LOCUS       NM_053577                947 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus secreted phosphoprotein 2 (Spp2), mRNA.
ACCESSION   NM_053577 XM_343622
VERSION     NM_053577.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Bennett,C.S., Khorram Khorshid,H.R., Kitchen,J.A., Arteta,D. and
            Dalgleish,R.
  TITLE     Characterization of the human secreted phosphoprotein 24 gene
            (SPP2) and comparison of the protein sequence in nine species
  JOURNAL   Matrix Biol 22 (8), 641-651 (2004)
   PUBMED   15062857
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Price,P.A., Nguyen,T.M. and Williamson,M.K.
  TITLE     Biochemical characterization of the serum fetuin-mineral complex
  JOURNAL   J Biol Chem 278 (24), 22153-22160 (2003)
   PUBMED   12676928
REFERENCE   4  (bases 1 to 947)
  AUTHORS   Kanematsu,T., Misumi,Y., Watanabe,Y., Ozaki,S., Koga,T.,
            Iwanaga,S., Ikehara,Y. and Hirata,M.
  TITLE     A new inositol 1,4,5-trisphosphate binding protein similar to
            phospholipase C-delta 1
  JOURNAL   Biochem J 313 (Pt 1) (Pt 1), 319-325 (1996)
   PUBMED   8546702
REFERENCE   5  (bases 1 to 947)
  AUTHORS   Hu,B., Coulson,L., Moyer,B. and Price,P.A.
  TITLE     Isolation and molecular cloning of a novel bone phosphoprotein
            related in sequence to the cystatin family of thiol protease
            inhibitors
  JOURNAL   J Biol Chem 270 (1), 431-436 (1995)
   PUBMED   7814406
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10359]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088193.1.
            
            On Jan 3, 2005 this sequence version replaced XM_343622.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088193.1, FQ210198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132267, SAMD00132286
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..947
                     /gene="Spp2"
                     /note="secreted phosphoprotein 2"
                     /db_xref="GeneID:94168"
                     /db_xref="RGD:708488"
     exon            1..217
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..762
                     /gene="Spp2"
                     /note="secreted phosphoprotein 24; secreted phosphoprotein
                     2, 24kDa; spp-24"
                     /codon_start=1
                     /product="secreted phosphoprotein 24 precursor"
                     /protein_id="NP_446029.1"
                     /db_xref="GeneID:94168"
                     /db_xref="RGD:708488"
                     /translation="MELATMKTLVMLVLGMHYWCASGFPVYDYDPSSLQEALSASVAK
                     VNSQSLSPYLFRATRSSLKRVNVLDEDTLVMNLEFTVQETTCLRESGDPSTCAFQRGY
                     SVPTAACRSTVQMSKGQVKDVWAHCRWASTSESNSSEEMIFGDMARSHRRRNDYLLGF
                     LYDEPKGEQFYDRSIEITRRGHPPAHRRFLNLQRRARVNSGFE"
     exon            218..342
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..462
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..570
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..625
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..676
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..772
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..879
                     /gene="Spp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgacacgg gaatcaatca tctctactga ggttccagac tgcttcagcc agccagggca
       61 gctaggtcgc aggtgacaag gataagacag tcaccctcgg aaagagctgt agagaggcca
      121 tctccttggc tctgggtcgc cgtcctcggg atggagctgg caacgatgaa gacgctggtt
      181 atgttggtgc tgggaatgca ctactggtgt gcctcaggtt tcccggtgta cgactacgac
      241 ccttcctctc tgcaagaagc tctcagtgcc tcagtggcta aggtgaactc gcaatccctg
      301 agtccttacc tgtttcgggc gacgcggagc tccctgaaga gagttaatgt cctggatgaa
      361 gacacactgg tcatgaactt agagttcacc gttcaggaaa ctacatgcct aagagagtct
      421 ggtgatccct ccacctgcgc cttccaaagg ggctactctg tgccaacagc tgcttgcagg
      481 agcacagtgc agatgtccaa gggacaggtg aaggatgtgt gggctcactg ccgctgggcg
      541 tccacatccg agtccaacag cagtgaggag atgatttttg gggacatggc aagatcccac
      601 cgacgaagaa atgattatct acttggcttt ctttatgatg aacccaaagg tgagcagttc
      661 tatgaccggt cgattgagat cacgaggagg ggacatcctc ctgcccatag aaggttcctg
      721 aacctccaac gcagagcaag agtcaattct ggctttgagt gacatcctgg agattccatg
      781 aaagaaagag aagcagaagc tgaaatgaag gacatggaga attgtgtctt tttcctttga
      841 taagctccac tttgcaataa agatcttccc cttcctgtaa aaaaaaaaaa aaaaaaaaaa
      901 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
