LOCUS       NM_019181               1204 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus sepiapterin reductase (Spr), mRNA.
ACCESSION   NM_019181 XM_001069367 XM_342714
VERSION     NM_019181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Mehri,M., Gheitasi,R., Pourbagher,R., Ranaee,M., Nayeri,K.,
            Rahimi,S.M., Khorasani,H.R., Hossein-Nattaj,H., Sabour,D.,
            Akhavan-Niaki,H., Fattahi,S., Kalali,B. and Mostafazadeh,A.
  TITLE     Ninety-six-hour starved peripheral blood mononuclear cell
            supernatant inhibited LA7 breast cancer stem cells induced tumor
            via reduction in angiogenesis and alternations in Gch1 and Spr
            expressions
  JOURNAL   Front Immunol 13, 1025933 (2023)
   PUBMED   36908807
  REMARK    GeneRIF: Ninety-six-hour starved peripheral blood mononuclear cell
            supernatant inhibited LA7 breast cancer stem cells induced tumor
            via reduction in angiogenesis and alternations in Gch1 and Spr
            expressions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Yang,S., Lee,Y.J., Kim,J.M., Park,S., Peris,J., Laipis,P.,
            Park,Y.S., Chung,J.H. and Oh,S.P.
  TITLE     A murine model for human sepiapterin-reductase deficiency
  JOURNAL   Am J Hum Genet 78 (4), 575-587 (2006)
   PUBMED   16532389
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Franscini,N., Bachli,E.B., Blau,N., Fischler,M., Walter,R.B.,
            Schaffner,A. and Schoedon,G.
  TITLE     Functional tetrahydrobiopterin synthesis in human platelets
  JOURNAL   Circulation 110 (2), 186-192 (2004)
   PUBMED   15197144
REFERENCE   6  (bases 1 to 1204)
  AUTHORS   Fujimoto,K., Ichinose,H., Nagatsu,T., Nonaka,T., Mitsui,Y. and
            Katoh,S.
  TITLE     Functionally important residues tyrosine-171 and serine-158 in
            sepiapterin reductase
  JOURNAL   Biochim Biophys Acta 1431 (2), 306-314 (1999)
   PUBMED   10350607
REFERENCE   7  (bases 1 to 1204)
  AUTHORS   Auerbach,G., Herrmann,A., Gutlich,M., Fischer,M., Jacob,U.,
            Bacher,A. and Huber,R.
  TITLE     The 1.25 A crystal structure of sepiapterin reductase reveals its
            binding mode to pterins and brain neurotransmitters
  JOURNAL   EMBO J 16 (24), 7219-7230 (1997)
   PUBMED   9405351
REFERENCE   8  (bases 1 to 1204)
  AUTHORS   Oyama,R., Katoh,S., Sueoka,T., Suzuki,M., Ichinose,H., Nagatsu,T.
            and Titani,K.
  TITLE     The complete amino acid sequence of the mature form of rat
            sepiapterin reductase
  JOURNAL   Biochem Biophys Res Commun 173 (2), 627-631 (1990)
   PUBMED   2260974
REFERENCE   9  (bases 1 to 1204)
  AUTHORS   Citron,B.A., Milstien,S., Gutierrez,J.C., Levine,R.A., Yanak,B.L.
            and Kaufman,S.
  TITLE     Isolation and expression of rat liver sepiapterin reductase cDNA
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6436-6440 (1990)
   PUBMED   2201030
REFERENCE   10 (bases 1 to 1204)
  AUTHORS   Levine,R.A., Kapatos,G., Kaufman,S. and Milstien,S.
  TITLE     Immunological evidence for the requirement of sepiapterin reductase
            for tetrahydrobiopterin biosynthesis in brain
  JOURNAL   J Neurochem 54 (4), 1218-1224 (1990)
   PUBMED   2179471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 7, 2023 this sequence version replaced NM_019181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225911.1, FQ211209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               JAXUCZ010000004.1  119232856-119233179 c
            325-615             JAXUCZ010000004.1  119232246-119232536 c
            616-1204            JAXUCZ010000004.1  119229447-119230035 c
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1204
                     /gene="Spr"
                     /note="sepiapterin reductase"
                     /db_xref="GeneID:29270"
                     /db_xref="RGD:3753"
     exon            1..324
                     /gene="Spr"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..806
                     /gene="Spr"
                     /EC_number="1.1.1.153"
                     /note="sepiapterin reductase (7,8-dihydrobiopterin:NADP+
                     oxidoreductase)"
                     /codon_start=1
                     /product="sepiapterin reductase"
                     /protein_id="NP_062054.1"
                     /db_xref="GeneID:29270"
                     /db_xref="RGD:3753"
                     /translation="MEGGRLGCAVCVLTGASRGFGRALAPQLAGLLSPGSVLLLSARS
                     DSMLRQLKEELCTQQPGLQVVLAAADLGTESGVQQLLSAVRELPRPERLQRLLLINNA
                     GTLGDVSKGFLNINDLAEVNNYWALNLTSMLCLTTGTLNAFSNSPGLSKTVVNISSLC
                     ALQPFKGWGLYCAGKAARDMLYQVLAVEEPSVRVLSYAPGPLDTNMQQLARETSMDPE
                     LRSRLQKLNSEGELVDCGTSAQKLLSLLQRDTFQSGAHVDFYDI"
     exon            325..615
                     /gene="Spr"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1204
                     /gene="Spr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtctgagt tccaggcatg gaaggaggca ggctaggttg cgctgtctgc gtgctgaccg
       61 gggcttcccg gggcttcggc cgcgccctgg ccccgcagct ggccgggttg ctgtcgcccg
      121 gttcggtgtt gcttctaagc gcacgcagtg actcgatgct gcggcaactg aaggaggagc
      181 tctgtacgca gcagccgggc ctgcaagtgg tgctggcagc cgccgatttg ggcaccgagt
      241 ccggcgtgca acagttgctg agcgcggtgc gcgagctccc taggcccgag aggctgcagc
      301 gcctcctgct catcaacaat gcaggcactc ttggggatgt ttccaaaggc ttcctgaaca
      361 tcaatgacct agctgaggtg aacaactact gggccctgaa cctaacctcc atgctctgct
      421 tgaccaccgg caccttgaat gccttctcca atagccctgg cctgagcaag actgtagtta
      481 acatctcatc tctgtgtgcc ctgcagccct tcaagggctg gggactctac tgtgcaggga
      541 aggctgcccg agacatgtta taccaggtcc tggctgttga ggaacccagt gtgagggtgc
      601 tgagctatgc cccaggtccc ctggacacca acatgcagca gttggcccgg gaaacctcca
      661 tggacccaga gttgaggagc agactgcaga agttgaattc tgagggggag ctggtggact
      721 gtgggacttc agcccagaaa ctgctgagct tgctgcaaag ggacaccttc caatctggag
      781 cccacgtgga cttctatgac atttaagccc atgtcctgtc acagtgcccc ccccccctca
      841 gccctgccta acacacatac aagccctcca acccagccag cggggagcca cgggcactgc
      901 cagtcctgag aaggcttctg cagaggctcg ggagagagct gatgtgtact ggagtcctct
      961 gtccccagga agagaactta gggctgggag agcaggagaa gcagaaacac tgagcagatg
     1021 aggcagagtc tctcgtctgt ggtcgttctc aggtgaagag ggcggggtct gattcacaga
     1081 gaggaccgag ggtattgaat ctttgttgta ctgccttcat cctggggtat tcactggtcc
     1141 tccctcgact ctggtcaaat acatggttat ggggcagatg ccctagagtg tgggctgtcc
     1201 ttca
//
