LOCUS       NM_012881               1503 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus secreted phosphoprotein 1 (Spp1), mRNA.
ACCESSION   NM_012881
VERSION     NM_012881.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1503)
  AUTHORS   Xie,H., Lu,F., Li,X., Wang,E., Mo,J. and Liang,W.
  TITLE     Silencing of secreted phosphoprotein 1 attenuates sciatic nerve
            injury-induced neuropathic pain: Regulating extracellular
            signal-regulated kinase and neuroinflammatory signaling pathways
  JOURNAL   Immun Inflamm Dis 12 (2), e1132 (2024)
   PUBMED   38415922
  REMARK    GeneRIF: Silencing of secreted phosphoprotein 1 attenuates sciatic
            nerve injury-induced neuropathic pain: Regulating extracellular
            signal-regulated kinase and neuroinflammatory signaling pathways.
REFERENCE   2  (bases 1 to 1503)
  AUTHORS   Yu,G., Wang,X., Luo,J., Su,X., Tao,H., Wen,Z. and Guan,H.
  TITLE     [Role of SPP1 in acute kidney injury induced by renal
            ischemia-reperfusion in rats]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (11), 1947-1954 (2023)
   PUBMED   38081614
  REMARK    GeneRIF: [Role of SPP1 in acute kidney injury induced by renal
            ischemia-reperfusion in rats].
REFERENCE   3  (bases 1 to 1503)
  AUTHORS   Ji,W., Sun,Z., Yang,Y., Hu,M., Zhang,Q., Fu,J., Chen,J., Huang,Y.
            and Cheng,Y.
  TITLE     Downregulation of RUNX1-Activated Osteopontin Facilitates Burn
            Wound Healing by Activating the MAPK Pathways
  JOURNAL   J Burn Care Res 44 (6), 1371-1381 (2023)
   PUBMED   36913234
  REMARK    GeneRIF: Downregulation of RUNX1-Activated Osteopontin Facilitates
            Burn Wound Healing by Activating the MAPK Pathways.
REFERENCE   4  (bases 1 to 1503)
  AUTHORS   Chang,C.J., Lai,Y.J., Tung,Y.C., Wu,L.S., Hsu,L.A., Tseng,C.N.,
            Chang,G.J., Yang,K.C. and Yeh,Y.H.
  TITLE     Osteopontin mediation of disturbed flow-induced endothelial
            mesenchymal transition through CD44 is a novel mechanism of
            neointimal hyperplasia in arteriovenous fistulae for hemodialysis
            access
  JOURNAL   Kidney Int 103 (4), 702-718 (2023)
   PUBMED   36646166
  REMARK    GeneRIF: Osteopontin mediation of disturbed flow-induced
            endothelial mesenchymal transition through CD44 is a novel
            mechanism of neointimal hyperplasia in arteriovenous fistulae for
            hemodialysis access.
REFERENCE   5  (bases 1 to 1503)
  AUTHORS   Zhang,R., Wang,M., Lu,H., Wang,J., Han,X., Liu,Z., Li,L., Li,M.,
            Tian,X., Chen,S., Zhang,G., Xiong,Y. and Li,J.
  TITLE     A miR-340/SPP1 axis inhibits the activation and proliferation of
            hepatic stellate cells by inhibiting the TGF-beta1/Smads pathway
  JOURNAL   Adv Clin Exp Med 32 (4), 469-479 (2023)
   PUBMED   36413180
  REMARK    GeneRIF: A miR-340/SPP1 axis inhibits the activation and
            proliferation of hepatic stellate cells by inhibiting the
            TGF-beta1/Smads pathway.
REFERENCE   6  (bases 1 to 1503)
  AUTHORS   Singh,K., Mukherjee,A.B., De Vouge,M.W. and Mukherjee,B.B.
  TITLE     Differential processing of osteopontin transcripts in rat kidney-
            and osteoblast-derived cell lines
  JOURNAL   J Biol Chem 267 (33), 23847-23851 (1992)
   PUBMED   1429723
REFERENCE   7  (bases 1 to 1503)
  AUTHORS   Senger,D.R., Perruzzi,C.A., Papadopoulos,A. and Tenen,D.G.
  TITLE     Purification of a human milk protein closely similar to
            tumor-secreted phosphoproteins and osteopontin
  JOURNAL   Biochim Biophys Acta 996 (1-2), 43-48 (1989)
   PUBMED   2736258
REFERENCE   8  (bases 1 to 1503)
  AUTHORS   Senger,D.R., Perruzzi,C.A., Gracey,C.F., Papadopoulos,A. and
            Tenen,D.G.
  TITLE     Secreted phosphoproteins associated with neoplastic transformation:
            close homology with plasma proteins cleaved during blood
            coagulation
  JOURNAL   Cancer Res 48 (20), 5770-5774 (1988)
   PUBMED   3167835
REFERENCE   9  (bases 1 to 1503)
  AUTHORS   Prince,C.W., Oosawa,T., Butler,W.T., Tomana,M., Bhown,A.S.,
            Bhown,M. and Schrohenloher,R.E.
  TITLE     Isolation, characterization, and biosynthesis of a phosphorylated
            glycoprotein from rat bone
  JOURNAL   J Biol Chem 262 (6), 2900-2907 (1987)
   PUBMED   3469201
REFERENCE   10 (bases 1 to 1503)
  AUTHORS   Oldberg,A., Franzen,A. and Heinegard,D.
  TITLE     Cloning and sequence analysis of rat bone sialoprotein
            (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 8819-8823 (1986)
   PUBMED   3024151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV102664.1, BC078874.1 and BU759036.1.
            
            On Apr 12, 2007 this sequence version replaced NM_012881.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078874.1, FQ222192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16093045
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CV102664.1         1-20
            21-1095             BC078874.1         1-1075
            1096-1503           BU759036.1         1-408               c
FEATURES             Location/Qualifiers
     source          1..1503
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1503
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /note="secreted phosphoprotein 1"
                     /db_xref="GeneID:25353"
                     /db_xref="RGD:3752"
     exon            1..92
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
     exon            93..160
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1060
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /note="osteopontin; SPP-1; bone sialoprotein 1;
                     Sialoprotein (osteopontin); osteopontin-like"
                     /codon_start=1
                     /product="osteopontin precursor"
                     /protein_id="NP_037013.2"
                     /db_xref="GeneID:25353"
                     /db_xref="RGD:3752"
                     /translation="MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWL
                     KPDPSQKQNLLAPQNSVSSEETDDFKQETLPSNSNESHDHMDDDDDDDDDGDHAESED
                     SVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDVPDGRGDSLAYGLRSKSRSFP
                     VSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSHESSQLDEP
                     SVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEH
                     QSHEFHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN"
     exon            161..199
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
     exon            200..280
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
     exon            281..322
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
     exon            323..601
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1487
                     /gene="Spp1"
                     /gene_synonym="OSP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccaccag cagcaggact gaaggagcta agcctcagca tccttggctt tgcagtctcc
       61 tgcggcaagc attctcgagg aagccagcca aggaccaact acaaccatga gactggcagt
      121 ggtttgcttt tgcctgttcg gccttgcctc ctgtctcccg gtgaaagtgg ctgagtttgg
      181 cagctcagag gagaaggcgc attacagcaa acactcagat gctgtagcca cttggctgaa
      241 gcctgaccca tctcagaagc agaatcttct agccccacag aattctgtgt cctctgaaga
      301 aacggatgac tttaagcaag aaactcttcc aagcaactcc aatgaaagcc atgaccacat
      361 ggacgatgat gacgacgacg atgacgacgg agaccatgca gagagcgagg attctgtgaa
      421 ctcggatgaa tctgacgaat ctcaccattc cgatgaatct gatgagtcct tcactgccag
      481 cacacaagca gacgttttga ctccaatcgc ccccacagtc gatgtccctg acggccgagg
      541 tgatagcttg gcttacggac tgaggtcaaa gtccaggagt ttccctgttt ctgatgaaca
      601 gtatcccgat gccacagatg aggacctcac ctcccgcatg aagagccagg agtccgatga
      661 ggctatcaag gtcatcccag ttgcccagcg tctgagcgtg ccctctgatc aggacagcaa
      721 cgggaagacc agccatgagt caagtcagct ggatgaacca agcgtggaaa cacacagcct
      781 ggagcagtcc aaggagtata agcagagggc cagccacgag agcactgagc agtcggatgc
      841 gatcgatagt gccgagaagc cggatgcaat cgatagtgcg gagcggtcgg atgctatcga
      901 cagtcaggcg agttccaaag ccagcctgga acatcagagc cacgagtttc acagccatga
      961 ggacaagcta gtcctagacc ctaagagtaa ggaagatgat aggtatctga aattccgcat
     1021 ttctcatgaa ttagagagtt catcttctga ggtcaattaa agaagaggca aaaccacagt
     1081 tccttacttt gctttaaata aaaacaaaaa gtaaattcca acaagcagga atactaactg
     1141 cttgtttctc agttcagtgg atacatgtat gtggagaaag aaatagatag tgttttgggc
     1201 cctgagctta gttcgttgtt tcatgcagac accactgtaa cctagaagtt tcagcatttt
     1261 gcttctgttc tttctgtgca agaaatgcaa atggccactg cattttaatg attgctattc
     1321 ttttatgaat aaaatgtatg tagaggcagg caaacttaca ggaacagcaa aattaaaaga
     1381 gaaactgtaa tagtctgtgt cactataatc ttttggtttt ataattagtg tatattttgt
     1441 tgtgattatt tttgttggtg tgaataaatc ttgtatcttg aatgtaaaaa aaaaaaaaaa
     1501 aaa
//
