaagtat atgttcaata
      781 ttcttcccct cattaaacac cttttaactc ca
//
