LOCUS       NM_001047089            6471 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus sprouty-related, EVH1 domain containing 1
            (Spred1), mRNA.
ACCESSION   NM_001047089 XM_001080680 XM_230454
VERSION     NM_001047089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6471)
  AUTHORS   Pitzler,L., Auler,M., Probst,K., Frie,C., Bergmeier,V., Holzer,T.,
            Belluoccio,D., van den Bergen,J., Etich,J., Ehlen,H., Zhou,Z.,
            Bielke,W., Poschl,E., Paulsson,M. and Brachvogel,B.
  TITLE     miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment,
            Migration and Intercellular Interaction
  JOURNAL   Stem Cells 34 (5), 1297-1309 (2016)
   PUBMED   26934179
  REMARK    Erratum:[Stem Cells. 2017 Jul;35(7):1866. PMID: 28649792]
REFERENCE   2  (bases 1 to 6471)
  AUTHORS   Zhao,G., Wojciechowski,M.C., Jee,S., Boros,J., McAvoy,J.W. and
            Lovicu,F.J.
  TITLE     Negative regulation of TGFbeta-induced lens epithelial to
            mesenchymal transition (EMT) by RTK antagonists
  JOURNAL   Exp Eye Res 132, 9-16 (2015)
   PUBMED   25576668
REFERENCE   3  (bases 1 to 6471)
  AUTHORS   Friedmacher,F., Gosemann,J.H., Fujiwara,N., Takahashi,H.,
            Hofmann,A. and Puri,P.
  TITLE     Expression of Sproutys and SPREDs is decreased during lung
            branching morphogenesis in nitrofen-induced pulmonary hypoplasia
  JOURNAL   Pediatr Surg Int 29 (11), 1193-1198 (2013)
   PUBMED   23982388
  REMARK    GeneRIF: Decreased expression of Sproutys and SPREDs during the
            terminal pseudoglandular stage may disrupt lung branching
            morphogenesis by interfering with epithelial-mesenchymal
            interactions contributing to PH.
REFERENCE   4  (bases 1 to 6471)
  AUTHORS   van Mil,A., Vrijsen,K.R., Goumans,M.J., Metz,C.H., Doevendans,P.A.
            and Sluijter,J.P.
  TITLE     MicroRNA-1 enhances the angiogenic differentiation of human
            cardiomyocyte progenitor cells
  JOURNAL   J Mol Med (Berl) 91 (8), 1001-1012 (2013)
   PUBMED   23625462
REFERENCE   5  (bases 1 to 6471)
  AUTHORS   Jakob,P., Doerries,C., Briand,S., Mocharla,P., Krankel,N.,
            Besler,C., Mueller,M., Manes,C., Templin,C., Baltes,C., Rudin,M.,
            Adams,H., Wolfrum,M., Noll,G., Ruschitzka,F., Luscher,T.F. and
            Landmesser,U.
  TITLE     Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells
            from patients with chronic heart failure: role for impaired in vivo
            neovascularization and cardiac repair capacity
  JOURNAL   Circulation 126 (25), 2962-2975 (2012)
   PUBMED   23136161
REFERENCE   6  (bases 1 to 6471)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   7  (bases 1 to 6471)
  AUTHORS   Fish,J.E., Santoro,M.M., Morton,S.U., Yu,S., Yeh,R.F., Wythe,J.D.,
            Ivey,K.N., Bruneau,B.G., Stainier,D.Y. and Srivastava,D.
  TITLE     miR-126 regulates angiogenic signaling and vascular integrity
  JOURNAL   Dev Cell 15 (2), 272-284 (2008)
   PUBMED   18694566
REFERENCE   8  (bases 1 to 6471)
  AUTHORS   Wang,S., Aurora,A.B., Johnson,B.A., Qi,X., McAnally,J., Hill,J.A.,
            Richardson,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     The endothelial-specific microRNA miR-126 governs vascular
            integrity and angiogenesis
  JOURNAL   Dev Cell 15 (2), 261-271 (2008)
   PUBMED   18694565
REFERENCE   9  (bases 1 to 6471)
  AUTHORS   Johne,C., Matenia,D., Li,X.Y., Timm,T., Balusamy,K. and
            Mandelkow,E.M.
  TITLE     Spred1 and TESK1--two new interaction partners of the kinase
            MARKK/TAO1 that link the microtubule and actin cytoskeleton
  JOURNAL   Mol Biol Cell 19 (4), 1391-1403 (2008)
   PUBMED   18216281
REFERENCE   10 (bases 1 to 6471)
  AUTHORS   Kato,R., Nonami,A., Taketomi,T., Wakioka,T., Kuroiwa,A., Matsuda,Y.
            and Yoshimura,A.
  TITLE     Molecular cloning of mammalian Spred-3 which suppresses tyrosine
            kinase-mediated Erk activation
  JOURNAL   Biochem Biophys Res Commun 302 (4), 767-772 (2003)
   PUBMED   12646235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001047089.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1622304.1,
                                           SRR26643429.12818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-876               JAXUCZ010000003.1  124437230-124438105
            877-1051            JAXUCZ010000003.1  124475899-124476073
            1052-1220           JAXUCZ010000003.1  124488089-124488257
            1221-1270           JAXUCZ010000003.1  124489674-124489723
            1271-1429           JAXUCZ010000003.1  124493662-124493820
            1430-1531           JAXUCZ010000003.1  124497258-124497359
            1532-6471           JAXUCZ010000003.1  124499419-124504358
FEATURES             Location/Qualifiers
     source          1..6471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..6471
                     /gene="Spred1"
                     /note="sprouty-related, EVH1 domain containing 1"
                     /db_xref="GeneID:296072"
                     /db_xref="RGD:1308735"
     exon            1..876
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
     CDS             845..2179
                     /gene="Spred1"
                     /note="sprouty protein with EVH-1 domain 1, related
                     sequence"
                     /codon_start=1
                     /product="sprouty-related, EVH1 domain-containing protein
                     1"
                     /protein_id="NP_001040554.1"
                     /db_xref="GeneID:296072"
                     /db_xref="RGD:1308735"
                     /translation="MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSIVTV
                     FRVPQQEENGCADFYIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLT
                     FQSPADARAFDRGIRRAIEDISQGCPASKTETEGGDDDLQTTEEDTSRSLVKDHFFQQ
                     ETVVTCDPYRSSDIRPLPFEDLNARRVYLQSQVSQIPFCQQGLDIQSRSMEYVQRQIS
                     KECGSLKSQARVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDD
                     TDSSVPFSKQDSKKSDYFYHCGDETKLSSLKDSVVFKTQPPSLKFKSKRRKEDGERSR
                     CVYCQERFNHEENGRGKCQDAPDPVKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCS
                     CDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG"
     exon            877..1051
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1220
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1270
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1429
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1531
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..6471
                     /gene="Spred1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgattcga ctgcgggccg cggctttcag gtctccccca cccctcagag gccccgcgcc
       61 tccggctcgc agccgtgccc cacgtcctcc cgcctgctcc cgcgcgagcc ccgccgcccc
      121 agaaatcgcg agggactact tcgcctgcct ctcccgcggg cgcccccggt tcgagcggcg
      181 gaaggagcgg gcggcgtgag cgcttccgcc gcccccctcg cggctcccct ctcgcgggcg
      241 tgaggagcgg gcagcggagc tgcgctggtc tcggccctcc tcaccgctgc tcggcactgt
      301 gccctcgggc tccgacactc gcctcgcgcc ctgtctgcgg cccccagctg gagcgcgtct
      361 gagggagccc ctgagggccg accaggcgcg ccgcgcgggc agccggcggc caggcgggag
      421 atggtgcgcg gcacctcggg accgcgccgc ctcccgcagc cagcgctcgg ctgcccccag
      481 ccggctcccg ccgcccgccc gtcgccgcgc ccctgagagc agcaccgcct tagccaccga
      541 ccgagttccc tcagcgccct cagtcgcccg caccgtctcg gcttcgcacc cgacctcggc
      601 gcggcgaacc gctggggtcg ccacggccgc gctcgccgcc gccgcccccc tgcgggggtg
      661 gccgggctgc ccagctcgta gggcgccgct ccgggtgagg cgtccaccat ggtgaggccc
      721 ccgagccgct gcccgcgcgc cccgccggcc gtcgtcgccc gctgcccctc ggtgccaccg
      781 ctgccgctgc ttccccgcct gctgttgctc ctccatctcc tgagcggatc acggtgaggg
      841 aaagatgagc gaggagacgg cgacttctga caacgataat agttatgcac gagtgcgagc
      901 tgtggtgatg accagagatg actcaagtgg tggatggcta ccactcggag ggagcggact
      961 gagcattgtc actgtcttca gagtccctca gcaggaagag aatggctgtg cagactttta
     1021 tatccgtgga gagagactca gagacaaaat ggtggttttg gaatgtatgc ttaagaaaga
     1081 cctcatctat aataaggtca ctcccacttt tcaccactgg aagatcgatg acaagaagtt
     1141 tggccttacc tttcagagtc ctgctgatgc cagggctttt gatcgaggca ttcgaagagc
     1201 tatagaagat atttctcaag ggtgcccagc atcaaaaact gagactgaag gaggagatga
     1261 tgatttacaa acaactgagg aggacacttc ccgttccctg gtgaaagatc acttttttca
     1321 gcaagagaca gttgttacct gtgatcctta cagaagctca gacataagac cattaccctt
     1381 tgaagatctg aatgccagaa gagtctactt gcaaagccaa gtgagccaga taccattttg
     1441 tcagcaaggc ctagacatac agagccgaag tatggaatat gtacagcggc agatatctaa
     1501 ggaatgtggg agcctcaagt cccaagctag ggtccccttg aagtctatca gacatgtcag
     1561 ctttcaagat gaggatgaga ttgttagaat aaatcctcga gatatcttaa tacgtcggta
     1621 tgcagactac agacatccgg acatgtggaa aaatgacttg gagagagatg atactgactc
     1681 cagtgttcca ttttctaaac aagacagtaa aaagtcagac tatttctacc actgtgggga
     1741 tgagactaag ttaagttctc tgaaagactc tgtggtattt aagacacagc ctccctcatt
     1801 aaaatttaag tcaaaacgaa gaaaagagga tggggaacgt tctcgctgcg tgtactgcca
     1861 ggaaaggttt aatcatgaag aaaatggcag ggggaaatgc caggatgctc cagatcctgt
     1921 taaaagatgc atatatcaag ttagttgcat gctctgtgcc gagagcatgc tgtatcattg
     1981 tatgtcagac tcagagggag acttttctga cccttgttcg tgtgacacta gcgatgacaa
     2041 gttctgccta aggtggttag ccctggtagc tctgtctttc attgtaccgt gtatgtgctg
     2101 ctacgtccct ttgagaatgt gccatcgctg tggtgaggca tgtgggtgct gtggtgggaa
     2161 acacaaggct gctgggtgaa gcagtccagg ccggcatgag cttgaaacct tcatctccag
     2221 gaattagcta acttggattt gtggaagctg ttggcaggca atatggaatc ttgcctggta
     2281 tcattggggc catgtgtgga ggaagcagaa ctcgtcagtt cttgtgattt acagatgcta
     2341 gccatgcctg atgttttccc tgagtgcatg gcatgttctg ggacagatca tagagcattt
     2401 acaaaaagaa gtcatttctg gttattgact acaaaaggtc aacatagaat atgatccaac
     2461 taaaagggat taattttggc atttttatat ttatgcacta ggtgatggga cttttaaaga
     2521 tttgaattct ttaggacatt aactaaaaag tgcactaaga gatggtgatt tcagtacaga
     2581 aaagttagta cttgggaaat tgagaaaaca agtgcaacta aatcattagt tgttttctga
     2641 aagcagtttt atgtataaat aacaaatgtt tatatttaac taaatgtaag gtacgaacta
     2701 tgacatatta aacttttctt gcccttccta gctctgaggt agatgtgcac acatctgcca
     2761 ccacattcca tatgtgttga gtatttaact catctagtta ataacgtttg tatccatgtg
     2821 aaggatttgg taagttcatc ctcacttctc tttggctgcg gtttatactg agttatgtct
     2881 gtacattctg gaagtctaaa atctttaaaa tactctaata gccttgagtg accaactttt
     2941 ttttaaagca cagatgtaat tgtctaatgt tctgatggaa atgtaacact tatttttata
     3001 taaagaaact gagtaaacat agaagaaagc gagggttctt ttagttgctg tttctgtggt
     3061 attcaaccag caagttgttt cctttcagag tttcctcctt cagagaactg catttatagc
     3121 cgttttacaa ggcagaagca ttaactggat agttagtgtg aaacagtttc cacttgagat
     3181 ctccgtttat cattctgcta agccagaatg tgcacagctg tttcactgat gttctgagct
     3241 taaccctctg tgcttattac tcacataaca atggattacc tttcagttgc attttattat
     3301 attccaggag caaactcact ttgcattaac acgtacacag aactctccca ggaagaaagt
     3361 attcaatcca ccattgtgaa tggaaatctc gtatatcaca ttcctgtcgc agagcatttg
     3421 tattatagga tatttgagtt acagagtggt gtgatatgtt ccaacaaaca agttaaaagt
     3481 attttgaggt caaattgtct ttaagtgtta cattaaaact ctaacctgtg agggattctt
     3541 tcaaaatact cccttaggaa agaaagttaa gcagtgtgcc ttttttgctt tttttttttt
     3601 ttttttttaa tggcttacag tttctggagt gatagaaatg aaaatcacac taccatttga
     3661 agttcattct acaggttttc agtgtcattt ctgtacagtg catttaatgt gtcacactta
     3721 ggcttgtgtt ggctttcttc ttttgcccca gatcaaactg aacgatgtat atataacact
     3781 atctgtctgt aaaatacttt ttttaagaaa gcatttatat ttatatgaca gcttgaactg
     3841 acaacattat gtatatagat catcttgaag tattatttca cattgaaaag aagaaaaata
     3901 tattgataac tatagatgtt atgaagaaga ggctatttct agttttgtac taaaaatcaa
     3961 ttggatgaac taaatccaaa accggacact gtagcagcaa ctttcagtct tatttttact
     4021 gtttctatat tggaggctgc tacacagata gatgatcttc atccttggcg ttttcagata
     4081 aacttggttt cctagagcag actgttaact ttcaaaattc ctttttattg ctgaaataga
     4141 atactggttt tccttatgag tggttattca tatttgtaag ttctgggttt ataattcagg
     4201 ttggagcaag gtatgaataa ctaaagaaaa taacttgctg gcaatatagg aaatgccatg
     4261 gagatgaact gtgtatatac ttctgagaag agtaaaatta atcatttttt tttctgttaa
     4321 gcactagtca ctatagtgca tctcctggtt ctgtactgta ttttatacgc aacgtacatg
     4381 ctttaatatt ttaatgtttg tgcattaata ttttcagttt gtttaaccac tttgctgcta
     4441 agattttgcc atcccgttcc catttttttt cctttacaat tttaaacatt tcttttcatt
     4501 aaaaactatg ataatgaaat tgggtttttt tttttttact ttgatttttg taattagcac
     4561 acatgaattc aagcagtcca gaaaagaaac tgatgatgta atgttattga gtccctttgt
     4621 gaattagatg gaccgtttaa tccaattcca aacatgtgca ggtggattca agaatgattt
     4681 ctttttgctg tacagatttg gcactgccat tgggcatttt ctttaaaact tctctttttg
     4741 tctaaagttt cagcagatgg ctcagaaaaa ctggtaaagt aaaagtaaat attgaaaatg
     4801 aatcatctga atggcatgac cagaaaattc tccacctgtc gtgcttcttt gctcagaatc
     4861 aggagttgtc agaggatgct tgtggcttat ggggagcctt tgatttcttg agcaggaatg
     4921 ctgtggagct ccatcgccac ctgctggatg attttagacc ggcactgaaa gatggggatg
     4981 gtgtcgccta gtaaaggggg ctgttcaggg tagcttctgc ccaccagaga aatcaggggt
     5041 aggaacagct cataggaatg taagtaaatc tttccccaaa tgcatatggt tgccgaaagg
     5101 ttttaagcac ttttttctta cacatcctgt tttaaaatat tcattgatac ttggcactgg
     5161 cagtcaaaca tccgtgtgta ctgaagcatt gatacagcca gttccttaac tcagaagcca
     5221 ttaccaaaac ggtattcttg tttccttccc agcaacagtc aggcagaaat tttttaaaca
     5281 tagttacctg tattttatca tgacaactcc agagagtatg tatgtttctg agtagatgtt
     5341 gatgaggcag gacttaaaat ttcaagagaa aaacttgaaa ctacctattt tcattggtta
     5401 ttcagcagtg cctaaattga gcttctgaag taacgcagtg cactttcagt ccgtgtgtat
     5461 agtgccatct aattctttgg gcgaacctcg ctttccccct ccctccctct cttcccttca
     5521 gtggcacata ggcatttctt agtgttcatg tcagtcttca aagtgcagaa aacgtggcgg
     5581 ggagaatttt atggattttt cttatgttga agtggaatgt ctgattatat ttgcaacatg
     5641 taacttggat taatgtattt taaagtaatt ttaattgtag tccaacaatg cattgagcaa
     5701 gtgtaacttt tttctgaaaa ataacttgga gaactttagt taaccgataa aaccaattca
     5761 tcactaaatg tcgctcttac tcttgatttg atccagatca catttctgcg tcttacagga
     5821 aacaccaaaa agtggttaat aaatgacagt agagccatag gtgagtcaaa cagaaaatat
     5881 taaagatgtg cacacacaga aaggcagaag tgatttattc aaaccaaaag gtaggtggag
     5941 agggaacgaa ccttacaggg gatgtaaggt tctagttacc tagcagctgg gcaattagaa
     6001 acctttcagt tgctttgctg cactcttatc cattgttccc aaaagataaa cttgcagaaa
     6061 gttacaagtt ttttaatttt ttcaagaata atttagtcgg aagcctttgt attaaagatg
     6121 cacagatttt tgtgtgagca ggttttttgt gaacaagtgt gcagtacatt ctgctttctg
     6181 tcttcttgac ttcagaagtg cctcacttgt atatgacccc cactaggaac ctgactgcat
     6241 cttactagta accagtggaa gcccgcttaa ctcctgtcct agtgcatctc cccatataga
     6301 gccaactggc tgagagttgt gagtatataa tgtaaatatg cacatctgag tttgtaactg
     6361 cttttgttcc gtcatatcat gtaattggac atatcagatg gtagacttat ttgtttcagt
     6421 gatttctcct cccctggaat tacccgatta aaccaaatca tgaaatttaa a
//
