LOCUS       NM_001107770            2173 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus signal peptide peptidase-like 2A (Sppl2a), mRNA.
ACCESSION   NM_001107770 XM_001081083 XM_230567
VERSION     NM_001107770.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2173)
  AUTHORS   Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P and
            Schroder B.
  TITLE     Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to
            lysosomes/late endosomes by a tyrosine motif in its C-terminal tail
  JOURNAL   FEBS Lett 585 (19), 2951-2957 (2011)
   PUBMED   21896273
REFERENCE   2  (bases 1 to 2173)
  AUTHORS   Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P and Haass C.
  TITLE     Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and
            SPPL2a/SPPL2b
  JOURNAL   J Biol Chem 283 (3), 1644-1652 (2008)
   PUBMED   17965014
REFERENCE   3  (bases 1 to 2173)
  AUTHORS   Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H,
            Elsasser HP, Mann M and Hasilik A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   4  (bases 1 to 2173)
  AUTHORS   Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Luckerath K,
            Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO and Zornig M.
  TITLE     The Fas ligand intracellular domain is released by ADAM10 and
            SPPL2a cleavage in T-cells
  JOURNAL   Cell Death Differ 14 (9), 1678-1687 (2007)
   PUBMED   17557115
REFERENCE   5  (bases 1 to 2173)
  AUTHORS   Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S,
            Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G and Martoglio B.
  TITLE     SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in
            activated dendritic cells to trigger IL-12 production
  JOURNAL   Nat Cell Biol 8 (8), 843-848 (2006)
   PUBMED   16829952
REFERENCE   6  (bases 1 to 2173)
  AUTHORS   Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E,
            Bohland C, Imhof A, Martoglio B, Teplow DB and Haass C.
  TITLE     A gamma-secretase-like intramembrane cleavage of TNFalpha by the
            GxGD aspartyl protease SPPL2b
  JOURNAL   Nat Cell Biol 8 (8), 894-896 (2006)
   PUBMED   16829951
REFERENCE   7  (bases 1 to 2173)
  AUTHORS   Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G
            and Martoglio B.
  TITLE     Consensus analysis of signal peptide peptidase and homologous human
            aspartic proteases reveals opposite topology of catalytic domains
            compared with presenilins
  JOURNAL   J Biol Chem 279 (49), 50790-50798 (2004)
   PUBMED   15385547
REFERENCE   8  (bases 1 to 2173)
  AUTHORS   Petroff OA, Novotny EJ, Ogino T, Avison M and Prichard JW.
  TITLE     In vivo measurements of ethanol concentration in rabbit brain by 1H
            magnetic resonance spectroscopy
  JOURNAL   J Neurochem 54 (4), 1188-1195 (1990)
   PUBMED   2313285
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081083.1, XM_230567.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760476
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2173
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2173
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /note="signal peptide peptidase-like 2A"
                     /db_xref="GeneID:311401"
                     /db_xref="RGD:1563001"
     exon            1..287
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1793
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /EC_number="3.4.23.-"
                     /codon_start=1
                     /product="signal peptide peptidase-like 2A precursor"
                     /protein_id="NP_001101240.1"
                     /db_xref="GeneID:311401"
                     /db_xref="RGD:1563001"
                     /translation="MGLLHSLHAPAAALLWSCLLGLSAAQEAILHASANGVSSLSKDY
                     CMYYNNNWTRLPSSLENATSLSLMNLTGTPLCHLSDIPPDGIKNKAVVVHWGPCHFLE
                     KAKIAQEGGAAALLIANNSVLIPSSRNKSAFQNVTILIAVITQKDFNDMKETLGDDIT
                     VKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKED
                     YLTFSPLTVVLFVVICCVMIVLLYFFYKWLVYVMIAIFCIASATSLYNCLAALIHRMP
                     CGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIK
                     TMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIR
                     VPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVG
                     MIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDYST
                     NEENPAATDEQIVQQ"
     exon            288..407
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            408..590
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            591..680
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            681..814
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            815..966
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1063
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1165
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1247
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1322
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1379
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1482
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1557
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1718
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2173
                     /gene="Sppl2a"
                     /gene_synonym="RGD1563001"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacctgaagc tccagtggct tggaatgggc ggcggccgca gttaagggga accgaacgag
       61 aacccggggt ttacgcagct agaaagactg ccaggagctg acagtcccca cagagtcccg
      121 gcccagcgtt ccgcgggagg aaccggaaga ggaagtcggg gctgcaccct agaggtccgg
      181 gtgctgccag cgcagcctgc gcctagctgc ccgcccgtgg gatggggttg ctgcactcgc
      241 tgcacgctcc cgctgctgcc ctgctgtgga gctgcctgct cggactgtca gctgctcagg
      301 aagccatcct tcatgcatct gcaaatggcg tatcttcact ttccaaggac tactgcatgt
      361 attataacaa caactggaca cggcttccaa gttccctaga aaatgcaact tctcttagct
      421 tgatgaatct gactggcaca ccactgtgcc acctttctga tattcctcct gatggcataa
      481 agaacaaggc agtggtggta cactggggac cctgccattt tcttgaaaaa gccaaaattg
      541 cacaggaagg tggtgctgca gcgttgctga ttgccaacaa cagtgtccta attccttcct
      601 caaggaacaa atctgcattt caaaatgtga ctatactaat tgcagttata acccaaaaag
      661 actttaatga tatgaaagag actcttggag atgacattac cgtgaaaatg tattctccat
      721 cctggcctaa ctttgactat actctggtgg tcatttttgt aattgctgtg ttcactgtgg
      781 cattaggagg atactggagt ggacttattg aattggaaag catgaaggca gtggaagatg
      841 ctgaagatag agaggcaagg aaaaagaagg aagactactt aacattcagt cctctcaccg
      901 ttgtcctgtt cgtggtcatc tgctgtgtaa tgattgtctt actgtatttc ttctacaagt
      961 ggcttgttta tgttatgata gcaattttct gcatagcatc agcaacgagc ttgtataact
     1021 gtctcgctgc attgattcat cggatgccat gtggacagtg cacgattttg tgttgtggca
     1081 aaaacattaa agtgagcctg attttccttt ctggactgtg catctcagtt gctgttgtgt
     1141 gggctgtgtt tcgaaatgag gacaggtggg cttggatttt acaggatatc ttaggaattg
     1201 ctttctgtct caacttaatt aaaacaatga agttacccaa tttcatgtca tgtgtgatac
     1261 tgctaggtct tctcctcatc tacgacgtgt tctttgtctt cataacacca ttcatcacaa
     1321 agaatggaga gagcatcatg gtggaacttg ctgctgggcc tttcgagaat gctgaaaagt
     1381 tgccagtagt tatcagggtg ccaaagctca tggattactc agtcatgagt gtgtgctcag
     1441 tgcccgtttc agtgctgggg ttcggagata tcattgttcc aggtctgttg attgcatatt
     1501 gtagaagatt tgatgttcag actggttctt ctatatacta tatatcatct acaattgcct
     1561 atgctgttgg catgataatt acctttgtgg tcctaatggt gatgaagaca ggacagcctg
     1621 ctctcctcta tttagtacct tgtacactta ttactgcctc aatcgttgct tggagtcgta
     1681 aggaaatgaa aaagttctgg aaaggtagca gctaccaggt gatggactac ctggactatt
     1741 caacaaatga agaaaaccca gcagctactg acgagcagat tgtacaacag taatacgtgg
     1801 acttataatg atgtgttttt gattttctac aaatagattt tggccttttt tgtctttttt
     1861 tctttttctt ttttgttctt ggagacaaga gtcaggactg gagttcaatc ccctgccttt
     1921 gcctcccaaa ggtttgggac tatagctggg taacaccaca cccagcaaga tttgagtcaa
     1981 agtttggatt gaaaactggg aacatttaca gcgatgtttg caaacccata tgtttttatg
     2041 agctggtgaa atcccatgct acatagtgaa aatgcatttt cttttaatta tgttaaagtt
     2101 gtgccttcac aatcagttaa aaacataggg tttatgtagt ttccaaaatg tattatatac
     2161 attatatttt tct
//
